Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ68_LEIMA

TriTrypDb:

LmjF.06.0110 , LMJLV39_060006000 , LMJSD75_060006000

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	2
GO:0031965	nuclear membrane	4	2
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QJ68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.536
CLV_NRD_NRD_1	318	320	PF00675	0.329
CLV_NRD_NRD_1	590	592	PF00675	0.501
CLV_PCSK_KEX2_1	154	156	PF00082	0.535
CLV_PCSK_KEX2_1	318	320	PF00082	0.404
CLV_PCSK_KEX2_1	590	592	PF00082	0.501
CLV_PCSK_SKI1_1	126	130	PF00082	0.564
CLV_PCSK_SKI1_1	496	500	PF00082	0.303
CLV_PCSK_SKI1_1	584	588	PF00082	0.458
CLV_PCSK_SKI1_1	7	11	PF00082	0.403
CLV_PCSK_SKI1_1	91	95	PF00082	0.429
DEG_APCC_DBOX_1	90	98	PF00400	0.465
DEG_Nend_UBRbox_1	1	4	PF02207	0.578
DEG_SPOP_SBC_1	280	284	PF00917	0.682
DEG_SPOP_SBC_1	285	289	PF00917	0.642
DOC_CYCLIN_RxL_1	2	13	PF00134	0.590
DOC_MAPK_gen_1	496	504	PF00069	0.497
DOC_MAPK_gen_1	50	60	PF00069	0.377
DOC_MAPK_MEF2A_6	413	422	PF00069	0.518
DOC_PP1_RVXF_1	195	202	PF00149	0.617
DOC_PP1_RVXF_1	588	595	PF00149	0.544
DOC_PP2B_LxvP_1	290	293	PF13499	0.558
DOC_USP7_MATH_1	100	104	PF00917	0.624
DOC_USP7_MATH_1	182	186	PF00917	0.658
DOC_USP7_MATH_1	285	289	PF00917	0.682
DOC_USP7_MATH_1	374	378	PF00917	0.747
DOC_WW_Pin1_4	281	286	PF00397	0.756
LIG_14-3-3_CanoR_1	154	162	PF00244	0.684
LIG_14-3-3_CanoR_1	191	201	PF00244	0.670
LIG_14-3-3_CanoR_1	2	10	PF00244	0.557
LIG_14-3-3_CanoR_1	397	405	PF00244	0.559
LIG_14-3-3_CanoR_1	417	421	PF00244	0.481
LIG_14-3-3_CanoR_1	453	458	PF00244	0.483
LIG_14-3-3_CanoR_1	461	467	PF00244	0.542
LIG_14-3-3_CanoR_1	492	496	PF00244	0.580
LIG_14-3-3_CanoR_1	572	576	PF00244	0.544
LIG_Actin_WH2_2	568	586	PF00022	0.598
LIG_BRCT_BRCA1_1	426	430	PF00533	0.561
LIG_Clathr_ClatBox_1	9	13	PF01394	0.561
LIG_deltaCOP1_diTrp_1	474	480	PF00928	0.587
LIG_deltaCOP1_diTrp_1	69	79	PF00928	0.364
LIG_FHA_1	144	150	PF00498	0.714
LIG_FHA_1	32	38	PF00498	0.304
LIG_FHA_1	384	390	PF00498	0.578
LIG_FHA_1	417	423	PF00498	0.511
LIG_FHA_1	43	49	PF00498	0.296
LIG_FHA_1	572	578	PF00498	0.533
LIG_FHA_2	113	119	PF00498	0.698
LIG_FHA_2	193	199	PF00498	0.663
LIG_FHA_2	595	601	PF00498	0.682
LIG_FHA_2	6	12	PF00498	0.668
LIG_LIR_Apic_2	366	372	PF02991	0.734
LIG_LIR_Gen_1	291	302	PF02991	0.553
LIG_LIR_Gen_1	31	40	PF02991	0.393
LIG_LIR_Gen_1	500	506	PF02991	0.562
LIG_LIR_Nem_3	291	297	PF02991	0.510
LIG_LIR_Nem_3	31	35	PF02991	0.403
LIG_LIR_Nem_3	500	504	PF02991	0.496
LIG_LIR_Nem_3	524	529	PF02991	0.506
LIG_LIR_Nem_3	566	571	PF02991	0.605
LIG_NRBOX	387	393	PF00104	0.560
LIG_NRBOX	89	95	PF00104	0.328
LIG_Pex14_1	476	480	PF04695	0.551
LIG_Pex14_2	527	531	PF04695	0.562
LIG_SH2_CRK	568	572	PF00017	0.572
LIG_SH2_SRC	462	465	PF00017	0.566
LIG_SH2_STAP1	414	418	PF00017	0.567
LIG_SH2_STAT3	449	452	PF00017	0.480
LIG_SH2_STAT5	41	44	PF00017	0.317
LIG_SH2_STAT5	449	452	PF00017	0.492
LIG_SH2_STAT5	462	465	PF00017	0.531
LIG_SH2_STAT5	501	504	PF00017	0.483
LIG_SH2_STAT5	518	521	PF00017	0.405
LIG_SH2_STAT5	526	529	PF00017	0.467
LIG_SH3_1	368	374	PF00018	0.628
LIG_SH3_2	189	194	PF14604	0.662
LIG_SH3_3	186	192	PF00018	0.665
LIG_SH3_3	347	353	PF00018	0.593
LIG_SH3_3	368	374	PF00018	0.694
LIG_SH3_3	94	100	PF00018	0.603
LIG_SH3_4	262	269	PF00018	0.655
LIG_SUMO_SIM_anti_2	253	261	PF11976	0.638
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.284
LIG_SUMO_SIM_par_1	573	579	PF11976	0.591
LIG_SUMO_SIM_par_1	61	71	PF11976	0.359
LIG_SUMO_SIM_par_1	8	13	PF11976	0.581
LIG_TRAF2_1	344	347	PF00917	0.573
LIG_TYR_ITIM	562	567	PF00017	0.535
LIG_UBA3_1	487	496	PF00899	0.568
LIG_WRC_WIRS_1	454	459	PF05994	0.471
LIG_WRC_WIRS_1	82	87	PF05994	0.439
MOD_CK1_1	136	142	PF00069	0.716
MOD_CK1_1	283	289	PF00069	0.718
MOD_CK1_1	431	437	PF00069	0.596
MOD_CK1_1	465	471	PF00069	0.570
MOD_CK1_1	535	541	PF00069	0.633
MOD_CK2_1	112	118	PF00069	0.667
MOD_CK2_1	341	347	PF00069	0.547
MOD_CK2_1	436	442	PF00069	0.563
MOD_CK2_1	545	551	PF00069	0.495
MOD_CK2_1	594	600	PF00069	0.677
MOD_Cter_Amidation	588	591	PF01082	0.472
MOD_GlcNHglycan	102	105	PF01048	0.480
MOD_GlcNHglycan	214	217	PF01048	0.436
MOD_GlcNHglycan	220	223	PF01048	0.402
MOD_GlcNHglycan	234	237	PF01048	0.472
MOD_GlcNHglycan	243	246	PF01048	0.482
MOD_GlcNHglycan	269	272	PF01048	0.538
MOD_GlcNHglycan	425	429	PF01048	0.354
MOD_GlcNHglycan	433	436	PF01048	0.401
MOD_GlcNHglycan	468	471	PF01048	0.442
MOD_GlcNHglycan	477	480	PF01048	0.450
MOD_GSK3_1	1	8	PF00069	0.669
MOD_GSK3_1	122	129	PF00069	0.764
MOD_GSK3_1	183	190	PF00069	0.674
MOD_GSK3_1	279	286	PF00069	0.738
MOD_GSK3_1	302	309	PF00069	0.534
MOD_GSK3_1	383	390	PF00069	0.561
MOD_GSK3_1	424	431	PF00069	0.555
MOD_GSK3_1	462	469	PF00069	0.575
MOD_GSK3_1	535	542	PF00069	0.630
MOD_GSK3_1	594	601	PF00069	0.784
MOD_LATS_1	265	271	PF00433	0.658
MOD_N-GLC_1	133	138	PF02516	0.476
MOD_N-GLC_1	466	471	PF02516	0.408
MOD_N-GLC_1	535	540	PF02516	0.343
MOD_NEK2_1	1	6	PF00069	0.560
MOD_NEK2_1	258	263	PF00069	0.778
MOD_NEK2_1	302	307	PF00069	0.609
MOD_NEK2_1	424	429	PF00069	0.550
MOD_NEK2_1	430	435	PF00069	0.606
MOD_NEK2_1	491	496	PF00069	0.575
MOD_NEK2_1	539	544	PF00069	0.632
MOD_NEK2_1	81	86	PF00069	0.345
MOD_PIKK_1	133	139	PF00454	0.647
MOD_PIKK_1	398	404	PF00454	0.645
MOD_PKA_1	154	160	PF00069	0.682
MOD_PKA_2	1	7	PF00069	0.567
MOD_PKA_2	154	160	PF00069	0.796
MOD_PKA_2	162	168	PF00069	0.620
MOD_PKA_2	398	404	PF00069	0.700
MOD_PKA_2	416	422	PF00069	0.452
MOD_PKA_2	491	497	PF00069	0.576
MOD_PKA_2	571	577	PF00069	0.606
MOD_PKB_1	124	132	PF00069	0.698
MOD_PKB_1	267	275	PF00069	0.708
MOD_PKB_1	530	538	PF00069	0.623
MOD_Plk_1	142	148	PF00069	0.721
MOD_Plk_1	302	308	PF00069	0.488
MOD_Plk_1	535	541	PF00069	0.558
MOD_Plk_4	136	142	PF00069	0.712
MOD_Plk_4	28	34	PF00069	0.484
MOD_Plk_4	387	393	PF00069	0.613
MOD_Plk_4	535	541	PF00069	0.572
MOD_Plk_4	545	551	PF00069	0.463
MOD_Plk_4	59	65	PF00069	0.443
MOD_ProDKin_1	281	287	PF00069	0.755
MOD_SUMO_rev_2	256	264	PF00179	0.641
TRG_ENDOCYTIC_2	501	504	PF00928	0.474
TRG_ENDOCYTIC_2	526	529	PF00928	0.491
TRG_ENDOCYTIC_2	564	567	PF00928	0.512
TRG_ENDOCYTIC_2	568	571	PF00928	0.519
TRG_ENDOCYTIC_2	82	85	PF00928	0.422
TRG_ER_diArg_1	154	156	PF00400	0.737
TRG_ER_diArg_1	318	320	PF00400	0.615
TRG_ER_diArg_1	590	592	PF00400	0.631
TRG_ER_diArg_1	75	78	PF00400	0.321
TRG_NES_CRM1_1	551	566	PF08389	0.574
TRG_NES_CRM1_1	576	588	PF08389	0.592
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	496	500	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR5	Leptomonas seymouri	56%	99%
A0A0S4J1D5	Bodo saltans	29%	94%
A0A1X0NL56	Trypanosomatidae	36%	100%
A0A3R7NA89	Trypanosoma rangeli	36%	100%
A0A3S5H5N1	Leishmania donovani	95%	100%
A4H4H7	Leishmania braziliensis	82%	100%
A4HSQ2	Leishmania infantum	95%	100%
C9ZT98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5AP94	Trypanosoma cruzi	34%	100%