Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ59_LEIMA

TriTrypDb:

LmjF.06.0200 , LMJLV39_060006900 , LMJSD75_060006900

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.620
CLV_NRD_NRD_1	138	140	PF00675	0.707
CLV_NRD_NRD_1	158	160	PF00675	0.629
CLV_NRD_NRD_1	201	203	PF00675	0.484
CLV_NRD_NRD_1	216	218	PF00675	0.606
CLV_NRD_NRD_1	250	252	PF00675	0.601
CLV_NRD_NRD_1	266	268	PF00675	0.618
CLV_NRD_NRD_1	50	52	PF00675	0.724
CLV_NRD_NRD_1	77	79	PF00675	0.797
CLV_PCSK_KEX2_1	138	140	PF00082	0.707
CLV_PCSK_KEX2_1	158	160	PF00082	0.625
CLV_PCSK_KEX2_1	201	203	PF00082	0.481
CLV_PCSK_KEX2_1	216	218	PF00082	0.606
CLV_PCSK_KEX2_1	250	252	PF00082	0.601
CLV_PCSK_KEX2_1	266	268	PF00082	0.618
CLV_PCSK_KEX2_1	290	292	PF00082	0.649
CLV_PCSK_KEX2_1	493	495	PF00082	0.470
CLV_PCSK_KEX2_1	50	52	PF00082	0.724
CLV_PCSK_KEX2_1	77	79	PF00082	0.797
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.639
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.470
CLV_PCSK_PC7_1	46	52	PF00082	0.652
CLV_PCSK_PC7_1	489	495	PF00082	0.433
CLV_PCSK_SKI1_1	201	205	PF00082	0.520
CLV_PCSK_SKI1_1	230	234	PF00082	0.702
CLV_PCSK_SKI1_1	489	493	PF00082	0.412
CLV_PCSK_SKI1_1	78	82	PF00082	0.591
DEG_APCC_DBOX_1	77	85	PF00400	0.613
DEG_SPOP_SBC_1	466	470	PF00917	0.399
DOC_MAPK_DCC_7	251	261	PF00069	0.644
DOC_MAPK_gen_1	429	439	PF00069	0.451
DOC_MAPK_MEF2A_6	4	11	PF00069	0.602
DOC_MAPK_MEF2A_6	432	439	PF00069	0.438
DOC_PP2B_LxvP_1	253	256	PF13499	0.661
DOC_PP2B_LxvP_1	332	335	PF13499	0.588
DOC_USP7_MATH_1	137	141	PF00917	0.611
DOC_USP7_MATH_1	177	181	PF00917	0.678
DOC_USP7_MATH_1	231	235	PF00917	0.613
DOC_USP7_MATH_1	260	264	PF00917	0.602
DOC_USP7_MATH_1	31	35	PF00917	0.590
DOC_USP7_MATH_1	324	328	PF00917	0.636
DOC_USP7_MATH_1	378	382	PF00917	0.558
DOC_USP7_MATH_1	438	442	PF00917	0.458
DOC_USP7_MATH_1	466	470	PF00917	0.480
DOC_USP7_MATH_1	73	77	PF00917	0.657
DOC_USP7_UBL2_3	432	436	PF12436	0.503
DOC_WW_Pin1_4	10	15	PF00397	0.622
DOC_WW_Pin1_4	35	40	PF00397	0.585
LIG_14-3-3_CanoR_1	138	142	PF00244	0.707
LIG_14-3-3_CanoR_1	169	175	PF00244	0.590
LIG_14-3-3_CanoR_1	23	28	PF00244	0.619
LIG_14-3-3_CanoR_1	266	275	PF00244	0.686
LIG_14-3-3_CanoR_1	291	296	PF00244	0.589
LIG_14-3-3_CanoR_1	331	335	PF00244	0.600
LIG_14-3-3_CanoR_1	395	401	PF00244	0.346
LIG_14-3-3_CanoR_1	460	465	PF00244	0.453
LIG_14-3-3_CanoR_1	467	475	PF00244	0.376
LIG_14-3-3_CanoR_1	77	84	PF00244	0.663
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BIR_III_2	134	138	PF00653	0.617
LIG_FHA_1	113	119	PF00498	0.550
LIG_FHA_1	202	208	PF00498	0.585
LIG_FHA_1	231	237	PF00498	0.692
LIG_FHA_1	238	244	PF00498	0.606
LIG_FHA_1	256	262	PF00498	0.668
LIG_FHA_1	364	370	PF00498	0.625
LIG_FHA_1	39	45	PF00498	0.609
LIG_FHA_1	411	417	PF00498	0.444
LIG_FHA_1	432	438	PF00498	0.566
LIG_FHA_1	445	451	PF00498	0.417
LIG_FHA_2	223	229	PF00498	0.620
LIG_FHA_2	479	485	PF00498	0.397
LIG_LIR_Apic_2	294	298	PF02991	0.627
LIG_LIR_Gen_1	459	466	PF02991	0.431
LIG_LIR_Nem_3	270	275	PF02991	0.633
LIG_LIR_Nem_3	459	465	PF02991	0.438
LIG_NRP_CendR_1	493	495	PF00754	0.470
LIG_SH2_CRK	462	466	PF00017	0.368
LIG_SH2_NCK_1	462	466	PF00017	0.417
LIG_SH2_STAP1	462	466	PF00017	0.368
LIG_SH2_STAT3	319	322	PF00017	0.671
LIG_SH2_STAT5	319	322	PF00017	0.608
LIG_SH2_STAT5	392	395	PF00017	0.392
LIG_SH2_STAT5	462	465	PF00017	0.373
LIG_SH3_3	242	248	PF00018	0.633
LIG_SH3_3	254	260	PF00018	0.639
LIG_SH3_3	295	301	PF00018	0.618
LIG_SH3_3	317	323	PF00018	0.753
LIG_SH3_3	69	75	PF00018	0.561
LIG_SH3_3	8	14	PF00018	0.621
LIG_SUMO_SIM_par_1	441	448	PF11976	0.457
LIG_WRC_WIRS_1	401	406	PF05994	0.387
MOD_CK1_1	108	114	PF00069	0.768
MOD_CK1_1	127	133	PF00069	0.675
MOD_CK1_1	13	19	PF00069	0.618
MOD_CK1_1	151	157	PF00069	0.643
MOD_CK1_1	170	176	PF00069	0.639
MOD_CK1_1	26	32	PF00069	0.643
MOD_CK1_1	270	276	PF00069	0.679
MOD_CK1_1	281	287	PF00069	0.557
MOD_CK1_1	314	320	PF00069	0.618
MOD_CK1_1	76	82	PF00069	0.802
MOD_CK2_1	151	157	PF00069	0.685
MOD_CK2_1	222	228	PF00069	0.597
MOD_CK2_1	291	297	PF00069	0.668
MOD_CK2_1	478	484	PF00069	0.400
MOD_GlcNHglycan	107	110	PF01048	0.565
MOD_GlcNHglycan	122	125	PF01048	0.582
MOD_GlcNHglycan	127	130	PF01048	0.611
MOD_GlcNHglycan	153	156	PF01048	0.687
MOD_GlcNHglycan	178	182	PF01048	0.721
MOD_GlcNHglycan	219	222	PF01048	0.626
MOD_GlcNHglycan	233	236	PF01048	0.787
MOD_GlcNHglycan	274	278	PF01048	0.713
MOD_GlcNHglycan	29	32	PF01048	0.701
MOD_GlcNHglycan	311	314	PF01048	0.662
MOD_GlcNHglycan	33	36	PF01048	0.766
MOD_GlcNHglycan	345	348	PF01048	0.653
MOD_GlcNHglycan	380	383	PF01048	0.747
MOD_GlcNHglycan	408	411	PF01048	0.401
MOD_GlcNHglycan	46	49	PF01048	0.649
MOD_GlcNHglycan	97	101	PF01048	0.656
MOD_GSK3_1	100	107	PF00069	0.596
MOD_GSK3_1	108	115	PF00069	0.611
MOD_GSK3_1	116	123	PF00069	0.656
MOD_GSK3_1	13	20	PF00069	0.587
MOD_GSK3_1	163	170	PF00069	0.652
MOD_GSK3_1	23	30	PF00069	0.607
MOD_GSK3_1	255	262	PF00069	0.705
MOD_GSK3_1	273	280	PF00069	0.625
MOD_GSK3_1	281	288	PF00069	0.690
MOD_GSK3_1	304	311	PF00069	0.646
MOD_GSK3_1	31	38	PF00069	0.619
MOD_GSK3_1	396	403	PF00069	0.374
MOD_GSK3_1	40	47	PF00069	0.650
MOD_GSK3_1	406	413	PF00069	0.386
MOD_GSK3_1	466	473	PF00069	0.425
MOD_GSK3_1	92	99	PF00069	0.785
MOD_N-GLC_1	151	156	PF02516	0.689
MOD_N-GLC_1	222	227	PF02516	0.597
MOD_N-GLC_1	238	243	PF02516	0.688
MOD_N-GLC_1	277	282	PF02516	0.669
MOD_N-GLC_1	363	368	PF02516	0.536
MOD_NEK2_1	163	168	PF00069	0.696
MOD_NEK2_1	282	287	PF00069	0.665
MOD_NEK2_1	400	405	PF00069	0.391
MOD_NEK2_1	421	426	PF00069	0.493
MOD_NEK2_1	44	49	PF00069	0.626
MOD_NEK2_1	89	94	PF00069	0.632
MOD_NEK2_2	431	436	PF00069	0.507
MOD_PIKK_1	304	310	PF00454	0.682
MOD_PIKK_1	421	427	PF00454	0.474
MOD_PIKK_1	470	476	PF00454	0.404
MOD_PK_1	23	29	PF00069	0.607
MOD_PKA_1	201	207	PF00069	0.578
MOD_PKA_2	113	119	PF00069	0.670
MOD_PKA_2	137	143	PF00069	0.707
MOD_PKA_2	201	207	PF00069	0.590
MOD_PKA_2	314	320	PF00069	0.780
MOD_PKA_2	330	336	PF00069	0.458
MOD_PKA_2	466	472	PF00069	0.405
MOD_PKA_2	76	82	PF00069	0.661
MOD_Plk_1	177	183	PF00069	0.658
MOD_Plk_1	238	244	PF00069	0.664
MOD_Plk_1	277	283	PF00069	0.612
MOD_Plk_4	314	320	PF00069	0.677
MOD_Plk_4	40	46	PF00069	0.659
MOD_Plk_4	438	444	PF00069	0.464
MOD_Plk_4	460	466	PF00069	0.394
MOD_ProDKin_1	10	16	PF00069	0.620
MOD_ProDKin_1	35	41	PF00069	0.586
MOD_SUMO_for_1	416	419	PF00179	0.416
TRG_ENDOCYTIC_2	462	465	PF00928	0.373
TRG_ER_diArg_1	137	139	PF00400	0.662
TRG_ER_diArg_1	200	202	PF00400	0.485
TRG_ER_diArg_1	215	217	PF00400	0.607
TRG_ER_diArg_1	266	269	PF00400	0.647
TRG_ER_diArg_1	49	51	PF00400	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H1	Leptomonas seymouri	40%	87%
A0A3S5H5N7	Leishmania donovani	90%	100%
A4H4I6	Leishmania braziliensis	71%	100%
A4HSR1	Leishmania infantum	92%	100%
E9AKP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%