Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4QJ76_LEIMA

TriTrypDb:

LmjF.06.0030 , LMJLV39_060005300 , LMJSD75_060005100

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:0097361	CIA complex	3	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

Q4QJ76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ76

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	3
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	3
GO:0000398	mRNA splicing, via spliceosome	8	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	4
GO:0008380	RNA splicing	7	3
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0006790	sulfur compound metabolic process	3	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.595
CLV_C14_Caspase3-7	526	530	PF00656	0.506
CLV_NRD_NRD_1	172	174	PF00675	0.547
CLV_NRD_NRD_1	175	177	PF00675	0.581
CLV_NRD_NRD_1	23	25	PF00675	0.539
CLV_NRD_NRD_1	299	301	PF00675	0.529
CLV_PCSK_KEX2_1	126	128	PF00082	0.596
CLV_PCSK_KEX2_1	23	25	PF00082	0.588
CLV_PCSK_KEX2_1	242	244	PF00082	0.759
CLV_PCSK_KEX2_1	299	301	PF00082	0.487
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.596
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.622
CLV_PCSK_PC7_1	238	244	PF00082	0.611
CLV_PCSK_SKI1_1	107	111	PF00082	0.523
CLV_PCSK_SKI1_1	299	303	PF00082	0.511
CLV_PCSK_SKI1_1	455	459	PF00082	0.307
CLV_PCSK_SKI1_1	467	471	PF00082	0.359
CLV_PCSK_SKI1_1	509	513	PF00082	0.293
CLV_PCSK_SKI1_1	541	545	PF00082	0.282
CLV_PCSK_SKI1_1	574	578	PF00082	0.311
CLV_PCSK_SKI1_1	657	661	PF00082	0.434
CLV_Separin_Metazoa	235	239	PF03568	0.534
DEG_SPOP_SBC_1	448	452	PF00917	0.549
DOC_MAPK_gen_1	126	133	PF00069	0.503
DOC_MAPK_gen_1	23	33	PF00069	0.424
DOC_MAPK_gen_1	295	305	PF00069	0.548
DOC_MAPK_HePTP_8	255	267	PF00069	0.662
DOC_MAPK_MEF2A_6	24	33	PF00069	0.456
DOC_MAPK_MEF2A_6	258	267	PF00069	0.664
DOC_PP1_RVXF_1	3	9	PF00149	0.450
DOC_USP7_MATH_1	193	197	PF00917	0.771
DOC_USP7_MATH_1	257	261	PF00917	0.738
DOC_USP7_MATH_1	282	286	PF00917	0.649
DOC_USP7_MATH_1	373	377	PF00917	0.481
DOC_USP7_MATH_1	449	453	PF00917	0.525
DOC_USP7_MATH_1	78	82	PF00917	0.551
DOC_USP7_MATH_1	84	88	PF00917	0.849
DOC_USP7_UBL2_3	177	181	PF12436	0.634
DOC_USP7_UBL2_3	5	9	PF12436	0.487
DOC_USP7_UBL2_3	75	79	PF12436	0.584
DOC_WW_Pin1_4	397	402	PF00397	0.524
DOC_WW_Pin1_4	439	444	PF00397	0.516
DOC_WW_Pin1_4	80	85	PF00397	0.706
LIG_14-3-3_CanoR_1	299	304	PF00244	0.667
LIG_14-3-3_CanoR_1	357	362	PF00244	0.749
LIG_14-3-3_CanoR_1	447	457	PF00244	0.515
LIG_14-3-3_CanoR_1	514	519	PF00244	0.480
LIG_14-3-3_CanoR_1	595	600	PF00244	0.561
LIG_14-3-3_CanoR_1	631	638	PF00244	0.368
LIG_APCC_ABBA_1	320	325	PF00400	0.495
LIG_APCC_ABBA_1	62	67	PF00400	0.600
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_BRCT_BRCA1_1	521	525	PF00533	0.500
LIG_BRCT_BRCA1_1	529	533	PF00533	0.529
LIG_deltaCOP1_diTrp_1	624	630	PF00928	0.482
LIG_FHA_1	118	124	PF00498	0.611
LIG_FHA_1	139	145	PF00498	0.622
LIG_FHA_1	273	279	PF00498	0.581
LIG_FHA_1	319	325	PF00498	0.424
LIG_FHA_1	367	373	PF00498	0.644
LIG_FHA_1	412	418	PF00498	0.618
LIG_FHA_1	454	460	PF00498	0.487
LIG_FHA_1	484	490	PF00498	0.554
LIG_FHA_1	496	502	PF00498	0.506
LIG_FHA_1	658	664	PF00498	0.384
LIG_FHA_2	181	187	PF00498	0.617
LIG_FHA_2	43	49	PF00498	0.511
LIG_FHA_2	631	637	PF00498	0.438
LIG_FHA_2	96	102	PF00498	0.620
LIG_Integrin_RGD_1	402	404	PF01839	0.271
LIG_LIR_Gen_1	161	170	PF02991	0.488
LIG_LIR_Gen_1	285	293	PF02991	0.462
LIG_LIR_Gen_1	321	328	PF02991	0.444
LIG_LIR_Gen_1	563	569	PF02991	0.606
LIG_LIR_Gen_1	580	591	PF02991	0.476
LIG_LIR_Gen_1	624	629	PF02991	0.467
LIG_LIR_Nem_3	118	122	PF02991	0.483
LIG_LIR_Nem_3	16	20	PF02991	0.595
LIG_LIR_Nem_3	161	167	PF02991	0.508
LIG_LIR_Nem_3	285	289	PF02991	0.471
LIG_LIR_Nem_3	563	568	PF02991	0.614
LIG_LIR_Nem_3	580	586	PF02991	0.408
LIG_NRP_CendR_1	673	675	PF00754	0.436
LIG_PCNA_TLS_4	215	222	PF02747	0.424
LIG_PCNA_yPIPBox_3	544	558	PF02747	0.434
LIG_Pex14_1	565	569	PF04695	0.482
LIG_Pex14_2	521	525	PF04695	0.482
LIG_SH2_CRK	119	123	PF00017	0.458
LIG_SH2_STAP1	583	587	PF00017	0.584
LIG_SH2_STAT5	119	122	PF00017	0.633
LIG_SH2_STAT5	266	269	PF00017	0.476
LIG_SH2_STAT5	395	398	PF00017	0.486
LIG_SH2_STAT5	479	482	PF00017	0.506
LIG_SH2_STAT5	575	578	PF00017	0.584
LIG_SH2_STAT5	617	620	PF00017	0.482
LIG_SH3_2	342	347	PF14604	0.601
LIG_SH3_3	151	157	PF00018	0.599
LIG_SH3_3	339	345	PF00018	0.570
LIG_SH3_3	90	96	PF00018	0.707
LIG_TRAF2_1	135	138	PF00917	0.480
LIG_TYR_ITIM	117	122	PF00017	0.607
LIG_UBA3_1	28	34	PF00899	0.420
LIG_WRC_WIRS_1	146	151	PF05994	0.512
LIG_WRC_WIRS_1	43	48	PF05994	0.576
MOD_CDK_SPK_2	397	402	PF00069	0.549
MOD_CDK_SPK_2	439	444	PF00069	0.493
MOD_CK1_1	180	186	PF00069	0.642
MOD_CK1_1	272	278	PF00069	0.550
MOD_CK1_1	388	394	PF00069	0.518
MOD_CK1_1	461	467	PF00069	0.543
MOD_CK1_1	494	500	PF00069	0.485
MOD_CK2_1	132	138	PF00069	0.588
MOD_CK2_1	155	161	PF00069	0.516
MOD_CK2_1	180	186	PF00069	0.610
MOD_CK2_1	208	214	PF00069	0.555
MOD_CK2_1	337	343	PF00069	0.619
MOD_CK2_1	372	378	PF00069	0.557
MOD_CK2_1	42	48	PF00069	0.522
MOD_CK2_1	630	636	PF00069	0.497
MOD_CK2_1	67	73	PF00069	0.619
MOD_CK2_1	95	101	PF00069	0.765
MOD_Cter_Amidation	124	127	PF01082	0.505
MOD_Cter_Amidation	297	300	PF01082	0.504
MOD_GlcNHglycan	123	126	PF01048	0.538
MOD_GlcNHglycan	188	191	PF01048	0.694
MOD_GlcNHglycan	259	262	PF01048	0.686
MOD_GlcNHglycan	375	378	PF01048	0.410
MOD_GlcNHglycan	387	390	PF01048	0.258
MOD_GlcNHglycan	491	494	PF01048	0.308
MOD_GlcNHglycan	529	532	PF01048	0.320
MOD_GlcNHglycan	535	538	PF01048	0.321
MOD_GlcNHglycan	577	580	PF01048	0.339
MOD_GlcNHglycan	591	594	PF01048	0.560
MOD_GlcNHglycan	69	72	PF01048	0.650
MOD_GlcNHglycan	86	89	PF01048	0.748
MOD_GSK3_1	117	124	PF00069	0.543
MOD_GSK3_1	182	189	PF00069	0.599
MOD_GSK3_1	253	260	PF00069	0.627
MOD_GSK3_1	278	285	PF00069	0.521
MOD_GSK3_1	353	360	PF00069	0.609
MOD_GSK3_1	379	386	PF00069	0.437
MOD_GSK3_1	407	414	PF00069	0.482
MOD_GSK3_1	419	426	PF00069	0.456
MOD_GSK3_1	435	442	PF00069	0.562
MOD_GSK3_1	449	456	PF00069	0.505
MOD_GSK3_1	491	498	PF00069	0.508
MOD_GSK3_1	519	526	PF00069	0.503
MOD_GSK3_1	563	570	PF00069	0.482
MOD_GSK3_1	587	594	PF00069	0.603
MOD_GSK3_1	63	70	PF00069	0.395
MOD_GSK3_1	80	87	PF00069	0.825
MOD_N-GLC_1	13	18	PF02516	0.644
MOD_N-GLC_1	177	182	PF02516	0.602
MOD_N-GLC_1	270	275	PF02516	0.542
MOD_N-GLC_1	379	384	PF02516	0.399
MOD_N-GLC_1	483	488	PF02516	0.290
MOD_NEK2_1	117	122	PF00069	0.490
MOD_NEK2_1	253	258	PF00069	0.650
MOD_NEK2_1	301	306	PF00069	0.474
MOD_NEK2_1	324	329	PF00069	0.499
MOD_NEK2_1	337	342	PF00069	0.591
MOD_NEK2_1	353	358	PF00069	0.729
MOD_NEK2_1	372	377	PF00069	0.492
MOD_NEK2_1	405	410	PF00069	0.537
MOD_NEK2_1	459	464	PF00069	0.631
MOD_NEK2_1	489	494	PF00069	0.485
MOD_NEK2_1	533	538	PF00069	0.572
MOD_NEK2_1	587	592	PF00069	0.624
MOD_NEK2_1	658	663	PF00069	0.340
MOD_NEK2_2	145	150	PF00069	0.557
MOD_NEK2_2	495	500	PF00069	0.482
MOD_PIKK_1	503	509	PF00454	0.548
MOD_PIKK_1	56	62	PF00454	0.607
MOD_PK_1	623	629	PF00069	0.549
MOD_PK_1	668	674	PF00069	0.360
MOD_PKA_1	299	305	PF00069	0.437
MOD_PKA_2	172	178	PF00069	0.692
MOD_PKA_2	257	263	PF00069	0.634
MOD_PKA_2	299	305	PF00069	0.417
MOD_PKA_2	351	357	PF00069	0.711
MOD_PKA_2	630	636	PF00069	0.368
MOD_Plk_1	13	19	PF00069	0.465
MOD_Plk_1	324	330	PF00069	0.501
MOD_Plk_1	411	417	PF00069	0.482
MOD_Plk_1	453	459	PF00069	0.521
MOD_Plk_1	495	501	PF00069	0.521
MOD_Plk_1	623	629	PF00069	0.513
MOD_Plk_2-3	156	162	PF00069	0.627
MOD_Plk_4	301	307	PF00069	0.504
MOD_Plk_4	318	324	PF00069	0.518
MOD_Plk_4	423	429	PF00069	0.428
MOD_Plk_4	553	559	PF00069	0.348
MOD_Plk_4	560	566	PF00069	0.462
MOD_Plk_4	637	643	PF00069	0.462
MOD_Plk_4	644	650	PF00069	0.302
MOD_ProDKin_1	397	403	PF00069	0.524
MOD_ProDKin_1	439	445	PF00069	0.516
MOD_ProDKin_1	80	86	PF00069	0.713
MOD_SUMO_rev_2	288	297	PF00179	0.441
MOD_SUMO_rev_2	325	335	PF00179	0.521
MOD_SUMO_rev_2	652	659	PF00179	0.540
MOD_SUMO_rev_2	66	71	PF00179	0.521
MOD_SUMO_rev_2	661	667	PF00179	0.485
TRG_DiLeu_BaEn_1	161	166	PF01217	0.522
TRG_DiLeu_BaEn_1	553	558	PF01217	0.445
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.596
TRG_ENDOCYTIC_2	119	122	PF00928	0.467
TRG_ENDOCYTIC_2	583	586	PF00928	0.584
TRG_ER_diArg_1	23	25	PF00400	0.491
TRG_ER_diArg_1	299	301	PF00400	0.413
TRG_ER_diArg_1	672	675	PF00400	0.544
TRG_NES_CRM1_1	27	38	PF08389	0.461
TRG_NES_CRM1_1	318	331	PF08389	0.631
TRG_NLS_MonoExtN_4	332	337	PF00514	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF5	Leptomonas seymouri	64%	98%
A0A0S4JTE0	Bodo saltans	41%	89%
A0A1X0NK47	Trypanosomatidae	48%	96%
A0A3R7K7N9	Trypanosoma rangeli	48%	97%
A0A3S5H5M7	Leishmania donovani	89%	100%
A0A3S7XBP3	Leishmania donovani	26%	100%
A4H4H1	Leishmania braziliensis	65%	100%
A4HSP6	Leishmania infantum	89%	100%
A4IDR0	Leishmania infantum	26%	100%
C9ZT89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
E9AKN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q0T1	Leishmania major	25%	100%
V5BDR9	Trypanosoma cruzi	50%	98%