Phosphatidylinositol 4-phosphate 5-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphatidylinositol 4-phosphate 5-kinase, putative

Species:

Leishmania major

UniProt:

Q4QJ94_LEIMA

TriTrypDb:

LmjF.05.1080 , LMJLV39_050016000 , LMJSD75_050016200

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ94

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.724
CLV_C14_Caspase3-7	495	499	PF00656	0.630
CLV_C14_Caspase3-7	580	584	PF00656	0.650
CLV_NRD_NRD_1	406	408	PF00675	0.493
CLV_NRD_NRD_1	679	681	PF00675	0.593
CLV_NRD_NRD_1	718	720	PF00675	0.635
CLV_PCSK_FUR_1	114	118	PF00082	0.520
CLV_PCSK_KEX2_1	113	115	PF00082	0.482
CLV_PCSK_KEX2_1	116	118	PF00082	0.524
CLV_PCSK_KEX2_1	161	163	PF00082	0.600
CLV_PCSK_KEX2_1	215	217	PF00082	0.656
CLV_PCSK_KEX2_1	302	304	PF00082	0.413
CLV_PCSK_KEX2_1	515	517	PF00082	0.521
CLV_PCSK_KEX2_1	679	681	PF00082	0.621
CLV_PCSK_KEX2_1	718	720	PF00082	0.554
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.482
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.524
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.605
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.656
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.449
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.521
CLV_PCSK_SKI1_1	113	117	PF00082	0.513
DEG_APCC_DBOX_1	705	713	PF00400	0.568
DEG_APCC_KENBOX_2	251	255	PF00400	0.449
DEG_COP1_1	398	406	PF00400	0.595
DEG_SIAH_1	685	693	PF03145	0.794
DOC_CKS1_1	695	700	PF01111	0.620
DOC_CYCLIN_yCln2_LP_2	602	605	PF00134	0.662
DOC_MAPK_gen_1	215	222	PF00069	0.635
DOC_MAPK_gen_1	48	58	PF00069	0.686
DOC_MAPK_MEF2A_6	215	224	PF00069	0.593
DOC_MAPK_MEF2A_6	412	421	PF00069	0.516
DOC_PP1_RVXF_1	257	264	PF00149	0.449
DOC_PP2B_LxvP_1	419	422	PF13499	0.613
DOC_PP2B_LxvP_1	537	540	PF13499	0.615
DOC_PP2B_LxvP_1	601	604	PF13499	0.640
DOC_USP7_MATH_1	136	140	PF00917	0.688
DOC_USP7_MATH_1	289	293	PF00917	0.344
DOC_USP7_MATH_1	312	316	PF00917	0.344
DOC_USP7_MATH_1	423	427	PF00917	0.633
DOC_USP7_MATH_1	520	524	PF00917	0.547
DOC_USP7_MATH_1	615	619	PF00917	0.627
DOC_USP7_MATH_1	646	650	PF00917	0.669
DOC_USP7_UBL2_3	302	306	PF12436	0.475
DOC_WW_Pin1_4	382	387	PF00397	0.447
DOC_WW_Pin1_4	553	558	PF00397	0.640
DOC_WW_Pin1_4	694	699	PF00397	0.645
LIG_14-3-3_CanoR_1	117	123	PF00244	0.674
LIG_14-3-3_CanoR_1	407	415	PF00244	0.459
LIG_14-3-3_CanoR_1	458	464	PF00244	0.494
LIG_14-3-3_CanoR_1	570	577	PF00244	0.710
LIG_14-3-3_CanoR_1	680	686	PF00244	0.627
LIG_14-3-3_CanoR_1	687	691	PF00244	0.676
LIG_14-3-3_CanoR_1	92	96	PF00244	0.578
LIG_Actin_WH2_2	443	460	PF00022	0.509
LIG_Actin_WH2_2	468	485	PF00022	0.625
LIG_APCC_ABBA_1	413	418	PF00400	0.579
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BIR_III_4	583	587	PF00653	0.707
LIG_CaM_NSCaTE_8	459	466	PF13499	0.617
LIG_CtBP_PxDLS_1	191	195	PF00389	0.651
LIG_FHA_1	329	335	PF00498	0.475
LIG_FHA_1	398	404	PF00498	0.483
LIG_FHA_1	540	546	PF00498	0.598
LIG_FHA_1	648	654	PF00498	0.610
LIG_FHA_2	142	148	PF00498	0.613
LIG_FHA_2	196	202	PF00498	0.743
LIG_FHA_2	31	37	PF00498	0.718
LIG_FHA_2	441	447	PF00498	0.468
LIG_FHA_2	493	499	PF00498	0.584
LIG_GBD_Chelix_1	107	115	PF00786	0.549
LIG_HP1_1	544	548	PF01393	0.485
LIG_LIR_Gen_1	133	143	PF02991	0.593
LIG_LIR_Gen_1	193	202	PF02991	0.617
LIG_LIR_Gen_1	329	340	PF02991	0.448
LIG_LIR_Gen_1	54	63	PF02991	0.711
LIG_LIR_Gen_1	649	660	PF02991	0.504
LIG_LIR_LC3C_4	418	421	PF02991	0.609
LIG_LIR_Nem_3	193	199	PF02991	0.618
LIG_LIR_Nem_3	329	335	PF02991	0.448
LIG_LIR_Nem_3	54	58	PF02991	0.736
LIG_LIR_Nem_3	649	655	PF02991	0.520
LIG_MYND_1	701	705	PF01753	0.653
LIG_MYND_1	707	711	PF01753	0.538
LIG_NRBOX	532	538	PF00104	0.583
LIG_Pex14_2	340	344	PF04695	0.381
LIG_SH2_CRK	453	457	PF00017	0.554
LIG_SH2_PTP2	18	21	PF00017	0.599
LIG_SH2_PTP2	223	226	PF00017	0.640
LIG_SH2_PTP2	55	58	PF00017	0.737
LIG_SH2_PTP2	652	655	PF00017	0.550
LIG_SH2_SRC	18	21	PF00017	0.599
LIG_SH2_SRC	309	312	PF00017	0.365
LIG_SH2_STAP1	132	136	PF00017	0.672
LIG_SH2_STAP1	622	626	PF00017	0.663
LIG_SH2_STAP1	713	717	PF00017	0.555
LIG_SH2_STAT5	110	113	PF00017	0.493
LIG_SH2_STAT5	18	21	PF00017	0.651
LIG_SH2_STAT5	223	226	PF00017	0.550
LIG_SH2_STAT5	247	250	PF00017	0.333
LIG_SH2_STAT5	271	274	PF00017	0.385
LIG_SH2_STAT5	294	297	PF00017	0.358
LIG_SH2_STAT5	309	312	PF00017	0.303
LIG_SH2_STAT5	363	366	PF00017	0.363
LIG_SH2_STAT5	378	381	PF00017	0.465
LIG_SH2_STAT5	55	58	PF00017	0.722
LIG_SH2_STAT5	652	655	PF00017	0.519
LIG_SH3_1	223	229	PF00018	0.622
LIG_SH3_3	223	229	PF00018	0.622
LIG_SH3_3	417	423	PF00018	0.501
LIG_SH3_3	514	520	PF00018	0.647
LIG_SH3_3	650	656	PF00018	0.567
LIG_SH3_3	689	695	PF00018	0.669
LIG_SH3_3	7	13	PF00018	0.661
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.698
LIG_SUMO_SIM_anti_2	501	507	PF11976	0.535
LIG_SUMO_SIM_anti_2	531	538	PF11976	0.481
LIG_SUMO_SIM_anti_2	542	549	PF11976	0.518
LIG_SUMO_SIM_par_1	506	511	PF11976	0.539
LIG_SUMO_SIM_par_1	533	538	PF11976	0.516
LIG_SUMO_SIM_par_1	542	549	PF11976	0.473
LIG_TRAF2_1	181	184	PF00917	0.775
LIG_TRAF2_1	29	32	PF00917	0.800
LIG_TYR_ITIM	194	199	PF00017	0.616
LIG_TYR_ITSM	648	655	PF00017	0.625
LIG_WRC_WIRS_1	341	346	PF05994	0.503
MOD_CK1_1	25	31	PF00069	0.725
MOD_CK1_1	426	432	PF00069	0.665
MOD_CK1_1	462	468	PF00069	0.532
MOD_CK1_1	551	557	PF00069	0.679
MOD_CK1_1	572	578	PF00069	0.696
MOD_CK1_1	595	601	PF00069	0.633
MOD_CK2_1	141	147	PF00069	0.640
MOD_CK2_1	178	184	PF00069	0.805
MOD_CK2_1	25	31	PF00069	0.790
MOD_CK2_1	553	559	PF00069	0.670
MOD_Cter_Amidation	300	303	PF01082	0.449
MOD_Cter_Amidation	513	516	PF01082	0.531
MOD_DYRK1A_RPxSP_1	694	698	PF00069	0.648
MOD_GlcNHglycan	170	173	PF01048	0.664
MOD_GlcNHglycan	242	245	PF01048	0.603
MOD_GlcNHglycan	303	306	PF01048	0.420
MOD_GlcNHglycan	328	331	PF01048	0.437
MOD_GlcNHglycan	350	353	PF01048	0.395
MOD_GlcNHglycan	357	360	PF01048	0.440
MOD_GlcNHglycan	395	398	PF01048	0.566
MOD_GlcNHglycan	425	428	PF01048	0.679
MOD_GlcNHglycan	464	467	PF01048	0.644
MOD_GlcNHglycan	553	556	PF01048	0.634
MOD_GlcNHglycan	60	63	PF01048	0.675
MOD_GlcNHglycan	641	644	PF01048	0.701
MOD_GSK3_1	22	29	PF00069	0.741
MOD_GSK3_1	236	243	PF00069	0.602
MOD_GSK3_1	336	343	PF00069	0.410
MOD_GSK3_1	393	400	PF00069	0.516
MOD_GSK3_1	518	525	PF00069	0.574
MOD_GSK3_1	569	576	PF00069	0.641
MOD_GSK3_1	662	669	PF00069	0.573
MOD_LATS_1	346	352	PF00433	0.470
MOD_NEK2_1	236	241	PF00069	0.525
MOD_NEK2_1	335	340	PF00069	0.348
MOD_NEK2_1	548	553	PF00069	0.512
MOD_NEK2_1	58	63	PF00069	0.692
MOD_NEK2_1	593	598	PF00069	0.613
MOD_NEK2_2	357	362	PF00069	0.561
MOD_PIKK_1	136	142	PF00454	0.731
MOD_PKA_1	407	413	PF00069	0.475
MOD_PKA_2	569	575	PF00069	0.718
MOD_PKA_2	627	633	PF00069	0.670
MOD_PKA_2	686	692	PF00069	0.758
MOD_PKA_2	91	97	PF00069	0.578
MOD_PKB_1	516	524	PF00069	0.584
MOD_Plk_1	501	507	PF00069	0.510
MOD_Plk_1	548	554	PF00069	0.552
MOD_Plk_1	572	578	PF00069	0.639
MOD_Plk_1	615	621	PF00069	0.671
MOD_Plk_2-3	123	129	PF00069	0.696
MOD_Plk_2-3	178	184	PF00069	0.801
MOD_Plk_2-3	30	36	PF00069	0.815
MOD_Plk_2-3	313	319	PF00069	0.344
MOD_Plk_4	236	242	PF00069	0.529
MOD_Plk_4	336	342	PF00069	0.438
MOD_Plk_4	398	404	PF00069	0.587
MOD_Plk_4	501	507	PF00069	0.488
MOD_Plk_4	615	621	PF00069	0.671
MOD_Plk_4	648	654	PF00069	0.588
MOD_Plk_4	91	97	PF00069	0.508
MOD_ProDKin_1	382	388	PF00069	0.444
MOD_ProDKin_1	553	559	PF00069	0.652
MOD_ProDKin_1	694	700	PF00069	0.646
MOD_SUMO_for_1	322	325	PF00179	0.449
MOD_SUMO_rev_2	474	480	PF00179	0.616
MOD_SUMO_rev_2	629	638	PF00179	0.622
MOD_SUMO_rev_2	708	717	PF00179	0.652
TRG_DiLeu_BaEn_1	543	548	PF01217	0.524
TRG_DiLeu_BaEn_4	616	622	PF01217	0.591
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.539
TRG_ENDOCYTIC_2	196	199	PF00928	0.609
TRG_ENDOCYTIC_2	283	286	PF00928	0.437
TRG_ENDOCYTIC_2	332	335	PF00928	0.482
TRG_ENDOCYTIC_2	453	456	PF00928	0.566
TRG_ENDOCYTIC_2	55	58	PF00928	0.737
TRG_ENDOCYTIC_2	652	655	PF00928	0.518
TRG_ER_diArg_1	516	519	PF00400	0.556
TRG_NES_CRM1_1	498	511	PF08389	0.581
TRG_NLS_MonoExtC_3	112	117	PF00514	0.501
TRG_NLS_MonoExtC_3	514	519	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V4	Leptomonas seymouri	72%	100%
A0A0S4IJQ0	Bodo saltans	37%	100%
A0A1X0NLQ2	Trypanosomatidae	43%	86%
A0A3S5H5L8	Leishmania donovani	96%	100%
A0A422NBM9	Trypanosoma rangeli	48%	93%
A4H4F3	Leishmania braziliensis	86%	100%
A4HSN0	Leishmania infantum	96%	100%
C9ZU66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	88%
E9AKL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BBF6	Trypanosoma cruzi	49%	100%