Vta1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vta1 like, putative

Species:

Leishmania major

UniProt:

Q4QJC8_LEIMA

TriTrypDb:

LmjF.05.0740 , LMJLV39_050012300 , LMJSD75_050012600

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0005770	late endosome	8	2
GO:0005771	multivesicular body	9	2
GO:0010008	endosome membrane	5	8
GO:0012506	vesicle membrane	4	8
GO:0016020	membrane	2	8
GO:0030659	cytoplasmic vesicle membrane	5	8
GO:0031090	organelle membrane	3	8
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2

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Expansion

Sequence features

Q4QJC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJC8

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0007034	vacuolar transport	4	8
GO:0008104	protein localization	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0016192	vesicle-mediated transport	4	8
GO:0016197	endosomal transport	4	8
GO:0032509	endosome transport via multivesicular body sorting pathway	5	8
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	8
GO:0033036	macromolecule localization	2	8

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.447
CLV_C14_Caspase3-7	65	69	PF00656	0.572
CLV_PCSK_SKI1_1	146	150	PF00082	0.337
CLV_PCSK_SKI1_1	156	160	PF00082	0.197
CLV_PCSK_SKI1_1	20	24	PF00082	0.294
CLV_PCSK_SKI1_1	87	91	PF00082	0.302
CLV_PCSK_SKI1_1	92	96	PF00082	0.284
DEG_COP1_1	287	295	PF00400	0.741
DOC_CKS1_1	240	245	PF01111	0.705
DOC_CKS1_1	247	252	PF01111	0.615

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8N6	Leptomonas seymouri	55%	98%
A0A0S4IWD6	Bodo saltans	42%	100%
A0A3S5H5J7	Leishmania donovani	92%	100%
A4H4B7	Leishmania braziliensis	73%	99%
A4HSJ6	Leishmania infantum	92%	100%
E9AKI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q32L63	Bos taurus	27%	100%
Q5R5W5	Pongo abelii	25%	100%
Q9CR26	Mus musculus	28%	100%
Q9NP79	Homo sapiens	25%	100%

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