FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FHA domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QJ58_LEIMA

TriTrypDb:

LmjF.06.0210 , LMJLV39_060007200 , LMJSD75_060007200

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ58

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.504
CLV_C14_Caspase3-7	534	538	PF00656	0.533
CLV_NRD_NRD_1	20	22	PF00675	0.508
CLV_NRD_NRD_1	331	333	PF00675	0.823
CLV_NRD_NRD_1	428	430	PF00675	0.811
CLV_NRD_NRD_1	591	593	PF00675	0.706
CLV_PCSK_KEX2_1	20	22	PF00082	0.508
CLV_PCSK_KEX2_1	331	333	PF00082	0.823
CLV_PCSK_KEX2_1	427	429	PF00082	0.755
CLV_PCSK_KEX2_1	443	445	PF00082	0.580
CLV_PCSK_KEX2_1	596	598	PF00082	0.744
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.723
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.685
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.736
CLV_PCSK_PC7_1	592	598	PF00082	0.797
CLV_PCSK_SKI1_1	222	226	PF00082	0.581
CLV_PCSK_SKI1_1	230	234	PF00082	0.587
CLV_PCSK_SKI1_1	242	246	PF00082	0.462
CLV_PCSK_SKI1_1	309	313	PF00082	0.820
DEG_SPOP_SBC_1	211	215	PF00917	0.432
DEG_SPOP_SBC_1	70	74	PF00917	0.504
DOC_CKS1_1	115	120	PF01111	0.504
DOC_CKS1_1	248	253	PF01111	0.807
DOC_CKS1_1	620	625	PF01111	0.559
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.817
DOC_CYCLIN_yCln2_LP_2	662	668	PF00134	0.603
DOC_MAPK_gen_1	20	26	PF00069	0.509
DOC_MAPK_gen_1	505	514	PF00069	0.687
DOC_MAPK_MEF2A_6	508	516	PF00069	0.639
DOC_MAPK_MEF2A_6	528	535	PF00069	0.248
DOC_PP1_RVXF_1	554	561	PF00149	0.501
DOC_PP2B_LxvP_1	217	220	PF13499	0.552
DOC_PP2B_LxvP_1	662	665	PF13499	0.697
DOC_PP4_FxxP_1	301	304	PF00568	0.728
DOC_USP7_MATH_1	211	215	PF00917	0.505
DOC_USP7_MATH_1	220	224	PF00917	0.651
DOC_USP7_MATH_1	236	240	PF00917	0.625
DOC_USP7_MATH_1	256	260	PF00917	0.472
DOC_USP7_MATH_1	274	278	PF00917	0.631
DOC_USP7_MATH_1	326	330	PF00917	0.812
DOC_USP7_MATH_1	422	426	PF00917	0.819
DOC_USP7_MATH_1	497	501	PF00917	0.826
DOC_USP7_MATH_1	515	519	PF00917	0.278
DOC_USP7_MATH_1	576	580	PF00917	0.738
DOC_USP7_MATH_1	71	75	PF00917	0.499
DOC_USP7_MATH_1	86	90	PF00917	0.255
DOC_USP7_MATH_1	92	96	PF00917	0.374
DOC_USP7_MATH_2	472	478	PF00917	0.664
DOC_USP7_UBL2_3	596	600	PF12436	0.755
DOC_WW_Pin1_4	104	109	PF00397	0.407
DOC_WW_Pin1_4	111	116	PF00397	0.385
DOC_WW_Pin1_4	212	217	PF00397	0.536
DOC_WW_Pin1_4	247	252	PF00397	0.730
DOC_WW_Pin1_4	28	33	PF00397	0.524
DOC_WW_Pin1_4	288	293	PF00397	0.688
DOC_WW_Pin1_4	300	305	PF00397	0.670
DOC_WW_Pin1_4	362	367	PF00397	0.791
DOC_WW_Pin1_4	420	425	PF00397	0.785
DOC_WW_Pin1_4	430	435	PF00397	0.684
DOC_WW_Pin1_4	458	463	PF00397	0.555
DOC_WW_Pin1_4	479	484	PF00397	0.690
DOC_WW_Pin1_4	598	603	PF00397	0.749
DOC_WW_Pin1_4	616	621	PF00397	0.659
DOC_WW_Pin1_4	656	661	PF00397	0.561
DOC_WW_Pin1_4	79	84	PF00397	0.417
DOC_WW_Pin1_4	88	93	PF00397	0.459
LIG_14-3-3_CanoR_1	13	19	PF00244	0.507
LIG_14-3-3_CanoR_1	200	207	PF00244	0.698
LIG_14-3-3_CanoR_1	21	27	PF00244	0.523
LIG_14-3-3_CanoR_1	249	258	PF00244	0.604
LIG_14-3-3_CanoR_1	331	337	PF00244	0.823
LIG_14-3-3_CanoR_1	37	45	PF00244	0.244
LIG_BIR_II_1	1	5	PF00653	0.567
LIG_BRCT_BRCA1_1	47	51	PF00533	0.504
LIG_deltaCOP1_diTrp_1	554	560	PF00928	0.498
LIG_deltaCOP1_diTrp_1	628	634	PF00928	0.429
LIG_DLG_GKlike_1	332	340	PF00625	0.817
LIG_eIF4E_1	187	193	PF01652	0.529
LIG_eIF4E_1	212	218	PF01652	0.633
LIG_EVH1_2	206	210	PF00568	0.622
LIG_FHA_1	131	137	PF00498	0.504
LIG_FHA_1	213	219	PF00498	0.546
LIG_FHA_1	253	259	PF00498	0.750
LIG_FHA_1	300	306	PF00498	0.822
LIG_FHA_1	351	357	PF00498	0.836
LIG_FHA_1	519	525	PF00498	0.486
LIG_FHA_1	599	605	PF00498	0.709
LIG_FHA_2	105	111	PF00498	0.504
LIG_FHA_2	121	127	PF00498	0.244
LIG_FHA_2	285	291	PF00498	0.762
LIG_FHA_2	313	319	PF00498	0.678
LIG_FHA_2	343	349	PF00498	0.828
LIG_FHA_2	363	369	PF00498	0.499
LIG_FHA_2	436	442	PF00498	0.695
LIG_FHA_2	76	82	PF00498	0.454
LIG_LIR_Apic_2	185	190	PF02991	0.547
LIG_LIR_Gen_1	474	483	PF02991	0.701
LIG_LIR_Gen_1	507	516	PF02991	0.448
LIG_LIR_Gen_1	6	15	PF02991	0.474
LIG_LIR_Nem_3	474	479	PF02991	0.686
LIG_LIR_Nem_3	6	12	PF02991	0.472
LIG_Pex14_1	630	634	PF04695	0.474
LIG_PTB_Apo_2	389	396	PF02174	0.512
LIG_PTB_Phospho_1	389	395	PF10480	0.602
LIG_RPA_C_Fungi	667	679	PF08784	0.572
LIG_SH2_CRK	385	389	PF00017	0.488
LIG_SH2_STAT3	638	641	PF00017	0.514
LIG_SH2_STAT5	137	140	PF00017	0.407
LIG_SH2_STAT5	212	215	PF00017	0.622
LIG_SH3_3	112	118	PF00018	0.304
LIG_SH3_3	21	27	PF00018	0.523
LIG_SH3_3	240	246	PF00018	0.623
LIG_SH3_3	373	379	PF00018	0.646
LIG_SH3_3	509	515	PF00018	0.634
LIG_SH3_3	520	526	PF00018	0.581
LIG_SH3_3	614	620	PF00018	0.724
LIG_SH3_3	640	646	PF00018	0.510
LIG_SH3_3	65	71	PF00018	0.334
LIG_SH3_3	9	15	PF00018	0.464
LIG_SUMO_SIM_anti_2	333	339	PF11976	0.816
LIG_SUMO_SIM_par_1	223	229	PF11976	0.680
LIG_SUMO_SIM_par_1	451	456	PF11976	0.520
LIG_SUMO_SIM_par_1	645	650	PF11976	0.602
LIG_TRAF2_1	316	319	PF00917	0.768
LIG_TRAF2_1	349	352	PF00917	0.837
LIG_TRAF2_1	401	404	PF00917	0.785
LIG_TRAF2_1	438	441	PF00917	0.632
LIG_TYR_ITIM	383	388	PF00017	0.501
LIG_UBA3_1	59	65	PF00899	0.407
LIG_WW_3	291	295	PF00397	0.591
MOD_CDK_SPxK_1	288	294	PF00069	0.593
MOD_CDK_SPxxK_3	420	427	PF00069	0.822
MOD_CDK_SPxxK_3	479	486	PF00069	0.738
MOD_CDK_SPxxK_3	619	626	PF00069	0.566
MOD_CK1_1	144	150	PF00069	0.407
MOD_CK1_1	247	253	PF00069	0.807
MOD_CK1_1	28	34	PF00069	0.581
MOD_CK1_1	303	309	PF00069	0.817
MOD_CK1_1	362	368	PF00069	0.773
MOD_CK1_1	433	439	PF00069	0.762
MOD_CK1_1	500	506	PF00069	0.817
MOD_CK1_1	518	524	PF00069	0.306
MOD_CK1_1	552	558	PF00069	0.577
MOD_CK1_1	563	569	PF00069	0.665
MOD_CK1_1	584	590	PF00069	0.753
MOD_CK1_1	619	625	PF00069	0.669
MOD_CK1_1	667	673	PF00069	0.643
MOD_CK1_1	72	78	PF00069	0.459
MOD_CK2_1	220	226	PF00069	0.471
MOD_CK2_1	312	318	PF00069	0.677
MOD_CK2_1	342	348	PF00069	0.824
MOD_CK2_1	351	357	PF00069	0.690
MOD_CK2_1	435	441	PF00069	0.632
MOD_CMANNOS	557	560	PF00535	0.471
MOD_Cter_Amidation	329	332	PF01082	0.823
MOD_Cter_Amidation	425	428	PF01082	0.627
MOD_GlcNHglycan	154	157	PF01048	0.393
MOD_GlcNHglycan	201	204	PF01048	0.714
MOD_GlcNHglycan	252	255	PF01048	0.804
MOD_GlcNHglycan	276	279	PF01048	0.772
MOD_GlcNHglycan	328	331	PF01048	0.818
MOD_GlcNHglycan	351	356	PF01048	0.792
MOD_GlcNHglycan	420	423	PF01048	0.826
MOD_GlcNHglycan	424	427	PF01048	0.752
MOD_GlcNHglycan	435	438	PF01048	0.589
MOD_GlcNHglycan	499	502	PF01048	0.774
MOD_GlcNHglycan	549	552	PF01048	0.563
MOD_GlcNHglycan	578	581	PF01048	0.788
MOD_GlcNHglycan	666	669	PF01048	0.726
MOD_GSK3_1	136	143	PF00069	0.407
MOD_GSK3_1	206	213	PF00069	0.661
MOD_GSK3_1	232	239	PF00069	0.596
MOD_GSK3_1	252	259	PF00069	0.476
MOD_GSK3_1	284	291	PF00069	0.645
MOD_GSK3_1	299	306	PF00069	0.790
MOD_GSK3_1	326	333	PF00069	0.774
MOD_GSK3_1	356	363	PF00069	0.634
MOD_GSK3_1	418	425	PF00069	0.823
MOD_GSK3_1	45	52	PF00069	0.504
MOD_GSK3_1	500	507	PF00069	0.757
MOD_GSK3_1	514	521	PF00069	0.400
MOD_GSK3_1	584	591	PF00069	0.694
MOD_GSK3_1	66	73	PF00069	0.495
MOD_GSK3_1	75	82	PF00069	0.368
MOD_GSK3_1	88	95	PF00069	0.266
MOD_LATS_1	307	313	PF00433	0.819
MOD_N-GLC_1	144	149	PF02516	0.407
MOD_N-GLC_1	28	33	PF02516	0.524
MOD_N-GLC_1	360	365	PF02516	0.625
MOD_N-GLC_1	391	396	PF02516	0.525
MOD_N-GLC_1	92	97	PF02516	0.304
MOD_NEK2_1	141	146	PF00069	0.407
MOD_NEK2_1	210	215	PF00069	0.532
MOD_NEK2_1	22	27	PF00069	0.619
MOD_NEK2_1	232	237	PF00069	0.590
MOD_NEK2_1	49	54	PF00069	0.407
MOD_PIKK_1	336	342	PF00454	0.812
MOD_PIKK_1	453	459	PF00454	0.651
MOD_PIKK_1	50	56	PF00454	0.407
MOD_PIKK_1	560	566	PF00454	0.643
MOD_PK_1	600	606	PF00069	0.802
MOD_PKA_2	131	137	PF00069	0.427
MOD_PKA_2	152	158	PF00069	0.393
MOD_PKA_2	199	205	PF00069	0.686
MOD_PKA_2	22	28	PF00069	0.619
MOD_PKA_2	312	318	PF00069	0.701
MOD_PKA_2	330	336	PF00069	0.753
MOD_PKA_2	36	42	PF00069	0.277
MOD_PKA_2	504	510	PF00069	0.740
MOD_PKA_2	576	582	PF00069	0.776
MOD_Plk_1	391	397	PF00069	0.530
MOD_Plk_2-3	266	272	PF00069	0.737
MOD_Plk_4	144	150	PF00069	0.407
MOD_Plk_4	332	338	PF00069	0.820
MOD_Plk_4	391	397	PF00069	0.427
MOD_Plk_4	45	51	PF00069	0.434
MOD_Plk_4	518	524	PF00069	0.491
MOD_Plk_4	55	61	PF00069	0.467
MOD_ProDKin_1	104	110	PF00069	0.407
MOD_ProDKin_1	111	117	PF00069	0.385
MOD_ProDKin_1	212	218	PF00069	0.536
MOD_ProDKin_1	247	253	PF00069	0.731
MOD_ProDKin_1	28	34	PF00069	0.520
MOD_ProDKin_1	288	294	PF00069	0.693
MOD_ProDKin_1	300	306	PF00069	0.666
MOD_ProDKin_1	362	368	PF00069	0.792
MOD_ProDKin_1	420	426	PF00069	0.784
MOD_ProDKin_1	430	436	PF00069	0.684
MOD_ProDKin_1	458	464	PF00069	0.556
MOD_ProDKin_1	479	485	PF00069	0.691
MOD_ProDKin_1	598	604	PF00069	0.751
MOD_ProDKin_1	616	622	PF00069	0.646
MOD_ProDKin_1	656	662	PF00069	0.575
MOD_ProDKin_1	79	85	PF00069	0.417
MOD_ProDKin_1	88	94	PF00069	0.459
MOD_SUMO_rev_2	436	445	PF00179	0.629
TRG_DiLeu_BaEn_1	228	233	PF01217	0.589
TRG_DiLeu_BaEn_4	228	234	PF01217	0.686
TRG_ENDOCYTIC_2	385	388	PF00928	0.491
TRG_ER_diArg_1	20	23	PF00400	0.530
TRG_ER_diArg_1	428	431	PF00400	0.824
TRG_NLS_Bipartite_1	427	447	PF00514	0.763
TRG_NLS_MonoExtC_3	426	431	PF00514	0.722
TRG_NLS_MonoExtC_3	442	448	PF00514	0.677
TRG_NLS_MonoExtN_4	424	431	PF00514	0.704
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	405	410	PF00026	0.807
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Z7	Leptomonas seymouri	43%	100%
A0A3S7WPD3	Leishmania donovani	91%	100%
A4HSR2	Leishmania infantum	91%	100%
E9AKP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%