Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJC9_LEIMA

TriTrypDb:

LmjF.05.0730 , LMJLV39_050012200 , LMJSD75_050012500

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.649
CLV_NRD_NRD_1	118	120	PF00675	0.688
CLV_NRD_NRD_1	305	307	PF00675	0.627
CLV_NRD_NRD_1	391	393	PF00675	0.720
CLV_NRD_NRD_1	432	434	PF00675	0.623
CLV_NRD_NRD_1	549	551	PF00675	0.811
CLV_NRD_NRD_1	576	578	PF00675	0.631
CLV_NRD_NRD_1	611	613	PF00675	0.497
CLV_PCSK_FUR_1	704	708	PF00082	0.516
CLV_PCSK_KEX2_1	118	120	PF00082	0.688
CLV_PCSK_KEX2_1	305	307	PF00082	0.627
CLV_PCSK_KEX2_1	391	393	PF00082	0.714
CLV_PCSK_KEX2_1	432	434	PF00082	0.615
CLV_PCSK_KEX2_1	548	550	PF00082	0.747
CLV_PCSK_KEX2_1	576	578	PF00082	0.622
CLV_PCSK_KEX2_1	610	612	PF00082	0.498
CLV_PCSK_KEX2_1	706	708	PF00082	0.518
CLV_PCSK_PC1ET2_1	706	708	PF00082	0.494
CLV_PCSK_SKI1_1	171	175	PF00082	0.645
CLV_PCSK_SKI1_1	34	38	PF00082	0.510
CLV_PCSK_SKI1_1	611	615	PF00082	0.530
CLV_PCSK_SKI1_1	707	711	PF00082	0.619
DEG_APCC_DBOX_1	33	41	PF00400	0.506
DEG_SCF_FBW7_1	521	528	PF00400	0.696
DEG_SPOP_SBC_1	178	182	PF00917	0.780
DEG_SPOP_SBC_1	204	208	PF00917	0.666
DOC_CKS1_1	132	137	PF01111	0.611
DOC_CKS1_1	522	527	PF01111	0.694
DOC_CYCLIN_RxL_1	608	617	PF00134	0.465
DOC_MAPK_gen_1	234	241	PF00069	0.679
DOC_MAPK_MEF2A_6	677	686	PF00069	0.523
DOC_PP1_RVXF_1	712	718	PF00149	0.498
DOC_PP2B_LxvP_1	284	287	PF13499	0.616
DOC_PP2B_LxvP_1	366	369	PF13499	0.645
DOC_USP7_MATH_1	178	182	PF00917	0.667
DOC_USP7_MATH_1	353	357	PF00917	0.659
DOC_USP7_MATH_1	427	431	PF00917	0.749
DOC_USP7_MATH_1	445	449	PF00917	0.706
DOC_USP7_MATH_1	477	481	PF00917	0.702
DOC_USP7_MATH_1	484	488	PF00917	0.660
DOC_USP7_MATH_1	621	625	PF00917	0.510
DOC_USP7_UBL2_3	706	710	PF12436	0.498
DOC_WW_Pin1_4	131	136	PF00397	0.706
DOC_WW_Pin1_4	209	214	PF00397	0.671
DOC_WW_Pin1_4	239	244	PF00397	0.693
DOC_WW_Pin1_4	266	271	PF00397	0.837
DOC_WW_Pin1_4	299	304	PF00397	0.580
DOC_WW_Pin1_4	351	356	PF00397	0.698
DOC_WW_Pin1_4	358	363	PF00397	0.704
DOC_WW_Pin1_4	466	471	PF00397	0.665
DOC_WW_Pin1_4	47	52	PF00397	0.522
DOC_WW_Pin1_4	521	526	PF00397	0.733
DOC_WW_Pin1_4	56	61	PF00397	0.641
DOC_WW_Pin1_4	577	582	PF00397	0.664
DOC_WW_Pin1_4	589	594	PF00397	0.458
DOC_WW_Pin1_4	730	735	PF00397	0.707
DOC_WW_Pin1_4	85	90	PF00397	0.636
LIG_14-3-3_CanoR_1	183	193	PF00244	0.836
LIG_14-3-3_CanoR_1	343	353	PF00244	0.656
LIG_14-3-3_CanoR_1	433	439	PF00244	0.621
LIG_14-3-3_CanoR_1	457	466	PF00244	0.690
LIG_14-3-3_CanoR_1	549	559	PF00244	0.721
LIG_14-3-3_CanoR_1	576	580	PF00244	0.592
LIG_14-3-3_CanoR_1	697	705	PF00244	0.601
LIG_Actin_WH2_2	705	722	PF00022	0.505
LIG_APCC_ABBAyCdc20_2	601	607	PF00400	0.404
LIG_BH_BH3_1	59	75	PF00452	0.412
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_EVH1_1	366	370	PF00568	0.618
LIG_FHA_1	184	190	PF00498	0.772
LIG_FHA_1	23	29	PF00498	0.490
LIG_FHA_1	522	528	PF00498	0.652
LIG_FHA_1	629	635	PF00498	0.626
LIG_FHA_2	205	211	PF00498	0.652
LIG_FHA_2	60	66	PF00498	0.416
LIG_FHA_2	656	662	PF00498	0.546
LIG_FHA_2	671	677	PF00498	0.310
LIG_LIR_Gen_1	38	45	PF02991	0.434
LIG_LIR_Gen_1	695	705	PF02991	0.550
LIG_LIR_Nem_3	38	44	PF02991	0.480
LIG_LIR_Nem_3	695	701	PF02991	0.563
LIG_NRBOX	62	68	PF00104	0.466
LIG_PCNA_yPIPBox_3	697	709	PF02747	0.534
LIG_PDZ_Class_1	733	738	PF00595	0.577
LIG_SH2_CRK	176	180	PF00017	0.675
LIG_SH2_CRK	698	702	PF00017	0.543
LIG_SH2_STAP1	205	209	PF00017	0.654
LIG_SH2_STAT5	205	208	PF00017	0.682
LIG_SH2_STAT5	43	46	PF00017	0.474
LIG_SH2_STAT5	523	526	PF00017	0.645
LIG_SH2_STAT5	633	636	PF00017	0.618
LIG_SH2_STAT5	698	701	PF00017	0.544
LIG_SH3_1	265	271	PF00018	0.647
LIG_SH3_3	120	126	PF00018	0.670
LIG_SH3_3	265	271	PF00018	0.702
LIG_SH3_3	295	301	PF00018	0.685
LIG_SH3_3	364	370	PF00018	0.656
LIG_SH3_3	486	492	PF00018	0.695
LIG_SH3_3	519	525	PF00018	0.697
LIG_SH3_3	555	561	PF00018	0.667
LIG_SH3_4	171	178	PF00018	0.671
LIG_SH3_CIN85_PxpxPR_1	225	230	PF14604	0.677
LIG_SxIP_EBH_1	481	491	PF03271	0.553
LIG_TRAF2_1	308	311	PF00917	0.542
LIG_TRAF2_1	659	662	PF00917	0.527
LIG_TYR_ITIM	174	179	PF00017	0.654
LIG_WW_1	202	205	PF00397	0.564
MOD_CDC14_SPxK_1	302	305	PF00782	0.571
MOD_CDK_SPK_2	131	136	PF00069	0.604
MOD_CDK_SPxK_1	299	305	PF00069	0.576
MOD_CDK_SPxK_1	525	531	PF00069	0.693
MOD_CDK_SPxxK_3	299	306	PF00069	0.573
MOD_CK1_1	139	145	PF00069	0.730
MOD_CK1_1	158	164	PF00069	0.784
MOD_CK1_1	181	187	PF00069	0.805
MOD_CK1_1	208	214	PF00069	0.678
MOD_CK1_1	22	28	PF00069	0.455
MOD_CK1_1	266	272	PF00069	0.661
MOD_CK1_1	333	339	PF00069	0.654
MOD_CK1_1	354	360	PF00069	0.619
MOD_CK1_1	380	386	PF00069	0.716
MOD_CK1_1	4	10	PF00069	0.582
MOD_CK1_1	402	408	PF00069	0.768
MOD_CK1_1	413	419	PF00069	0.737
MOD_CK1_1	440	446	PF00069	0.721
MOD_CK1_1	460	466	PF00069	0.652
MOD_CK1_1	482	488	PF00069	0.810
MOD_CK1_1	59	65	PF00069	0.501
MOD_CK1_1	592	598	PF00069	0.646
MOD_CK2_1	134	140	PF00069	0.727
MOD_CK2_1	47	53	PF00069	0.556
MOD_CK2_1	564	570	PF00069	0.675
MOD_CK2_1	59	65	PF00069	0.525
MOD_CK2_1	655	661	PF00069	0.551
MOD_CK2_1	670	676	PF00069	0.310
MOD_CK2_1	90	96	PF00069	0.667
MOD_Cter_Amidation	430	433	PF01082	0.581
MOD_DYRK1A_RPxSP_1	589	593	PF00069	0.553
MOD_DYRK1A_RPxSP_1	730	734	PF00069	0.647
MOD_GlcNHglycan	156	160	PF01048	0.683
MOD_GlcNHglycan	207	210	PF01048	0.713
MOD_GlcNHglycan	253	256	PF01048	0.684
MOD_GlcNHglycan	271	274	PF01048	0.524
MOD_GlcNHglycan	325	328	PF01048	0.595
MOD_GlcNHglycan	332	335	PF01048	0.551
MOD_GlcNHglycan	346	349	PF01048	0.611
MOD_GlcNHglycan	394	397	PF01048	0.833
MOD_GlcNHglycan	412	415	PF01048	0.706
MOD_GlcNHglycan	429	432	PF01048	0.667
MOD_GlcNHglycan	452	455	PF01048	0.749
MOD_GlcNHglycan	581	584	PF01048	0.655
MOD_GlcNHglycan	735	738	PF01048	0.624
MOD_GlcNHglycan	99	102	PF01048	0.607
MOD_GSK3_1	155	162	PF00069	0.734
MOD_GSK3_1	177	184	PF00069	0.732
MOD_GSK3_1	19	26	PF00069	0.450
MOD_GSK3_1	204	211	PF00069	0.692
MOD_GSK3_1	288	295	PF00069	0.652
MOD_GSK3_1	351	358	PF00069	0.747
MOD_GSK3_1	400	407	PF00069	0.829
MOD_GSK3_1	436	443	PF00069	0.762
MOD_GSK3_1	445	452	PF00069	0.717
MOD_GSK3_1	457	464	PF00069	0.704
MOD_GSK3_1	479	486	PF00069	0.748
MOD_GSK3_1	511	518	PF00069	0.726
MOD_GSK3_1	521	528	PF00069	0.632
MOD_GSK3_1	560	567	PF00069	0.745
MOD_GSK3_1	575	582	PF00069	0.536
MOD_GSK3_1	628	635	PF00069	0.623
MOD_GSK3_1	696	703	PF00069	0.588
MOD_GSK3_1	726	733	PF00069	0.652
MOD_N-GLC_1	234	239	PF02516	0.643
MOD_N-GLC_1	563	568	PF02516	0.682
MOD_NEK2_1	179	184	PF00069	0.679
MOD_NEK2_1	219	224	PF00069	0.594
MOD_NEK2_1	23	28	PF00069	0.480
MOD_NEK2_1	459	464	PF00069	0.681
MOD_NEK2_1	632	637	PF00069	0.640
MOD_NEK2_1	680	685	PF00069	0.479
MOD_NEK2_2	628	633	PF00069	0.601
MOD_PIKK_1	213	219	PF00454	0.659
MOD_PIKK_1	511	517	PF00454	0.688
MOD_PIKK_1	552	558	PF00454	0.731
MOD_PIKK_1	564	570	PF00454	0.631
MOD_PIKK_1	621	627	PF00454	0.504
MOD_PIKK_1	670	676	PF00454	0.505
MOD_PIKK_1	696	702	PF00454	0.569
MOD_PIKK_1	728	734	PF00454	0.539
MOD_PK_1	185	191	PF00069	0.673
MOD_PKA_1	391	397	PF00069	0.719
MOD_PKA_2	114	120	PF00069	0.646
MOD_PKA_2	142	148	PF00069	0.687
MOD_PKA_2	184	190	PF00069	0.828
MOD_PKA_2	338	344	PF00069	0.647
MOD_PKA_2	391	397	PF00069	0.721
MOD_PKA_2	400	406	PF00069	0.720
MOD_PKA_2	530	536	PF00069	0.810
MOD_PKA_2	575	581	PF00069	0.594
MOD_PKA_2	696	702	PF00069	0.617
MOD_PKA_2	726	732	PF00069	0.571
MOD_PKB_1	183	191	PF00069	0.674
MOD_PKB_1	548	556	PF00069	0.648
MOD_Plk_1	19	25	PF00069	0.357
MOD_Plk_1	4	10	PF00069	0.503
MOD_Plk_1	564	570	PF00069	0.675
MOD_Plk_1	655	661	PF00069	0.520
MOD_Plk_1	680	686	PF00069	0.485
MOD_Plk_4	185	191	PF00069	0.721
MOD_Plk_4	23	29	PF00069	0.442
MOD_Plk_4	377	383	PF00069	0.670
MOD_Plk_4	4	10	PF00069	0.510
MOD_Plk_4	569	575	PF00069	0.660
MOD_Plk_4	628	634	PF00069	0.621
MOD_ProDKin_1	131	137	PF00069	0.708
MOD_ProDKin_1	209	215	PF00069	0.667
MOD_ProDKin_1	239	245	PF00069	0.689
MOD_ProDKin_1	266	272	PF00069	0.833
MOD_ProDKin_1	299	305	PF00069	0.582
MOD_ProDKin_1	351	357	PF00069	0.702
MOD_ProDKin_1	358	364	PF00069	0.704
MOD_ProDKin_1	466	472	PF00069	0.665
MOD_ProDKin_1	47	53	PF00069	0.527
MOD_ProDKin_1	521	527	PF00069	0.733
MOD_ProDKin_1	56	62	PF00069	0.635
MOD_ProDKin_1	577	583	PF00069	0.661
MOD_ProDKin_1	589	595	PF00069	0.450
MOD_ProDKin_1	730	736	PF00069	0.716
MOD_ProDKin_1	85	91	PF00069	0.639
MOD_SUMO_rev_2	319	324	PF00179	0.554
TRG_DiLeu_BaEn_2	593	599	PF01217	0.560
TRG_DiLeu_BaEn_4	310	316	PF01217	0.543
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.593
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.427
TRG_ENDOCYTIC_2	176	179	PF00928	0.725
TRG_ENDOCYTIC_2	41	44	PF00928	0.492
TRG_ENDOCYTIC_2	698	701	PF00928	0.544
TRG_ER_diArg_1	13	16	PF00400	0.501
TRG_ER_diArg_1	227	230	PF00400	0.695
TRG_ER_diArg_1	233	236	PF00400	0.623
TRG_ER_diArg_1	390	392	PF00400	0.737
TRG_ER_diArg_1	548	550	PF00400	0.747
TRG_ER_diArg_1	610	612	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	611	616	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WP68	Leishmania donovani	91%	100%
A4H4B6	Leishmania braziliensis	48%	97%
A4HSJ5	Leishmania infantum	90%	100%
E9AKH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%