SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ89_LEIMA

TriTrypDb:

LmjF.05.1130 , LMJLV39_050016500 , LMJSD75_050016700

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJ89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.721
CLV_C14_Caspase3-7	545	549	PF00656	0.766
CLV_NRD_NRD_1	119	121	PF00675	0.531
CLV_NRD_NRD_1	21	23	PF00675	0.546
CLV_NRD_NRD_1	277	279	PF00675	0.511
CLV_NRD_NRD_1	71	73	PF00675	0.714
CLV_PCSK_KEX2_1	119	121	PF00082	0.559
CLV_PCSK_KEX2_1	277	279	PF00082	0.511
CLV_PCSK_KEX2_1	412	414	PF00082	0.495
CLV_PCSK_KEX2_1	71	73	PF00082	0.617
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.519
CLV_PCSK_SKI1_1	158	162	PF00082	0.475
CLV_PCSK_SKI1_1	269	273	PF00082	0.371
CLV_PCSK_SKI1_1	339	343	PF00082	0.461
CLV_PCSK_SKI1_1	367	371	PF00082	0.403
CLV_PCSK_SKI1_1	483	487	PF00082	0.575
CLV_PCSK_SKI1_1	514	518	PF00082	0.430
CLV_PCSK_SKI1_1	58	62	PF00082	0.538
DEG_SPOP_SBC_1	500	504	PF00917	0.556
DOC_CKS1_1	235	240	PF01111	0.730
DOC_CYCLIN_RxL_1	388	398	PF00134	0.561
DOC_CYCLIN_RxL_1	6	17	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.407
DOC_MAPK_gen_1	481	490	PF00069	0.591
DOC_MAPK_gen_1	512	520	PF00069	0.424
DOC_MAPK_gen_1	8	16	PF00069	0.528
DOC_MAPK_JIP1_4	10	16	PF00069	0.489
DOC_MAPK_MEF2A_6	269	276	PF00069	0.410
DOC_MAPK_MEF2A_6	391	399	PF00069	0.481
DOC_MAPK_MEF2A_6	512	520	PF00069	0.553
DOC_MAPK_MEF2A_6	8	16	PF00069	0.528
DOC_PP2B_LxvP_1	12	15	PF13499	0.493
DOC_PP2B_LxvP_1	16	19	PF13499	0.479
DOC_PP2B_LxvP_1	393	396	PF13499	0.425
DOC_PP2B_LxvP_1	397	400	PF13499	0.383
DOC_PP2B_LxvP_1	418	421	PF13499	0.405
DOC_SPAK_OSR1_1	222	226	PF12202	0.641
DOC_SPAK_OSR1_1	403	407	PF12202	0.371
DOC_USP7_MATH_1	282	286	PF00917	0.374
DOC_USP7_MATH_1	389	393	PF00917	0.572
DOC_USP7_MATH_1	492	496	PF00917	0.529
DOC_USP7_MATH_1	550	554	PF00917	0.634
DOC_USP7_MATH_1	89	93	PF00917	0.616
DOC_USP7_UBL2_3	69	73	PF12436	0.684
DOC_WW_Pin1_4	14	19	PF00397	0.504
DOC_WW_Pin1_4	177	182	PF00397	0.454
DOC_WW_Pin1_4	231	236	PF00397	0.601
DOC_WW_Pin1_4	442	447	PF00397	0.424
DOC_WW_Pin1_4	495	500	PF00397	0.363
DOC_WW_Pin1_4	557	562	PF00397	0.729
LIG_14-3-3_CanoR_1	125	129	PF00244	0.445
LIG_14-3-3_CanoR_1	140	147	PF00244	0.497
LIG_Actin_WH2_2	195	213	PF00022	0.544
LIG_BIR_III_4	451	455	PF00653	0.381
LIG_BRCT_BRCA1_1	125	129	PF00533	0.464
LIG_deltaCOP1_diTrp_1	407	414	PF00928	0.376
LIG_FHA_1	178	184	PF00498	0.418
LIG_FHA_1	240	246	PF00498	0.725
LIG_FHA_1	359	365	PF00498	0.386
LIG_FHA_1	368	374	PF00498	0.405
LIG_FHA_1	47	53	PF00498	0.502
LIG_FHA_1	473	479	PF00498	0.570
LIG_FHA_1	496	502	PF00498	0.365
LIG_FHA_1	63	69	PF00498	0.617
LIG_FHA_2	125	131	PF00498	0.440
LIG_FHA_2	348	354	PF00498	0.530
LIG_FHA_2	425	431	PF00498	0.545
LIG_FHA_2	45	51	PF00498	0.423
LIG_FHA_2	462	468	PF00498	0.505
LIG_FHA_2	500	506	PF00498	0.489
LIG_Integrin_RGD_1	351	353	PF01839	0.569
LIG_LIR_Gen_1	37	46	PF02991	0.484
LIG_LIR_Gen_1	464	473	PF02991	0.519
LIG_LIR_Gen_1	59	68	PF02991	0.561
LIG_LIR_LC3C_4	515	519	PF02991	0.555
LIG_LIR_Nem_3	37	42	PF02991	0.487
LIG_LIR_Nem_3	398	404	PF02991	0.402
LIG_LIR_Nem_3	408	414	PF02991	0.333
LIG_LIR_Nem_3	464	468	PF02991	0.534
LIG_LIR_Nem_3	495	500	PF02991	0.474
LIG_LIR_Nem_3	59	64	PF02991	0.557
LIG_PCNA_PIPBox_1	203	212	PF02747	0.512
LIG_Pex14_1	411	415	PF04695	0.421
LIG_Pex14_2	151	155	PF04695	0.478
LIG_Pex14_2	410	414	PF04695	0.360
LIG_PTB_Apo_2	285	292	PF02174	0.477
LIG_SH2_CRK	319	323	PF00017	0.405
LIG_SH2_CRK	415	419	PF00017	0.466
LIG_SH2_CRK	497	501	PF00017	0.554
LIG_SH2_STAT5	266	269	PF00017	0.351
LIG_SH2_STAT5	359	362	PF00017	0.415
LIG_SH2_STAT5	448	451	PF00017	0.453
LIG_SH2_STAT5	497	500	PF00017	0.368
LIG_SH3_1	71	77	PF00018	0.644
LIG_SH3_3	12	18	PF00018	0.544
LIG_SH3_3	232	238	PF00018	0.690
LIG_SH3_3	418	424	PF00018	0.419
LIG_SH3_3	553	559	PF00018	0.757
LIG_SH3_3	71	77	PF00018	0.626
LIG_SH3_3	85	91	PF00018	0.398
LIG_SH3_4	327	334	PF00018	0.554
LIG_Sin3_3	307	314	PF02671	0.500
LIG_SUMO_SIM_anti_2	515	522	PF11976	0.509
LIG_SUMO_SIM_par_1	515	522	PF11976	0.568
LIG_TRAF2_1	190	193	PF00917	0.491
LIG_TRAF2_1	426	429	PF00917	0.529
LIG_TYR_ITIM	317	322	PF00017	0.404
LIG_WRC_WIRS_1	462	467	PF05994	0.544
LIG_WRC_WIRS_1	520	525	PF05994	0.572
LIG_WRC_WIRS_1	57	62	PF05994	0.542
MOD_CDK_SPK_2	234	239	PF00069	0.722
MOD_CDK_SPxxK_3	177	184	PF00069	0.446
MOD_CDK_SPxxK_3	557	564	PF00069	0.734
MOD_CK1_1	495	501	PF00069	0.358
MOD_CK1_1	59	65	PF00069	0.572
MOD_CK2_1	110	116	PF00069	0.560
MOD_CK2_1	424	430	PF00069	0.523
MOD_CK2_1	499	505	PF00069	0.456
MOD_CK2_1	557	563	PF00069	0.732
MOD_GlcNHglycan	531	534	PF01048	0.563
MOD_GlcNHglycan	544	547	PF01048	0.529
MOD_GlcNHglycan	552	555	PF01048	0.707
MOD_GSK3_1	14	21	PF00069	0.505
MOD_GSK3_1	237	244	PF00069	0.697
MOD_GSK3_1	318	325	PF00069	0.528
MOD_GSK3_1	34	41	PF00069	0.526
MOD_GSK3_1	354	361	PF00069	0.442
MOD_GSK3_1	363	370	PF00069	0.353
MOD_GSK3_1	371	378	PF00069	0.331
MOD_GSK3_1	42	49	PF00069	0.465
MOD_GSK3_1	495	502	PF00069	0.363
MOD_GSK3_1	52	59	PF00069	0.645
MOD_GSK3_1	63	70	PF00069	0.637
MOD_N-GLC_1	62	67	PF02516	0.482
MOD_NEK2_1	322	327	PF00069	0.590
MOD_NEK2_1	347	352	PF00069	0.515
MOD_NEK2_1	4	9	PF00069	0.512
MOD_NEK2_2	241	246	PF00069	0.704
MOD_PIKK_1	424	430	PF00454	0.585
MOD_PKA_2	124	130	PF00069	0.446
MOD_PKA_2	139	145	PF00069	0.496
MOD_PKA_2	529	535	PF00069	0.592
MOD_Plk_1	260	266	PF00069	0.472
MOD_Plk_1	296	302	PF00069	0.533
MOD_Plk_4	124	130	PF00069	0.426
MOD_Plk_4	261	267	PF00069	0.451
MOD_Plk_4	282	288	PF00069	0.394
MOD_Plk_4	52	58	PF00069	0.467
MOD_ProDKin_1	14	20	PF00069	0.507
MOD_ProDKin_1	177	183	PF00069	0.446
MOD_ProDKin_1	231	237	PF00069	0.601
MOD_ProDKin_1	442	448	PF00069	0.411
MOD_ProDKin_1	495	501	PF00069	0.358
MOD_ProDKin_1	557	563	PF00069	0.732
MOD_SUMO_rev_2	429	433	PF00179	0.680
MOD_SUMO_rev_2	480	488	PF00179	0.523
TRG_DiLeu_BaEn_1	182	187	PF01217	0.546
TRG_DiLeu_BaEn_1	338	343	PF01217	0.539
TRG_DiLeu_BaEn_4	260	266	PF01217	0.462
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.408
TRG_ENDOCYTIC_2	319	322	PF00928	0.385
TRG_ENDOCYTIC_2	401	404	PF00928	0.370
TRG_ENDOCYTIC_2	415	418	PF00928	0.356
TRG_ENDOCYTIC_2	497	500	PF00928	0.457
TRG_ER_diArg_1	276	278	PF00400	0.524
TRG_ER_diArg_1	298	301	PF00400	0.439
TRG_ER_diArg_1	8	11	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F7	Leptomonas seymouri	80%	100%
A0A0S4IPB6	Bodo saltans	43%	100%
A0A1X0NKA7	Trypanosomatidae	51%	97%
A0A3R7NCC1	Trypanosoma rangeli	55%	100%
A0A3S7WPA3	Leishmania donovani	97%	100%
A4H4F8	Leishmania braziliensis	89%	100%
A4HSN5	Leishmania infantum	97%	100%
C9ZND9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	85%
E9AKM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5D7S2	Trypanosoma cruzi	54%	100%