HD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HD domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QJ63_LEIMA

TriTrypDb:

LmjF.06.0160 , LMJLV39_060006500 , LMJSD75_060006500

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QJ63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ63

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006163	purine nucleotide metabolic process	5	3
GO:0006195	purine nucleotide catabolic process	6	3
GO:0006203	dGTP catabolic process	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006753	nucleoside phosphate metabolic process	4	3
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009117	nucleotide metabolic process	5	3
GO:0009141	nucleoside triphosphate metabolic process	5	3
GO:0009143	nucleoside triphosphate catabolic process	6	3
GO:0009144	purine nucleoside triphosphate metabolic process	6	3
GO:0009146	purine nucleoside triphosphate catabolic process	7	3
GO:0009151	purine deoxyribonucleotide metabolic process	6	3
GO:0009155	purine deoxyribonucleotide catabolic process	6	3
GO:0009166	nucleotide catabolic process	6	3
GO:0009200	deoxyribonucleoside triphosphate metabolic process	6	3
GO:0009204	deoxyribonucleoside triphosphate catabolic process	7	3
GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	7	3
GO:0009217	purine deoxyribonucleoside triphosphate catabolic process	8	3
GO:0009262	deoxyribonucleotide metabolic process	4	3
GO:0009264	deoxyribonucleotide catabolic process	5	3
GO:0009394	2'-deoxyribonucleotide metabolic process	5	3
GO:0009987	cellular process	1	3
GO:0019439	aromatic compound catabolic process	4	3
GO:0019637	organophosphate metabolic process	3	3
GO:0019692	deoxyribose phosphate metabolic process	4	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034655	nucleobase-containing compound catabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044248	cellular catabolic process	3	3
GO:0044270	cellular nitrogen compound catabolic process	4	3
GO:0044281	small molecule metabolic process	2	3
GO:0046070	dGTP metabolic process	7	3
GO:0046386	deoxyribose phosphate catabolic process	5	3
GO:0046434	organophosphate catabolic process	4	3
GO:0046483	heterocycle metabolic process	3	3
GO:0046700	heterocycle catabolic process	4	3
GO:0055086	nucleobase-containing small molecule metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0072521	purine-containing compound metabolic process	4	3
GO:0072523	purine-containing compound catabolic process	5	3
GO:1901135	carbohydrate derivative metabolic process	3	3
GO:1901136	carbohydrate derivative catabolic process	4	3
GO:1901292	nucleoside phosphate catabolic process	5	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901361	organic cyclic compound catabolic process	4	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901565	organonitrogen compound catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008832	dGTPase activity	6	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016793	triphosphoric monoester hydrolase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.377
CLV_NRD_NRD_1	147	149	PF00675	0.268
CLV_NRD_NRD_1	15	17	PF00675	0.535
CLV_NRD_NRD_1	433	435	PF00675	0.403
CLV_PCSK_KEX2_1	10	12	PF00082	0.518
CLV_PCSK_KEX2_1	130	132	PF00082	0.414
CLV_PCSK_KEX2_1	147	149	PF00082	0.270
CLV_PCSK_KEX2_1	183	185	PF00082	0.279
CLV_PCSK_KEX2_1	433	435	PF00082	0.403
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.609
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.279
CLV_PCSK_SKI1_1	147	151	PF00082	0.245
CLV_PCSK_SKI1_1	169	173	PF00082	0.376
CLV_PCSK_SKI1_1	21	25	PF00082	0.404
CLV_PCSK_SKI1_1	235	239	PF00082	0.307
CLV_PCSK_SKI1_1	241	245	PF00082	0.267
CLV_PCSK_SKI1_1	83	87	PF00082	0.260
CLV_Separin_Metazoa	13	17	PF03568	0.351
DEG_APCC_DBOX_1	146	154	PF00400	0.279
DEG_APCC_DBOX_1	82	90	PF00400	0.256
DEG_Nend_UBRbox_4	1	3	PF02207	0.400
DOC_CKS1_1	417	422	PF01111	0.408
DOC_CKS1_1	43	48	PF01111	0.358
DOC_CYCLIN_RxL_1	166	175	PF00134	0.230
DOC_CYCLIN_yCln2_LP_2	417	423	PF00134	0.378
DOC_MAPK_FxFP_2	62	65	PF00069	0.351
DOC_MAPK_gen_1	130	136	PF00069	0.391
DOC_MAPK_gen_1	16	25	PF00069	0.541
DOC_MAPK_gen_1	167	174	PF00069	0.426
DOC_MAPK_gen_1	183	189	PF00069	0.279
DOC_MAPK_JIP1_4	19	25	PF00069	0.342
DOC_MAPK_MEF2A_6	205	212	PF00069	0.351
DOC_MAPK_RevD_3	170	184	PF00069	0.230
DOC_PP4_FxxP_1	203	206	PF00568	0.333
DOC_PP4_FxxP_1	392	395	PF00568	0.405
DOC_PP4_FxxP_1	62	65	PF00568	0.351
DOC_USP7_MATH_1	333	337	PF00917	0.405
DOC_USP7_MATH_1	359	363	PF00917	0.354
DOC_USP7_MATH_1	386	390	PF00917	0.347
DOC_WW_Pin1_4	412	417	PF00397	0.458
DOC_WW_Pin1_4	42	47	PF00397	0.393
LIG_14-3-3_CanoR_1	214	222	PF00244	0.290
LIG_14-3-3_CanoR_1	331	340	PF00244	0.422
LIG_14-3-3_CanoR_1	50	55	PF00244	0.313
LIG_Actin_WH2_2	398	414	PF00022	0.453
LIG_BRCT_BRCA1_1	120	124	PF00533	0.279
LIG_BRCT_BRCA1_1	388	392	PF00533	0.326
LIG_BRCT_BRCA1_1	414	418	PF00533	0.428
LIG_BRCT_BRCA1_1	459	463	PF00533	0.488
LIG_Clathr_ClatBox_1	428	432	PF01394	0.331
LIG_deltaCOP1_diTrp_1	224	232	PF00928	0.361
LIG_DLG_GKlike_1	50	57	PF00625	0.306
LIG_FHA_1	205	211	PF00498	0.342
LIG_FHA_1	258	264	PF00498	0.405
LIG_FHA_1	291	297	PF00498	0.313
LIG_FHA_1	324	330	PF00498	0.447
LIG_FHA_1	425	431	PF00498	0.343
LIG_FHA_1	456	462	PF00498	0.484
LIG_FHA_1	82	88	PF00498	0.373
LIG_FHA_2	155	161	PF00498	0.422
LIG_FHA_2	173	179	PF00498	0.391
LIG_FHA_2	22	28	PF00498	0.325
LIG_FHA_2	282	288	PF00498	0.321
LIG_FHA_2	68	74	PF00498	0.233
LIG_FHA_2	7	13	PF00498	0.453
LIG_LIR_Apic_2	389	395	PF02991	0.379
LIG_LIR_Apic_2	60	65	PF02991	0.340
LIG_LIR_Gen_1	121	128	PF02991	0.290
LIG_LIR_Gen_1	27	38	PF02991	0.373
LIG_LIR_Gen_1	292	303	PF02991	0.351
LIG_LIR_Gen_1	45	54	PF02991	0.207
LIG_LIR_Gen_1	450	461	PF02991	0.557
LIG_LIR_Nem_3	121	127	PF02991	0.290
LIG_LIR_Nem_3	175	179	PF02991	0.333
LIG_LIR_Nem_3	27	33	PF02991	0.426
LIG_LIR_Nem_3	292	298	PF02991	0.359
LIG_LIR_Nem_3	415	421	PF02991	0.438
LIG_LIR_Nem_3	45	51	PF02991	0.238
LIG_LIR_Nem_3	450	456	PF02991	0.413
LIG_NRBOX	107	113	PF00104	0.372
LIG_Pex14_1	228	232	PF04695	0.283
LIG_Pex14_2	120	124	PF04695	0.233
LIG_Rb_LxCxE_1	218	239	PF01857	0.290
LIG_SH2_NCK_1	30	34	PF00017	0.424
LIG_SH2_SRC	30	33	PF00017	0.384
LIG_SH2_STAP1	334	338	PF00017	0.450
LIG_SH2_STAP1	453	457	PF00017	0.461
LIG_SH2_STAT3	255	258	PF00017	0.406
LIG_SH2_STAT5	194	197	PF00017	0.279
LIG_SH3_3	346	352	PF00018	0.489
LIG_SH3_3	358	364	PF00018	0.411
LIG_SH3_3	392	398	PF00018	0.351
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.354
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.478
LIG_SUMO_SIM_anti_2	373	378	PF11976	0.329
LIG_SUMO_SIM_par_1	424	432	PF11976	0.336
LIG_TYR_ITIM	174	179	PF00017	0.339
LIG_UBA3_1	243	249	PF00899	0.271
MOD_CK2_1	172	178	PF00069	0.391
MOD_CK2_1	236	242	PF00069	0.340
MOD_CK2_1	281	287	PF00069	0.319
MOD_CK2_1	6	12	PF00069	0.474
MOD_CK2_1	67	73	PF00069	0.320
MOD_GlcNHglycan	217	220	PF01048	0.309
MOD_GlcNHglycan	335	338	PF01048	0.435
MOD_GSK3_1	396	403	PF00069	0.458
MOD_GSK3_1	412	419	PF00069	0.462
MOD_NEK2_1	172	177	PF00069	0.230
MOD_NEK2_1	215	220	PF00069	0.329
MOD_NEK2_1	236	241	PF00069	0.337
MOD_NEK2_1	338	343	PF00069	0.414
MOD_NEK2_1	457	462	PF00069	0.446
MOD_NEK2_1	57	62	PF00069	0.316
MOD_NEK2_1	72	77	PF00069	0.279
MOD_NEK2_1	81	86	PF00069	0.279
MOD_PIKK_1	396	402	PF00454	0.414
MOD_PKA_1	396	402	PF00069	0.414
MOD_PKA_1	433	439	PF00069	0.385
MOD_PKA_2	196	202	PF00069	0.303
MOD_PKA_2	433	439	PF00069	0.397
MOD_PKB_1	19	27	PF00069	0.398
MOD_Plk_1	21	27	PF00069	0.329
MOD_Plk_1	290	296	PF00069	0.517
MOD_Plk_1	338	344	PF00069	0.484
MOD_Plk_1	424	430	PF00069	0.303
MOD_Plk_1	72	78	PF00069	0.279
MOD_Plk_4	21	27	PF00069	0.405
MOD_Plk_4	281	287	PF00069	0.373
MOD_Plk_4	290	296	PF00069	0.401
MOD_Plk_4	386	392	PF00069	0.366
MOD_Plk_4	58	64	PF00069	0.322
MOD_ProDKin_1	412	418	PF00069	0.450
MOD_ProDKin_1	42	48	PF00069	0.388
MOD_SUMO_rev_2	445	454	PF00179	0.312
TRG_DiLeu_BaEn_1	424	429	PF01217	0.338
TRG_DiLeu_BaEn_3	424	430	PF01217	0.317
TRG_ENDOCYTIC_2	176	179	PF00928	0.260
TRG_ENDOCYTIC_2	30	33	PF00928	0.414
TRG_ENDOCYTIC_2	453	456	PF00928	0.462
TRG_ER_diArg_1	147	149	PF00400	0.288
TRG_ER_diArg_1	324	327	PF00400	0.335
TRG_ER_diArg_1	433	435	PF00400	0.429
TRG_NLS_MonoExtC_3	15	20	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL39	Leptomonas seymouri	82%	100%
A0A0N1PD02	Leptomonas seymouri	35%	75%
A0A0S4J2F4	Bodo saltans	51%	100%
A0A0S4J714	Bodo saltans	43%	66%
A0A1X0NJC9	Trypanosomatidae	66%	100%
A0A3Q8IGB9	Leishmania donovani	35%	69%
A0A3R7NIH1	Trypanosoma rangeli	67%	100%
A0A3S7WPC5	Leishmania donovani	98%	100%
A4H4I2	Leishmania braziliensis	93%	100%
A4HKP4	Leishmania braziliensis	34%	69%
A4HSQ7	Leishmania infantum	98%	100%
A4I875	Leishmania infantum	35%	69%
B0G107	Dictyostelium discoideum	32%	91%
C9ZTA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AKP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B333	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	69%
Q09374	Caenorhabditis elegans	30%	80%
Q0VCA5	Bos taurus	31%	79%
Q4Q521	Leishmania major	34%	69%
Q502K2	Danio rerio	30%	75%
Q5UQ48	Acanthamoeba polyphaga mimivirus	29%	100%
Q5ZJL9	Gallus gallus	32%	76%
Q60710	Mus musculus	30%	71%
Q6INN8	Xenopus laevis	30%	74%
Q9Y3Z3	Homo sapiens	29%	75%
V5B971	Trypanosoma cruzi	66%	100%