LeishMANIAdb
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DUF5683 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF5683 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QJ99_LEIMA
TriTrypDb:
LmjF.05.1030 , LMJLV39_050015400 , LMJSD75_050015800
Length:
145

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 2, no: 9
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

Q4QJ99
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ99

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.688
CLV_NRD_NRD_1 129 131 PF00675 0.357
CLV_PCSK_KEX2_1 11 13 PF00082 0.688
CLV_PCSK_SKI1_1 57 61 PF00082 0.637
DEG_Nend_UBRbox_3 1 3 PF02207 0.627
DOC_CYCLIN_RxL_1 54 64 PF00134 0.355
DOC_MAPK_gen_1 130 138 PF00069 0.584
DOC_PP2B_LxvP_1 94 97 PF13499 0.425
DOC_USP7_UBL2_3 63 67 PF12436 0.517
DOC_WW_Pin1_4 103 108 PF00397 0.145
DOC_WW_Pin1_4 83 88 PF00397 0.484
LIG_FHA_1 133 139 PF00498 0.625
LIG_LIR_Gen_1 106 117 PF02991 0.363
LIG_LIR_Nem_3 106 112 PF02991 0.363
LIG_LIR_Nem_3 4 8 PF02991 0.669
LIG_LIR_Nem_3 76 82 PF02991 0.439
LIG_Pex14_1 120 124 PF04695 0.328
LIG_SH2_CRK 109 113 PF00017 0.344
LIG_SH2_STAP1 133 137 PF00017 0.613
LIG_SH2_STAT5 109 112 PF00017 0.344
LIG_SH2_STAT5 128 131 PF00017 0.558
LIG_SUMO_SIM_anti_2 19 24 PF11976 0.405
LIG_SUMO_SIM_par_1 101 106 PF11976 0.287
LIG_WRC_WIRS_1 82 87 PF05994 0.450
MOD_CK2_1 55 61 PF00069 0.477
MOD_GlcNHglycan 13 16 PF01048 0.668
MOD_GlcNHglycan 64 67 PF01048 0.644
MOD_GlcNHglycan 90 93 PF01048 0.699
MOD_GSK3_1 7 14 PF00069 0.601
MOD_NEK2_1 1 6 PF00069 0.578
MOD_NEK2_1 16 21 PF00069 0.514
MOD_NEK2_1 23 28 PF00069 0.480
MOD_NEK2_1 43 48 PF00069 0.493
MOD_PIKK_1 23 29 PF00454 0.597
MOD_PKA_1 11 17 PF00069 0.584
MOD_PKA_2 11 17 PF00069 0.601
MOD_Plk_4 1 7 PF00069 0.708
MOD_Plk_4 132 138 PF00069 0.608
MOD_Plk_4 16 22 PF00069 0.645
MOD_ProDKin_1 103 109 PF00069 0.145
MOD_ProDKin_1 83 89 PF00069 0.482
MOD_SUMO_rev_2 58 65 PF00179 0.521
TRG_ENDOCYTIC_2 109 112 PF00928 0.344
TRG_ENDOCYTIC_2 124 127 PF00928 0.544
TRG_ENDOCYTIC_2 133 136 PF00928 0.590
TRG_ENDOCYTIC_2 82 85 PF00928 0.403
TRG_Pf-PMV_PEXEL_1 57 61 PF00026 0.552

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCY8 Leptomonas seymouri 72% 100%
A0A0S4IJQ1 Bodo saltans 43% 100%
A0A1X0NKT0 Trypanosomatidae 52% 99%
A0A3R7K2B2 Trypanosoma rangeli 57% 100%
A0A3S5H5L3 Leishmania donovani 94% 100%
A4H4E8 Leishmania braziliensis 84% 100%
A4HSM5 Leishmania infantum 94% 100%
C9ZND7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
E9AKK9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5BBW2 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS