L-type lectin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Legume-like lectin family, putative

Species:

Leishmania major

UniProt:

Q4QJ95_LEIMA

TriTrypDb:

LmjF.05.1070 , LMJLV39_050015900 , LMJSD75_050016100

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 6
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0005737	cytoplasm	2	2
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	2
GO:0016020	membrane	2	10
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031090	organelle membrane	3	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QJ95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ95

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006996	organelle organization	4	2
GO:0007029	endoplasmic reticulum organization	5	2
GO:0007030	Golgi organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005537	mannose binding	4	2
GO:0030246	carbohydrate binding	2	3
GO:0036094	small molecule binding	2	2
GO:0048029	monosaccharide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.631
CLV_NRD_NRD_1	209	211	PF00675	0.564
CLV_NRD_NRD_1	214	216	PF00675	0.548
CLV_NRD_NRD_1	363	365	PF00675	0.410
CLV_NRD_NRD_1	371	373	PF00675	0.398
CLV_NRD_NRD_1	432	434	PF00675	0.565
CLV_NRD_NRD_1	435	437	PF00675	0.583
CLV_NRD_NRD_1	490	492	PF00675	0.482
CLV_PCSK_FUR_1	433	437	PF00082	0.566
CLV_PCSK_KEX2_1	209	211	PF00082	0.527
CLV_PCSK_KEX2_1	214	216	PF00082	0.530
CLV_PCSK_KEX2_1	226	228	PF00082	0.510
CLV_PCSK_KEX2_1	363	365	PF00082	0.405
CLV_PCSK_KEX2_1	371	373	PF00082	0.400
CLV_PCSK_KEX2_1	377	379	PF00082	0.496
CLV_PCSK_KEX2_1	434	436	PF00082	0.578
CLV_PCSK_KEX2_1	490	492	PF00082	0.478
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.554
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.495
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.446
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.538
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.601
CLV_PCSK_PC7_1	210	216	PF00082	0.583
CLV_PCSK_SKI1_1	210	214	PF00082	0.564
CLV_PCSK_SKI1_1	222	226	PF00082	0.489
CLV_PCSK_SKI1_1	346	350	PF00082	0.558
CLV_PCSK_SKI1_1	364	368	PF00082	0.288
CLV_PCSK_SKI1_1	428	432	PF00082	0.655
CLV_PCSK_SKI1_1	439	443	PF00082	0.617
CLV_PCSK_SKI1_1	448	452	PF00082	0.509
CLV_Separin_Metazoa	395	399	PF03568	0.489
DEG_APCC_DBOX_1	434	442	PF00400	0.665
DEG_APCC_DBOX_1	459	467	PF00400	0.344
DOC_CYCLIN_RxL_1	216	229	PF00134	0.606
DOC_MAPK_gen_1	236	245	PF00069	0.488
DOC_MAPK_gen_1	360	370	PF00069	0.348
DOC_MAPK_gen_1	447	455	PF00069	0.617
DOC_MAPK_gen_1	490	496	PF00069	0.598
DOC_MAPK_MEF2A_6	236	245	PF00069	0.488
DOC_MAPK_MEF2A_6	363	370	PF00069	0.342
DOC_PP1_RVXF_1	104	110	PF00149	0.231
DOC_PP1_RVXF_1	491	497	PF00149	0.538
DOC_PP2B_LxvP_1	289	292	PF13499	0.439
DOC_PP4_FxxP_1	50	53	PF00568	0.244
DOC_SPAK_OSR1_1	108	112	PF12202	0.244
DOC_USP7_MATH_1	21	25	PF00917	0.667
DOC_USP7_MATH_1	437	441	PF00917	0.693
DOC_USP7_MATH_1	53	57	PF00917	0.264
DOC_USP7_UBL2_3	222	226	PF12436	0.610
DOC_WW_Pin1_4	154	159	PF00397	0.651
DOC_WW_Pin1_4	313	318	PF00397	0.394
LIG_14-3-3_CanoR_1	227	232	PF00244	0.536
LIG_14-3-3_CanoR_1	321	325	PF00244	0.560
LIG_14-3-3_CanoR_1	364	369	PF00244	0.280
LIG_14-3-3_CanoR_1	436	442	PF00244	0.627
LIG_14-3-3_CanoR_1	80	86	PF00244	0.267
LIG_deltaCOP1_diTrp_1	101	109	PF00928	0.338
LIG_deltaCOP1_diTrp_1	168	176	PF00928	0.597
LIG_FHA_1	280	286	PF00498	0.499
LIG_FHA_1	3	9	PF00498	0.559
LIG_FHA_1	343	349	PF00498	0.370
LIG_FHA_1	365	371	PF00498	0.411
LIG_FHA_1	389	395	PF00498	0.546
LIG_FHA_1	476	482	PF00498	0.646
LIG_FHA_1	81	87	PF00498	0.275
LIG_FHA_1	93	99	PF00498	0.275
LIG_FHA_2	194	200	PF00498	0.670
LIG_FHA_2	227	233	PF00498	0.519
LIG_FHA_2	347	353	PF00498	0.415
LIG_FHA_2	397	403	PF00498	0.462
LIG_FHA_2	449	455	PF00498	0.479
LIG_FHA_2	80	86	PF00498	0.343
LIG_LIR_Apic_2	47	53	PF02991	0.244
LIG_LIR_Gen_1	284	292	PF02991	0.504
LIG_LIR_Gen_1	449	458	PF02991	0.523
LIG_LIR_Gen_1	76	86	PF02991	0.275
LIG_LIR_LC3C_4	11	15	PF02991	0.412
LIG_LIR_Nem_3	218	224	PF02991	0.460
LIG_LIR_Nem_3	284	289	PF02991	0.488
LIG_LIR_Nem_3	449	453	PF02991	0.531
LIG_LIR_Nem_3	76	81	PF02991	0.275
LIG_PDZ_Class_3	504	509	PF00595	0.620
LIG_Pex14_2	221	225	PF04695	0.608
LIG_Pex14_2	248	252	PF04695	0.419
LIG_PTB_Apo_2	72	79	PF02174	0.257
LIG_SH2_STAP1	152	156	PF00017	0.616
LIG_SH2_STAP1	400	404	PF00017	0.486
LIG_SH2_STAP1	475	479	PF00017	0.518
LIG_SH2_STAT3	137	140	PF00017	0.257
LIG_SH2_STAT3	334	337	PF00017	0.536
LIG_SH2_STAT5	137	140	PF00017	0.244
LIG_SH2_STAT5	286	289	PF00017	0.492
LIG_SH2_STAT5	400	403	PF00017	0.402
LIG_SH3_1	498	504	PF00018	0.534
LIG_SH3_3	330	336	PF00018	0.607
LIG_SH3_3	498	504	PF00018	0.534
LIG_SUMO_SIM_anti_2	11	16	PF11976	0.415
LIG_SUMO_SIM_anti_2	352	359	PF11976	0.338
LIG_SUMO_SIM_anti_2	391	399	PF11976	0.496
LIG_TRAF2_1	196	199	PF00917	0.578
LIG_TRAF2_1	350	353	PF00917	0.454
LIG_TRAF2_1	49	52	PF00917	0.294
LIG_UBA3_1	220	226	PF00899	0.608
MOD_CDK_SPxxK_3	154	161	PF00069	0.647
MOD_CK1_1	298	304	PF00069	0.575
MOD_CK1_1	422	428	PF00069	0.418
MOD_CK2_1	193	199	PF00069	0.645
MOD_CK2_1	227	233	PF00069	0.507
MOD_CK2_1	346	352	PF00069	0.484
MOD_CK2_1	396	402	PF00069	0.471
MOD_CK2_1	46	52	PF00069	0.359
MOD_GlcNHglycan	297	300	PF01048	0.680
MOD_GlcNHglycan	421	424	PF01048	0.371
MOD_GlcNHglycan	70	73	PF01048	0.453
MOD_GSK3_1	150	157	PF00069	0.663
MOD_GSK3_1	227	234	PF00069	0.504
MOD_GSK3_1	294	301	PF00069	0.591
MOD_GSK3_1	342	349	PF00069	0.579
MOD_GSK3_1	384	391	PF00069	0.603
MOD_GSK3_1	396	403	PF00069	0.434
MOD_N-GLC_1	120	125	PF02516	0.526
MOD_N-GLC_1	292	297	PF02516	0.572
MOD_NEK2_1	120	125	PF00069	0.345
MOD_NEK2_1	3	8	PF00069	0.637
MOD_NEK2_1	419	424	PF00069	0.375
MOD_NEK2_1	473	478	PF00069	0.501
MOD_NEK2_1	494	499	PF00069	0.618
MOD_NEK2_1	79	84	PF00069	0.347
MOD_NEK2_2	437	442	PF00069	0.574
MOD_PK_1	227	233	PF00069	0.544
MOD_PKA_1	216	222	PF00069	0.475
MOD_PKA_1	226	232	PF00069	0.503
MOD_PKA_1	364	370	PF00069	0.298
MOD_PKA_2	107	113	PF00069	0.244
MOD_PKA_2	216	222	PF00069	0.450
MOD_PKA_2	226	232	PF00069	0.485
MOD_PKA_2	320	326	PF00069	0.503
MOD_PKA_2	79	85	PF00069	0.267
MOD_Plk_1	378	384	PF00069	0.540
MOD_Plk_1	46	52	PF00069	0.257
MOD_Plk_2-3	193	199	PF00069	0.655
MOD_Plk_2-3	379	385	PF00069	0.453
MOD_Plk_4	216	222	PF00069	0.375
MOD_Plk_4	281	287	PF00069	0.460
MOD_Plk_4	298	304	PF00069	0.551
MOD_Plk_4	364	370	PF00069	0.371
MOD_Plk_4	379	385	PF00069	0.480
MOD_Plk_4	8	14	PF00069	0.554
MOD_ProDKin_1	154	160	PF00069	0.648
MOD_ProDKin_1	313	319	PF00069	0.396
MOD_SUMO_for_1	376	379	PF00179	0.492
MOD_SUMO_rev_2	440	450	PF00179	0.528
MOD_SUMO_rev_2	465	473	PF00179	0.391
TRG_DiLeu_BaEn_1	353	358	PF01217	0.415
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.431
TRG_ENDOCYTIC_2	286	289	PF00928	0.492
TRG_ER_diArg_1	106	109	PF00400	0.248
TRG_ER_diArg_1	370	372	PF00400	0.397
TRG_ER_diArg_1	433	436	PF00400	0.617
TRG_NES_CRM1_1	457	469	PF08389	0.533
TRG_NLS_MonoCore_2	212	217	PF00514	0.599
TRG_NLS_MonoCore_2	432	437	PF00514	0.602
TRG_NLS_MonoExtC_3	212	217	PF00514	0.616
TRG_NLS_MonoExtC_3	432	437	PF00514	0.592
TRG_NLS_MonoExtN_4	210	217	PF00514	0.622
TRG_NLS_MonoExtN_4	360	367	PF00514	0.323
TRG_NLS_MonoExtN_4	431	438	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	464	469	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIA0	Leptomonas seymouri	78%	100%
A0A1X0NKB0	Trypanosomatidae	42%	79%
A0A3R7LT82	Trypanosoma rangeli	47%	93%
A0A3S5H5L7	Leishmania donovani	96%	84%
A4H4F2	Leishmania braziliensis	87%	100%
A4HSM9	Leishmania infantum	96%	98%
C9ZU67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	82%
E8NHN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	83%
E9AKL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	98%
V5ARI9	Trypanosoma cruzi	47%	87%