Adenylate cyclase regulatory protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylate cyclase regulatory protein-like protein

Species:

Leishmania major

UniProt:

Q4QJ80_LEIMA

TriTrypDb:

LmjF.05.1220 , LMJLV39_050018500 , LMJSD75_030005000

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	23
GO:0042995	cell projection	2	23
GO:0043226	organelle	2	23
GO:0043227	membrane-bounded organelle	3	23
GO:0110165	cellular anatomical entity	1	23
GO:0120025	plasma membrane bounded cell projection	3	23
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4QJ80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ80

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2
GO:0006468	protein phosphorylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006457	protein folding	2	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0007023	post-chaperonin tubulin folding pathway	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	4
GO:0005488	binding	1	3
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0000166	nucleotide binding	3	1
GO:0004672	protein kinase activity	3	1
GO:0005524	ATP binding	5	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.657
CLV_C14_Caspase3-7	247	251	PF00656	0.264
CLV_C14_Caspase3-7	58	62	PF00656	0.587
CLV_NRD_NRD_1	124	126	PF00675	0.597
CLV_NRD_NRD_1	558	560	PF00675	0.529
CLV_PCSK_KEX2_1	124	126	PF00082	0.534
CLV_PCSK_KEX2_1	558	560	PF00082	0.530
CLV_PCSK_SKI1_1	124	128	PF00082	0.558
CLV_PCSK_SKI1_1	276	280	PF00082	0.467
CLV_PCSK_SKI1_1	346	350	PF00082	0.498
DOC_CDC14_PxL_1	230	238	PF14671	0.356
DOC_CDC14_PxL_1	413	421	PF14671	0.497
DOC_CDC14_PxL_1	482	490	PF14671	0.257
DOC_CYCLIN_RxL_1	172	181	PF00134	0.453
DOC_CYCLIN_RxL_1	276	289	PF00134	0.250
DOC_CYCLIN_RxL_1	417	428	PF00134	0.497
DOC_CYCLIN_yClb5_NLxxxL_5	303	312	PF00134	0.250
DOC_MAPK_gen_1	124	131	PF00069	0.464
DOC_MAPK_gen_1	237	246	PF00069	0.262
DOC_MAPK_gen_1	253	263	PF00069	0.503
DOC_MAPK_gen_1	276	286	PF00069	0.250
DOC_MAPK_gen_1	343	353	PF00069	0.466
DOC_MAPK_gen_1	35	43	PF00069	0.633
DOC_MAPK_MEF2A_6	124	133	PF00069	0.453
DOC_MAPK_MEF2A_6	66	73	PF00069	0.671
DOC_MAPK_NFAT4_5	124	132	PF00069	0.341
DOC_MIT_MIM_1	121	129	PF04212	0.348
DOC_PP2B_LxvP_1	95	98	PF13499	0.478
DOC_PP4_FxxP_1	219	222	PF00568	0.320
DOC_USP7_MATH_1	418	422	PF00917	0.518
DOC_USP7_MATH_1	50	54	PF00917	0.424
DOC_USP7_UBL2_3	100	104	PF12436	0.401
DOC_WW_Pin1_4	405	410	PF00397	0.502
DOC_WW_Pin1_4	476	481	PF00397	0.401
DOC_WW_Pin1_4	522	527	PF00397	0.546
LIG_14-3-3_CanoR_1	154	162	PF00244	0.442
LIG_14-3-3_CanoR_1	184	190	PF00244	0.443
LIG_14-3-3_CanoR_1	243	252	PF00244	0.412
LIG_14-3-3_CanoR_1	313	318	PF00244	0.441
LIG_14-3-3_CanoR_1	452	459	PF00244	0.473
LIG_14-3-3_CanoR_1	528	537	PF00244	0.402
LIG_14-3-3_CanoR_1	66	72	PF00244	0.621
LIG_Actin_WH2_2	335	351	PF00022	0.300
LIG_Actin_WH2_2	498	514	PF00022	0.441
LIG_BIR_II_1	1	5	PF00653	0.414
LIG_BIR_III_2	169	173	PF00653	0.352
LIG_BIR_III_2	415	419	PF00653	0.398
LIG_BIR_III_2	46	50	PF00653	0.421
LIG_DLG_GKlike_1	245	252	PF00625	0.313
LIG_DLG_GKlike_1	313	320	PF00625	0.250
LIG_FHA_1	163	169	PF00498	0.516
LIG_FHA_1	6	12	PF00498	0.660
LIG_FHA_1	68	74	PF00498	0.623
LIG_FHA_2	116	122	PF00498	0.429
LIG_FHA_2	299	305	PF00498	0.406
LIG_FHA_2	332	338	PF00498	0.526
LIG_FHA_2	370	376	PF00498	0.362
LIG_FHA_2	377	383	PF00498	0.411
LIG_LIR_Apic_2	217	222	PF02991	0.307
LIG_LIR_Apic_2	406	410	PF02991	0.340
LIG_LIR_Gen_1	375	384	PF02991	0.532
LIG_LIR_Nem_3	375	381	PF02991	0.528
LIG_LIR_Nem_3	46	51	PF02991	0.643
LIG_LYPXL_yS_3	48	51	PF13949	0.421
LIG_SH2_CRK	407	411	PF00017	0.346
LIG_SH2_STAP1	24	28	PF00017	0.384
LIG_SH2_STAT5	283	286	PF00017	0.431
LIG_SH2_STAT5	403	406	PF00017	0.463
LIG_SH2_STAT5	79	82	PF00017	0.528
LIG_SH3_3	109	115	PF00018	0.517
LIG_SUMO_SIM_anti_2	38	46	PF11976	0.344
LIG_SUMO_SIM_anti_2	454	463	PF11976	0.530
LIG_SUMO_SIM_anti_2	500	507	PF11976	0.552
LIG_SUMO_SIM_par_1	130	136	PF11976	0.310
LIG_SUMO_SIM_par_1	212	217	PF11976	0.464
LIG_SUMO_SIM_par_1	512	517	PF11976	0.372
LIG_TRAF2_1	199	202	PF00917	0.667
LIG_TRAF2_1	487	490	PF00917	0.322
LIG_TYR_ITIM	281	286	PF00017	0.411
LIG_WW_3	438	442	PF00397	0.333
MOD_CDC14_SPxK_1	525	528	PF00782	0.365
MOD_CDK_SPxK_1	522	528	PF00069	0.368
MOD_CK1_1	17	23	PF00069	0.513
MOD_CK1_1	196	202	PF00069	0.592
MOD_CK1_1	298	304	PF00069	0.350
MOD_CK1_1	316	322	PF00069	0.215
MOD_CK1_1	369	375	PF00069	0.423
MOD_CK1_1	425	431	PF00069	0.397
MOD_CK1_1	454	460	PF00069	0.364
MOD_CK1_1	474	480	PF00069	0.354
MOD_CK1_1	500	506	PF00069	0.454
MOD_CK1_1	520	526	PF00069	0.516
MOD_CK1_1	67	73	PF00069	0.422
MOD_CK2_1	196	202	PF00069	0.599
MOD_CK2_1	298	304	PF00069	0.401
MOD_CK2_1	331	337	PF00069	0.482
MOD_CK2_1	388	394	PF00069	0.517
MOD_CK2_1	428	434	PF00069	0.511
MOD_CK2_1	529	535	PF00069	0.497
MOD_DYRK1A_RPxSP_1	522	526	PF00069	0.368
MOD_GlcNHglycan	202	206	PF01048	0.656
MOD_GlcNHglycan	230	233	PF01048	0.536
MOD_GlcNHglycan	3	6	PF01048	0.683
MOD_GlcNHglycan	308	311	PF01048	0.378
MOD_GlcNHglycan	352	356	PF01048	0.401
MOD_GlcNHglycan	38	41	PF01048	0.602
MOD_GlcNHglycan	390	393	PF01048	0.393
MOD_GlcNHglycan	506	509	PF01048	0.530
MOD_GlcNHglycan	52	55	PF01048	0.596
MOD_GSK3_1	1	8	PF00069	0.663
MOD_GSK3_1	196	203	PF00069	0.659
MOD_GSK3_1	331	338	PF00069	0.422
MOD_GSK3_1	388	395	PF00069	0.473
MOD_GSK3_1	418	425	PF00069	0.401
MOD_GSK3_1	454	461	PF00069	0.507
MOD_GSK3_1	470	477	PF00069	0.362
MOD_GSK3_1	500	507	PF00069	0.397
MOD_GSK3_1	516	523	PF00069	0.348
MOD_GSK3_1	562	569	PF00069	0.611
MOD_N-GLC_1	14	19	PF02516	0.411
MOD_N-GLC_1	306	311	PF02516	0.349
MOD_N-GLC_1	425	430	PF02516	0.519
MOD_N-GLC_1	471	476	PF02516	0.375
MOD_N-GLC_1	517	522	PF02516	0.573
MOD_N-GLC_2	448	450	PF02516	0.475
MOD_NEK2_1	1	6	PF00069	0.655
MOD_NEK2_1	162	167	PF00069	0.453
MOD_NEK2_1	200	205	PF00069	0.658
MOD_NEK2_1	214	219	PF00069	0.421
MOD_NEK2_1	284	289	PF00069	0.374
MOD_NEK2_1	329	334	PF00069	0.312
MOD_NEK2_1	36	41	PF00069	0.519
MOD_NEK2_1	376	381	PF00069	0.360
MOD_NEK2_1	422	427	PF00069	0.391
MOD_NEK2_1	459	464	PF00069	0.345
MOD_NEK2_1	470	475	PF00069	0.264
MOD_NEK2_1	516	521	PF00069	0.386
MOD_NEK2_1	551	556	PF00069	0.662
MOD_NEK2_1	562	567	PF00069	0.474
MOD_NEK2_1	64	69	PF00069	0.630
MOD_NEK2_2	106	111	PF00069	0.405
MOD_NEK2_2	392	397	PF00069	0.472
MOD_NEK2_2	471	476	PF00069	0.256
MOD_OFUCOSY	63	68	PF10250	0.413
MOD_PIKK_1	193	199	PF00454	0.450
MOD_PIKK_1	295	301	PF00454	0.370
MOD_PIKK_1	366	372	PF00454	0.480
MOD_PKA_2	153	159	PF00069	0.518
MOD_PKA_2	183	189	PF00069	0.458
MOD_PKA_2	244	250	PF00069	0.488
MOD_PKA_2	451	457	PF00069	0.520
MOD_PKB_1	243	251	PF00069	0.267
MOD_Plk_1	374	380	PF00069	0.421
MOD_Plk_1	382	388	PF00069	0.434
MOD_Plk_1	425	431	PF00069	0.416
MOD_Plk_1	454	460	PF00069	0.298
MOD_Plk_1	471	477	PF00069	0.257
MOD_Plk_1	500	506	PF00069	0.489
MOD_Plk_1	516	522	PF00069	0.488
MOD_Plk_1	540	546	PF00069	0.663
MOD_Plk_1	64	70	PF00069	0.614
MOD_Plk_4	214	220	PF00069	0.496
MOD_Plk_4	335	341	PF00069	0.385
MOD_ProDKin_1	405	411	PF00069	0.510
MOD_ProDKin_1	476	482	PF00069	0.406
MOD_ProDKin_1	522	528	PF00069	0.552
TRG_DiLeu_BaEn_1	158	163	PF01217	0.487
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.261
TRG_DiLeu_LyEn_5	147	152	PF01217	0.334
TRG_ENDOCYTIC_2	283	286	PF00928	0.431
TRG_ENDOCYTIC_2	390	393	PF00928	0.325
TRG_ENDOCYTIC_2	48	51	PF00928	0.594
TRG_ER_diArg_1	123	125	PF00400	0.595
TRG_ER_diArg_1	243	246	PF00400	0.272
TRG_ER_diArg_1	312	315	PF00400	0.333
TRG_ER_diArg_1	396	399	PF00400	0.500
TRG_ER_diArg_1	510	513	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N9	Leptomonas seymouri	27%	87%
A0A0N1P921	Leptomonas seymouri	27%	70%
A0A0S4JC97	Bodo saltans	24%	68%
A0A0S4JR29	Bodo saltans	25%	100%
A0A1X0NEN5	Trypanosomatidae	23%	98%
A0A1X0P4M6	Trypanosomatidae	26%	98%
A0A3Q8IAE2	Leishmania donovani	81%	91%
A0A3Q8IGD6	Leishmania donovani	24%	71%
A0A3S5ISR4	Trypanosoma rangeli	26%	68%
A0A3S7X2V4	Leishmania donovani	28%	74%
A4H3R1	Leishmania braziliensis	27%	83%
A4HCY0	Leishmania braziliensis	26%	100%
A4I6T8	Leishmania infantum	24%	71%
C9ZK22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	70%
C9ZS86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AGT5	Leishmania infantum	81%	100%
E9AHJ6	Leishmania infantum	28%	74%
E9AIU4	Leishmania braziliensis	26%	100%
Q4Q6A2	Leishmania major	25%	71%
Q4QD45	Leishmania major	100%	100%
V5BKI3	Trypanosoma cruzi	27%	69%