WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ72_LEIMA

TriTrypDb:

LmjF.06.0070 , LMJLV39_060005700 , LMJSD75_060005500

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.458
CLV_NRD_NRD_1	305	307	PF00675	0.356
CLV_NRD_NRD_1	366	368	PF00675	0.578
CLV_NRD_NRD_1	415	417	PF00675	0.508
CLV_NRD_NRD_1	426	428	PF00675	0.393
CLV_PCSK_KEX2_1	305	307	PF00082	0.356
CLV_PCSK_KEX2_1	366	368	PF00082	0.589
CLV_PCSK_KEX2_1	415	417	PF00082	0.468
CLV_PCSK_SKI1_1	185	189	PF00082	0.299
CLV_PCSK_SKI1_1	315	319	PF00082	0.372
CLV_PCSK_SKI1_1	335	339	PF00082	0.365
CLV_PCSK_SKI1_1	367	371	PF00082	0.364
CLV_PCSK_SKI1_1	415	419	PF00082	0.476
DEG_APCC_DBOX_1	307	315	PF00400	0.374
DEG_APCC_DBOX_1	444	452	PF00400	0.317
DOC_CDC14_PxL_1	277	285	PF14671	0.380
DOC_CDC14_PxL_1	293	301	PF14671	0.371
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.468
DOC_MAPK_gen_1	305	313	PF00069	0.331
DOC_MAPK_MEF2A_6	132	140	PF00069	0.377
DOC_PP1_RVXF_1	413	420	PF00149	0.592
DOC_PP2B_LxvP_1	161	164	PF13499	0.490
DOC_PP2B_LxvP_1	348	351	PF13499	0.495
DOC_PP4_FxxP_1	176	179	PF00568	0.516
DOC_PP4_FxxP_1	324	327	PF00568	0.313
DOC_USP7_MATH_1	12	16	PF00917	0.496
DOC_USP7_MATH_1	263	267	PF00917	0.477
DOC_USP7_MATH_1	411	415	PF00917	0.412
DOC_USP7_MATH_1	73	77	PF00917	0.550
DOC_USP7_MATH_1	94	98	PF00917	0.524
DOC_WW_Pin1_4	132	137	PF00397	0.388
DOC_WW_Pin1_4	323	328	PF00397	0.418
DOC_WW_Pin1_4	342	347	PF00397	0.669
DOC_WW_Pin1_4	350	355	PF00397	0.542
LIG_14-3-3_CanoR_1	233	237	PF00244	0.445
LIG_14-3-3_CanoR_1	282	286	PF00244	0.429
LIG_14-3-3_CanoR_1	366	372	PF00244	0.391
LIG_14-3-3_CanoR_1	376	384	PF00244	0.378
LIG_14-3-3_CanoR_1	40	47	PF00244	0.488
LIG_14-3-3_CanoR_1	421	427	PF00244	0.372
LIG_CSL_BTD_1	351	354	PF09270	0.491
LIG_FHA_1	175	181	PF00498	0.315
LIG_FHA_1	229	235	PF00498	0.431
LIG_FHA_1	24	30	PF00498	0.374
LIG_FHA_1	336	342	PF00498	0.572
LIG_FHA_1	343	349	PF00498	0.571
LIG_FHA_1	368	374	PF00498	0.441
LIG_FHA_1	381	387	PF00498	0.327
LIG_FHA_1	79	85	PF00498	0.437
LIG_FHA_2	213	219	PF00498	0.529
LIG_FHA_2	55	61	PF00498	0.766
LIG_LIR_Apic_2	175	179	PF02991	0.523
LIG_LIR_Apic_2	276	281	PF02991	0.273
LIG_LIR_Apic_2	323	327	PF02991	0.326
LIG_LIR_Gen_1	139	149	PF02991	0.493
LIG_LIR_Gen_1	368	379	PF02991	0.400
LIG_LIR_Gen_1	430	441	PF02991	0.470
LIG_LIR_Gen_1	86	94	PF02991	0.474
LIG_LIR_LC3C_4	6	11	PF02991	0.464
LIG_LIR_Nem_3	139	145	PF02991	0.389
LIG_LIR_Nem_3	20	24	PF02991	0.606
LIG_LIR_Nem_3	302	307	PF02991	0.328
LIG_LIR_Nem_3	368	374	PF02991	0.385
LIG_LIR_Nem_3	392	397	PF02991	0.319
LIG_LIR_Nem_3	430	436	PF02991	0.483
LIG_LIR_Nem_3	67	71	PF02991	0.456
LIG_LIR_Nem_3	86	90	PF02991	0.473
LIG_Pex14_1	208	212	PF04695	0.379
LIG_SH2_CRK	142	146	PF00017	0.452
LIG_SH2_CRK	278	282	PF00017	0.292
LIG_SH2_CRK	304	308	PF00017	0.363
LIG_SH2_CRK	87	91	PF00017	0.456
LIG_SH2_SRC	404	407	PF00017	0.488
LIG_SH2_STAP1	119	123	PF00017	0.397
LIG_SH2_STAP1	142	146	PF00017	0.290
LIG_SH2_STAT5	200	203	PF00017	0.343
LIG_SH2_STAT5	404	407	PF00017	0.576
LIG_SH2_STAT5	87	90	PF00017	0.500
LIG_SH3_3	343	349	PF00018	0.510
LIG_SH3_4	209	216	PF00018	0.302
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.464
LIG_SUMO_SIM_par_1	326	331	PF11976	0.424
LIG_SUMO_SIM_par_1	440	447	PF11976	0.409
LIG_TYR_ITIM	85	90	PF00017	0.507
LIG_TYR_ITSM	300	307	PF00017	0.306
LIG_WRC_WIRS_1	173	178	PF05994	0.352
LIG_WRC_WIRS_1	267	272	PF05994	0.331
MOD_CK1_1	266	272	PF00069	0.336
MOD_CK1_1	396	402	PF00069	0.441
MOD_CK1_1	422	428	PF00069	0.456
MOD_CK2_1	212	218	PF00069	0.408
MOD_CK2_1	387	393	PF00069	0.547
MOD_CK2_1	54	60	PF00069	0.568
MOD_DYRK1A_RPxSP_1	132	136	PF00069	0.386
MOD_GlcNHglycan	132	135	PF01048	0.416
MOD_GlcNHglycan	150	153	PF01048	0.482
MOD_GlcNHglycan	167	171	PF01048	0.408
MOD_GlcNHglycan	32	35	PF01048	0.574
MOD_GlcNHglycan	329	333	PF01048	0.486
MOD_GlcNHglycan	342	345	PF01048	0.612
MOD_GlcNHglycan	389	392	PF01048	0.450
MOD_GlcNHglycan	421	424	PF01048	0.551
MOD_GlcNHglycan	451	454	PF01048	0.388
MOD_GlcNHglycan	75	78	PF01048	0.593
MOD_GSK3_1	132	139	PF00069	0.339
MOD_GSK3_1	208	215	PF00069	0.398
MOD_GSK3_1	220	227	PF00069	0.381
MOD_GSK3_1	228	235	PF00069	0.472
MOD_GSK3_1	266	273	PF00069	0.385
MOD_GSK3_1	374	381	PF00069	0.502
MOD_GSK3_1	393	400	PF00069	0.288
MOD_GSK3_1	417	424	PF00069	0.467
MOD_LATS_1	222	228	PF00433	0.328
MOD_N-GLC_1	78	83	PF02516	0.523
MOD_NEK2_1	166	171	PF00069	0.524
MOD_NEK2_1	180	185	PF00069	0.462
MOD_NEK2_1	199	204	PF00069	0.368
MOD_NEK2_1	270	275	PF00069	0.335
MOD_NEK2_1	299	304	PF00069	0.322
MOD_NEK2_1	30	35	PF00069	0.565
MOD_NEK2_1	365	370	PF00069	0.556
MOD_NEK2_1	380	385	PF00069	0.344
MOD_NEK2_1	419	424	PF00069	0.397
MOD_NEK2_1	451	456	PF00069	0.454
MOD_NEK2_2	114	119	PF00069	0.308
MOD_NEK2_2	154	159	PF00069	0.386
MOD_PIKK_1	39	45	PF00454	0.489
MOD_PKA_2	232	238	PF00069	0.467
MOD_PKA_2	281	287	PF00069	0.382
MOD_PKA_2	365	371	PF00069	0.565
MOD_PKA_2	375	381	PF00069	0.358
MOD_PKA_2	39	45	PF00069	0.551
MOD_PKA_2	444	450	PF00069	0.398
MOD_Plk_1	299	305	PF00069	0.305
MOD_Plk_1	85	91	PF00069	0.416
MOD_Plk_2-3	393	399	PF00069	0.370
MOD_Plk_2-3	54	60	PF00069	0.525
MOD_Plk_4	141	147	PF00069	0.409
MOD_Plk_4	17	23	PF00069	0.445
MOD_Plk_4	237	243	PF00069	0.359
MOD_Plk_4	25	31	PF00069	0.364
MOD_Plk_4	263	269	PF00069	0.462
MOD_Plk_4	299	305	PF00069	0.435
MOD_Plk_4	85	91	PF00069	0.419
MOD_ProDKin_1	132	138	PF00069	0.379
MOD_ProDKin_1	323	329	PF00069	0.423
MOD_ProDKin_1	342	348	PF00069	0.665
MOD_ProDKin_1	350	356	PF00069	0.543
TRG_DiLeu_BaEn_2	308	314	PF01217	0.288
TRG_ENDOCYTIC_2	142	145	PF00928	0.447
TRG_ENDOCYTIC_2	200	203	PF00928	0.323
TRG_ENDOCYTIC_2	304	307	PF00928	0.484
TRG_ENDOCYTIC_2	87	90	PF00928	0.470
TRG_ER_diArg_1	243	246	PF00400	0.360
TRG_ER_diArg_1	304	306	PF00400	0.359
TRG_ER_diArg_1	365	367	PF00400	0.358
TRG_ER_diArg_1	415	417	PF00400	0.502
TRG_NES_CRM1_1	309	323	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NL12	Trypanosomatidae	28%	100%
A4H4H5	Leishmania braziliensis	74%	100%
C9ZT97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AKN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B4P7	Trypanosoma cruzi	30%	100%