Putative glutaminyl cyclase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaminyl cyclase, putative

Species:

Leishmania major

UniProt:

Q4QJA7_LEIMA

TriTrypDb:

LmjF.05.0950 , LMJLV39_050014400 , LMJSD75_050014700

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QJA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJA7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase	7	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018199	peptidyl-glutamine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0016603	glutaminyl-peptide cyclotransferase activity	4	5
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016755	aminoacyltransferase activity	3	5
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.516
CLV_C14_Caspase3-7	228	232	PF00656	0.502
CLV_C14_Caspase3-7	275	279	PF00656	0.494
CLV_C14_Caspase3-7	872	876	PF00656	0.223
CLV_NRD_NRD_1	10	12	PF00675	0.479
CLV_NRD_NRD_1	125	127	PF00675	0.673
CLV_NRD_NRD_1	13	15	PF00675	0.453
CLV_NRD_NRD_1	142	144	PF00675	0.588
CLV_NRD_NRD_1	161	163	PF00675	0.571
CLV_NRD_NRD_1	17	19	PF00675	0.421
CLV_NRD_NRD_1	245	247	PF00675	0.715
CLV_NRD_NRD_1	336	338	PF00675	0.632
CLV_NRD_NRD_1	365	367	PF00675	0.705
CLV_NRD_NRD_1	371	373	PF00675	0.709
CLV_NRD_NRD_1	49	51	PF00675	0.273
CLV_NRD_NRD_1	747	749	PF00675	0.673
CLV_NRD_NRD_1	837	839	PF00675	0.468
CLV_NRD_NRD_1	904	906	PF00675	0.664
CLV_PCSK_FUR_1	11	15	PF00082	0.474
CLV_PCSK_FUR_1	47	51	PF00082	0.389
CLV_PCSK_KEX2_1	13	15	PF00082	0.450
CLV_PCSK_KEX2_1	142	144	PF00082	0.697
CLV_PCSK_KEX2_1	150	152	PF00082	0.633
CLV_PCSK_KEX2_1	161	163	PF00082	0.570
CLV_PCSK_KEX2_1	17	19	PF00082	0.417
CLV_PCSK_KEX2_1	229	231	PF00082	0.656
CLV_PCSK_KEX2_1	244	246	PF00082	0.672
CLV_PCSK_KEX2_1	29	31	PF00082	0.312
CLV_PCSK_KEX2_1	336	338	PF00082	0.632
CLV_PCSK_KEX2_1	364	366	PF00082	0.705
CLV_PCSK_KEX2_1	49	51	PF00082	0.273
CLV_PCSK_KEX2_1	747	749	PF00082	0.672
CLV_PCSK_KEX2_1	837	839	PF00082	0.468
CLV_PCSK_KEX2_1	9	11	PF00082	0.485
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.654
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.656
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.439
CLV_PCSK_PC7_1	9	15	PF00082	0.468
CLV_PCSK_SKI1_1	150	154	PF00082	0.681
CLV_PCSK_SKI1_1	230	234	PF00082	0.773
CLV_PCSK_SKI1_1	266	270	PF00082	0.695
CLV_PCSK_SKI1_1	351	355	PF00082	0.711
CLV_PCSK_SKI1_1	373	377	PF00082	0.730
CLV_PCSK_SKI1_1	409	413	PF00082	0.725
CLV_PCSK_SKI1_1	420	424	PF00082	0.710
CLV_PCSK_SKI1_1	485	489	PF00082	0.468
CLV_PCSK_SKI1_1	49	53	PF00082	0.271
CLV_PCSK_SKI1_1	528	532	PF00082	0.657
CLV_PCSK_SKI1_1	747	751	PF00082	0.677
CLV_PCSK_SKI1_1	840	844	PF00082	0.488
DEG_APCC_DBOX_1	141	149	PF00400	0.491
DEG_APCC_DBOX_1	48	56	PF00400	0.471
DEG_APCC_DBOX_1	536	544	PF00400	0.403
DEG_APCC_DBOX_1	586	594	PF00400	0.349
DEG_APCC_KENBOX_2	128	132	PF00400	0.396
DEG_Nend_UBRbox_3	1	3	PF02207	0.677
DOC_CDC14_PxL_1	465	473	PF14671	0.288
DOC_CYCLIN_RxL_1	260	270	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	543	549	PF00134	0.392
DOC_MAPK_DCC_7	29	37	PF00069	0.600
DOC_MAPK_DCC_7	857	866	PF00069	0.312
DOC_MAPK_FxFP_2	200	203	PF00069	0.446
DOC_MAPK_FxFP_2	327	330	PF00069	0.358
DOC_MAPK_gen_1	29	37	PF00069	0.600
DOC_MAPK_gen_1	47	57	PF00069	0.507
DOC_MAPK_gen_1	720	729	PF00069	0.449
DOC_MAPK_gen_1	837	844	PF00069	0.288
DOC_MAPK_MEF2A_6	29	37	PF00069	0.600
DOC_MAPK_MEF2A_6	49	57	PF00069	0.471
DOC_MAPK_MEF2A_6	720	729	PF00069	0.437
DOC_MAPK_MEF2A_6	857	866	PF00069	0.312
DOC_MAPK_MEF2A_6	96	103	PF00069	0.485
DOC_MAPK_RevD_3	232	246	PF00069	0.479
DOC_PP2B_LxvP_1	201	204	PF13499	0.444
DOC_PP2B_LxvP_1	438	441	PF13499	0.440
DOC_PP2B_PxIxI_1	596	602	PF00149	0.346
DOC_PP4_FxxP_1	200	203	PF00568	0.446
DOC_PP4_FxxP_1	327	330	PF00568	0.362
DOC_PP4_FxxP_1	557	560	PF00568	0.390
DOC_PP4_FxxP_1	827	830	PF00568	0.268
DOC_USP7_MATH_1	152	156	PF00917	0.467
DOC_USP7_MATH_1	163	167	PF00917	0.437
DOC_USP7_MATH_1	272	276	PF00917	0.464
DOC_USP7_MATH_1	341	345	PF00917	0.466
DOC_USP7_MATH_1	473	477	PF00917	0.268
DOC_USP7_MATH_1	506	510	PF00917	0.448
DOC_USP7_MATH_1	672	676	PF00917	0.410
DOC_USP7_MATH_1	737	741	PF00917	0.466
DOC_USP7_MATH_1	808	812	PF00917	0.351
DOC_USP7_MATH_1	88	92	PF00917	0.541
DOC_WW_Pin1_4	259	264	PF00397	0.586
DOC_WW_Pin1_4	421	426	PF00397	0.470
DOC_WW_Pin1_4	542	547	PF00397	0.404
DOC_WW_Pin1_4	629	634	PF00397	0.422
DOC_WW_Pin1_4	730	735	PF00397	0.558
DOC_WW_Pin1_4	768	773	PF00397	0.540
DOC_WW_Pin1_4	79	84	PF00397	0.497
DOC_WW_Pin1_4	826	831	PF00397	0.411
LIG_14-3-3_CanoR_1	142	146	PF00244	0.496
LIG_14-3-3_CanoR_1	162	172	PF00244	0.379
LIG_14-3-3_CanoR_1	298	304	PF00244	0.358
LIG_14-3-3_CanoR_1	38	43	PF00244	0.663
LIG_14-3-3_CanoR_1	528	536	PF00244	0.421
LIG_14-3-3_CanoR_1	539	544	PF00244	0.402
LIG_14-3-3_CanoR_1	628	633	PF00244	0.416
LIG_14-3-3_CanoR_1	637	647	PF00244	0.395
LIG_14-3-3_CanoR_1	783	791	PF00244	0.265
LIG_Actin_RPEL_3	749	768	PF02755	0.468
LIG_AP2alpha_2	105	107	PF02296	0.464
LIG_AP2alpha_2	724	726	PF02296	0.457
LIG_BIR_III_4	426	430	PF00653	0.516
LIG_BRCT_BRCA1_1	196	200	PF00533	0.484
LIG_BRCT_BRCA1_1	461	465	PF00533	0.312
LIG_BRCT_BRCA1_1	674	678	PF00533	0.397
LIG_deltaCOP1_diTrp_1	294	303	PF00928	0.428
LIG_EH1_1	64	72	PF00400	0.239
LIG_eIF4E_1	648	654	PF01652	0.358
LIG_FHA_1	305	311	PF00498	0.385
LIG_FHA_1	417	423	PF00498	0.522
LIG_FHA_1	46	52	PF00498	0.636
LIG_FHA_1	59	65	PF00498	0.227
LIG_FHA_1	630	636	PF00498	0.523
LIG_FHA_1	744	750	PF00498	0.417
LIG_FHA_1	783	789	PF00498	0.288
LIG_FHA_1	853	859	PF00498	0.333
LIG_FHA_2	134	140	PF00498	0.443
LIG_FHA_2	166	172	PF00498	0.508
LIG_FHA_2	226	232	PF00498	0.459
LIG_FHA_2	365	371	PF00498	0.529
LIG_FHA_2	530	536	PF00498	0.553
LIG_FHA_2	578	584	PF00498	0.459
LIG_FHA_2	586	592	PF00498	0.332
LIG_FHA_2	782	788	PF00498	0.406
LIG_FHA_2	80	86	PF00498	0.496
LIG_FHA_2	870	876	PF00498	0.324
LIG_FHA_2	882	888	PF00498	0.226
LIG_FHA_2	893	899	PF00498	0.319
LIG_LIR_Apic_2	197	203	PF02991	0.495
LIG_LIR_Gen_1	193	203	PF02991	0.486
LIG_LIR_Gen_1	21	32	PF02991	0.618
LIG_LIR_Gen_1	300	311	PF02991	0.345
LIG_LIR_Gen_1	462	473	PF02991	0.312
LIG_LIR_Gen_1	646	656	PF02991	0.319
LIG_LIR_Gen_1	724	734	PF02991	0.464
LIG_LIR_Gen_1	792	800	PF02991	0.304
LIG_LIR_Nem_3	136	140	PF02991	0.445
LIG_LIR_Nem_3	193	198	PF02991	0.450
LIG_LIR_Nem_3	21	27	PF02991	0.617
LIG_LIR_Nem_3	300	306	PF02991	0.345
LIG_LIR_Nem_3	462	468	PF02991	0.277
LIG_LIR_Nem_3	646	651	PF02991	0.333
LIG_LIR_Nem_3	652	657	PF02991	0.295
LIG_LIR_Nem_3	724	729	PF02991	0.474
LIG_LIR_Nem_3	765	769	PF02991	0.407
LIG_LIR_Nem_3	792	797	PF02991	0.304
LIG_MAD2	857	865	PF02301	0.268
LIG_MLH1_MIPbox_1	461	465	PF16413	0.312
LIG_MYND_1	259	263	PF01753	0.522
LIG_NRBOX	539	545	PF00104	0.398
LIG_NRBOX	65	71	PF00104	0.320
LIG_NRBOX	887	893	PF00104	0.312
LIG_Pex14_1	460	464	PF04695	0.312
LIG_Pex14_2	790	794	PF04695	0.288
LIG_Pex14_2	866	870	PF04695	0.268
LIG_PTB_Apo_2	321	328	PF02174	0.391
LIG_Rb_pABgroove_1	651	659	PF01858	0.295
LIG_REV1ctd_RIR_1	554	559	PF16727	0.420
LIG_SH2_CRK	679	683	PF00017	0.344
LIG_SH2_CRK	769	773	PF00017	0.398
LIG_SH2_GRB2like	818	821	PF00017	0.296
LIG_SH2_NCK_1	648	652	PF00017	0.365
LIG_SH2_NCK_1	708	712	PF00017	0.359
LIG_SH2_SRC	708	711	PF00017	0.359
LIG_SH2_STAP1	745	749	PF00017	0.444
LIG_SH2_STAT3	671	674	PF00017	0.386
LIG_SH2_STAT5	391	394	PF00017	0.397
LIG_SH2_STAT5	464	467	PF00017	0.392
LIG_SH2_STAT5	555	558	PF00017	0.370
LIG_SH2_STAT5	745	748	PF00017	0.568
LIG_SH2_STAT5	818	821	PF00017	0.312
LIG_SH3_1	30	36	PF00018	0.560
LIG_SH3_2	33	38	PF14604	0.572
LIG_SH3_3	100	106	PF00018	0.469
LIG_SH3_3	253	259	PF00018	0.533
LIG_SH3_3	274	280	PF00018	0.474
LIG_SH3_3	30	36	PF00018	0.560
LIG_SH3_3	402	408	PF00018	0.502
LIG_SH3_3	419	425	PF00018	0.414
LIG_SH3_3	430	436	PF00018	0.462
LIG_SH3_3	80	86	PF00018	0.503
LIG_SH3_3	92	98	PF00018	0.439
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.450
LIG_SUMO_SIM_par_1	774	780	PF11976	0.433
LIG_SUMO_SIM_par_1	894	901	PF11976	0.371
LIG_TRAF2_1	831	834	PF00917	0.296
LIG_TRAF2_2	830	835	PF00917	0.288
LIG_TYR_ITIM	677	682	PF00017	0.409
LIG_UBA3_1	483	488	PF00899	0.302
LIG_UBA3_1	69	76	PF00899	0.421
LIG_UBA3_1	861	868	PF00899	0.262
MOD_CDK_SPK_2	259	264	PF00069	0.657
MOD_CDK_SPxxK_3	259	266	PF00069	0.613
MOD_CDK_SPxxK_3	421	428	PF00069	0.651
MOD_CK1_1	542	548	PF00069	0.548
MOD_CK1_1	631	637	PF00069	0.565
MOD_CK1_1	638	644	PF00069	0.528
MOD_CK1_1	698	704	PF00069	0.492
MOD_CK1_1	755	761	PF00069	0.498
MOD_CK1_1	77	83	PF00069	0.605
MOD_CK1_1	869	875	PF00069	0.363
MOD_CK2_1	133	139	PF00069	0.611
MOD_CK2_1	152	158	PF00069	0.423
MOD_CK2_1	315	321	PF00069	0.509
MOD_CK2_1	529	535	PF00069	0.527
MOD_CK2_1	577	583	PF00069	0.587
MOD_CK2_1	680	686	PF00069	0.439
MOD_CK2_1	730	736	PF00069	0.536
MOD_CK2_1	768	774	PF00069	0.506
MOD_CK2_1	79	85	PF00069	0.618
MOD_CK2_1	828	834	PF00069	0.341
MOD_CK2_1	892	898	PF00069	0.371
MOD_CK2_1	901	907	PF00069	0.489
MOD_CMANNOS	589	592	PF00535	0.405
MOD_Cter_Amidation	11	14	PF01082	0.548
MOD_Cter_Amidation	159	162	PF01082	0.577
MOD_Cter_Amidation	242	245	PF01082	0.636
MOD_DYRK1A_RPxSP_1	79	83	PF00069	0.562
MOD_GlcNHglycan	165	168	PF01048	0.673
MOD_GlcNHglycan	20	23	PF01048	0.491
MOD_GlcNHglycan	343	346	PF01048	0.589
MOD_GlcNHglycan	438	441	PF01048	0.667
MOD_GlcNHglycan	475	478	PF01048	0.302
MOD_GlcNHglycan	507	511	PF01048	0.588
MOD_GlcNHglycan	515	519	PF01048	0.536
MOD_GlcNHglycan	613	616	PF01048	0.472
MOD_GlcNHglycan	674	677	PF01048	0.429
MOD_GlcNHglycan	697	700	PF01048	0.557
MOD_GSK3_1	341	348	PF00069	0.587
MOD_GSK3_1	38	45	PF00069	0.567
MOD_GSK3_1	631	638	PF00069	0.500
MOD_GSK3_1	643	650	PF00069	0.432
MOD_GSK3_1	694	701	PF00069	0.497
MOD_GSK3_1	758	765	PF00069	0.580
MOD_GSK3_1	777	784	PF00069	0.272
MOD_N-GLC_1	304	309	PF02516	0.399
MOD_N-GLC_1	528	533	PF02516	0.591
MOD_N-GLC_1	752	757	PF02516	0.595
MOD_N-GLC_1	77	82	PF02516	0.527
MOD_N-GLC_1	875	880	PF02516	0.239
MOD_NEK2_1	194	199	PF00069	0.629
MOD_NEK2_1	23	28	PF00069	0.429
MOD_NEK2_1	483	488	PF00069	0.334
MOD_NEK2_1	500	505	PF00069	0.520
MOD_NEK2_1	523	528	PF00069	0.525
MOD_NEK2_1	59	64	PF00069	0.306
MOD_NEK2_1	694	699	PF00069	0.507
MOD_NEK2_1	891	896	PF00069	0.374
MOD_NEK2_2	663	668	PF00069	0.389
MOD_PIKK_1	389	395	PF00454	0.575
MOD_PIKK_1	444	450	PF00454	0.591
MOD_PIKK_1	670	676	PF00454	0.447
MOD_PIKK_1	680	686	PF00454	0.411
MOD_PIKK_1	828	834	PF00454	0.329
MOD_PIKK_1	852	858	PF00454	0.302
MOD_PK_1	38	44	PF00069	0.524
MOD_PK_1	559	565	PF00069	0.588
MOD_PKA_1	364	370	PF00069	0.671
MOD_PKA_2	133	139	PF00069	0.651
MOD_PKA_2	141	147	PF00069	0.545
MOD_PKA_2	297	303	PF00069	0.452
MOD_PKA_2	364	370	PF00069	0.633
MOD_PKA_2	638	644	PF00069	0.489
MOD_PKA_2	755	761	PF00069	0.523
MOD_PKA_2	782	788	PF00069	0.298
MOD_PKB_1	537	545	PF00069	0.552
MOD_Plk_1	616	622	PF00069	0.375
MOD_Plk_1	709	715	PF00069	0.614
MOD_Plk_1	809	815	PF00069	0.329
MOD_Plk_2-3	585	591	PF00069	0.465
MOD_Plk_4	133	139	PF00069	0.549
MOD_Plk_4	152	158	PF00069	0.533
MOD_Plk_4	23	29	PF00069	0.433
MOD_Plk_4	386	392	PF00069	0.555
MOD_Plk_4	539	545	PF00069	0.546
MOD_Plk_4	59	65	PF00069	0.306
MOD_Plk_4	631	637	PF00069	0.581
MOD_Plk_4	643	649	PF00069	0.381
MOD_Plk_4	892	898	PF00069	0.371
MOD_ProDKin_1	259	265	PF00069	0.739
MOD_ProDKin_1	421	427	PF00069	0.583
MOD_ProDKin_1	542	548	PF00069	0.486
MOD_ProDKin_1	629	635	PF00069	0.529
MOD_ProDKin_1	730	736	PF00069	0.708
MOD_ProDKin_1	768	774	PF00069	0.686
MOD_ProDKin_1	79	85	PF00069	0.628
MOD_ProDKin_1	826	832	PF00069	0.502
MOD_SUMO_rev_2	370	375	PF00179	0.665
MOD_SUMO_rev_2	424	430	PF00179	0.614
TRG_DiLeu_BaEn_1	321	326	PF01217	0.468
TRG_DiLeu_BaEn_2	565	571	PF01217	0.509
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.586
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.406
TRG_ENDOCYTIC_2	137	140	PF00928	0.548
TRG_ENDOCYTIC_2	553	556	PF00928	0.516
TRG_ENDOCYTIC_2	648	651	PF00928	0.427
TRG_ENDOCYTIC_2	657	660	PF00928	0.289
TRG_ENDOCYTIC_2	679	682	PF00928	0.404
TRG_ENDOCYTIC_2	800	803	PF00928	0.380
TRG_ER_diArg_1	117	120	PF00400	0.548
TRG_ER_diArg_1	13	15	PF00400	0.560
TRG_ER_diArg_1	244	246	PF00400	0.650
TRG_ER_diArg_1	335	337	PF00400	0.506
TRG_ER_diArg_1	364	366	PF00400	0.678
TRG_ER_diArg_1	47	50	PF00400	0.508
TRG_ER_diArg_1	636	639	PF00400	0.587
TRG_ER_diArg_1	689	692	PF00400	0.528
TRG_ER_diArg_1	747	749	PF00400	0.586
TRG_ER_diArg_1	836	838	PF00400	0.302
TRG_ER_diArg_1	9	11	PF00400	0.600
TRG_NES_CRM1_1	645	658	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR2	Leptomonas seymouri	51%	99%
A0A3S7WP80	Leishmania donovani	95%	100%
A4H4D8	Leishmania braziliensis	80%	100%
A4HSL7	Leishmania infantum	95%	100%
E9AKK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%