Sre-2/carboxylate carrier-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sre-2/carboxylate carrier-like protein

Species:

Leishmania major

UniProt:

Q4QJD4_LEIMA

TriTrypDb:

LmjF.05.0680 , LMJLV39_050011700 , LMJSD75_050012000

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	6
GO:0016020	membrane	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QJD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJD4

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	8
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006820	monoatomic anion transport	5	2
GO:0006865	amino acid transport	5	8
GO:0009987	cellular process	1	2
GO:0015711	organic anion transport	5	2
GO:0015804	neutral amino acid transport	6	2
GO:0015849	organic acid transport	5	8
GO:0032329	serine transport	6	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0046942	carboxylic acid transport	6	2
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8
GO:0098655	monoatomic cation transmembrane transport	4	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:0140300	serine import into mitochondrion	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2
GO:1990542	mitochondrial transmembrane transport	3	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0015175	neutral L-amino acid transmembrane transporter activity	6	2
GO:0022857	transmembrane transporter activity	2	8
GO:0022889	serine transmembrane transporter activity	5	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.329
CLV_C14_Caspase3-7	74	78	PF00656	0.522
CLV_NRD_NRD_1	283	285	PF00675	0.329
CLV_NRD_NRD_1	62	64	PF00675	0.385
CLV_PCSK_KEX2_1	283	285	PF00082	0.322
CLV_PCSK_KEX2_1	62	64	PF00082	0.329
CLV_PCSK_SKI1_1	124	128	PF00082	0.520
CLV_PCSK_SKI1_1	214	218	PF00082	0.514
CLV_PCSK_SKI1_1	41	45	PF00082	0.306
CLV_PCSK_SKI1_1	49	53	PF00082	0.279
CLV_PCSK_SKI1_1	92	96	PF00082	0.333
DEG_APCC_DBOX_1	213	221	PF00400	0.333
DEG_SPOP_SBC_1	182	186	PF00917	0.529
DOC_CKS1_1	119	124	PF01111	0.333
DOC_CYCLIN_RxL_1	27	38	PF00134	0.533
DOC_CYCLIN_yClb5_NLxxxL_5	106	115	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	261	264	PF00134	0.354
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.495
DOC_MAPK_DCC_7	252	261	PF00069	0.354
DOC_MAPK_gen_1	283	291	PF00069	0.497
DOC_MAPK_HePTP_8	281	293	PF00069	0.527
DOC_MAPK_MEF2A_6	252	261	PF00069	0.354
DOC_MAPK_MEF2A_6	283	291	PF00069	0.497
DOC_MAPK_NFAT4_5	284	292	PF00069	0.585
DOC_PP1_RVXF_1	273	280	PF00149	0.520
DOC_PP1_RVXF_1	28	35	PF00149	0.533
DOC_PP2B_LxvP_1	193	196	PF13499	0.407
DOC_PP2B_LxvP_1	261	264	PF13499	0.354
DOC_PP2B_LxvP_1	287	290	PF13499	0.495
DOC_SPAK_OSR1_1	278	282	PF12202	0.557
DOC_USP7_MATH_1	182	186	PF00917	0.549
DOC_USP7_MATH_1	22	26	PF00917	0.520
DOC_WW_Pin1_4	118	123	PF00397	0.295
DOC_WW_Pin1_4	2	7	PF00397	0.647
DOC_WW_Pin1_4	43	48	PF00397	0.533
LIG_14-3-3_CanoR_1	33	38	PF00244	0.551
LIG_14-3-3_CanoR_1	41	47	PF00244	0.514
LIG_14-3-3_CanoR_1	49	57	PF00244	0.494
LIG_14-3-3_CanoR_1	99	106	PF00244	0.495
LIG_Actin_WH2_2	204	220	PF00022	0.401
LIG_DCNL_PONY_1	1	4	PF03556	0.587
LIG_FHA_1	132	138	PF00498	0.289
LIG_FHA_1	272	278	PF00498	0.529
LIG_FHA_1	67	73	PF00498	0.585
LIG_FHA_2	225	231	PF00498	0.330
LIG_FHA_2	336	342	PF00498	0.387
LIG_FHA_2	7	13	PF00498	0.628
LIG_GBD_Chelix_1	296	304	PF00786	0.407
LIG_IRF3_LxIS_1	151	158	PF10401	0.329
LIG_LIR_Gen_1	64	75	PF02991	0.533
LIG_LIR_Nem_3	64	70	PF02991	0.533
LIG_MYND_1	93	97	PF01753	0.533
LIG_PCNA_yPIPBox_3	242	254	PF02747	0.295
LIG_PTB_Apo_2	129	136	PF02174	0.295
LIG_PTB_Apo_2	265	272	PF02174	0.407
LIG_PTB_Phospho_1	129	135	PF10480	0.295
LIG_REV1ctd_RIR_1	277	288	PF16727	0.520
LIG_SH2_CRK	197	201	PF00017	0.407
LIG_SH2_NCK_1	197	201	PF00017	0.407
LIG_SH2_SRC	75	78	PF00017	0.533
LIG_SH2_STAP1	197	201	PF00017	0.367
LIG_SH2_STAT5	141	144	PF00017	0.285
LIG_SH2_STAT5	159	162	PF00017	0.354
LIG_SH2_STAT5	197	200	PF00017	0.367
LIG_SH2_STAT5	75	78	PF00017	0.533
LIG_SH3_3	11	17	PF00018	0.704
LIG_SH3_3	219	225	PF00018	0.309
LIG_SH3_3	250	256	PF00018	0.334
LIG_SH3_3	299	305	PF00018	0.394
LIG_Sin3_3	187	194	PF02671	0.529
LIG_SUMO_SIM_anti_2	295	301	PF11976	0.388
LIG_SUMO_SIM_par_1	292	298	PF11976	0.407
LIG_TRAF2_1	9	12	PF00917	0.490
LIG_TYR_ITIM	195	200	PF00017	0.407
MOD_CDC14_SPxK_1	46	49	PF00782	0.585
MOD_CDK_SPxK_1	118	124	PF00069	0.295
MOD_CDK_SPxK_1	43	49	PF00069	0.533
MOD_CK1_1	118	124	PF00069	0.333
MOD_CK1_1	131	137	PF00069	0.333
MOD_CK1_1	178	184	PF00069	0.516
MOD_CK2_1	317	323	PF00069	0.295
MOD_CK2_1	335	341	PF00069	0.295
MOD_CK2_1	6	12	PF00069	0.688
MOD_GlcNHglycan	100	103	PF01048	0.306
MOD_GlcNHglycan	144	147	PF01048	0.495
MOD_GlcNHglycan	177	180	PF01048	0.390
MOD_GlcNHglycan	185	188	PF01048	0.343
MOD_GlcNHglycan	236	239	PF01048	0.558
MOD_GlcNHglycan	89	92	PF01048	0.332
MOD_GSK3_1	162	169	PF00069	0.397
MOD_GSK3_1	171	178	PF00069	0.336
MOD_GSK3_1	2	9	PF00069	0.629
MOD_GSK3_1	35	42	PF00069	0.482
MOD_N-GLC_1	131	136	PF02516	0.495
MOD_N-GLC_1	142	147	PF02516	0.495
MOD_N-GLC_2	110	112	PF02516	0.407
MOD_N-GLC_2	140	142	PF02516	0.495
MOD_NEK2_1	155	160	PF00069	0.328
MOD_NEK2_1	180	185	PF00069	0.541
MOD_NEK2_1	322	327	PF00069	0.346
MOD_NEK2_1	98	103	PF00069	0.518
MOD_NEK2_2	66	71	PF00069	0.585
MOD_PIKK_1	115	121	PF00454	0.407
MOD_PKA_2	98	104	PF00069	0.494
MOD_Plk_1	131	137	PF00069	0.295
MOD_Plk_1	22	28	PF00069	0.550
MOD_Plk_1	322	328	PF00069	0.385
MOD_Plk_1	6	12	PF00069	0.632
MOD_Plk_4	292	298	PF00069	0.407
MOD_Plk_4	312	318	PF00069	0.149
MOD_ProDKin_1	118	124	PF00069	0.295
MOD_ProDKin_1	2	8	PF00069	0.635
MOD_ProDKin_1	43	49	PF00069	0.533
MOD_SUMO_rev_2	230	237	PF00179	0.329
TRG_ENDOCYTIC_2	197	200	PF00928	0.407
TRG_ER_diArg_1	79	82	PF00400	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P786	Leptomonas seymouri	76%	100%
A0A0N1I4E4	Leptomonas seymouri	29%	100%
A0A0S4IJR6	Bodo saltans	44%	100%
A0A1X0P3C3	Trypanosomatidae	30%	100%
A0A3R7KD90	Trypanosoma rangeli	30%	100%
A0A3S5H4W1	Leishmania donovani	29%	100%
A0A3S5H5J2	Leishmania donovani	97%	100%
A4H380	Leishmania braziliensis	29%	100%
A4H4B2	Leishmania braziliensis	87%	100%
A4HRI0	Leishmania infantum	29%	100%
A4HSJ0	Leishmania infantum	97%	100%
A5A761	Sus scrofa	33%	100%
A6QP55	Bos taurus	32%	100%
A8E7G5	Danio rerio	25%	100%
B2LU20	Ovis aries	33%	100%
C9ZXK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AC48	Leishmania major	29%	98%
E9AJE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AKH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O13793	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q09201	Caenorhabditis elegans	31%	100%
Q12029	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q3T0M2	Bos taurus	26%	100%
Q54NQ9	Dictyostelium discoideum	33%	100%
Q5E9M8	Bos taurus	33%	100%
Q5EA43	Bos taurus	32%	100%
Q5FC79	Caenorhabditis elegans	32%	100%
Q5RD16	Pongo abelii	33%	100%
Q63965	Rattus norvegicus	33%	100%
Q6P4A7	Homo sapiens	24%	100%
Q8CFD0	Rattus norvegicus	33%	100%
Q8TD22	Homo sapiens	33%	100%
Q91V61	Mus musculus	34%	100%
Q925N0	Mus musculus	33%	100%
Q925N1	Mus musculus	22%	100%
Q925N2	Mus musculus	30%	100%
Q96NB2	Homo sapiens	31%	100%
Q99JR1	Mus musculus	33%	100%
Q9BWM7	Homo sapiens	32%	100%
Q9H9B4	Homo sapiens	33%	100%
Q9JHY2	Rattus norvegicus	33%	100%
Q9VN13	Drosophila melanogaster	30%	100%
Q9VVW3	Drosophila melanogaster	29%	100%
V5BCG0	Trypanosoma cruzi	30%	100%