Putative pumillio protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio/PUF RNA binding protein 5, putative

Species:

Leishmania major

UniProt:

Q4QJ74_LEIMA

TriTrypDb:

LmjF.06.0050 , LMJLV39_060005500 , LMJSD75_060005300

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QJ74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ74

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009894	regulation of catabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0043487	regulation of RNA stability	3	2
GO:0043488	regulation of mRNA stability	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903311	regulation of mRNA metabolic process	6	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	258	260	PF00675	0.301
CLV_PCSK_KEX2_1	258	260	PF00082	0.301
CLV_PCSK_KEX2_1	309	311	PF00082	0.345
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.393
CLV_PCSK_SKI1_1	184	188	PF00082	0.298
CLV_PCSK_SKI1_1	258	262	PF00082	0.341
DEG_APCC_DBOX_1	183	191	PF00400	0.306
DEG_APCC_DBOX_1	257	265	PF00400	0.312
DEG_MDM2_SWIB_1	353	360	PF02201	0.266
DEG_SCF_FBW7_2	230	236	PF00400	0.303
DEG_SPOP_SBC_1	107	111	PF00917	0.459
DOC_CKS1_1	230	235	PF01111	0.303
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.581
DOC_MAPK_gen_1	182	190	PF00069	0.417
DOC_MAPK_gen_1	382	391	PF00069	0.393
DOC_MAPK_MEF2A_6	182	190	PF00069	0.410
DOC_MAPK_MEF2A_6	67	74	PF00069	0.565
DOC_PP4_FxxP_1	117	120	PF00568	0.564
DOC_PP4_FxxP_1	49	52	PF00568	0.620
DOC_PP4_MxPP_1	132	135	PF00568	0.515
DOC_USP7_MATH_1	178	182	PF00917	0.396
DOC_USP7_MATH_1	94	98	PF00917	0.489
DOC_USP7_UBL2_3	305	309	PF12436	0.303
DOC_USP7_UBL2_3	84	88	PF12436	0.699
DOC_WW_Pin1_4	116	121	PF00397	0.568
DOC_WW_Pin1_4	130	135	PF00397	0.566
DOC_WW_Pin1_4	229	234	PF00397	0.426
DOC_WW_Pin1_4	26	31	PF00397	0.712
DOC_WW_Pin1_4	427	432	PF00397	0.351
DOC_WW_Pin1_4	433	438	PF00397	0.308
DOC_WW_Pin1_4	460	465	PF00397	0.612
DOC_WW_Pin1_4	54	59	PF00397	0.671
DOC_WW_Pin1_4	98	103	PF00397	0.558
LIG_14-3-3_CanoR_1	128	135	PF00244	0.651
LIG_14-3-3_CanoR_1	286	295	PF00244	0.418
LIG_14-3-3_CanoR_1	310	320	PF00244	0.347
LIG_APCC_ABBA_1	238	243	PF00400	0.358
LIG_BIR_III_2	9	13	PF00653	0.583
LIG_BRCT_BRCA1_1	113	117	PF00533	0.690
LIG_EH1_1	330	338	PF00400	0.286
LIG_FHA_1	121	127	PF00498	0.609
LIG_FHA_1	140	146	PF00498	0.644
LIG_FHA_1	255	261	PF00498	0.358
LIG_FHA_1	428	434	PF00498	0.494
LIG_FHA_1	460	466	PF00498	0.495
LIG_FHA_1	67	73	PF00498	0.766
LIG_FHA_2	108	114	PF00498	0.680
LIG_FHA_2	223	229	PF00498	0.286
LIG_FHA_2	461	467	PF00498	0.552
LIG_GBD_Chelix_1	332	340	PF00786	0.263
LIG_GBD_Chelix_1	373	381	PF00786	0.303
LIG_IBAR_NPY_1	93	95	PF08397	0.476
LIG_LIR_Apic_2	114	120	PF02991	0.559
LIG_LIR_Apic_2	302	306	PF02991	0.393
LIG_LIR_Gen_1	164	175	PF02991	0.430
LIG_LIR_Gen_1	341	350	PF02991	0.467
LIG_LIR_Nem_3	141	146	PF02991	0.645
LIG_LIR_Nem_3	164	170	PF02991	0.350
LIG_LIR_Nem_3	341	346	PF02991	0.472
LIG_LIR_Nem_3	403	407	PF02991	0.301
LIG_LIR_Nem_3	421	425	PF02991	0.267
LIG_PCNA_yPIPBox_3	382	390	PF02747	0.408
LIG_Pex14_2	353	357	PF04695	0.334
LIG_SH2_CRK	27	31	PF00017	0.666
LIG_SH2_CRK	303	307	PF00017	0.393
LIG_SH2_CRK	422	426	PF00017	0.445
LIG_SH2_NCK_1	303	307	PF00017	0.393
LIG_SH2_NCK_1	32	36	PF00017	0.588
LIG_SH2_NCK_1	426	430	PF00017	0.357
LIG_SH2_NCK_1	454	458	PF00017	0.366
LIG_SH2_PTP2	241	244	PF00017	0.375
LIG_SH2_PTP2	343	346	PF00017	0.457
LIG_SH2_SRC	420	423	PF00017	0.350
LIG_SH2_STAP1	203	207	PF00017	0.433
LIG_SH2_STAP1	365	369	PF00017	0.398
LIG_SH2_STAP1	454	458	PF00017	0.521
LIG_SH2_STAT3	331	334	PF00017	0.238
LIG_SH2_STAT3	407	410	PF00017	0.393
LIG_SH2_STAT5	121	124	PF00017	0.649
LIG_SH2_STAT5	229	232	PF00017	0.345
LIG_SH2_STAT5	241	244	PF00017	0.376
LIG_SH2_STAT5	331	334	PF00017	0.272
LIG_SH2_STAT5	343	346	PF00017	0.449
LIG_SH2_STAT5	407	410	PF00017	0.393
LIG_SH2_STAT5	90	93	PF00017	0.520
LIG_SH3_3	67	73	PF00018	0.723
LIG_SH3_4	305	312	PF00018	0.303
LIG_SUMO_SIM_par_1	275	283	PF11976	0.351
LIG_TYR_ITIM	239	244	PF00017	0.219
LIG_TYR_ITIM	424	429	PF00017	0.456
LIG_UBA3_1	297	305	PF00899	0.303
LIG_UBA3_1	319	325	PF00899	0.303
LIG_WRC_WIRS_1	350	355	PF05994	0.462
MOD_CDK_SPK_2	54	59	PF00069	0.753
MOD_CK1_1	111	117	PF00069	0.502
MOD_CK1_1	138	144	PF00069	0.654
MOD_CK1_1	149	155	PF00069	0.454
MOD_CK1_1	33	39	PF00069	0.530
MOD_CK1_1	83	89	PF00069	0.635
MOD_CK1_1	97	103	PF00069	0.473
MOD_CK2_1	107	113	PF00069	0.705
MOD_CK2_1	149	155	PF00069	0.535
MOD_CK2_1	222	228	PF00069	0.302
MOD_CK2_1	72	78	PF00069	0.482
MOD_GlcNHglycan	102	105	PF01048	0.454
MOD_GlcNHglycan	313	316	PF01048	0.393
MOD_GlcNHglycan	33	36	PF01048	0.592
MOD_GlcNHglycan	414	417	PF01048	0.391
MOD_GlcNHglycan	74	77	PF01048	0.519
MOD_GlcNHglycan	85	88	PF01048	0.674
MOD_GSK3_1	107	114	PF00069	0.507
MOD_GSK3_1	116	123	PF00069	0.532
MOD_GSK3_1	126	133	PF00069	0.528
MOD_GSK3_1	135	142	PF00069	0.581
MOD_GSK3_1	173	180	PF00069	0.476
MOD_GSK3_1	250	257	PF00069	0.363
MOD_GSK3_1	26	33	PF00069	0.549
MOD_GSK3_1	37	44	PF00069	0.560
MOD_GSK3_1	72	79	PF00069	0.669
MOD_GSK3_1	94	101	PF00069	0.508
MOD_NEK2_1	106	111	PF00069	0.599
MOD_NEK2_1	112	117	PF00069	0.530
MOD_NEK2_1	250	255	PF00069	0.442
MOD_NEK2_1	287	292	PF00069	0.283
MOD_NEK2_1	319	324	PF00069	0.454
MOD_NEK2_1	349	354	PF00069	0.417
MOD_NEK2_1	377	382	PF00069	0.440
MOD_NEK2_1	400	405	PF00069	0.419
MOD_NEK2_1	432	437	PF00069	0.341
MOD_PIKK_1	251	257	PF00454	0.317
MOD_PIKK_1	287	293	PF00454	0.278
MOD_PKA_2	127	133	PF00069	0.607
MOD_PKA_2	285	291	PF00069	0.436
MOD_PKA_2	66	72	PF00069	0.718
MOD_Plk_1	112	118	PF00069	0.631
MOD_Plk_4	166	172	PF00069	0.440
MOD_Plk_4	41	47	PF00069	0.642
MOD_Plk_4	66	72	PF00069	0.606
MOD_ProDKin_1	116	122	PF00069	0.567
MOD_ProDKin_1	130	136	PF00069	0.567
MOD_ProDKin_1	229	235	PF00069	0.426
MOD_ProDKin_1	26	32	PF00069	0.715
MOD_ProDKin_1	427	433	PF00069	0.348
MOD_ProDKin_1	460	466	PF00069	0.658
MOD_ProDKin_1	54	60	PF00069	0.671
MOD_ProDKin_1	98	104	PF00069	0.560
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.450
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.330
TRG_ENDOCYTIC_2	203	206	PF00928	0.435
TRG_ENDOCYTIC_2	241	244	PF00928	0.336
TRG_ENDOCYTIC_2	343	346	PF00928	0.457
TRG_ENDOCYTIC_2	422	425	PF00928	0.456
TRG_ENDOCYTIC_2	426	429	PF00928	0.463
TRG_ER_diArg_1	258	260	PF00400	0.314
TRG_ER_diArg_1	381	384	PF00400	0.347
TRG_ER_FFAT_2	111	123	PF00635	0.516
TRG_NES_CRM1_1	334	348	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.238

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSE0	Leptomonas seymouri	63%	98%
A0A0N1ILR0	Leptomonas seymouri	32%	71%
A0A0S4J2F9	Bodo saltans	48%	100%
A0A1X0NJM4	Trypanosomatidae	48%	100%
A0A3S5IQY1	Trypanosoma rangeli	47%	100%
A0A3S7WPA1	Leishmania donovani	95%	100%
A4H4H3	Leishmania braziliensis	85%	98%
A4HSP8	Leishmania infantum	95%	98%
C9ZT94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AKN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q9LVC3	Arabidopsis thaliana	24%	79%
V5B968	Trypanosoma cruzi	47%	100%