Putative ATP-binding cassette protein subfamily G,member 3

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily G, member 3, putative

Species:

Leishmania major

UniProt:

Q4QJ69_LEIMA

TriTrypDb:

LmjF.06.0100 , LMJLV39_000015600 , LMJSD75_060005900

Length:

362

Annotations

LeishMANIAdb annotations

Proteins belonging to the subfamily G of Eukaryotic ABC transporters. Probably functional as dimers, with broad substrate specificity.. Expanded in Kinetoplastids (also in free-living forms)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QJ69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ69

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0009987	cellular process	1	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005215	transporter activity	1	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0015399	primary active transmembrane transporter activity	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0022804	active transmembrane transporter activity	3	6
GO:0022857	transmembrane transporter activity	2	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0042626	ATPase-coupled transmembrane transporter activity	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140359	ABC-type transporter activity	3	6
GO:0140657	ATP-dependent activity	1	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.610
CLV_NRD_NRD_1	190	192	PF00675	0.448
CLV_NRD_NRD_1	241	243	PF00675	0.416
CLV_NRD_NRD_1	27	29	PF00675	0.367
CLV_NRD_NRD_1	358	360	PF00675	0.462
CLV_NRD_NRD_1	69	71	PF00675	0.367
CLV_PCSK_FUR_1	25	29	PF00082	0.367
CLV_PCSK_KEX2_1	188	190	PF00082	0.465
CLV_PCSK_KEX2_1	241	243	PF00082	0.465
CLV_PCSK_KEX2_1	27	29	PF00082	0.367
CLV_PCSK_KEX2_1	358	360	PF00082	0.462
CLV_PCSK_KEX2_1	71	73	PF00082	0.329
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.465
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.329
CLV_PCSK_PC7_1	354	360	PF00082	0.412
CLV_PCSK_SKI1_1	192	196	PF00082	0.490
CLV_PCSK_SKI1_1	207	211	PF00082	0.327
CLV_PCSK_SKI1_1	242	246	PF00082	0.312
CLV_PCSK_SKI1_1	358	362	PF00082	0.463
CLV_PCSK_SKI1_1	84	88	PF00082	0.367
DOC_CKS1_1	13	18	PF01111	0.567
DOC_CKS1_1	198	203	PF01111	0.698
DOC_CYCLIN_yCln2_LP_2	13	19	PF00134	0.567
DOC_MAPK_gen_1	70	79	PF00069	0.567
DOC_MAPK_MEF2A_6	227	236	PF00069	0.669
DOC_MAPK_MEF2A_6	70	79	PF00069	0.567
DOC_PP4_FxxP_1	161	164	PF00568	0.609
DOC_USP7_MATH_1	322	326	PF00917	0.611
DOC_USP7_UBL2_3	184	188	PF12436	0.646
DOC_WW_Pin1_4	165	170	PF00397	0.557
DOC_WW_Pin1_4	197	202	PF00397	0.697
DOC_WW_Pin1_4	228	233	PF00397	0.668
DOC_WW_Pin1_4	8	13	PF00397	0.542
LIG_14-3-3_CanoR_1	112	118	PF00244	0.639
LIG_14-3-3_CanoR_1	199	208	PF00244	0.705
LIG_14-3-3_CanoR_1	241	251	PF00244	0.646
LIG_14-3-3_CanoR_1	307	312	PF00244	0.650
LIG_14-3-3_CanoR_1	319	326	PF00244	0.538
LIG_14-3-3_CanoR_1	328	334	PF00244	0.590
LIG_Actin_WH2_2	305	321	PF00022	0.500
LIG_BRCT_BRCA1_1	157	161	PF00533	0.560
LIG_FHA_1	123	129	PF00498	0.609
LIG_FHA_1	180	186	PF00498	0.609
LIG_FHA_1	201	207	PF00498	0.668
LIG_FHA_1	291	297	PF00498	0.515
LIG_FHA_1	90	96	PF00498	0.490
LIG_FHA_2	13	19	PF00498	0.526
LIG_FHA_2	166	172	PF00498	0.609
LIG_FHA_2	241	247	PF00498	0.618
LIG_LIR_Apic_2	158	164	PF02991	0.541
LIG_LIR_Gen_1	130	138	PF02991	0.554
LIG_LIR_Gen_1	14	24	PF02991	0.567
LIG_LIR_Gen_1	154	164	PF02991	0.605
LIG_LIR_Gen_1	170	181	PF02991	0.447
LIG_LIR_Gen_1	248	259	PF02991	0.489
LIG_LIR_Gen_1	285	294	PF02991	0.311
LIG_LIR_Nem_3	130	135	PF02991	0.554
LIG_LIR_Nem_3	14	20	PF02991	0.567
LIG_LIR_Nem_3	154	159	PF02991	0.605
LIG_LIR_Nem_3	170	176	PF02991	0.447
LIG_LIR_Nem_3	248	254	PF02991	0.552
LIG_LIR_Nem_3	285	290	PF02991	0.482
LIG_NRBOX	82	88	PF00104	0.463
LIG_RPA_C_Fungi	207	219	PF08784	0.624
LIG_SH2_CRK	173	177	PF00017	0.406
LIG_SH2_SRC	329	332	PF00017	0.566
LIG_SH2_STAP1	17	21	PF00017	0.442
LIG_SH2_STAT3	257	260	PF00017	0.500
LIG_SH2_STAT5	119	122	PF00017	0.594
LIG_SH2_STAT5	131	134	PF00017	0.308
LIG_SH2_STAT5	155	158	PF00017	0.394
LIG_SH2_STAT5	167	170	PF00017	0.316
LIG_SH2_STAT5	193	196	PF00017	0.459
LIG_SH2_STAT5	224	227	PF00017	0.517
LIG_SH2_STAT5	251	254	PF00017	0.578
LIG_SH2_STAT5	329	332	PF00017	0.566
LIG_SH3_1	195	201	PF00018	0.629
LIG_SH3_3	195	201	PF00018	0.543
LIG_SH3_3	311	317	PF00018	0.542
LIG_SH3_3	53	59	PF00018	0.479
LIG_SUMO_SIM_anti_2	133	139	PF11976	0.406
LIG_SUMO_SIM_par_1	173	180	PF11976	0.480
LIG_SUMO_SIM_par_1	290	295	PF11976	0.372
LIG_SUMO_SIM_par_1	84	90	PF11976	0.390
LIG_TYR_ITSM	168	175	PF00017	0.500
LIG_UBA3_1	79	84	PF00899	0.296
MOD_CK1_1	11	17	PF00069	0.442
MOD_CK1_1	162	168	PF00069	0.398
MOD_CK1_1	180	186	PF00069	0.316
MOD_CK1_1	23	29	PF00069	0.285
MOD_CK1_1	282	288	PF00069	0.497
MOD_CK1_1	310	316	PF00069	0.596
MOD_CK1_1	332	338	PF00069	0.484
MOD_CK1_1	63	69	PF00069	0.484
MOD_CK1_1	97	103	PF00069	0.528
MOD_CK2_1	208	214	PF00069	0.643
MOD_CK2_1	240	246	PF00069	0.580
MOD_CK2_1	28	34	PF00069	0.449
MOD_CK2_1	63	69	PF00069	0.390
MOD_CMANNOS	297	300	PF00535	0.375
MOD_GlcNHglycan	214	218	PF01048	0.576
MOD_GlcNHglycan	281	284	PF01048	0.489
MOD_GlcNHglycan	334	337	PF01048	0.508
MOD_GlcNHglycan	62	65	PF01048	0.336
MOD_GlcNHglycan	92	95	PF01048	0.536
MOD_GlcNHglycan	99	102	PF01048	0.429
MOD_GSK3_1	113	120	PF00069	0.488
MOD_GSK3_1	145	152	PF00069	0.500
MOD_GSK3_1	155	162	PF00069	0.340
MOD_GSK3_1	208	215	PF00069	0.536
MOD_GSK3_1	23	30	PF00069	0.282
MOD_GSK3_1	318	325	PF00069	0.587
MOD_GSK3_1	332	339	PF00069	0.378
MOD_GSK3_1	8	15	PF00069	0.498
MOD_GSK3_1	90	97	PF00069	0.455
MOD_NEK2_1	110	115	PF00069	0.557
MOD_NEK2_1	136	141	PF00069	0.445
MOD_NEK2_1	177	182	PF00069	0.500
MOD_NEK2_1	20	25	PF00069	0.390
MOD_NEK2_1	208	213	PF00069	0.545
MOD_NEK2_1	292	297	PF00069	0.446
MOD_NEK2_1	318	323	PF00069	0.534
MOD_PIKK_1	136	142	PF00454	0.500
MOD_PK_1	307	313	PF00069	0.556
MOD_PK_1	71	77	PF00069	0.442
MOD_PKA_1	27	33	PF00069	0.442
MOD_PKA_1	71	77	PF00069	0.394
MOD_PKA_2	240	246	PF00069	0.526
MOD_PKA_2	27	33	PF00069	0.442
MOD_PKA_2	318	324	PF00069	0.516
MOD_PKA_2	51	57	PF00069	0.355
MOD_PKA_2	71	77	PF00069	0.180
MOD_PKB_1	25	33	PF00069	0.442
MOD_Plk_2-3	127	133	PF00069	0.500
MOD_Plk_4	127	133	PF00069	0.500
MOD_Plk_4	282	288	PF00069	0.533
MOD_Plk_4	292	298	PF00069	0.334
MOD_Plk_4	307	313	PF00069	0.414
MOD_Plk_4	329	335	PF00069	0.542
MOD_ProDKin_1	165	171	PF00069	0.428
MOD_ProDKin_1	197	203	PF00069	0.621
MOD_ProDKin_1	228	234	PF00069	0.578
MOD_ProDKin_1	8	14	PF00069	0.408
MOD_SUMO_rev_2	78	86	PF00179	0.456
TRG_ENDOCYTIC_2	17	20	PF00928	0.442
TRG_ENDOCYTIC_2	172	175	PF00928	0.410
TRG_ENDOCYTIC_2	251	254	PF00928	0.394
TRG_ER_diArg_1	24	27	PF00400	0.394
TRG_NES_CRM1_1	127	140	PF08389	0.433
TRG_NES_CRM1_1	78	90	PF08389	0.296
TRG_NLS_MonoExtC_3	187	192	PF00514	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J724	Bodo saltans	42%	70%
A0A3S7WPC2	Leishmania donovani	95%	100%
E9AG66	Leishmania infantum	95%	100%
E9AKN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%