Dipeptidyl peptidase 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan M-, Family M49

Species:

Leishmania major

UniProt:

Q4QJA6_LEIMA

TriTrypDb:

LmjF.05.0960 , LMJLV39_050014500 , LMJSD75_050014800

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	yes	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 3

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Previous1Next

Expansion

Sequence features

Q4QJA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJA6

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0019538	protein metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004177	aminopeptidase activity	5	7
GO:0005488	binding	1	8
GO:0008233	peptidase activity	3	7
GO:0008235	metalloexopeptidase activity	5	7
GO:0008237	metallopeptidase activity	4	7
GO:0008238	exopeptidase activity	4	7
GO:0008239	dipeptidyl-peptidase activity	5	7
GO:0016787	hydrolase activity	2	8
GO:0043167	ion binding	2	8

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.419
CLV_NRD_NRD_1	242	244	PF00675	0.414
CLV_NRD_NRD_1	635	637	PF00675	0.355
CLV_NRD_NRD_1	638	640	PF00675	0.355
CLV_PCSK_KEX2_1	609	611	PF00082	0.483
CLV_PCSK_KEX2_1	635	637	PF00082	0.429
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.483
CLV_PCSK_SKI1_1	123	127	PF00082	0.452
CLV_PCSK_SKI1_1	160	164	PF00082	0.414
CLV_PCSK_SKI1_1	193	197	PF00082	0.355

Previous1 2 3 4 5…22Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I084	Leptomonas seymouri	81%	100%
A0A0S4JJ29	Bodo saltans	55%	73%
A0A3S7WP65	Leishmania donovani	97%	100%
A4H4D9	Leishmania braziliensis	88%	100%
A4HSL8	Leishmania infantum	97%	100%
A7RZW4	Nematostella vectensis	45%	93%
E9AKK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O55096	Rattus norvegicus	43%	92%
Q08225	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	95%
Q557H1	Dictyostelium discoideum	43%	98%

Previous1 2Next