Stomatin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stomatin-like protein

Species:

Leishmania major

UniProt:

Q4QJ98_LEIMA

TriTrypDb:

LmjF.05.1040 , LMJLV39_050015500 , LMJSD75_050015900

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QJ98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	186	188	PF00675	0.310
CLV_NRD_NRD_1	211	213	PF00675	0.267
CLV_NRD_NRD_1	221	223	PF00675	0.238
CLV_NRD_NRD_1	224	226	PF00675	0.231
CLV_NRD_NRD_1	3	5	PF00675	0.503
CLV_PCSK_FUR_1	222	226	PF00082	0.249
CLV_PCSK_KEX2_1	186	188	PF00082	0.294
CLV_PCSK_KEX2_1	197	199	PF00082	0.288
CLV_PCSK_KEX2_1	211	213	PF00082	0.272
CLV_PCSK_KEX2_1	224	226	PF00082	0.261
CLV_PCSK_KEX2_1	3	5	PF00082	0.502
CLV_PCSK_KEX2_1	350	352	PF00082	0.448
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.286
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.261
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.448
CLV_PCSK_SKI1_1	226	230	PF00082	0.343
CLV_PCSK_SKI1_1	44	48	PF00082	0.659
CLV_Separin_Metazoa	183	187	PF03568	0.264
CLV_Separin_Metazoa	208	212	PF03568	0.264
DEG_APCC_DBOX_1	163	171	PF00400	0.264
DEG_APCC_DBOX_1	57	65	PF00400	0.361
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DOC_CYCLIN_RxL_1	222	232	PF00134	0.249
DOC_CYCLIN_yCln2_LP_2	46	52	PF00134	0.582
DOC_MAPK_gen_1	222	229	PF00069	0.249
DOC_MAPK_gen_1	3	9	PF00069	0.630
DOC_USP7_MATH_1	111	115	PF00917	0.249
DOC_USP7_MATH_1	19	23	PF00917	0.759
DOC_USP7_MATH_1	276	280	PF00917	0.487
DOC_USP7_MATH_1	292	296	PF00917	0.208
DOC_USP7_MATH_1	315	319	PF00917	0.343
DOC_USP7_MATH_2	24	30	PF00917	0.558
DOC_WW_Pin1_4	349	354	PF00397	0.663
LIG_14-3-3_CanoR_1	164	168	PF00244	0.365
LIG_14-3-3_CanoR_1	174	178	PF00244	0.309
LIG_14-3-3_CanoR_1	211	215	PF00244	0.259
LIG_14-3-3_CanoR_1	58	62	PF00244	0.533
LIG_14-3-3_CanoR_1	78	84	PF00244	0.123
LIG_Actin_WH2_2	118	134	PF00022	0.249
LIG_APCC_ABBA_1	90	95	PF00400	0.343
LIG_deltaCOP1_diTrp_1	84	93	PF00928	0.283
LIG_EH1_1	198	206	PF00400	0.393
LIG_FHA_1	179	185	PF00498	0.321
LIG_FHA_1	234	240	PF00498	0.501
LIG_FHA_1	333	339	PF00498	0.343
LIG_LIR_Gen_1	339	349	PF02991	0.283
LIG_LIR_Gen_1	60	66	PF02991	0.435
LIG_LIR_Gen_1	85	94	PF02991	0.409
LIG_LIR_Nem_3	309	314	PF02991	0.249
LIG_LIR_Nem_3	339	344	PF02991	0.264
LIG_LIR_Nem_3	60	65	PF02991	0.436
LIG_LIR_Nem_3	84	90	PF02991	0.270
LIG_PTB_Apo_2	142	149	PF02174	0.249
LIG_SH2_STAT3	11	14	PF00017	0.569
LIG_SH2_STAT5	258	261	PF00017	0.425
LIG_SH2_STAT5	307	310	PF00017	0.249
LIG_SH2_STAT5	71	74	PF00017	0.249
LIG_SH3_3	324	330	PF00018	0.253
LIG_SH3_3	86	92	PF00018	0.375
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.321
LIG_SUMO_SIM_anti_2	279	287	PF11976	0.425
LIG_SUMO_SIM_par_1	121	126	PF11976	0.249
LIG_TRAF2_1	23	26	PF00917	0.629
LIG_UBA3_1	129	138	PF00899	0.249
LIG_WW_3	55	59	PF00397	0.538
MOD_CK1_1	114	120	PF00069	0.249
MOD_CK1_1	166	172	PF00069	0.393
MOD_CK1_1	235	241	PF00069	0.520
MOD_CK1_1	283	289	PF00069	0.329
MOD_CK1_1	29	35	PF00069	0.627
MOD_CK2_1	177	183	PF00069	0.334
MOD_CK2_1	228	234	PF00069	0.264
MOD_CK2_1	303	309	PF00069	0.406
MOD_CK2_1	48	54	PF00069	0.502
MOD_GlcNHglycan	113	116	PF01048	0.249
MOD_GlcNHglycan	21	24	PF01048	0.639
MOD_GlcNHglycan	28	31	PF01048	0.587
MOD_GlcNHglycan	346	349	PF01048	0.578
MOD_GlcNHglycan	84	87	PF01048	0.346
MOD_GSK3_1	111	118	PF00069	0.283
MOD_GSK3_1	133	140	PF00069	0.343
MOD_GSK3_1	153	160	PF00069	0.249
MOD_GSK3_1	173	180	PF00069	0.321
MOD_GSK3_1	228	235	PF00069	0.372
MOD_GSK3_1	276	283	PF00069	0.391
MOD_GSK3_1	317	324	PF00069	0.343
MOD_GSK3_1	332	339	PF00069	0.123
MOD_GSK3_1	340	347	PF00069	0.238
MOD_N-GLC_1	111	116	PF02516	0.249
MOD_N-GLC_1	177	182	PF02516	0.321
MOD_N-GLC_1	280	285	PF02516	0.474
MOD_NEK2_1	153	158	PF00069	0.273
MOD_NEK2_1	177	182	PF00069	0.321
MOD_NEK2_1	332	337	PF00069	0.228
MOD_NEK2_1	39	44	PF00069	0.589
MOD_NEK2_2	154	159	PF00069	0.249
MOD_NEK2_2	57	62	PF00069	0.458
MOD_PIKK_1	321	327	PF00454	0.366
MOD_PIKK_1	332	338	PF00454	0.306
MOD_PIKK_1	39	45	PF00454	0.651
MOD_PKA_2	163	169	PF00069	0.365
MOD_PKA_2	173	179	PF00069	0.309
MOD_PKA_2	210	216	PF00069	0.261
MOD_PKA_2	261	267	PF00069	0.539
MOD_PKA_2	57	63	PF00069	0.410
MOD_Plk_1	111	117	PF00069	0.249
MOD_Plk_1	177	183	PF00069	0.365
MOD_Plk_1	280	286	PF00069	0.486
MOD_Plk_2-3	48	54	PF00069	0.571
MOD_Plk_4	166	172	PF00069	0.249
MOD_Plk_4	303	309	PF00069	0.351
MOD_Plk_4	317	323	PF00069	0.173
MOD_Plk_4	336	342	PF00069	0.264
MOD_Plk_4	48	54	PF00069	0.451
MOD_Plk_4	57	63	PF00069	0.379
MOD_ProDKin_1	349	355	PF00069	0.668
TRG_ER_diArg_1	185	187	PF00400	0.283
TRG_ER_diArg_1	2	4	PF00400	0.502
TRG_ER_diArg_1	210	212	PF00400	0.258
TRG_NES_CRM1_1	124	135	PF08389	0.249
TRG_NLS_Bipartite_1	211	228	PF00514	0.264
TRG_NLS_MonoCore_2	222	227	PF00514	0.343
TRG_NLS_MonoExtN_4	222	228	PF00514	0.249
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.249

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTU5	Leptomonas seymouri	85%	99%
A0A0S4INS2	Bodo saltans	62%	100%
A0A1X0NKE1	Trypanosomatidae	70%	83%
A0A3R7M6V7	Trypanosoma rangeli	63%	93%
A0A3S5H5L4	Leishmania donovani	99%	100%
A4H4E9	Leishmania braziliensis	93%	100%
A4HSM6	Leishmania infantum	99%	100%
C9ZND8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	67%
E9AKL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AS80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O60121	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
P0AA53	Escherichia coli (strain K12)	36%	100%
P0AA54	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	36%	100%
P0AA55	Escherichia coli O157:H7	36%	100%
P0AA56	Shigella flexneri	36%	100%
P0DKS0	Wigglesworthia glossinidia brevipalpis	33%	100%
P63694	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	94%
P72655	Synechocystis sp. (strain PCC 6803 / Kazusa)	36%	100%
P9WPR8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	94%
P9WPR9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	94%
Q32LL2	Bos taurus	47%	100%
Q4FZT0	Rattus norvegicus	47%	100%
Q99JB2	Mus musculus	47%	100%
Q9FHM7	Arabidopsis thaliana	22%	100%
Q9UJZ1	Homo sapiens	45%	100%
V5BBU5	Trypanosoma cruzi	62%	88%