MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJC0_LEIMA

TriTrypDb:

LmjF.05.0820 , LMJLV39_050013100 , LMJSD75_050013400

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QJC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.755
CLV_C14_Caspase3-7	405	409	PF00656	0.344
CLV_C14_Caspase3-7	916	920	PF00656	0.429
CLV_MEL_PAP_1	426	432	PF00089	0.654
CLV_NRD_NRD_1	199	201	PF00675	0.378
CLV_NRD_NRD_1	243	245	PF00675	0.453
CLV_NRD_NRD_1	336	338	PF00675	0.304
CLV_NRD_NRD_1	732	734	PF00675	0.339
CLV_NRD_NRD_1	8	10	PF00675	0.593
CLV_NRD_NRD_1	839	841	PF00675	0.359
CLV_NRD_NRD_1	899	901	PF00675	0.535
CLV_PCSK_FUR_1	241	245	PF00082	0.478
CLV_PCSK_KEX2_1	198	200	PF00082	0.383
CLV_PCSK_KEX2_1	243	245	PF00082	0.488
CLV_PCSK_KEX2_1	335	337	PF00082	0.308
CLV_PCSK_KEX2_1	7	9	PF00082	0.576
CLV_PCSK_KEX2_1	839	841	PF00082	0.358
CLV_PCSK_KEX2_1	890	892	PF00082	0.545
CLV_PCSK_KEX2_1	898	900	PF00082	0.518
CLV_PCSK_KEX2_1	908	910	PF00082	0.551
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.322
CLV_PCSK_PC1ET2_1	890	892	PF00082	0.545
CLV_PCSK_PC1ET2_1	898	900	PF00082	0.518
CLV_PCSK_PC1ET2_1	908	910	PF00082	0.551
CLV_PCSK_PC7_1	332	338	PF00082	0.317
CLV_PCSK_SKI1_1	137	141	PF00082	0.390
CLV_PCSK_SKI1_1	297	301	PF00082	0.316
CLV_PCSK_SKI1_1	332	336	PF00082	0.350
CLV_PCSK_SKI1_1	585	589	PF00082	0.511
CLV_PCSK_SKI1_1	673	677	PF00082	0.369
CLV_PCSK_SKI1_1	800	804	PF00082	0.311
DEG_APCC_DBOX_1	672	680	PF00400	0.526
DEG_APCC_DBOX_1	799	807	PF00400	0.507
DEG_ODPH_VHL_1	471	484	PF01847	0.518
DEG_SPOP_SBC_1	298	302	PF00917	0.580
DEG_SPOP_SBC_1	380	384	PF00917	0.563
DOC_CKS1_1	36	41	PF01111	0.651
DOC_CYCLIN_RxL_1	477	488	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	665	671	PF00134	0.237
DOC_MAPK_gen_1	246	256	PF00069	0.468
DOC_MAPK_gen_1	839	848	PF00069	0.610
DOC_MAPK_gen_1	890	897	PF00069	0.358
DOC_MAPK_MEF2A_6	419	426	PF00069	0.421
DOC_MAPK_MEF2A_6	890	897	PF00069	0.412
DOC_PP1_RVXF_1	250	257	PF00149	0.525
DOC_PP1_RVXF_1	583	590	PF00149	0.487
DOC_PP1_RVXF_1	761	767	PF00149	0.503
DOC_PP2B_LxvP_1	658	661	PF13499	0.387
DOC_PP4_FxxP_1	98	101	PF00568	0.654
DOC_USP7_MATH_1	165	169	PF00917	0.655
DOC_USP7_MATH_1	227	231	PF00917	0.799
DOC_USP7_MATH_1	236	240	PF00917	0.698
DOC_USP7_MATH_1	267	271	PF00917	0.577
DOC_USP7_MATH_1	322	326	PF00917	0.682
DOC_USP7_MATH_1	380	384	PF00917	0.560
DOC_USP7_MATH_1	388	392	PF00917	0.537
DOC_USP7_MATH_1	627	631	PF00917	0.384
DOC_USP7_MATH_1	661	665	PF00917	0.439
DOC_USP7_MATH_1	768	772	PF00917	0.607
DOC_USP7_MATH_1	812	816	PF00917	0.702
DOC_USP7_UBL2_3	11	15	PF12436	0.825
DOC_USP7_UBL2_3	937	941	PF12436	0.426
DOC_WW_Pin1_4	111	116	PF00397	0.598
DOC_WW_Pin1_4	35	40	PF00397	0.748
DOC_WW_Pin1_4	354	359	PF00397	0.506
DOC_WW_Pin1_4	389	394	PF00397	0.551
DOC_WW_Pin1_4	44	49	PF00397	0.710
DOC_WW_Pin1_4	588	593	PF00397	0.439
DOC_WW_Pin1_4	914	919	PF00397	0.446
DOC_WW_Pin1_4	96	101	PF00397	0.670
LIG_14-3-3_CanoR_1	249	255	PF00244	0.533
LIG_14-3-3_CanoR_1	297	307	PF00244	0.571
LIG_14-3-3_CanoR_1	429	436	PF00244	0.448
LIG_14-3-3_CanoR_1	459	463	PF00244	0.433
LIG_14-3-3_CanoR_1	528	538	PF00244	0.586
LIG_14-3-3_CanoR_1	9	18	PF00244	0.817
LIG_Actin_WH2_2	517	532	PF00022	0.463
LIG_Actin_WH2_2	70	87	PF00022	0.595
LIG_APCC_ABBA_1	762	767	PF00400	0.454
LIG_APCC_ABBA_1	864	869	PF00400	0.320
LIG_APCC_ABBAyCdc20_2	682	688	PF00400	0.610
LIG_BIR_III_2	112	116	PF00653	0.743
LIG_BRCT_BRCA1_1	252	256	PF00533	0.478
LIG_BRCT_BRCA1_1	381	385	PF00533	0.489
LIG_Clathr_ClatBox_1	290	294	PF01394	0.591
LIG_eIF4E_1	578	584	PF01652	0.330
LIG_EVH1_2	42	46	PF00568	0.680
LIG_FHA_1	112	118	PF00498	0.791
LIG_FHA_1	150	156	PF00498	0.642
LIG_FHA_1	249	255	PF00498	0.561
LIG_FHA_1	284	290	PF00498	0.571
LIG_FHA_1	347	353	PF00498	0.436
LIG_FHA_1	398	404	PF00498	0.362
LIG_FHA_1	459	465	PF00498	0.433
LIG_FHA_1	524	530	PF00498	0.585
LIG_FHA_1	610	616	PF00498	0.461
LIG_FHA_1	653	659	PF00498	0.296
LIG_FHA_1	711	717	PF00498	0.574
LIG_FHA_1	779	785	PF00498	0.560
LIG_FHA_1	816	822	PF00498	0.623
LIG_FHA_1	905	911	PF00498	0.416
LIG_FHA_2	107	113	PF00498	0.742
LIG_FHA_2	23	29	PF00498	0.736
LIG_FHA_2	300	306	PF00498	0.607
LIG_FHA_2	403	409	PF00498	0.402
LIG_FHA_2	752	758	PF00498	0.557
LIG_FHA_2	860	866	PF00498	0.428
LIG_GBD_Chelix_1	474	482	PF00786	0.530
LIG_GBD_Chelix_1	652	660	PF00786	0.552
LIG_LIR_Apic_2	586	592	PF02991	0.424
LIG_LIR_Apic_2	99	105	PF02991	0.714
LIG_LIR_Gen_1	189	197	PF02991	0.527
LIG_LIR_Gen_1	204	213	PF02991	0.738
LIG_LIR_Gen_1	253	262	PF02991	0.545
LIG_LIR_Gen_1	301	312	PF02991	0.627
LIG_LIR_Gen_1	57	66	PF02991	0.575
LIG_LIR_Gen_1	822	832	PF02991	0.610
LIG_LIR_LC3C_4	152	155	PF02991	0.543
LIG_LIR_Nem_3	189	194	PF02991	0.485
LIG_LIR_Nem_3	204	209	PF02991	0.719
LIG_LIR_Nem_3	253	259	PF02991	0.545
LIG_LIR_Nem_3	301	307	PF02991	0.569
LIG_LIR_Nem_3	57	63	PF02991	0.589
LIG_LIR_Nem_3	822	827	PF02991	0.609
LIG_MLH1_MIPbox_1	252	256	PF16413	0.519
LIG_NRBOX	288	294	PF00104	0.523
LIG_NRBOX	351	357	PF00104	0.377
LIG_NRBOX	453	459	PF00104	0.379
LIG_NRBOX	91	97	PF00104	0.559
LIG_RPA_C_Fungi	523	535	PF08784	0.433
LIG_SH2_CRK	824	828	PF00017	0.511
LIG_SH2_NCK_1	102	106	PF00017	0.645
LIG_SH2_STAP1	315	319	PF00017	0.594
LIG_SH2_STAP1	824	828	PF00017	0.476
LIG_SH2_STAT5	255	258	PF00017	0.458
LIG_SH2_STAT5	896	899	PF00017	0.432
LIG_SH3_3	114	120	PF00018	0.719
LIG_SH3_3	33	39	PF00018	0.704
LIG_SH3_3	830	836	PF00018	0.532
LIG_SUMO_SIM_anti_2	284	294	PF11976	0.503
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.447
LIG_SUMO_SIM_anti_2	654	660	PF11976	0.357
LIG_SUMO_SIM_anti_2	757	762	PF11976	0.385
LIG_SUMO_SIM_par_1	114	119	PF11976	0.523
LIG_SUMO_SIM_par_1	151	158	PF11976	0.435
LIG_SUMO_SIM_par_1	263	270	PF11976	0.455
LIG_SUMO_SIM_par_1	284	294	PF11976	0.400
LIG_SUMO_SIM_par_1	351	357	PF11976	0.447
LIG_SUMO_SIM_par_1	639	646	PF11976	0.382
LIG_TRAF2_1	128	131	PF00917	0.803
LIG_UBA3_1	727	734	PF00899	0.363
LIG_WRC_WIRS_1	435	440	PF05994	0.509
MOD_CDK_SPK_2	44	49	PF00069	0.460
MOD_CK1_1	123	129	PF00069	0.712
MOD_CK1_1	248	254	PF00069	0.467
MOD_CK1_1	284	290	PF00069	0.527
MOD_CK1_1	381	387	PF00069	0.733
MOD_CK1_1	431	437	PF00069	0.477
MOD_CK1_1	591	597	PF00069	0.569
MOD_CK1_1	710	716	PF00069	0.497
MOD_CK1_1	736	742	PF00069	0.595
MOD_CK1_1	769	775	PF00069	0.502
MOD_CK1_1	815	821	PF00069	0.525
MOD_CK1_1	914	920	PF00069	0.556
MOD_CK2_1	22	28	PF00069	0.694
MOD_CK2_1	227	233	PF00069	0.644
MOD_CK2_1	299	305	PF00069	0.452
MOD_GlcNHglycan	12	15	PF01048	0.812
MOD_GlcNHglycan	122	125	PF01048	0.752
MOD_GlcNHglycan	167	170	PF01048	0.647
MOD_GlcNHglycan	174	177	PF01048	0.637
MOD_GlcNHglycan	219	222	PF01048	0.806
MOD_GlcNHglycan	238	241	PF01048	0.636
MOD_GlcNHglycan	310	313	PF01048	0.579
MOD_GlcNHglycan	386	389	PF01048	0.757
MOD_GlcNHglycan	572	575	PF01048	0.434
MOD_GlcNHglycan	595	599	PF01048	0.711
MOD_GlcNHglycan	709	712	PF01048	0.450
MOD_GlcNHglycan	738	741	PF01048	0.643
MOD_GlcNHglycan	754	757	PF01048	0.353
MOD_GlcNHglycan	767	771	PF01048	0.510
MOD_GSK3_1	116	123	PF00069	0.749
MOD_GSK3_1	279	286	PF00069	0.521
MOD_GSK3_1	299	306	PF00069	0.264
MOD_GSK3_1	341	348	PF00069	0.447
MOD_GSK3_1	376	383	PF00069	0.697
MOD_GSK3_1	384	391	PF00069	0.725
MOD_GSK3_1	393	400	PF00069	0.404
MOD_GSK3_1	519	526	PF00069	0.466
MOD_GSK3_1	739	746	PF00069	0.649
MOD_GSK3_1	774	781	PF00069	0.371
MOD_GSK3_1	811	818	PF00069	0.500
MOD_N-GLC_1	359	364	PF02516	0.477
MOD_N-GLC_1	549	554	PF02516	0.619
MOD_N-GLC_2	929	931	PF02516	0.459
MOD_NEK2_1	1	6	PF00069	0.832
MOD_NEK2_1	186	191	PF00069	0.313
MOD_NEK2_1	250	255	PF00069	0.385
MOD_NEK2_1	283	288	PF00069	0.443
MOD_NEK2_1	341	346	PF00069	0.438
MOD_NEK2_1	402	407	PF00069	0.448
MOD_NEK2_1	458	463	PF00069	0.410
MOD_NEK2_1	485	490	PF00069	0.505
MOD_NEK2_1	529	534	PF00069	0.518
MOD_NEK2_1	570	575	PF00069	0.274
MOD_NEK2_1	707	712	PF00069	0.523
MOD_NEK2_1	727	732	PF00069	0.234
MOD_NEK2_1	774	779	PF00069	0.440
MOD_NEK2_1	785	790	PF00069	0.380
MOD_NEK2_2	851	856	PF00069	0.433
MOD_PIKK_1	529	535	PF00454	0.461
MOD_PKA_1	733	739	PF00069	0.492
MOD_PKA_2	245	251	PF00069	0.516
MOD_PKA_2	428	434	PF00069	0.566
MOD_PKA_2	458	464	PF00069	0.433
MOD_PKA_2	529	535	PF00069	0.477
MOD_PKA_2	54	60	PF00069	0.502
MOD_Plk_1	359	365	PF00069	0.483
MOD_Plk_1	397	403	PF00069	0.539
MOD_Plk_1	431	437	PF00069	0.482
MOD_Plk_1	485	491	PF00069	0.500
MOD_Plk_4	285	291	PF00069	0.386
MOD_Plk_4	303	309	PF00069	0.400
MOD_Plk_4	324	330	PF00069	0.531
MOD_Plk_4	434	440	PF00069	0.485
MOD_Plk_4	652	658	PF00069	0.310
MOD_Plk_4	769	775	PF00069	0.414
MOD_Plk_4	859	865	PF00069	0.507
MOD_ProDKin_1	111	117	PF00069	0.496
MOD_ProDKin_1	35	41	PF00069	0.705
MOD_ProDKin_1	354	360	PF00069	0.504
MOD_ProDKin_1	389	395	PF00069	0.692
MOD_ProDKin_1	44	50	PF00069	0.636
MOD_ProDKin_1	588	594	PF00069	0.565
MOD_ProDKin_1	914	920	PF00069	0.560
MOD_ProDKin_1	96	102	PF00069	0.599
MOD_SUMO_rev_2	904	910	PF00179	0.508
TRG_DiLeu_BaEn_2	397	403	PF01217	0.539
TRG_DiLeu_BaEn_4	263	269	PF01217	0.468
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.489
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.370
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.475
TRG_ENDOCYTIC_2	255	258	PF00928	0.459
TRG_ENDOCYTIC_2	60	63	PF00928	0.531
TRG_ENDOCYTIC_2	824	827	PF00928	0.519
TRG_ENDOCYTIC_2	877	880	PF00928	0.372
TRG_ER_diArg_1	198	200	PF00400	0.507
TRG_ER_diArg_1	241	244	PF00400	0.647
TRG_ER_diArg_1	6	9	PF00400	0.744
TRG_ER_diArg_1	839	841	PF00400	0.450
TRG_NES_CRM1_1	639	651	PF08389	0.479
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF34	Leptomonas seymouri	60%	100%
A0A1X0NLT0	Trypanosomatidae	34%	100%
A0A3S5H5K4	Leishmania donovani	93%	100%
A0A422NJC1	Trypanosoma rangeli	36%	100%
A4H4C4	Leishmania braziliensis	76%	100%
A4HSK4	Leishmania infantum	92%	100%
C9ZU88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
E9AKI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BBH0	Trypanosoma cruzi	34%	96%