LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QJ77_LEIMA
TriTrypDb:
LmjF.06.0020 , LMJLV39_060005200 * , LMJSD75_060005000
Length:
535

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0005929 cilium 4 21
GO:0042995 cell projection 2 21
GO:0043226 organelle 2 21
GO:0043227 membrane-bounded organelle 3 21
GO:0110165 cellular anatomical entity 1 21
GO:0120025 plasma membrane bounded cell projection 3 21
GO:0005743 mitochondrial inner membrane 5 1
GO:0016020 membrane 2 2
GO:0019866 organelle inner membrane 4 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0000151 ubiquitin ligase complex 3 1
GO:0019005 SCF ubiquitin ligase complex 5 1
GO:0031461 cullin-RING ubiquitin ligase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

Q4QJ77
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ77

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0016310 phosphorylation 5 2
GO:0044237 cellular metabolic process 2 3
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 7 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0003824 catalytic activity 1 2
GO:0016301 kinase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 267 271 PF00656 0.498
CLV_NRD_NRD_1 187 189 PF00675 0.507
CLV_NRD_NRD_1 190 192 PF00675 0.471
CLV_PCSK_SKI1_1 427 431 PF00082 0.494
DEG_SCF_FBW7_1 56 62 PF00400 0.521
DOC_CDC14_PxL_1 206 214 PF14671 0.428
DOC_CDC14_PxL_1 325 333 PF14671 0.312
DOC_CKS1_1 344 349 PF01111 0.294
DOC_CKS1_1 56 61 PF01111 0.714
DOC_CYCLIN_RxL_1 199 208 PF00134 0.531
DOC_MAPK_gen_1 188 195 PF00069 0.491
DOC_MAPK_gen_1 521 531 PF00069 0.602
DOC_MAPK_MEF2A_6 374 383 PF00069 0.294
DOC_PP1_RVXF_1 102 109 PF00149 0.572
DOC_PP4_FxxP_1 43 46 PF00568 0.516
DOC_USP7_MATH_1 102 106 PF00917 0.608
DOC_USP7_MATH_1 229 233 PF00917 0.344
DOC_USP7_MATH_1 26 30 PF00917 0.651
DOC_USP7_MATH_1 288 292 PF00917 0.409
DOC_USP7_MATH_1 422 426 PF00917 0.309
DOC_USP7_MATH_1 442 446 PF00917 0.427
DOC_USP7_MATH_1 491 495 PF00917 0.437
DOC_WW_Pin1_4 28 33 PF00397 0.614
DOC_WW_Pin1_4 296 301 PF00397 0.403
DOC_WW_Pin1_4 343 348 PF00397 0.505
DOC_WW_Pin1_4 390 395 PF00397 0.414
DOC_WW_Pin1_4 406 411 PF00397 0.441
DOC_WW_Pin1_4 438 443 PF00397 0.457
DOC_WW_Pin1_4 485 490 PF00397 0.357
DOC_WW_Pin1_4 52 57 PF00397 0.733
LIG_14-3-3_CanoR_1 235 240 PF00244 0.456
LIG_14-3-3_CanoR_1 258 264 PF00244 0.531
LIG_14-3-3_CanoR_1 294 301 PF00244 0.470
LIG_14-3-3_CanoR_1 380 389 PF00244 0.430
LIG_14-3-3_CanoR_1 397 401 PF00244 0.483
LIG_14-3-3_CanoR_1 435 443 PF00244 0.469
LIG_14-3-3_CanoR_1 524 531 PF00244 0.567
LIG_Actin_WH2_2 67 83 PF00022 0.449
LIG_BIR_II_1 1 5 PF00653 0.505
LIG_BRCT_BRCA1_1 104 108 PF00533 0.576
LIG_FHA_1 164 170 PF00498 0.619
LIG_FHA_1 178 184 PF00498 0.532
LIG_FHA_1 221 227 PF00498 0.417
LIG_FHA_1 236 242 PF00498 0.340
LIG_FHA_1 270 276 PF00498 0.452
LIG_FHA_1 56 62 PF00498 0.719
LIG_FHA_1 75 81 PF00498 0.550
LIG_FHA_2 265 271 PF00498 0.341
LIG_FHA_2 360 366 PF00498 0.418
LIG_FHA_2 507 513 PF00498 0.476
LIG_LIR_Apic_2 97 102 PF02991 0.470
LIG_LIR_Gen_1 306 317 PF02991 0.324
LIG_LIR_Nem_3 105 110 PF02991 0.566
LIG_LIR_Nem_3 197 201 PF02991 0.435
LIG_LIR_Nem_3 248 253 PF02991 0.427
LIG_LIR_Nem_3 296 301 PF02991 0.326
LIG_LIR_Nem_3 306 312 PF02991 0.248
LIG_LIR_Nem_3 343 348 PF02991 0.500
LIG_LIR_Nem_3 390 395 PF02991 0.463
LIG_LIR_Nem_3 438 443 PF02991 0.384
LIG_LIR_Nem_3 84 88 PF02991 0.640
LIG_MLH1_MIPbox_1 104 108 PF16413 0.425
LIG_MYND_3 209 213 PF01753 0.351
LIG_MYND_3 328 332 PF01753 0.305
LIG_PDZ_Class_1 530 535 PF00595 0.637
LIG_PTB_Apo_2 93 100 PF02174 0.409
LIG_PTB_Phospho_1 93 99 PF10480 0.409
LIG_SH2_SRC 309 312 PF00017 0.312
LIG_SH2_STAT5 107 110 PF00017 0.605
LIG_SH2_STAT5 199 202 PF00017 0.442
LIG_SH2_STAT5 309 312 PF00017 0.513
LIG_SH2_STAT5 498 501 PF00017 0.353
LIG_SH3_3 53 59 PF00018 0.719
LIG_SUMO_SIM_anti_2 117 122 PF11976 0.543
LIG_SUMO_SIM_anti_2 299 306 PF11976 0.324
LIG_SUMO_SIM_anti_2 69 77 PF11976 0.474
LIG_SUMO_SIM_par_1 237 242 PF11976 0.392
LIG_SUMO_SIM_par_1 340 346 PF11976 0.506
LIG_SUMO_SIM_par_1 355 362 PF11976 0.355
LIG_TRAF2_1 448 451 PF00917 0.339
LIG_TRAF2_1 517 520 PF00917 0.417
LIG_TYR_ITIM 307 312 PF00017 0.311
LIG_TYR_ITIM 496 501 PF00017 0.432
LIG_WRC_WIRS_1 247 252 PF05994 0.470
MOD_CDK_SPxxK_3 28 35 PF00069 0.605
MOD_CDK_SPxxK_3 390 397 PF00069 0.482
MOD_CK1_1 129 135 PF00069 0.564
MOD_CK1_1 2 8 PF00069 0.666
MOD_CK1_1 409 415 PF00069 0.357
MOD_CK1_1 438 444 PF00069 0.472
MOD_CK1_1 445 451 PF00069 0.395
MOD_CK1_1 508 514 PF00069 0.521
MOD_CK1_1 55 61 PF00069 0.622
MOD_CK2_1 109 115 PF00069 0.527
MOD_CK2_1 396 402 PF00069 0.409
MOD_CK2_1 445 451 PF00069 0.477
MOD_CK2_1 506 512 PF00069 0.525
MOD_CK2_1 514 520 PF00069 0.458
MOD_CK2_1 63 69 PF00069 0.601
MOD_GlcNHglycan 111 114 PF01048 0.658
MOD_GlcNHglycan 19 22 PF01048 0.686
MOD_GlcNHglycan 216 220 PF01048 0.448
MOD_GlcNHglycan 241 244 PF01048 0.380
MOD_GlcNHglycan 383 386 PF01048 0.337
MOD_GSK3_1 164 171 PF00069 0.524
MOD_GSK3_1 235 242 PF00069 0.387
MOD_GSK3_1 411 418 PF00069 0.348
MOD_GSK3_1 438 445 PF00069 0.398
MOD_GSK3_1 479 486 PF00069 0.479
MOD_GSK3_1 501 508 PF00069 0.515
MOD_GSK3_1 55 62 PF00069 0.626
MOD_N-GLC_1 164 169 PF02516 0.513
MOD_N-GLC_1 381 386 PF02516 0.421
MOD_N-GLC_1 404 409 PF02516 0.433
MOD_N-GLC_2 290 292 PF02516 0.459
MOD_N-GLC_2 432 434 PF02516 0.398
MOD_NEK2_1 1 6 PF00069 0.504
MOD_NEK2_1 108 113 PF00069 0.658
MOD_NEK2_1 126 131 PF00069 0.546
MOD_NEK2_1 163 168 PF00069 0.549
MOD_NEK2_1 169 174 PF00069 0.658
MOD_NEK2_1 17 22 PF00069 0.519
MOD_NEK2_1 217 222 PF00069 0.362
MOD_NEK2_1 239 244 PF00069 0.318
MOD_NEK2_1 25 30 PF00069 0.644
MOD_NEK2_1 262 267 PF00069 0.372
MOD_NEK2_1 277 282 PF00069 0.388
MOD_NEK2_1 381 386 PF00069 0.361
MOD_NEK2_1 404 409 PF00069 0.341
MOD_NEK2_1 506 511 PF00069 0.557
MOD_NEK2_1 87 92 PF00069 0.631
MOD_NEK2_2 102 107 PF00069 0.538
MOD_NEK2_2 229 234 PF00069 0.352
MOD_NEK2_2 350 355 PF00069 0.543
MOD_NEK2_2 422 427 PF00069 0.471
MOD_OFUCOSY 408 415 PF10250 0.358
MOD_PIKK_1 177 183 PF00454 0.560
MOD_PIKK_1 257 263 PF00454 0.501
MOD_PIKK_1 74 80 PF00454 0.681
MOD_PKA_2 257 263 PF00069 0.504
MOD_PKA_2 293 299 PF00069 0.511
MOD_PKA_2 359 365 PF00069 0.384
MOD_PKA_2 396 402 PF00069 0.451
MOD_PKA_2 504 510 PF00069 0.503
MOD_PKA_2 523 529 PF00069 0.312
MOD_Plk_1 114 120 PF00069 0.580
MOD_Plk_1 164 170 PF00069 0.552
MOD_Plk_1 305 311 PF00069 0.459
MOD_Plk_2-3 514 520 PF00069 0.538
MOD_Plk_4 164 170 PF00069 0.531
MOD_Plk_4 305 311 PF00069 0.369
MOD_Plk_4 359 365 PF00069 0.387
MOD_Plk_4 396 402 PF00069 0.521
MOD_Plk_4 63 69 PF00069 0.519
MOD_ProDKin_1 28 34 PF00069 0.608
MOD_ProDKin_1 296 302 PF00069 0.407
MOD_ProDKin_1 343 349 PF00069 0.503
MOD_ProDKin_1 390 396 PF00069 0.414
MOD_ProDKin_1 406 412 PF00069 0.445
MOD_ProDKin_1 438 444 PF00069 0.459
MOD_ProDKin_1 485 491 PF00069 0.364
MOD_ProDKin_1 52 58 PF00069 0.730
TRG_ENDOCYTIC_2 107 110 PF00928 0.577
TRG_ENDOCYTIC_2 309 312 PF00928 0.312
TRG_ENDOCYTIC_2 498 501 PF00928 0.436
TRG_ER_diArg_1 314 317 PF00400 0.387
TRG_ER_diArg_1 88 91 PF00400 0.655
TRG_NLS_MonoExtC_3 187 192 PF00514 0.345

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8N9 Leptomonas seymouri 25% 81%
A0A0N1IHY9 Leptomonas seymouri 57% 100%
A0A0S4ITQ8 Bodo saltans 24% 100%
A0A0S4J578 Bodo saltans 28% 71%
A0A1X0P4M6 Trypanosomatidae 24% 92%
A0A3S5H5M6 Leishmania donovani 97% 100%
A0A3S7X2V4 Leishmania donovani 28% 69%
A4H3R1 Leishmania braziliensis 23% 77%
A4H4H0 Leishmania braziliensis 85% 100%
A4HSP5 Leishmania infantum 97% 100%
C9ZRQ1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 100%
C9ZS86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 99%
C9ZUA8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 72%
C9ZZI9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 88%
D0A0X4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 79%
E9AEF0 Leishmania major 26% 69%
E9AHJ6 Leishmania infantum 28% 69%
E9AKN0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
P26337 Trypanosoma equiperdum 25% 85%
V5BMQ2 Trypanosoma cruzi 26% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS