Mitochondrial glyco protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial glycoprotein, putative

Species:

Leishmania major

UniProt:

Q4QJC3_LEIMA

TriTrypDb:

LmjF.05.0790 , LMJLV39_050012800 , LMJSD75_050013100

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QJC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.620
CLV_C14_Caspase3-7	211	215	PF00656	0.533
CLV_C14_Caspase3-7	289	293	PF00656	0.465
CLV_C14_Caspase3-7	341	345	PF00656	0.435
CLV_NRD_NRD_1	145	147	PF00675	0.390
CLV_NRD_NRD_1	27	29	PF00675	0.672
CLV_NRD_NRD_1	3	5	PF00675	0.727
CLV_PCSK_FUR_1	25	29	PF00082	0.573
CLV_PCSK_KEX2_1	145	147	PF00082	0.390
CLV_PCSK_KEX2_1	27	29	PF00082	0.672
CLV_PCSK_KEX2_1	3	5	PF00082	0.734
CLV_PCSK_SKI1_1	109	113	PF00082	0.500
CLV_PCSK_SKI1_1	192	196	PF00082	0.664
CLV_PCSK_SKI1_1	203	207	PF00082	0.468
CLV_PCSK_SKI1_1	88	92	PF00082	0.542
DEG_Kelch_Keap1_1	252	257	PF01344	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DEG_SPOP_SBC_1	152	156	PF00917	0.613
DEG_SPOP_SBC_1	312	316	PF00917	0.532
DEG_SPOP_SBC_1	33	37	PF00917	0.578
DOC_MAPK_DCC_7	120	129	PF00069	0.532
DOC_MAPK_MEF2A_6	120	129	PF00069	0.532
DOC_MAPK_MEF2A_6	203	210	PF00069	0.362
DOC_PP2B_LxvP_1	147	150	PF13499	0.453
DOC_PP4_MxPP_1	149	152	PF00568	0.532
DOC_USP7_MATH_1	153	157	PF00917	0.647
DOC_USP7_MATH_1	174	178	PF00917	0.586
DOC_USP7_MATH_1	262	266	PF00917	0.619
DOC_USP7_MATH_1	313	317	PF00917	0.579
DOC_USP7_MATH_1	33	37	PF00917	0.725
DOC_USP7_MATH_1	99	103	PF00917	0.432
DOC_USP7_UBL2_3	105	109	PF12436	0.380
DOC_WW_Pin1_4	156	161	PF00397	0.641
DOC_WW_Pin1_4	16	21	PF00397	0.721
DOC_WW_Pin1_4	48	53	PF00397	0.637
LIG_14-3-3_CanoR_1	207	217	PF00244	0.402
LIG_14-3-3_CanoR_1	3	7	PF00244	0.670
LIG_14-3-3_CanoR_1	45	53	PF00244	0.644
LIG_CSL_BTD_1	147	150	PF09270	0.392
LIG_EH_1	324	328	PF12763	0.530
LIG_FHA_1	137	143	PF00498	0.503
LIG_FHA_2	209	215	PF00498	0.393
LIG_LIR_Gen_1	202	210	PF02991	0.498
LIG_LIR_Nem_3	202	208	PF02991	0.494
LIG_LIR_Nem_3	324	330	PF02991	0.504
LIG_PDZ_Class_2	383	388	PF00595	0.435
LIG_Pex14_2	228	232	PF04695	0.412
LIG_REV1ctd_RIR_1	230	238	PF16727	0.436
LIG_SH2_CRK	302	306	PF00017	0.479
LIG_SH2_CRK	323	327	PF00017	0.448
LIG_SH2_GRB2like	280	283	PF00017	0.429
LIG_SH2_GRB2like	323	326	PF00017	0.490
LIG_SH2_NCK_1	323	327	PF00017	0.465
LIG_SH2_STAP1	366	370	PF00017	0.435
LIG_SH2_STAP1	375	379	PF00017	0.435
LIG_SH2_STAT5	323	326	PF00017	0.479
LIG_SH2_STAT5	385	388	PF00017	0.601
LIG_SH3_1	302	308	PF00018	0.454
LIG_SH3_3	122	128	PF00018	0.438
LIG_SH3_3	147	153	PF00018	0.444
LIG_SH3_3	302	308	PF00018	0.554
LIG_TRAF2_1	178	181	PF00917	0.627
LIG_TRAF2_1	273	276	PF00917	0.468
LIG_TRAF2_1	338	341	PF00917	0.446
MOD_CK1_1	154	160	PF00069	0.620
MOD_CK1_1	161	167	PF00069	0.634
MOD_CK1_1	252	258	PF00069	0.607
MOD_CK2_1	175	181	PF00069	0.625
MOD_CK2_1	251	257	PF00069	0.769
MOD_CK2_1	270	276	PF00069	0.364
MOD_CK2_1	91	97	PF00069	0.638
MOD_Cter_Amidation	143	146	PF01082	0.360
MOD_GlcNHglycan	163	166	PF01048	0.703
MOD_GlcNHglycan	243	248	PF01048	0.655
MOD_GlcNHglycan	254	257	PF01048	0.629
MOD_GlcNHglycan	315	318	PF01048	0.317
MOD_GlcNHglycan	53	56	PF01048	0.638
MOD_GlcNHglycan	88	91	PF01048	0.620
MOD_GlcNHglycan	93	96	PF01048	0.570
MOD_GSK3_1	151	158	PF00069	0.620
MOD_GSK3_1	175	182	PF00069	0.752
MOD_GSK3_1	209	216	PF00069	0.431
MOD_GSK3_1	248	255	PF00069	0.653
MOD_GSK3_1	258	265	PF00069	0.667
MOD_GSK3_1	307	314	PF00069	0.516
MOD_GSK3_1	47	54	PF00069	0.634
MOD_NEK2_1	129	134	PF00069	0.406
MOD_NEK2_1	2	7	PF00069	0.591
MOD_NEK2_1	34	39	PF00069	0.649
MOD_NEK2_1	41	46	PF00069	0.613
MOD_PIKK_1	176	182	PF00454	0.623
MOD_PIKK_1	262	268	PF00454	0.584
MOD_PKA_2	174	180	PF00069	0.564
MOD_PKA_2	2	8	PF00069	0.681
MOD_PKA_2	252	258	PF00069	0.596
MOD_PKA_2	321	327	PF00069	0.507
MOD_Plk_1	213	219	PF00069	0.547
MOD_Plk_1	275	281	PF00069	0.438
MOD_Plk_1	99	105	PF00069	0.420
MOD_Plk_4	137	143	PF00069	0.369
MOD_Plk_4	275	281	PF00069	0.546
MOD_Plk_4	345	351	PF00069	0.530
MOD_Plk_4	364	370	PF00069	0.448
MOD_Plk_4	99	105	PF00069	0.480
MOD_ProDKin_1	156	162	PF00069	0.640
MOD_ProDKin_1	16	22	PF00069	0.722
MOD_ProDKin_1	48	54	PF00069	0.638
MOD_SUMO_rev_2	108	116	PF00179	0.546
MOD_SUMO_rev_2	188	197	PF00179	0.538
TRG_DiLeu_BaEn_2	136	142	PF01217	0.505
TRG_ER_diArg_1	145	147	PF00400	0.408
TRG_ER_diArg_1	2	4	PF00400	0.554
TRG_ER_diArg_1	24	27	PF00400	0.660
TRG_ER_diArg_1	319	322	PF00400	0.390
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY6	Leptomonas seymouri	56%	100%
A0A1X0NK60	Trypanosomatidae	43%	100%
A0A3S5H5K1	Leishmania donovani	91%	100%
A0A422NJ89	Trypanosoma rangeli	49%	100%
A4H4C2	Leishmania braziliensis	81%	100%
A4HSK1	Leishmania infantum	92%	99%
C9ZU92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AKI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B710	Trypanosoma cruzi	50%	99%