NADAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved hypothetical protein, putative

Species:

Leishmania major

UniProt:

Q4QJ66_LEIMA

TriTrypDb:

LmjF.06.0130 , LMJLV39_060006200 , LMJSD75_060006200

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ66

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.313
CLV_PCSK_SKI1_1	109	113	PF00082	0.325
CLV_PCSK_SKI1_1	139	143	PF00082	0.339
CLV_PCSK_SKI1_1	71	75	PF00082	0.358
DOC_CKS1_1	122	127	PF01111	0.450
DOC_MAPK_gen_1	137	144	PF00069	0.404
DOC_MAPK_gen_1	6	13	PF00069	0.600
DOC_MAPK_gen_1	88	96	PF00069	0.323
DOC_MAPK_MEF2A_6	88	95	PF00069	0.325
DOC_USP7_MATH_1	2	6	PF00917	0.683
DOC_WW_Pin1_4	121	126	PF00397	0.450
DOC_WW_Pin1_4	175	180	PF00397	0.503
DOC_WW_Pin1_4	22	27	PF00397	0.308
DOC_WW_Pin1_4	51	56	PF00397	0.349
LIG_14-3-3_CanoR_1	169	179	PF00244	0.510
LIG_14-3-3_CanoR_1	71	81	PF00244	0.347
LIG_APCC_ABBAyCdc20_2	150	156	PF00400	0.412
LIG_FHA_2	10	16	PF00498	0.418
LIG_FHA_2	122	128	PF00498	0.310
LIG_FHA_2	73	79	PF00498	0.371
LIG_LIR_Gen_1	12	21	PF02991	0.373
LIG_LIR_LC3C_4	30	34	PF02991	0.418
LIG_LIR_Nem_3	12	16	PF02991	0.340
LIG_LIR_Nem_3	18	24	PF02991	0.309
LIG_LIR_Nem_3	98	102	PF02991	0.392
LIG_LYPXL_yS_3	39	42	PF13949	0.325
LIG_SH2_CRK	122	126	PF00017	0.450
LIG_SH2_CRK	21	25	PF00017	0.418
LIG_SH2_STAT5	45	48	PF00017	0.325
LIG_SH2_STAT5	99	102	PF00017	0.418
LIG_SH3_3	13	19	PF00018	0.334
LIG_SH3_3	176	182	PF00018	0.497
LIG_SH3_3	23	29	PF00018	0.274
LIG_SH3_3	34	40	PF00018	0.295
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.307
LIG_TRAF2_1	155	158	PF00917	0.544
LIG_TRAF2_1	75	78	PF00917	0.371
LIG_TYR_ITIM	37	42	PF00017	0.418
LIG_WRC_WIRS_1	10	15	PF05994	0.561
MOD_CK1_1	25	31	PF00069	0.348
MOD_CK2_1	152	158	PF00069	0.573
MOD_CK2_1	51	57	PF00069	0.340
MOD_CK2_1	72	78	PF00069	0.359
MOD_CK2_1	9	15	PF00069	0.534
MOD_GlcNHglycan	166	169	PF01048	0.670
MOD_GlcNHglycan	172	175	PF01048	0.701
MOD_GSK3_1	111	118	PF00069	0.436
MOD_GSK3_1	164	171	PF00069	0.717
MOD_GSK3_1	61	68	PF00069	0.407
MOD_NEK2_1	112	117	PF00069	0.219
MOD_NEK2_1	95	100	PF00069	0.385
MOD_PIKK_1	112	118	PF00454	0.404
MOD_PKA_2	168	174	PF00069	0.717
MOD_PKB_1	150	158	PF00069	0.538
MOD_Plk_1	61	67	PF00069	0.418
MOD_Plk_4	115	121	PF00069	0.120
MOD_Plk_4	62	68	PF00069	0.306
MOD_Plk_4	95	101	PF00069	0.395
MOD_ProDKin_1	121	127	PF00069	0.450
MOD_ProDKin_1	175	181	PF00069	0.500
MOD_ProDKin_1	22	28	PF00069	0.308
MOD_ProDKin_1	51	57	PF00069	0.349
TRG_ENDOCYTIC_2	21	24	PF00928	0.331
TRG_ENDOCYTIC_2	39	42	PF00928	0.221
TRG_ENDOCYTIC_2	99	102	PF00928	0.290
TRG_ER_diArg_1	149	152	PF00400	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I812	Leptomonas seymouri	78%	100%
A0A0S4IYE8	Bodo saltans	53%	100%
A0A0S4JDI7	Bodo saltans	29%	86%
A0A1X0NJB1	Trypanosomatidae	59%	100%
A0A3R7KBB5	Trypanosoma rangeli	60%	100%
A0A3S5H5N3	Leishmania donovani	98%	100%
A4H4H9	Leishmania braziliensis	84%	98%
A4HSQ4	Leishmania infantum	98%	100%
B2J4E5	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	29%	100%
C9ZTA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AKP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P30176	Escherichia coli (strain K12)	32%	100%
Q0T6G3	Shigella flexneri serotype 5b (strain 8401)	32%	100%
Q323Z6	Shigella boydii serotype 4 (strain Sb227)	32%	100%
Q3Z3Y7	Shigella sonnei (strain Ss046)	32%	100%
Q83LU8	Shigella flexneri	32%	100%