Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-like protein

Species:

Leishmania major

UniProt:

Q4QJ61_LEIMA

TriTrypDb:

LmjF.06.0180 , LMJLV39_060006700 , LMJSD75_060006700

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	12
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QJ61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ61

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	14
GO:0007018	microtubule-based movement	3	14
GO:0009987	cellular process	1	14

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003774	cytoskeletal motor activity	1	14
GO:0003777	microtubule motor activity	2	14
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	14
GO:0005515	protein binding	2	14
GO:0005524	ATP binding	5	14
GO:0008017	microtubule binding	5	14
GO:0008092	cytoskeletal protein binding	3	14
GO:0015631	tubulin binding	4	14
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	14
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140657	ATP-dependent activity	1	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.412
CLV_C14_Caspase3-7	340	344	PF00656	0.439
CLV_NRD_NRD_1	191	193	PF00675	0.390
CLV_NRD_NRD_1	197	199	PF00675	0.367
CLV_NRD_NRD_1	201	203	PF00675	0.349
CLV_NRD_NRD_1	524	526	PF00675	0.563
CLV_NRD_NRD_1	578	580	PF00675	0.684
CLV_PCSK_KEX2_1	191	193	PF00082	0.390
CLV_PCSK_KEX2_1	197	199	PF00082	0.367
CLV_PCSK_KEX2_1	201	203	PF00082	0.349
CLV_PCSK_KEX2_1	206	208	PF00082	0.302
CLV_PCSK_KEX2_1	524	526	PF00082	0.582
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.410
CLV_PCSK_PC7_1	197	203	PF00082	0.202
CLV_PCSK_SKI1_1	191	195	PF00082	0.422
CLV_PCSK_SKI1_1	201	205	PF00082	0.426
CLV_PCSK_SKI1_1	367	371	PF00082	0.403
CLV_PCSK_SKI1_1	38	42	PF00082	0.577
CLV_PCSK_SKI1_1	395	399	PF00082	0.313
CLV_PCSK_SKI1_1	506	510	PF00082	0.579
CLV_PCSK_SKI1_1	524	528	PF00082	0.371
CLV_PCSK_SKI1_1	587	591	PF00082	0.730
CLV_Separin_Metazoa	57	61	PF03568	0.628
DEG_Nend_UBRbox_2	1	3	PF02207	0.751
DEG_SCF_FBW7_2	556	562	PF00400	0.477
DEG_SPOP_SBC_1	347	351	PF00917	0.342
DEG_SPOP_SBC_1	359	363	PF00917	0.205
DEG_SPOP_SBC_1	624	628	PF00917	0.743
DOC_CKS1_1	556	561	PF01111	0.576
DOC_CYCLIN_RxL_1	392	399	PF00134	0.418
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.412
DOC_MAPK_gen_1	289	298	PF00069	0.410
DOC_MAPK_gen_1	305	314	PF00069	0.272
DOC_MAPK_gen_1	364	373	PF00069	0.362
DOC_MAPK_gen_1	489	499	PF00069	0.519
DOC_MAPK_MEF2A_6	364	373	PF00069	0.387
DOC_MAPK_MEF2A_6	492	499	PF00069	0.572
DOC_PP1_RVXF_1	365	371	PF00149	0.357
DOC_PP2B_LxvP_1	123	126	PF13499	0.412
DOC_PP2B_LxvP_1	159	162	PF13499	0.380
DOC_PP2B_LxvP_1	527	530	PF13499	0.526
DOC_PP2B_LxvP_1	59	62	PF13499	0.663
DOC_USP7_MATH_1	110	114	PF00917	0.459
DOC_USP7_MATH_1	233	237	PF00917	0.440
DOC_USP7_MATH_1	243	247	PF00917	0.384
DOC_USP7_MATH_1	273	277	PF00917	0.403
DOC_USP7_MATH_1	354	358	PF00917	0.418
DOC_USP7_MATH_1	359	363	PF00917	0.395
DOC_USP7_MATH_1	412	416	PF00917	0.438
DOC_USP7_MATH_1	422	426	PF00917	0.459
DOC_USP7_MATH_1	431	435	PF00917	0.399
DOC_USP7_MATH_1	442	446	PF00917	0.313
DOC_USP7_MATH_1	600	604	PF00917	0.672
DOC_USP7_MATH_1	653	657	PF00917	0.606
DOC_USP7_MATH_1	7	11	PF00917	0.760
DOC_WW_Pin1_4	10	15	PF00397	0.794
DOC_WW_Pin1_4	170	175	PF00397	0.399
DOC_WW_Pin1_4	348	353	PF00397	0.419
DOC_WW_Pin1_4	407	412	PF00397	0.326
DOC_WW_Pin1_4	466	471	PF00397	0.275
DOC_WW_Pin1_4	49	54	PF00397	0.661
DOC_WW_Pin1_4	491	496	PF00397	0.523
DOC_WW_Pin1_4	555	560	PF00397	0.636
DOC_WW_Pin1_4	561	566	PF00397	0.662
DOC_WW_Pin1_4	568	573	PF00397	0.608
DOC_WW_Pin1_4	590	595	PF00397	0.760
DOC_WW_Pin1_4	616	621	PF00397	0.732
DOC_WW_Pin1_4	633	638	PF00397	0.712
LIG_14-3-3_CanoR_1	197	203	PF00244	0.421
LIG_14-3-3_CanoR_1	268	278	PF00244	0.401
LIG_14-3-3_CanoR_1	378	384	PF00244	0.406
LIG_14-3-3_CanoR_1	38	46	PF00244	0.614
LIG_14-3-3_CanoR_1	444	448	PF00244	0.348
LIG_14-3-3_CanoR_1	48	53	PF00244	0.604
LIG_14-3-3_CanoR_1	566	572	PF00244	0.778
LIG_14-3-3_CanoR_1	587	592	PF00244	0.780
LIG_14-3-3_CanoR_1	616	620	PF00244	0.769
LIG_14-3-3_CanoR_1	80	84	PF00244	0.586
LIG_14-3-3_CterR_2	668	672	PF00244	0.727
LIG_Actin_WH2_2	182	199	PF00022	0.412
LIG_Actin_WH2_2	366	382	PF00022	0.384
LIG_Actin_WH2_2	509	526	PF00022	0.554
LIG_APCC_ABBA_1	248	253	PF00400	0.286
LIG_APCC_ABBA_1	323	328	PF00400	0.384
LIG_BIR_III_2	426	430	PF00653	0.307
LIG_BRCT_BRCA1_1	275	279	PF00533	0.412
LIG_Clathr_ClatBox_1	368	372	PF01394	0.384
LIG_FHA_1	135	141	PF00498	0.373
LIG_FHA_1	149	155	PF00498	0.315
LIG_FHA_1	171	177	PF00498	0.437
LIG_FHA_1	27	33	PF00498	0.743
LIG_FHA_1	447	453	PF00498	0.275
LIG_FHA_1	45	51	PF00498	0.646
LIG_FHA_1	460	466	PF00498	0.275
LIG_FHA_1	492	498	PF00498	0.475
LIG_FHA_2	112	118	PF00498	0.358
LIG_FHA_2	335	341	PF00498	0.442
LIG_FHA_2	626	632	PF00498	0.747
LIG_Integrin_RGD_1	207	209	PF01839	0.233
LIG_LIR_Apic_2	590	594	PF02991	0.526
LIG_LIR_Gen_1	117	128	PF02991	0.351
LIG_LIR_Gen_1	246	255	PF02991	0.313
LIG_LIR_Gen_1	292	298	PF02991	0.384
LIG_LIR_Nem_3	117	123	PF02991	0.326
LIG_LIR_Nem_3	246	250	PF02991	0.300
LIG_LIR_Nem_3	253	259	PF02991	0.288
LIG_LIR_Nem_3	292	297	PF02991	0.375
LIG_LIR_Nem_3	324	329	PF02991	0.311
LIG_LIR_Nem_3	362	368	PF02991	0.371
LIG_MLH1_MIPbox_1	275	279	PF16413	0.412
LIG_NRBOX	254	260	PF00104	0.384
LIG_NRBOX	447	453	PF00104	0.286
LIG_Pex14_2	323	327	PF04695	0.419
LIG_REV1ctd_RIR_1	324	334	PF16727	0.412
LIG_SH2_CRK	183	187	PF00017	0.412
LIG_SH2_CRK	256	260	PF00017	0.357
LIG_SH2_CRK	365	369	PF00017	0.414
LIG_SH2_PTP2	247	250	PF00017	0.414
LIG_SH2_SRC	251	254	PF00017	0.412
LIG_SH2_STAP1	104	108	PF00017	0.406
LIG_SH2_STAP1	33	37	PF00017	0.597
LIG_SH2_STAP1	484	488	PF00017	0.334
LIG_SH2_STAT5	108	111	PF00017	0.417
LIG_SH2_STAT5	188	191	PF00017	0.384
LIG_SH2_STAT5	247	250	PF00017	0.359
LIG_SH3_2	439	444	PF14604	0.419
LIG_SH3_2	75	80	PF14604	0.679
LIG_SH3_3	408	414	PF00018	0.398
LIG_SH3_3	436	442	PF00018	0.382
LIG_SH3_3	55	61	PF00018	0.630
LIG_SH3_3	591	597	PF00018	0.737
LIG_SH3_3	72	78	PF00018	0.752
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.377
LIG_SUMO_SIM_anti_2	292	300	PF11976	0.358
LIG_SUMO_SIM_anti_2	656	662	PF11976	0.682
LIG_SUMO_SIM_par_1	292	300	PF11976	0.363
LIG_SUMO_SIM_par_1	402	408	PF11976	0.419
LIG_SUMO_SIM_par_1	656	662	PF11976	0.628
LIG_TRAF2_1	114	117	PF00917	0.386
LIG_TRAF2_1	508	511	PF00917	0.552
LIG_TYR_ITIM	181	186	PF00017	0.412
LIG_TYR_ITIM	31	36	PF00017	0.530
MOD_CDC14_SPxK_1	593	596	PF00782	0.623
MOD_CDK_SPK_2	561	566	PF00069	0.761
MOD_CDK_SPxK_1	590	596	PF00069	0.628
MOD_CK1_1	10	16	PF00069	0.769
MOD_CK1_1	148	154	PF00069	0.286
MOD_CK1_1	155	161	PF00069	0.286
MOD_CK1_1	227	233	PF00069	0.387
MOD_CK1_1	236	242	PF00069	0.302
MOD_CK1_1	316	322	PF00069	0.282
MOD_CK1_1	396	402	PF00069	0.363
MOD_CK1_1	446	452	PF00069	0.286
MOD_CK1_1	478	484	PF00069	0.337
MOD_CK1_1	564	570	PF00069	0.678
MOD_CK1_1	575	581	PF00069	0.669
MOD_CK1_1	619	625	PF00069	0.740
MOD_CK1_1	627	633	PF00069	0.747
MOD_CK1_1	76	82	PF00069	0.786
MOD_CK2_1	111	117	PF00069	0.337
MOD_CK2_1	243	249	PF00069	0.314
MOD_CK2_1	334	340	PF00069	0.442
MOD_CK2_1	383	389	PF00069	0.364
MOD_CK2_1	575	581	PF00069	0.605
MOD_CK2_1	623	629	PF00069	0.744
MOD_GlcNHglycan	147	150	PF01048	0.297
MOD_GlcNHglycan	154	157	PF01048	0.288
MOD_GlcNHglycan	216	219	PF01048	0.355
MOD_GlcNHglycan	226	229	PF01048	0.357
MOD_GlcNHglycan	233	236	PF01048	0.326
MOD_GlcNHglycan	271	274	PF01048	0.364
MOD_GlcNHglycan	337	340	PF01048	0.441
MOD_GlcNHglycan	356	359	PF01048	0.377
MOD_GlcNHglycan	407	410	PF01048	0.401
MOD_GlcNHglycan	420	423	PF01048	0.286
MOD_GlcNHglycan	470	473	PF01048	0.419
MOD_GlcNHglycan	566	569	PF01048	0.743
MOD_GlcNHglycan	609	612	PF01048	0.677
MOD_GlcNHglycan	637	640	PF01048	0.714
MOD_GlcNHglycan	70	73	PF01048	0.730
MOD_GlcNHglycan	9	12	PF01048	0.753
MOD_GlcNHglycan	91	94	PF01048	0.700
MOD_GSK3_1	148	155	PF00069	0.363
MOD_GSK3_1	166	173	PF00069	0.426
MOD_GSK3_1	227	234	PF00069	0.402
MOD_GSK3_1	239	246	PF00069	0.394
MOD_GSK3_1	269	276	PF00069	0.431
MOD_GSK3_1	354	361	PF00069	0.414
MOD_GSK3_1	379	386	PF00069	0.338
MOD_GSK3_1	389	396	PF00069	0.356
MOD_GSK3_1	413	420	PF00069	0.302
MOD_GSK3_1	44	51	PF00069	0.709
MOD_GSK3_1	442	449	PF00069	0.331
MOD_GSK3_1	564	571	PF00069	0.637
MOD_GSK3_1	600	607	PF00069	0.649
MOD_GSK3_1	615	622	PF00069	0.608
MOD_GSK3_1	623	630	PF00069	0.749
MOD_GSK3_1	633	640	PF00069	0.673
MOD_N-GLC_1	393	398	PF02516	0.275
MOD_NEK2_1	143	148	PF00069	0.328
MOD_NEK2_1	196	201	PF00069	0.414
MOD_NEK2_1	314	319	PF00069	0.377
MOD_NEK2_1	360	365	PF00069	0.453
MOD_NEK2_1	379	384	PF00069	0.254
MOD_NEK2_1	475	480	PF00069	0.374
MOD_NEK2_1	574	579	PF00069	0.680
MOD_NEK2_1	615	620	PF00069	0.632
MOD_NEK2_2	251	256	PF00069	0.408
MOD_NEK2_2	274	279	PF00069	0.403
MOD_PIKK_1	112	118	PF00454	0.352
MOD_PIKK_1	12	18	PF00454	0.790
MOD_PIKK_1	413	419	PF00454	0.233
MOD_PIKK_1	432	438	PF00454	0.371
MOD_PIKK_1	446	452	PF00454	0.301
MOD_PIKK_1	500	506	PF00454	0.522
MOD_PKA_1	197	203	PF00069	0.440
MOD_PKA_2	196	202	PF00069	0.403
MOD_PKA_2	23	29	PF00069	0.653
MOD_PKA_2	269	275	PF00069	0.316
MOD_PKA_2	306	312	PF00069	0.363
MOD_PKA_2	44	50	PF00069	0.694
MOD_PKA_2	443	449	PF00069	0.275
MOD_PKA_2	615	621	PF00069	0.773
MOD_PKA_2	73	79	PF00069	0.743
MOD_Plk_1	393	399	PF00069	0.275
MOD_Plk_1	475	481	PF00069	0.328
MOD_Plk_4	136	142	PF00069	0.292
MOD_Plk_4	236	242	PF00069	0.339
MOD_Plk_4	243	249	PF00069	0.263
MOD_Plk_4	251	257	PF00069	0.226
MOD_Plk_4	274	280	PF00069	0.362
MOD_Plk_4	393	399	PF00069	0.359
MOD_Plk_4	443	449	PF00069	0.330
MOD_Plk_4	587	593	PF00069	0.749
MOD_Plk_4	619	625	PF00069	0.774
MOD_Plk_4	653	659	PF00069	0.674
MOD_ProDKin_1	10	16	PF00069	0.795
MOD_ProDKin_1	170	176	PF00069	0.399
MOD_ProDKin_1	348	354	PF00069	0.419
MOD_ProDKin_1	407	413	PF00069	0.326
MOD_ProDKin_1	466	472	PF00069	0.275
MOD_ProDKin_1	49	55	PF00069	0.659
MOD_ProDKin_1	491	497	PF00069	0.522
MOD_ProDKin_1	555	561	PF00069	0.643
MOD_ProDKin_1	568	574	PF00069	0.610
MOD_ProDKin_1	590	596	PF00069	0.760
MOD_ProDKin_1	616	622	PF00069	0.734
MOD_ProDKin_1	633	639	PF00069	0.712
MOD_SUMO_rev_2	25	32	PF00179	0.498
TRG_DiLeu_BaEn_1	292	297	PF01217	0.404
TRG_DiLeu_BaEn_3	117	123	PF01217	0.412
TRG_ENDOCYTIC_2	183	186	PF00928	0.438
TRG_ENDOCYTIC_2	247	250	PF00928	0.319
TRG_ENDOCYTIC_2	256	259	PF00928	0.310
TRG_ENDOCYTIC_2	33	36	PF00928	0.614
TRG_ENDOCYTIC_2	365	368	PF00928	0.418
TRG_ER_diArg_1	191	193	PF00400	0.370
TRG_ER_diArg_1	196	198	PF00400	0.358
TRG_ER_diArg_1	201	203	PF00400	0.355
TRG_ER_diArg_1	267	270	PF00400	0.347
TRG_ER_diArg_1	523	525	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM1	Leptomonas seymouri	27%	72%
A0A0N1HY56	Leptomonas seymouri	51%	98%
A0A0S4ILK1	Bodo saltans	28%	79%
A0A0S4JUR0	Bodo saltans	26%	77%
A0A0S4KL43	Bodo saltans	30%	100%
A0A1X0NJN6	Trypanosomatidae	39%	100%
A0A1X0NQ03	Trypanosomatidae	25%	81%
A0A1X0P9E3	Trypanosomatidae	29%	100%
A0A3Q8IBS7	Leishmania donovani	26%	100%
A0A3Q8IHG6	Leishmania donovani	26%	100%
A0A3R7MC35	Trypanosoma rangeli	39%	100%
A0A3R7RD86	Trypanosoma rangeli	27%	84%
A0A3S5H5N6	Leishmania donovani	92%	100%
A0A3S5IRH3	Trypanosoma rangeli	26%	100%
A0A3S7X2P9	Leishmania donovani	26%	100%
A0A422NE49	Trypanosoma rangeli	26%	76%
A0A422NEQ8	Trypanosoma rangeli	26%	89%
A4H4I4	Leishmania braziliensis	76%	100%
A4HAQ7	Leishmania braziliensis	28%	100%
A4HCA1	Leishmania braziliensis	24%	75%
A4HHY2	Leishmania braziliensis	27%	100%
A4HSA6	Leishmania infantum	24%	100%
A4HSQ9	Leishmania infantum	92%	100%
A4I4V2	Leishmania infantum	26%	100%
A4I562	Leishmania infantum	26%	100%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	83%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	90%
D0A7F3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	68%
D0A992	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	73%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	76%
F4IL57	Arabidopsis thaliana	27%	68%
F4J2M6	Arabidopsis thaliana	26%	70%
O14343	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	76%
P46864	Arabidopsis thaliana	25%	90%
P46865	Leishmania chagasi	28%	70%
P46870	Chlamydomonas reinhardtii	28%	87%
P53086	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	83%
P97329	Mus musculus	24%	76%
Q0IMS9	Oryza sativa subsp. japonica	26%	70%
Q29RT6	Bos taurus	24%	76%
Q4Q7S4	Leishmania major	27%	100%
Q6PFD6	Mus musculus	27%	81%
Q6ZMV9	Homo sapiens	24%	83%
Q75HV1	Oryza sativa subsp. japonica	26%	80%
V5B325	Trypanosoma cruzi	25%	81%
V5BK25	Trypanosoma cruzi	29%	93%
V5BLH7	Trypanosoma cruzi	26%	78%