Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ73_LEIMA

TriTrypDb:

LmjF.06.0060 , LMJLV39_060005600 , LMJSD75_060005400

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.435
CLV_NRD_NRD_1	239	241	PF00675	0.595
CLV_NRD_NRD_1	57	59	PF00675	0.516
CLV_NRD_NRD_1	87	89	PF00675	0.460
CLV_PCSK_KEX2_1	154	156	PF00082	0.537
CLV_PCSK_KEX2_1	167	169	PF00082	0.382
CLV_PCSK_KEX2_1	276	278	PF00082	0.501
CLV_PCSK_KEX2_1	57	59	PF00082	0.507
CLV_PCSK_KEX2_1	86	88	PF00082	0.468
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.528
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.501
DEG_APCC_DBOX_1	216	224	PF00400	0.510
DEG_Nend_UBRbox_3	1	3	PF02207	0.714
DOC_PP2B_LxvP_1	296	299	PF13499	0.686
DOC_USP7_MATH_1	108	112	PF00917	0.445
DOC_USP7_MATH_1	133	137	PF00917	0.461
DOC_USP7_MATH_1	225	229	PF00917	0.572
DOC_USP7_MATH_1	290	294	PF00917	0.633
DOC_USP7_UBL2_3	128	132	PF12436	0.466
DOC_WW_Pin1_4	232	237	PF00397	0.683
DOC_WW_Pin1_4	266	271	PF00397	0.512
DOC_WW_Pin1_4	308	313	PF00397	0.602
LIG_14-3-3_CanoR_1	181	191	PF00244	0.502
LIG_14-3-3_CanoR_1	222	231	PF00244	0.649
LIG_14-3-3_CanoR_1	277	284	PF00244	0.619
LIG_14-3-3_CanoR_1	87	93	PF00244	0.502
LIG_Actin_WH2_2	203	221	PF00022	0.508
LIG_Actin_WH2_2	42	59	PF00022	0.412
LIG_FHA_1	143	149	PF00498	0.510
LIG_FHA_1	183	189	PF00498	0.397
LIG_FHA_1	237	243	PF00498	0.502
LIG_FHA_2	122	128	PF00498	0.502
LIG_FHA_2	233	239	PF00498	0.676
LIG_FHA_2	25	31	PF00498	0.437
LIG_FHA_2	42	48	PF00498	0.536
LIG_FHA_2	89	95	PF00498	0.498
LIG_LIR_Apic_2	274	278	PF02991	0.647
LIG_LIR_Apic_2	291	297	PF02991	0.511
LIG_LIR_Nem_3	178	183	PF02991	0.364
LIG_MYND_1	250	254	PF01753	0.549
LIG_PCNA_yPIPBox_3	90	103	PF02747	0.498
LIG_SH2_CRK	275	279	PF00017	0.502
LIG_SH2_CRK	294	298	PF00017	0.481
LIG_SH2_NCK_1	198	202	PF00017	0.386
LIG_SH2_NCK_1	294	298	PF00017	0.551
LIG_SH2_STAT5	79	82	PF00017	0.523
LIG_SH3_3	14	20	PF00018	0.501
LIG_SH3_3	264	270	PF00018	0.519
LIG_SH3_3	281	287	PF00018	0.705
LIG_TRAF2_1	205	208	PF00917	0.553
LIG_TRAF2_1	235	238	PF00917	0.597
LIG_TRFH_1	294	298	PF08558	0.551
LIG_UBA3_1	33	39	PF00899	0.453
MOD_CK1_1	111	117	PF00069	0.504
MOD_CK1_1	142	148	PF00069	0.497
MOD_CK1_1	182	188	PF00069	0.482
MOD_CK1_1	230	236	PF00069	0.634
MOD_CK1_1	6	12	PF00069	0.629
MOD_CK1_1	78	84	PF00069	0.483
MOD_CK2_1	121	127	PF00069	0.501
MOD_CK2_1	133	139	PF00069	0.409
MOD_CK2_1	170	176	PF00069	0.538
MOD_CK2_1	202	208	PF00069	0.481
MOD_CK2_1	232	238	PF00069	0.683
MOD_CK2_1	24	30	PF00069	0.526
MOD_CK2_1	41	47	PF00069	0.346
MOD_Cter_Amidation	152	155	PF01082	0.373
MOD_GlcNHglycan	109	113	PF01048	0.600
MOD_GlcNHglycan	136	139	PF01048	0.362
MOD_GlcNHglycan	171	175	PF01048	0.481
MOD_GlcNHglycan	225	228	PF01048	0.664
MOD_GlcNHglycan	232	235	PF01048	0.574
MOD_GlcNHglycan	245	248	PF01048	0.641
MOD_GlcNHglycan	6	9	PF01048	0.644
MOD_GSK3_1	175	182	PF00069	0.465
MOD_GSK3_1	223	230	PF00069	0.568
MOD_GSK3_1	232	239	PF00069	0.683
MOD_GSK3_1	288	295	PF00069	0.679
MOD_NEK2_1	149	154	PF00069	0.429
MOD_NEK2_1	183	188	PF00069	0.447
MOD_NEK2_1	271	276	PF00069	0.597
MOD_NEK2_1	4	9	PF00069	0.614
MOD_NEK2_1	41	46	PF00069	0.592
MOD_PIKK_1	121	127	PF00454	0.478
MOD_PIKK_1	175	181	PF00454	0.364
MOD_PIKK_1	277	283	PF00454	0.541
MOD_PKA_1	97	103	PF00069	0.496
MOD_PKB_1	86	94	PF00069	0.531
MOD_Plk_1	108	114	PF00069	0.442
MOD_Plk_1	170	176	PF00069	0.538
MOD_Plk_4	75	81	PF00069	0.550
MOD_ProDKin_1	232	238	PF00069	0.683
MOD_ProDKin_1	266	272	PF00069	0.513
MOD_ProDKin_1	308	314	PF00069	0.604
MOD_SUMO_rev_2	136	143	PF00179	0.419
MOD_SUMO_rev_2	93	99	PF00179	0.517
TRG_ER_diArg_1	166	168	PF00400	0.451
TRG_ER_diArg_1	217	220	PF00400	0.521
TRG_ER_diArg_1	56	58	PF00400	0.453
TRG_ER_diArg_1	85	88	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D4	Leptomonas seymouri	39%	80%
A0A3S5H5M8	Leishmania donovani	86%	100%
A4H4H4	Leishmania braziliensis	67%	75%
A4HSP9	Leishmania infantum	87%	100%
E9AKN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%