C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type, putative

Species:

Leishmania major

UniProt:

Q4QJB7_LEIMA

TriTrypDb:

LmjF.05.0850 , LMJLV39_050013400 , LMJSD75_050013700

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.646
CLV_NRD_NRD_1	425	427	PF00675	0.640
CLV_NRD_NRD_1	503	505	PF00675	0.378
CLV_NRD_NRD_1	524	526	PF00675	0.556
CLV_NRD_NRD_1	634	636	PF00675	0.304
CLV_PCSK_KEX2_1	21	23	PF00082	0.482
CLV_PCSK_KEX2_1	212	214	PF00082	0.509
CLV_PCSK_KEX2_1	425	427	PF00082	0.640
CLV_PCSK_KEX2_1	503	505	PF00082	0.303
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.482
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.480
CLV_PCSK_PC7_1	499	505	PF00082	0.303
CLV_PCSK_SKI1_1	127	131	PF00082	0.466
CLV_PCSK_SKI1_1	413	417	PF00082	0.706
CLV_PCSK_SKI1_1	525	529	PF00082	0.509
CLV_PCSK_SKI1_1	648	652	PF00082	0.456
CLV_PCSK_SKI1_1	95	99	PF00082	0.637
DEG_COP1_1	59	69	PF00400	0.538
DEG_SPOP_SBC_1	240	244	PF00917	0.622
DEG_SPOP_SBC_1	368	372	PF00917	0.675
DEG_SPOP_SBC_1	473	477	PF00917	0.578
DOC_CKS1_1	134	139	PF01111	0.458
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.688
DOC_MAPK_DCC_7	82	91	PF00069	0.651
DOC_MAPK_gen_1	503	509	PF00069	0.369
DOC_MAPK_MEF2A_6	503	511	PF00069	0.369
DOC_MAPK_MEF2A_6	82	91	PF00069	0.651
DOC_PP2B_LxvP_1	292	295	PF13499	0.651
DOC_PP2B_LxvP_1	89	92	PF13499	0.662
DOC_PP4_MxPP_1	471	474	PF00568	0.642
DOC_PP4_MxPP_1	613	616	PF00568	0.613
DOC_SPAK_OSR1_1	504	508	PF12202	0.303
DOC_USP7_MATH_1	230	234	PF00917	0.653
DOC_USP7_MATH_1	240	244	PF00917	0.610
DOC_USP7_MATH_1	314	318	PF00917	0.579
DOC_USP7_MATH_1	367	371	PF00917	0.730
DOC_USP7_MATH_1	375	379	PF00917	0.599
DOC_USP7_MATH_1	417	421	PF00917	0.605
DOC_USP7_MATH_1	48	52	PF00917	0.634
DOC_USP7_MATH_1	548	552	PF00917	0.569
DOC_USP7_MATH_1	56	60	PF00917	0.550
DOC_USP7_MATH_1	65	69	PF00917	0.500
DOC_WW_Pin1_4	106	111	PF00397	0.552
DOC_WW_Pin1_4	133	138	PF00397	0.508
DOC_WW_Pin1_4	153	158	PF00397	0.440
DOC_WW_Pin1_4	241	246	PF00397	0.662
DOC_WW_Pin1_4	369	374	PF00397	0.645
DOC_WW_Pin1_4	44	49	PF00397	0.589
DOC_WW_Pin1_4	57	62	PF00397	0.705
DOC_WW_Pin1_4	6	11	PF00397	0.560
DOC_WW_Pin1_4	95	100	PF00397	0.673
LIG_14-3-3_CanoR_1	238	248	PF00244	0.662
LIG_14-3-3_CanoR_1	356	361	PF00244	0.622
LIG_14-3-3_CanoR_1	44	48	PF00244	0.570
LIG_14-3-3_CanoR_1	504	510	PF00244	0.310
LIG_14-3-3_CanoR_1	8	18	PF00244	0.513
LIG_Actin_WH2_2	192	207	PF00022	0.515
LIG_FHA_1	10	16	PF00498	0.513
LIG_FHA_1	355	361	PF00498	0.699
LIG_LIR_Gen_1	60	69	PF02991	0.626
LIG_LIR_Nem_3	60	66	PF02991	0.626
LIG_NRP_CendR_1	663	664	PF00754	0.604
LIG_Pex14_1	463	467	PF04695	0.572
LIG_PTAP_UEV_1	431	436	PF05743	0.586
LIG_PTB_Apo_2	171	178	PF02174	0.565
LIG_PTB_Phospho_1	171	177	PF10480	0.562
LIG_SH2_CRK	63	67	PF00017	0.629
LIG_SH2_NCK_1	63	67	PF00017	0.673
LIG_SH2_STAP1	624	628	PF00017	0.477
LIG_SH2_STAT3	402	405	PF00017	0.542
LIG_SH2_STAT5	120	123	PF00017	0.483
LIG_SH2_STAT5	210	213	PF00017	0.548
LIG_SH2_STAT5	277	280	PF00017	0.555
LIG_SH2_STAT5	63	66	PF00017	0.677
LIG_SH3_3	151	157	PF00018	0.551
LIG_SH3_3	249	255	PF00018	0.555
LIG_SH3_3	401	407	PF00018	0.635
LIG_SH3_3	429	435	PF00018	0.618
LIG_SH3_3	613	619	PF00018	0.566
LIG_SH3_3	625	631	PF00018	0.302
LIG_SH3_3	81	87	PF00018	0.654
LIG_SUMO_SIM_par_1	167	173	PF11976	0.621
LIG_TRAF2_1	490	493	PF00917	0.554
LIG_TRAF2_1	494	497	PF00917	0.345
MOD_CDC14_SPxK_1	109	112	PF00782	0.615
MOD_CDK_SPK_2	44	49	PF00069	0.554
MOD_CDK_SPxK_1	106	112	PF00069	0.628
MOD_CK1_1	103	109	PF00069	0.677
MOD_CK1_1	165	171	PF00069	0.587
MOD_CK1_1	173	179	PF00069	0.667
MOD_CK1_1	200	206	PF00069	0.470
MOD_CK1_1	301	307	PF00069	0.573
MOD_CK1_1	337	343	PF00069	0.667
MOD_CK1_1	430	436	PF00069	0.720
MOD_CK1_1	47	53	PF00069	0.585
MOD_CK1_1	59	65	PF00069	0.555
MOD_CK2_1	314	320	PF00069	0.622
MOD_CK2_1	389	395	PF00069	0.583
MOD_Cter_Amidation	501	504	PF01082	0.303
MOD_Cter_Amidation	633	636	PF01082	0.304
MOD_DYRK1A_RPxSP_1	153	157	PF00069	0.626
MOD_GlcNHglycan	102	105	PF01048	0.658
MOD_GlcNHglycan	157	160	PF01048	0.562
MOD_GlcNHglycan	179	182	PF01048	0.647
MOD_GlcNHglycan	300	303	PF01048	0.674
MOD_GlcNHglycan	343	346	PF01048	0.620
MOD_GlcNHglycan	377	380	PF01048	0.824
MOD_GlcNHglycan	383	386	PF01048	0.611
MOD_GlcNHglycan	408	411	PF01048	0.711
MOD_GlcNHglycan	419	422	PF01048	0.591
MOD_GlcNHglycan	438	441	PF01048	0.710
MOD_GlcNHglycan	50	53	PF01048	0.658
MOD_GlcNHglycan	550	553	PF01048	0.782
MOD_GlcNHglycan	609	612	PF01048	0.591
MOD_GlcNHglycan	67	70	PF01048	0.578
MOD_GSK3_1	173	180	PF00069	0.623
MOD_GSK3_1	186	193	PF00069	0.514
MOD_GSK3_1	200	207	PF00069	0.504
MOD_GSK3_1	334	341	PF00069	0.656
MOD_GSK3_1	417	424	PF00069	0.642
MOD_GSK3_1	43	50	PF00069	0.601
MOD_GSK3_1	544	551	PF00069	0.573
MOD_GSK3_1	57	64	PF00069	0.555
MOD_GSK3_1	67	74	PF00069	0.585
MOD_GSK3_1	91	98	PF00069	0.635
MOD_N-GLC_1	173	178	PF02516	0.563
MOD_N-GLC_1	57	62	PF02516	0.622
MOD_NEK2_1	170	175	PF00069	0.553
MOD_NEK2_1	195	200	PF00069	0.532
MOD_NEK2_1	204	209	PF00069	0.473
MOD_NEK2_1	248	253	PF00069	0.672
MOD_NEK2_1	256	261	PF00069	0.590
MOD_NEK2_1	298	303	PF00069	0.633
MOD_NEK2_1	381	386	PF00069	0.642
MOD_NEK2_1	505	510	PF00069	0.304
MOD_PIKK_1	127	133	PF00454	0.472
MOD_PIKK_1	254	260	PF00454	0.614
MOD_PKA_2	204	210	PF00069	0.467
MOD_PKA_2	298	304	PF00069	0.634
MOD_PKA_2	43	49	PF00069	0.570
MOD_PKA_2	430	436	PF00069	0.748
MOD_PKA_2	505	511	PF00069	0.304
MOD_Plk_1	173	179	PF00069	0.572
MOD_Plk_4	165	171	PF00069	0.544
MOD_ProDKin_1	106	112	PF00069	0.549
MOD_ProDKin_1	133	139	PF00069	0.507
MOD_ProDKin_1	153	159	PF00069	0.438
MOD_ProDKin_1	241	247	PF00069	0.665
MOD_ProDKin_1	369	375	PF00069	0.647
MOD_ProDKin_1	44	50	PF00069	0.595
MOD_ProDKin_1	57	63	PF00069	0.708
MOD_ProDKin_1	6	12	PF00069	0.554
MOD_ProDKin_1	95	101	PF00069	0.673
MOD_SUMO_for_1	211	214	PF00179	0.475
MOD_SUMO_rev_2	123	129	PF00179	0.452
TRG_ENDOCYTIC_2	63	66	PF00928	0.633
TRG_ER_diArg_1	425	427	PF00400	0.639
TRG_ER_diArg_1	503	505	PF00400	0.303
TRG_ER_diArg_1	662	664	PF00400	0.598
TRG_ER_diArg_1	92	95	PF00400	0.691
TRG_NLS_MonoCore_2	349	354	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II98	Leptomonas seymouri	56%	100%
A0A3S7WP70	Leishmania donovani	93%	100%
A4H4C7	Leishmania braziliensis	73%	100%
A4HSK7	Leishmania infantum	93%	100%
E9AKJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%