Vta1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vta1 like, putative

Species:

Leishmania major

UniProt:

Q4QJC8_LEIMA

TriTrypDb:

LmjF.05.0740 , LMJLV39_050012300 , LMJSD75_050012600

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0005770	late endosome	8	2
GO:0005771	multivesicular body	9	2
GO:0010008	endosome membrane	5	8
GO:0012506	vesicle membrane	4	8
GO:0016020	membrane	2	8
GO:0030659	cytoplasmic vesicle membrane	5	8
GO:0031090	organelle membrane	3	8
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0098588	bounding membrane of organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QJC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJC8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0007034	vacuolar transport	4	8
GO:0008104	protein localization	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0016192	vesicle-mediated transport	4	8
GO:0016197	endosomal transport	4	8
GO:0032509	endosome transport via multivesicular body sorting pathway	5	8
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	8
GO:0033036	macromolecule localization	2	8
GO:0045184	establishment of protein localization	3	8
GO:0045324	late endosome to vacuole transport	5	8
GO:0046907	intracellular transport	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0051649	establishment of localization in cell	3	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8
GO:0071985	multivesicular body sorting pathway	5	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.447
CLV_C14_Caspase3-7	65	69	PF00656	0.572
CLV_PCSK_SKI1_1	146	150	PF00082	0.337
CLV_PCSK_SKI1_1	156	160	PF00082	0.197
CLV_PCSK_SKI1_1	20	24	PF00082	0.294
CLV_PCSK_SKI1_1	87	91	PF00082	0.302
CLV_PCSK_SKI1_1	92	96	PF00082	0.284
DEG_COP1_1	287	295	PF00400	0.741
DOC_CKS1_1	240	245	PF01111	0.705
DOC_CKS1_1	247	252	PF01111	0.615
DOC_CKS1_1	296	301	PF01111	0.592
DOC_PP4_FxxP_1	202	205	PF00568	0.747
DOC_USP7_MATH_1	142	146	PF00917	0.557
DOC_USP7_MATH_1	291	295	PF00917	0.800
DOC_USP7_MATH_1	297	301	PF00917	0.708
DOC_USP7_MATH_1	307	311	PF00917	0.700
DOC_USP7_UBL2_3	157	161	PF12436	0.541
DOC_WW_Pin1_4	164	169	PF00397	0.568
DOC_WW_Pin1_4	239	244	PF00397	0.711
DOC_WW_Pin1_4	246	251	PF00397	0.729
DOC_WW_Pin1_4	257	262	PF00397	0.570
DOC_WW_Pin1_4	295	300	PF00397	0.665
LIG_14-3-3_CanoR_1	116	125	PF00244	0.536
LIG_14-3-3_CanoR_1	204	209	PF00244	0.671
LIG_BIR_III_4	177	181	PF00653	0.758
LIG_BRCT_BRCA1_1	121	125	PF00533	0.520
LIG_BRCT_BRCA1_1	25	29	PF00533	0.536
LIG_eIF4E_1	119	125	PF01652	0.494
LIG_EVH1_1	295	299	PF00568	0.552
LIG_FHA_1	118	124	PF00498	0.539
LIG_FHA_1	235	241	PF00498	0.662
LIG_FHA_1	58	64	PF00498	0.498
LIG_FHA_2	171	177	PF00498	0.570
LIG_FHA_2	219	225	PF00498	0.816
LIG_FHA_2	63	69	PF00498	0.604
LIG_LIR_Apic_2	163	168	PF02991	0.563
LIG_LIR_Apic_2	200	205	PF02991	0.745
LIG_LIR_Apic_2	270	274	PF02991	0.584
LIG_LIR_Gen_1	91	101	PF02991	0.536
LIG_LIR_Nem_3	145	150	PF02991	0.479
LIG_MYND_1	293	297	PF01753	0.709
LIG_NRBOX	62	68	PF00104	0.536
LIG_SH2_CRK	231	235	PF00017	0.756
LIG_SH2_CRK	271	275	PF00017	0.721
LIG_SH2_CRK	306	310	PF00017	0.611
LIG_SH2_GRB2like	347	350	PF00017	0.520
LIG_SH2_NCK_1	231	235	PF00017	0.756
LIG_SH2_NCK_1	271	275	PF00017	0.721
LIG_SH2_NCK_1	306	310	PF00017	0.611
LIG_SH2_PTP2	165	168	PF00017	0.556
LIG_SH2_SRC	231	234	PF00017	0.615
LIG_SH2_SRC	271	274	PF00017	0.722
LIG_SH2_SRC	347	350	PF00017	0.520
LIG_SH2_STAP1	119	123	PF00017	0.497
LIG_SH2_STAP1	147	151	PF00017	0.494
LIG_SH2_STAT5	119	122	PF00017	0.539
LIG_SH2_STAT5	150	153	PF00017	0.494
LIG_SH2_STAT5	165	168	PF00017	0.556
LIG_SH2_STAT5	39	42	PF00017	0.497
LIG_SH3_3	224	230	PF00018	0.762
LIG_SH3_3	240	246	PF00018	0.532
LIG_SH3_3	258	264	PF00018	0.650
LIG_SH3_3	270	276	PF00018	0.710
LIG_SH3_3	290	296	PF00018	0.682
LIG_SH3_3	8	14	PF00018	0.566
LIG_UBA3_1	66	74	PF00899	0.504
MOD_CDC14_SPxK_1	167	170	PF00782	0.664
MOD_CDC14_SPxK_1	265	268	PF00782	0.610
MOD_CDK_SPxK_1	164	170	PF00069	0.651
MOD_CDK_SPxK_1	262	268	PF00069	0.607
MOD_CK1_1	207	213	PF00069	0.690
MOD_CK1_1	287	293	PF00069	0.759
MOD_CK1_1	3	9	PF00069	0.507
MOD_CK2_1	218	224	PF00069	0.721
MOD_CK2_1	3	9	PF00069	0.575
MOD_DYRK1A_RPxSP_1	257	261	PF00069	0.689
MOD_GlcNHglycan	289	292	PF01048	0.804
MOD_GlcNHglycan	3	6	PF01048	0.546
MOD_GlcNHglycan	300	303	PF01048	0.735
MOD_GlcNHglycan	310	313	PF01048	0.797
MOD_GlcNHglycan	339	342	PF01048	0.336
MOD_GSK3_1	104	111	PF00069	0.538
MOD_GSK3_1	125	132	PF00069	0.541
MOD_GSK3_1	189	196	PF00069	0.694
MOD_GSK3_1	203	210	PF00069	0.660
MOD_GSK3_1	251	258	PF00069	0.740
MOD_GSK3_1	287	294	PF00069	0.805
MOD_GSK3_1	333	340	PF00069	0.536
MOD_N-GLC_1	108	113	PF02516	0.391
MOD_NEK2_1	1	6	PF00069	0.498
MOD_NEK2_1	117	122	PF00069	0.508
MOD_NEK2_1	125	130	PF00069	0.476
MOD_NEK2_1	267	272	PF00069	0.615
MOD_NEK2_1	286	291	PF00069	0.787
MOD_NEK2_1	354	359	PF00069	0.541
MOD_NEK2_1	62	67	PF00069	0.536
MOD_NEK2_1	70	75	PF00069	0.536
MOD_PIKK_1	204	210	PF00454	0.707
MOD_PIKK_1	234	240	PF00454	0.710
MOD_PIKK_1	251	257	PF00454	0.677
MOD_PIKK_1	277	283	PF00454	0.725
MOD_PIKK_1	333	339	PF00454	0.612
MOD_PKA_2	203	209	PF00069	0.665
MOD_Plk_1	108	114	PF00069	0.591
MOD_Plk_4	119	125	PF00069	0.539
MOD_Plk_4	3	9	PF00069	0.560
MOD_Plk_4	62	68	PF00069	0.549
MOD_ProDKin_1	164	170	PF00069	0.579
MOD_ProDKin_1	239	245	PF00069	0.708
MOD_ProDKin_1	246	252	PF00069	0.731
MOD_ProDKin_1	257	263	PF00069	0.567
MOD_ProDKin_1	295	301	PF00069	0.667
MOD_SUMO_rev_2	26	34	PF00179	0.591
TRG_ER_diArg_1	49	52	PF00400	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8N6	Leptomonas seymouri	55%	98%
A0A0S4IWD6	Bodo saltans	42%	100%
A0A3S5H5J7	Leishmania donovani	92%	100%
A4H4B7	Leishmania braziliensis	73%	99%
A4HSJ6	Leishmania infantum	92%	100%
E9AKI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q32L63	Bos taurus	27%	100%
Q5R5W5	Pongo abelii	25%	100%
Q9CR26	Mus musculus	28%	100%
Q9NP79	Homo sapiens	25%	100%