MYND zinc finger (ZnF) domain-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MYND zinc finger (ZnF) domain-like protein

Species:

Leishmania major

UniProt:

Q4QJC2_LEIMA

TriTrypDb:

LmjF.05.0800 , LMJLV39_050012900 , LMJSD75_050013200

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJC2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.490
CLV_NRD_NRD_1	256	258	PF00675	0.496
CLV_NRD_NRD_1	411	413	PF00675	0.490
CLV_NRD_NRD_1	88	90	PF00675	0.513
CLV_PCSK_KEX2_1	256	258	PF00082	0.496
CLV_PCSK_KEX2_1	321	323	PF00082	0.344
CLV_PCSK_KEX2_1	411	413	PF00082	0.476
CLV_PCSK_KEX2_1	88	90	PF00082	0.516
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.344
CLV_PCSK_SKI1_1	210	214	PF00082	0.557
CLV_PCSK_SKI1_1	256	260	PF00082	0.419
CLV_PCSK_SKI1_1	388	392	PF00082	0.672
CLV_PCSK_SKI1_1	49	53	PF00082	0.488
CLV_PCSK_SKI1_1	91	95	PF00082	0.554
DEG_SPOP_SBC_1	205	209	PF00917	0.644
DEG_SPOP_SBC_1	325	329	PF00917	0.299
DEG_SPOP_SBC_1	60	64	PF00917	0.556
DEG_SPOP_SBC_1	71	75	PF00917	0.490
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.473
DOC_MAPK_gen_1	386	398	PF00069	0.569
DOC_MAPK_gen_1	88	98	PF00069	0.617
DOC_MAPK_MEF2A_6	391	400	PF00069	0.600
DOC_PP1_RVXF_1	288	295	PF00149	0.590
DOC_PP1_RVXF_1	92	99	PF00149	0.528
DOC_PP1_SILK_1	166	171	PF00149	0.423
DOC_PP2B_LxvP_1	398	401	PF13499	0.488
DOC_PP4_FxxP_1	53	56	PF00568	0.591
DOC_PP4_MxPP_1	1	4	PF00568	0.558
DOC_USP7_MATH_1	164	168	PF00917	0.547
DOC_USP7_MATH_1	205	209	PF00917	0.690
DOC_USP7_MATH_1	231	235	PF00917	0.544
DOC_USP7_MATH_1	28	32	PF00917	0.626
DOC_USP7_MATH_1	297	301	PF00917	0.545
DOC_USP7_MATH_1	324	328	PF00917	0.408
DOC_USP7_MATH_1	59	63	PF00917	0.548
DOC_USP7_UBL2_3	387	391	PF12436	0.670
DOC_WW_Pin1_4	358	363	PF00397	0.467
DOC_WW_Pin1_4	65	70	PF00397	0.694
DOC_WW_Pin1_4	74	79	PF00397	0.554
LIG_14-3-3_CanoR_1	336	345	PF00244	0.341
LIG_14-3-3_CanoR_1	72	78	PF00244	0.754
LIG_Actin_WH2_2	80	96	PF00022	0.522
LIG_APCC_ABBA_1	50	55	PF00400	0.579
LIG_APCC_ABBAyCdc20_2	290	296	PF00400	0.608
LIG_APCC_ABBAyCdc20_2	49	55	PF00400	0.572
LIG_BIR_III_4	179	183	PF00653	0.610
LIG_BRCT_BRCA1_1	404	408	PF00533	0.514
LIG_BRCT_BRCA1_1	427	431	PF00533	0.531
LIG_BRCT_BRCA1_2	427	433	PF00533	0.494
LIG_Clathr_ClatBox_1	292	296	PF01394	0.491
LIG_Clathr_ClatBox_1	50	54	PF01394	0.495
LIG_FHA_1	113	119	PF00498	0.457
LIG_FHA_1	132	138	PF00498	0.672
LIG_FHA_1	297	303	PF00498	0.518
LIG_FHA_1	390	396	PF00498	0.609
LIG_FHA_2	173	179	PF00498	0.663
LIG_FHA_2	21	27	PF00498	0.476
LIG_LIR_Gen_1	110	119	PF02991	0.491
LIG_LIR_Gen_1	16	27	PF02991	0.458
LIG_LIR_Gen_1	31	42	PF02991	0.458
LIG_LIR_Gen_1	353	362	PF02991	0.400
LIG_LIR_Gen_1	419	430	PF02991	0.494
LIG_LIR_Nem_3	110	116	PF02991	0.496
LIG_LIR_Nem_3	16	22	PF02991	0.457
LIG_LIR_Nem_3	31	37	PF02991	0.465
LIG_LIR_Nem_3	353	358	PF02991	0.374
LIG_LIR_Nem_3	419	425	PF02991	0.492
LIG_LIR_Nem_3	426	430	PF02991	0.368
LIG_MLH1_MIPbox_1	404	408	PF16413	0.514
LIG_MLH1_MIPbox_1	427	431	PF16413	0.531
LIG_PROFILIN_1	2	8	PF00235	0.560
LIG_PTB_Apo_2	92	99	PF02174	0.471
LIG_REV1ctd_RIR_1	405	416	PF16727	0.526
LIG_SH2_CRK	34	38	PF00017	0.492
LIG_SH2_NCK_1	147	151	PF00017	0.366
LIG_SH2_STAP1	29	33	PF00017	0.612
LIG_SH2_STAP1	427	431	PF00017	0.544
LIG_SH2_STAT3	154	157	PF00017	0.498
LIG_SH2_STAT5	154	157	PF00017	0.538
LIG_SH2_STAT5	345	348	PF00017	0.284
LIG_SH2_STAT5	413	416	PF00017	0.461
LIG_SH2_STAT5	430	433	PF00017	0.453
LIG_SH2_STAT5	434	437	PF00017	0.584
LIG_SH3_2	4	9	PF14604	0.611
LIG_SH3_3	1	7	PF00018	0.606
LIG_SH3_3	398	404	PF00018	0.506
LIG_SH3_CIN85_PxpxPR_1	4	9	PF14604	0.611
LIG_SUMO_SIM_anti_2	114	121	PF11976	0.491
LIG_SUMO_SIM_anti_2	394	399	PF11976	0.518
LIG_SUMO_SIM_par_1	11	16	PF11976	0.512
LIG_SUMO_SIM_par_1	243	254	PF11976	0.581
LIG_SUMO_SIM_par_1	35	41	PF11976	0.436
LIG_SUMO_SIM_par_1	394	399	PF11976	0.580
LIG_TRAF2_1	241	244	PF00917	0.569
LIG_WW_3	6	10	PF00397	0.606
MOD_CDK_SPxK_1	358	364	PF00069	0.404
MOD_CDK_SPxxK_3	65	72	PF00069	0.589
MOD_CK1_1	127	133	PF00069	0.713
MOD_CK1_1	200	206	PF00069	0.720
MOD_CK1_1	208	214	PF00069	0.714
MOD_CK1_1	381	387	PF00069	0.582
MOD_CK1_1	62	68	PF00069	0.591
MOD_CK1_1	73	79	PF00069	0.483
MOD_Cter_Amidation	384	387	PF01082	0.659
MOD_GlcNHglycan	126	129	PF01048	0.664
MOD_GlcNHglycan	134	137	PF01048	0.678
MOD_GlcNHglycan	210	213	PF01048	0.684
MOD_GlcNHglycan	265	268	PF01048	0.628
MOD_GlcNHglycan	328	331	PF01048	0.358
MOD_GlcNHglycan	346	349	PF01048	0.415
MOD_GlcNHglycan	383	386	PF01048	0.547
MOD_GSK3_1	127	134	PF00069	0.659
MOD_GSK3_1	200	207	PF00069	0.657
MOD_GSK3_1	265	272	PF00069	0.602
MOD_GSK3_1	350	357	PF00069	0.418
MOD_GSK3_1	377	384	PF00069	0.590
MOD_GSK3_1	432	439	PF00069	0.544
MOD_GSK3_1	59	66	PF00069	0.597
MOD_GSK3_1	70	77	PF00069	0.558
MOD_NEK2_1	335	340	PF00069	0.403
MOD_NEK2_1	407	412	PF00069	0.448
MOD_NEK2_1	432	437	PF00069	0.537
MOD_PKA_2	224	230	PF00069	0.686
MOD_PKA_2	263	269	PF00069	0.652
MOD_PKA_2	335	341	PF00069	0.350
MOD_PKA_2	71	77	PF00069	0.768
MOD_PKB_1	228	236	PF00069	0.724
MOD_Plk_1	182	188	PF00069	0.654
MOD_Plk_1	418	424	PF00069	0.477
MOD_Plk_2-3	11	17	PF00069	0.498
MOD_Plk_4	114	120	PF00069	0.579
MOD_Plk_4	164	170	PF00069	0.616
MOD_Plk_4	297	303	PF00069	0.487
MOD_Plk_4	402	408	PF00069	0.456
MOD_ProDKin_1	358	364	PF00069	0.467
MOD_ProDKin_1	65	71	PF00069	0.694
MOD_ProDKin_1	74	80	PF00069	0.550
MOD_SUMO_rev_2	135	144	PF00179	0.607
MOD_SUMO_rev_2	26	33	PF00179	0.572
MOD_SUMO_rev_2	384	392	PF00179	0.493
TRG_DiLeu_BaEn_1	114	119	PF01217	0.485
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.312
TRG_ENDOCYTIC_2	34	37	PF00928	0.545
TRG_ER_diArg_1	255	257	PF00400	0.509
TRG_ER_diArg_1	411	413	PF00400	0.490
TRG_ER_diArg_1	87	89	PF00400	0.505
TRG_NES_CRM1_1	16	30	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V4	Leptomonas seymouri	62%	100%
A0A3S5H5K2	Leishmania donovani	94%	87%
A0A422NJC5	Trypanosoma rangeli	47%	100%
A4H4C3	Leishmania braziliensis	81%	100%
A4HSK2	Leishmania infantum	94%	89%
C9ZU91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	99%
E9AKI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BG20	Trypanosoma cruzi	43%	100%