S-methyl-5'-thioadenosine phosphorylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylthioadenosine phosphorylase, putative

Species:

Leishmania major

UniProt:

Q4QJB9_LEIMA

TriTrypDb:

LmjF.05.0830 , LMJLV39_050013200 , LMJSD75_050013500

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	8

Expansion

Sequence features

Q4QJB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJB9

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	8
GO:0000097	sulfur amino acid biosynthetic process	5	8
GO:0006082	organic acid metabolic process	3	8
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006166	purine ribonucleoside salvage	5	10
GO:0006520	amino acid metabolic process	3	8
GO:0006555	methionine metabolic process	5	8
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006790	sulfur compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008652	amino acid biosynthetic process	4	8
GO:0009058	biosynthetic process	2	10
GO:0009066	aspartate family amino acid metabolic process	5	8
GO:0009067	aspartate family amino acid biosynthetic process	6	8
GO:0009086	methionine biosynthetic process	6	8
GO:0009116	nucleoside metabolic process	4	10
GO:0009119	ribonucleoside metabolic process	5	10
GO:0009163	nucleoside biosynthetic process	5	10
GO:0009987	cellular process	1	10
GO:0016053	organic acid biosynthetic process	4	8
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0019509	L-methionine salvage from methylthioadenosine	6	8
GO:0019752	carboxylic acid metabolic process	5	8
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0042278	purine nucleoside metabolic process	5	10
GO:0042451	purine nucleoside biosynthetic process	6	10
GO:0042455	ribonucleoside biosynthetic process	6	10
GO:0043094	cellular metabolic compound salvage	3	10
GO:0043101	purine-containing compound salvage	4	10
GO:0043102	amino acid salvage	4	8
GO:0043174	nucleoside salvage	4	10
GO:0043436	oxoacid metabolic process	4	8
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0044272	sulfur compound biosynthetic process	4	8
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0046128	purine ribonucleoside metabolic process	6	10
GO:0046129	purine ribonucleoside biosynthetic process	7	10
GO:0046394	carboxylic acid biosynthetic process	5	8
GO:0046483	heterocycle metabolic process	3	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0071265	L-methionine biosynthetic process	7	8
GO:0071267	L-methionine salvage	5	8
GO:0071704	organic substance metabolic process	2	10
GO:0072521	purine-containing compound metabolic process	4	10
GO:0072522	purine-containing compound biosynthetic process	5	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901137	carbohydrate derivative biosynthetic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901605	alpha-amino acid metabolic process	4	8
GO:1901607	alpha-amino acid biosynthetic process	5	8
GO:1901657	glycosyl compound metabolic process	4	10
GO:1901659	glycosyl compound biosynthetic process	5	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004731	purine-nucleoside phosphorylase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	10
GO:0016763	pentosyltransferase activity	4	10
GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	6	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.349
CLV_NRD_NRD_1	119	121	PF00675	0.346
CLV_PCSK_SKI1_1	120	124	PF00082	0.392
CLV_PCSK_SKI1_1	87	91	PF00082	0.456
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DOC_CKS1_1	34	39	PF01111	0.343
DOC_MAPK_DCC_7	49	58	PF00069	0.423
DOC_MAPK_JIP1_4	103	109	PF00069	0.437
DOC_MAPK_MEF2A_6	49	58	PF00069	0.423
DOC_MAPK_MEF2A_6	7	14	PF00069	0.430
DOC_PP4_FxxP_1	135	138	PF00568	0.456
DOC_PP4_FxxP_1	266	269	PF00568	0.426
DOC_USP7_MATH_1	94	98	PF00917	0.321
DOC_WW_Pin1_4	33	38	PF00397	0.343
LIG_14-3-3_CanoR_1	120	125	PF00244	0.347
LIG_APCC_ABBA_1	129	134	PF00400	0.357
LIG_BRCT_BRCA1_1	139	143	PF00533	0.416
LIG_Clathr_ClatBox_1	173	177	PF01394	0.453
LIG_eIF4E_1	102	108	PF01652	0.348
LIG_FHA_1	137	143	PF00498	0.392
LIG_FHA_1	162	168	PF00498	0.537
LIG_FHA_2	121	127	PF00498	0.403
LIG_FHA_2	181	187	PF00498	0.344
LIG_FHA_2	221	227	PF00498	0.345
LIG_FHA_2	278	284	PF00498	0.483
LIG_LIR_Apic_2	134	138	PF02991	0.321
LIG_LIR_Apic_2	36	41	PF02991	0.345
LIG_LIR_Gen_1	140	151	PF02991	0.392
LIG_LIR_Gen_1	213	222	PF02991	0.343
LIG_LIR_Gen_1	273	282	PF02991	0.494
LIG_LIR_Gen_1	28	38	PF02991	0.270
LIG_LIR_Nem_3	140	146	PF02991	0.345
LIG_LIR_Nem_3	213	219	PF02991	0.343
LIG_LIR_Nem_3	273	279	PF02991	0.500
LIG_LIR_Nem_3	28	34	PF02991	0.345
LIG_LIR_Nem_3	299	304	PF02991	0.527
LIG_SH2_CRK	2	6	PF00017	0.511
LIG_SH2_CRK	216	220	PF00017	0.453
LIG_SH2_CRK	276	280	PF00017	0.546
LIG_SH2_CRK	38	42	PF00017	0.464
LIG_SH2_NCK_1	216	220	PF00017	0.453
LIG_SH2_NCK_1	276	280	PF00017	0.546
LIG_SH2_SRC	276	279	PF00017	0.506
LIG_SH2_STAP1	216	220	PF00017	0.453
LIG_SH2_STAT5	88	91	PF00017	0.343
LIG_SH3_3	276	282	PF00018	0.547
LIG_SH3_3	31	37	PF00018	0.466
LIG_SH3_3	53	59	PF00018	0.538
LIG_TYR_ITIM	214	219	PF00017	0.466
LIG_TYR_ITIM	274	279	PF00017	0.498
MOD_CK1_1	169	175	PF00069	0.453
MOD_CK2_1	120	126	PF00069	0.368
MOD_CK2_1	180	186	PF00069	0.344
MOD_CK2_1	199	205	PF00069	0.444
MOD_CK2_1	277	283	PF00069	0.483
MOD_CK2_1	94	100	PF00069	0.362
MOD_GlcNHglycan	169	172	PF01048	0.351
MOD_GlcNHglycan	17	20	PF01048	0.343
MOD_GlcNHglycan	201	204	PF01048	0.436
MOD_GlcNHglycan	41	44	PF01048	0.343
MOD_GSK3_1	180	187	PF00069	0.343
MOD_GSK3_1	94	101	PF00069	0.453
MOD_N-GLC_2	77	79	PF02516	0.456
MOD_NEK2_1	296	301	PF00069	0.443
MOD_NEK2_1	98	103	PF00069	0.453
MOD_PKA_1	120	126	PF00069	0.345
MOD_Plk_1	114	120	PF00069	0.355
MOD_Plk_1	98	104	PF00069	0.482
MOD_Plk_4	114	120	PF00069	0.357
MOD_Plk_4	142	148	PF00069	0.270
MOD_Plk_4	169	175	PF00069	0.361
MOD_Plk_4	184	190	PF00069	0.298
MOD_ProDKin_1	33	39	PF00069	0.343
TRG_ENDOCYTIC_2	216	219	PF00928	0.365
TRG_ENDOCYTIC_2	276	279	PF00928	0.551
TRG_ENDOCYTIC_2	301	304	PF00928	0.443
TRG_ENDOCYTIC_2	31	34	PF00928	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ0	Leptomonas seymouri	68%	99%
A0A1X0NKF0	Trypanosomatidae	57%	95%
A0A3S5H5K5	Leishmania donovani	96%	100%
A0A422NJG4	Trypanosoma rangeli	60%	100%
A0QR54	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	36%	100%
A0RVQ7	Cenarchaeum symbiosum (strain A)	38%	100%
A1RXU2	Thermofilum pendens (strain DSM 2475 / Hrk 5)	43%	100%
A2BIU4	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	44%	100%
A4H4C5	Leishmania braziliensis	83%	100%
A4HSK5	Leishmania infantum	96%	100%
A7EAA1	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	42%	100%
A7SN31	Nematostella vectensis	41%	100%
A8P7Y3	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	45%	94%
A8XGS6	Caenorhabditis briggsae	43%	100%
A9A3N5	Nitrosopumilus maritimus (strain SCM1)	40%	100%
A9WAL0	Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)	49%	100%
B1L719	Korarchaeum cryptofilum (strain OPF8)	31%	100%
B5YKP5	Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)	37%	100%
B8E181	Dictyoglomus turgidum (strain DSM 6724 / Z-1310)	40%	100%
C0NRX4	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	40%	98%
C4YQD9	Candida albicans (strain WO-1)	39%	89%
C7YLQ3	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	43%	100%
C8VP37	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	86%
C9ZU87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
D5GFR0	Tuber melanosporum (strain Mel28)	42%	99%
E3K7C1	Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)	37%	100%
E3K7C3	Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)	39%	100%
E3XFR6	Anopheles darlingi	40%	100%
E9AKI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F6RQL9	Macaca mulatta	38%	100%
F6V515	Xenopus tropicalis	39%	100%
F6X2V8	Ciona intestinalis	40%	100%
O06401	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	38%	100%
O27633	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	38%	100%
O28486	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
O57865	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	43%	100%
O66839	Aquifex aeolicus (strain VF5)	31%	100%
P0DJF8	Synechocystis sp. (strain PCC 6803 / Kazusa)	44%	94%
P0DJF9	Synechocystis sp. (strain PCC 6803 / GT-S)	44%	94%
Q07938	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	91%
Q09438	Caenorhabditis elegans	41%	100%
Q09816	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q0U796	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	42%	89%
Q13126	Homo sapiens	38%	100%
Q16MW6	Aedes aegypti	42%	100%
Q1INC3	Koribacter versatilis (strain Ellin345)	40%	100%
Q291H4	Drosophila pseudoobscura pseudoobscura	37%	100%
Q297F5	Drosophila pseudoobscura pseudoobscura	34%	100%
Q2RKL6	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	38%	100%
Q2RXH9	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	45%	100%
Q3J5E8	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	43%	100%
Q3MHF7	Bos taurus	37%	100%
Q4PH43	Ustilago maydis (strain 521 / FGSC 9021)	39%	97%
Q4WMU1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	40%	89%
Q59ST1	Candida albicans (strain SC5314 / ATCC MYA-2876)	39%	89%
Q5JEQ6	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	46%	100%
Q5JJB8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	41%	100%
Q5KPU2	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	36%	100%
Q6CES3	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	95%
Q72LZ4	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	41%	100%
Q74E52	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	41%	100%
Q7NHW1	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	42%	100%
Q7Q9N9	Anopheles gambiae	41%	100%
Q7RZA5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	99%
Q7VDN6	Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)	40%	97%
Q7ZV22	Danio rerio	41%	100%
Q87BR7	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	38%	100%
Q87ZC3	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	35%	100%
Q89VT5	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	42%	100%
Q8CXR2	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	41%	100%
Q8DJE4	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	45%	100%
Q8IMU4	Drosophila melanogaster	33%	100%
Q8PB40	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	41%	100%
Q8TQX8	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	31%	100%
Q8TZB4	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	36%	100%
Q8U2I1	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	40%	100%
Q8U4Q8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	43%	100%
Q8ZTB2	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	38%	100%
Q97W94	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	42%	100%
Q9CQ65	Mus musculus	38%	100%
Q9HL98	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	42%	100%
Q9HZK1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	34%	100%
Q9KYV7	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	41%	100%
Q9PAZ2	Xylella fastidiosa (strain 9a5c)	40%	100%
Q9V2F1	Pyrococcus abyssi (strain GE5 / Orsay)	44%	100%
Q9V813	Drosophila melanogaster	38%	100%
Q9YAQ8	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	45%	100%