Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ60_LEIMA

TriTrypDb:

LmjF.06.0190 , LMJLV39_060006800 , LMJSD75_060006800

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.505
CLV_C14_Caspase3-7	293	297	PF00656	0.438
CLV_NRD_NRD_1	151	153	PF00675	0.611
CLV_NRD_NRD_1	581	583	PF00675	0.600
CLV_PCSK_KEX2_1	151	153	PF00082	0.648
CLV_PCSK_KEX2_1	417	419	PF00082	0.592
CLV_PCSK_KEX2_1	583	585	PF00082	0.615
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.619
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.615
CLV_PCSK_PC7_1	413	419	PF00082	0.622
CLV_PCSK_SKI1_1	418	422	PF00082	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_SCF_FBW7_2	538	544	PF00400	0.529
DEG_SPOP_SBC_1	230	234	PF00917	0.609
DOC_CDC14_PxL_1	443	451	PF14671	0.541
DOC_CKS1_1	342	347	PF01111	0.570
DOC_CKS1_1	538	543	PF01111	0.522
DOC_CKS1_1	578	583	PF01111	0.507
DOC_CKS1_1	92	97	PF01111	0.471
DOC_CYCLIN_RxL_1	528	542	PF00134	0.530
DOC_MAPK_gen_1	330	338	PF00069	0.548
DOC_PP1_RVXF_1	198	205	PF00149	0.469
DOC_PP2B_LxvP_1	227	230	PF13499	0.485
DOC_PP2B_LxvP_1	449	452	PF13499	0.608
DOC_PP4_FxxP_1	498	501	PF00568	0.476
DOC_USP7_MATH_1	130	134	PF00917	0.615
DOC_USP7_MATH_1	17	21	PF00917	0.479
DOC_USP7_MATH_1	219	223	PF00917	0.641
DOC_USP7_MATH_1	239	243	PF00917	0.571
DOC_USP7_MATH_1	252	256	PF00917	0.619
DOC_USP7_MATH_1	555	559	PF00917	0.588
DOC_USP7_MATH_1	562	566	PF00917	0.676
DOC_USP7_MATH_1	567	571	PF00917	0.775
DOC_USP7_MATH_1	573	577	PF00917	0.570
DOC_USP7_UBL2_3	417	421	PF12436	0.581
DOC_USP7_UBL2_3	583	587	PF12436	0.613
DOC_WW_Pin1_4	180	185	PF00397	0.628
DOC_WW_Pin1_4	341	346	PF00397	0.550
DOC_WW_Pin1_4	388	393	PF00397	0.619
DOC_WW_Pin1_4	537	542	PF00397	0.508
DOC_WW_Pin1_4	551	556	PF00397	0.490
DOC_WW_Pin1_4	577	582	PF00397	0.644
DOC_WW_Pin1_4	88	93	PF00397	0.550
LIG_14-3-3_CanoR_1	231	236	PF00244	0.624
LIG_14-3-3_CanoR_1	547	555	PF00244	0.662
LIG_14-3-3_CanoR_1	571	581	PF00244	0.649
LIG_14-3-3_CanoR_1	75	81	PF00244	0.503
LIG_APCC_ABBA_1	494	499	PF00400	0.490
LIG_deltaCOP1_diTrp_1	207	212	PF00928	0.574
LIG_FHA_1	181	187	PF00498	0.692
LIG_FHA_1	23	29	PF00498	0.405
LIG_FHA_1	65	71	PF00498	0.371
LIG_FHA_1	9	15	PF00498	0.614
LIG_FHA_1	92	98	PF00498	0.497
LIG_FHA_2	13	19	PF00498	0.486
LIG_FHA_2	187	193	PF00498	0.570
LIG_FHA_2	289	295	PF00498	0.377
LIG_FHA_2	373	379	PF00498	0.615
LIG_FHA_2	429	435	PF00498	0.495
LIG_FHA_2	452	458	PF00498	0.540
LIG_Integrin_RGD_1	82	84	PF01839	0.457
LIG_LIR_Gen_1	296	303	PF02991	0.450
LIG_LIR_Gen_1	35	45	PF02991	0.461
LIG_LIR_Nem_3	209	215	PF02991	0.540
LIG_LIR_Nem_3	296	301	PF02991	0.450
LIG_LIR_Nem_3	35	41	PF02991	0.491
LIG_LIR_Nem_3	52	56	PF02991	0.387
LIG_LIR_Nem_3	60	65	PF02991	0.389
LIG_PCNA_TLS_4	292	299	PF02747	0.460
LIG_PCNA_yPIPBox_3	500	511	PF02747	0.516
LIG_PCNA_yPIPBox_3	521	530	PF02747	0.414
LIG_Pex14_1	73	77	PF04695	0.382
LIG_REV1ctd_RIR_1	495	500	PF16727	0.487
LIG_SH2_CRK	77	81	PF00017	0.462
LIG_SH2_NCK_1	511	515	PF00017	0.534
LIG_SH2_STAP1	187	191	PF00017	0.581
LIG_SH2_STAP1	474	478	PF00017	0.440
LIG_SH2_STAT5	23	26	PF00017	0.522
LIG_SH2_STAT5	56	59	PF00017	0.441
LIG_SH3_1	213	219	PF00018	0.562
LIG_SH3_2	392	397	PF14604	0.519
LIG_SH3_3	213	219	PF00018	0.606
LIG_SH3_3	248	254	PF00018	0.569
LIG_SH3_3	339	345	PF00018	0.584
LIG_SH3_3	389	395	PF00018	0.527
LIG_SH3_3	441	447	PF00018	0.620
LIG_SH3_3	575	581	PF00018	0.513
LIG_SH3_3	89	95	PF00018	0.563
LIG_SUMO_SIM_par_1	528	533	PF11976	0.499
LIG_SUMO_SIM_par_1	94	100	PF11976	0.595
LIG_TRAF2_1	473	476	PF00917	0.457
LIG_WW_3	394	398	PF00397	0.517
MOD_CDK_SPK_2	577	582	PF00069	0.509
MOD_CDK_SPxK_1	577	583	PF00069	0.644
MOD_CDK_SPxxK_3	577	584	PF00069	0.643
MOD_CK1_1	118	124	PF00069	0.587
MOD_CK1_1	12	18	PF00069	0.555
MOD_CK1_1	133	139	PF00069	0.590
MOD_CK1_1	154	160	PF00069	0.684
MOD_CK1_1	234	240	PF00069	0.651
MOD_CK1_1	244	250	PF00069	0.549
MOD_CK1_1	363	369	PF00069	0.548
MOD_CK1_1	370	376	PF00069	0.570
MOD_CK1_1	539	545	PF00069	0.540
MOD_CK1_1	565	571	PF00069	0.593
MOD_CK1_1	576	582	PF00069	0.632
MOD_CK2_1	12	18	PF00069	0.502
MOD_CK2_1	186	192	PF00069	0.521
MOD_CK2_1	252	258	PF00069	0.563
MOD_CK2_1	288	294	PF00069	0.385
MOD_CK2_1	372	378	PF00069	0.618
MOD_CK2_1	428	434	PF00069	0.496
MOD_CK2_1	451	457	PF00069	0.489
MOD_Cter_Amidation	149	152	PF01082	0.617
MOD_GlcNHglycan	113	116	PF01048	0.599
MOD_GlcNHglycan	120	123	PF01048	0.635
MOD_GlcNHglycan	128	131	PF01048	0.761
MOD_GlcNHglycan	132	135	PF01048	0.700
MOD_GlcNHglycan	140	144	PF01048	0.693
MOD_GlcNHglycan	18	22	PF01048	0.361
MOD_GlcNHglycan	221	224	PF01048	0.667
MOD_GlcNHglycan	236	239	PF01048	0.598
MOD_GlcNHglycan	243	246	PF01048	0.560
MOD_GlcNHglycan	330	333	PF01048	0.711
MOD_GlcNHglycan	357	360	PF01048	0.680
MOD_GlcNHglycan	363	366	PF01048	0.669
MOD_GlcNHglycan	369	372	PF01048	0.623
MOD_GlcNHglycan	408	411	PF01048	0.590
MOD_GlcNHglycan	541	544	PF01048	0.564
MOD_GlcNHglycan	549	552	PF01048	0.523
MOD_GlcNHglycan	556	560	PF01048	0.535
MOD_GlcNHglycan	575	578	PF01048	0.536
MOD_GSK3_1	111	118	PF00069	0.551
MOD_GSK3_1	126	133	PF00069	0.549
MOD_GSK3_1	154	161	PF00069	0.533
MOD_GSK3_1	225	232	PF00069	0.683
MOD_GSK3_1	233	240	PF00069	0.609
MOD_GSK3_1	324	331	PF00069	0.660
MOD_GSK3_1	363	370	PF00069	0.590
MOD_GSK3_1	447	454	PF00069	0.557
MOD_GSK3_1	547	554	PF00069	0.537
MOD_GSK3_1	562	569	PF00069	0.592
MOD_GSK3_1	572	579	PF00069	0.608
MOD_GSK3_1	8	15	PF00069	0.546
MOD_LATS_1	137	143	PF00433	0.628
MOD_LATS_1	404	410	PF00433	0.690
MOD_N-GLC_1	115	120	PF02516	0.598
MOD_N-GLC_1	367	372	PF02516	0.660
MOD_NEK2_1	170	175	PF00069	0.620
MOD_NEK2_1	186	191	PF00069	0.483
MOD_NEK2_1	2	7	PF00069	0.542
MOD_NEK2_1	22	27	PF00069	0.398
MOD_NEK2_1	308	313	PF00069	0.542
MOD_NEK2_1	315	320	PF00069	0.501
MOD_NEK2_1	328	333	PF00069	0.592
MOD_NEK2_1	360	365	PF00069	0.624
MOD_NEK2_1	478	483	PF00069	0.469
MOD_NEK2_1	536	541	PF00069	0.548
MOD_NEK2_2	64	69	PF00069	0.400
MOD_PKA_1	151	157	PF00069	0.616
MOD_PKA_2	104	110	PF00069	0.527
MOD_PKA_2	144	150	PF00069	0.647
MOD_PKA_2	151	157	PF00069	0.630
MOD_PKA_2	230	236	PF00069	0.749
MOD_PKA_2	240	246	PF00069	0.583
MOD_PKA_2	355	361	PF00069	0.606
MOD_PKA_2	396	402	PF00069	0.633
MOD_PKB_1	411	419	PF00069	0.619
MOD_Plk_1	17	23	PF00069	0.364
MOD_Plk_1	367	373	PF00069	0.626
MOD_Plk_1	382	388	PF00069	0.530
MOD_Plk_1	447	453	PF00069	0.531
MOD_Plk_4	344	350	PF00069	0.474
MOD_ProDKin_1	180	186	PF00069	0.630
MOD_ProDKin_1	341	347	PF00069	0.546
MOD_ProDKin_1	388	394	PF00069	0.620
MOD_ProDKin_1	537	543	PF00069	0.513
MOD_ProDKin_1	551	557	PF00069	0.492
MOD_ProDKin_1	577	583	PF00069	0.644
MOD_ProDKin_1	88	94	PF00069	0.555
TRG_DiLeu_BaEn_2	196	202	PF01217	0.465
TRG_DiLeu_BaEn_2	293	299	PF01217	0.361
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.627
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.579
TRG_ENDOCYTIC_2	511	514	PF00928	0.446
TRG_ENDOCYTIC_2	77	80	PF00928	0.391
TRG_ER_diArg_1	151	153	PF00400	0.614
TRG_ER_diArg_1	581	584	PF00400	0.503
TRG_ER_diLys_1	583	587	PF00400	0.667
TRG_NES_CRM1_1	293	306	PF08389	0.463
TRG_NLS_MonoCore_2	581	586	PF00514	0.502
TRG_NLS_MonoExtC_3	147	152	PF00514	0.617
TRG_NLS_MonoExtC_3	582	587	PF00514	0.613
TRG_NLS_MonoExtN_4	145	152	PF00514	0.619
TRG_NLS_MonoExtN_4	581	587	PF00514	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W1	Leptomonas seymouri	47%	79%
A0A3S7WPD9	Leishmania donovani	92%	100%
A4H4I5	Leishmania braziliensis	71%	85%
A4HSR0	Leishmania infantum	92%	100%
E9AKP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%