Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ57_LEIMA

TriTrypDb:

LmjF.06.0220 , LMJLV39_060007300 , LMJSD75_060007300

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJ57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.330
CLV_NRD_NRD_1	119	121	PF00675	0.339
CLV_NRD_NRD_1	25	27	PF00675	0.439
CLV_NRD_NRD_1	277	279	PF00675	0.648
CLV_PCSK_KEX2_1	110	112	PF00082	0.350
CLV_PCSK_KEX2_1	25	27	PF00082	0.357
CLV_PCSK_KEX2_1	276	278	PF00082	0.699
CLV_PCSK_KEX2_1	34	36	PF00082	0.467
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.699
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.371
CLV_PCSK_PC7_1	273	279	PF00082	0.448
CLV_PCSK_PC7_1	30	36	PF00082	0.266
CLV_PCSK_SKI1_1	17	21	PF00082	0.405
CLV_PCSK_SKI1_1	253	257	PF00082	0.529
CLV_PCSK_SKI1_1	273	277	PF00082	0.655
CLV_PCSK_SKI1_1	56	60	PF00082	0.314
CLV_Separin_Metazoa	22	26	PF03568	0.241
DEG_APCC_DBOX_1	55	63	PF00400	0.334
DEG_Nend_UBRbox_1	1	4	PF02207	0.663
DEG_SPOP_SBC_1	7	11	PF00917	0.553
DOC_ANK_TNKS_1	232	239	PF00023	0.607
DOC_CKS1_1	106	111	PF01111	0.282
DOC_CYCLIN_yCln2_LP_2	46	52	PF00134	0.462
DOC_MAPK_gen_1	110	119	PF00069	0.336
DOC_MAPK_MEF2A_6	110	119	PF00069	0.328
DOC_MAPK_MEF2A_6	152	161	PF00069	0.343
DOC_MAPK_MEF2A_6	182	190	PF00069	0.356
DOC_MAPK_RevD_3	97	111	PF00069	0.474
DOC_USP7_MATH_1	8	12	PF00917	0.689
DOC_USP7_UBL2_3	121	125	PF12436	0.344
DOC_WW_Pin1_4	105	110	PF00397	0.338
DOC_WW_Pin1_4	168	173	PF00397	0.462
DOC_WW_Pin1_4	253	258	PF00397	0.472
DOC_WW_Pin1_4	45	50	PF00397	0.538
LIG_14-3-3_CanoR_1	38	47	PF00244	0.376
LIG_AP2alpha_1	161	165	PF02296	0.363
LIG_CtBP_PxDLS_1	187	193	PF00389	0.335
LIG_deltaCOP1_diTrp_1	199	206	PF00928	0.443
LIG_FHA_1	102	108	PF00498	0.414
LIG_FHA_1	125	131	PF00498	0.439
LIG_FHA_1	169	175	PF00498	0.412
LIG_FHA_1	217	223	PF00498	0.566
LIG_FHA_1	270	276	PF00498	0.604
LIG_FHA_1	93	99	PF00498	0.458
LIG_FHA_2	132	138	PF00498	0.337
LIG_FHA_2	175	181	PF00498	0.334
LIG_FHA_2	194	200	PF00498	0.325
LIG_FHA_2	244	250	PF00498	0.551
LIG_FHA_2	254	260	PF00498	0.540
LIG_LIR_Apic_2	258	263	PF02991	0.630
LIG_LIR_Gen_1	129	139	PF02991	0.410
LIG_LIR_Nem_3	129	135	PF02991	0.411
LIG_LIR_Nem_3	136	142	PF02991	0.392
LIG_NRBOX	230	236	PF00104	0.480
LIG_Pex14_2	161	165	PF04695	0.349
LIG_SH2_CRK	132	136	PF00017	0.499
LIG_SH2_CRK	139	143	PF00017	0.475
LIG_SH2_CRK	260	264	PF00017	0.619
LIG_SH2_STAT5	184	187	PF00017	0.302
LIG_SH2_STAT5	244	247	PF00017	0.527
LIG_SH3_2	106	111	PF14604	0.439
LIG_SH3_3	103	109	PF00018	0.447
LIG_TRAF2_1	247	250	PF00917	0.616
LIG_TRAF2_1	67	70	PF00917	0.385
LIG_TYR_ITIM	130	135	PF00017	0.471
MOD_CDK_SPK_2	105	110	PF00069	0.348
MOD_CDK_SPxK_1	105	111	PF00069	0.341
MOD_CDK_SPxxK_3	105	112	PF00069	0.277
MOD_CK1_1	101	107	PF00069	0.499
MOD_CK1_1	131	137	PF00069	0.444
MOD_CK1_1	216	222	PF00069	0.597
MOD_CK1_1	229	235	PF00069	0.556
MOD_CK2_1	174	180	PF00069	0.331
MOD_CK2_1	193	199	PF00069	0.470
MOD_CK2_1	243	249	PF00069	0.597
MOD_CK2_1	38	44	PF00069	0.440
MOD_CK2_1	64	70	PF00069	0.296
MOD_CK2_1	7	13	PF00069	0.577
MOD_GlcNHglycan	94	98	PF01048	0.404
MOD_GSK3_1	101	108	PF00069	0.471
MOD_GSK3_1	124	131	PF00069	0.413
MOD_GSK3_1	2	9	PF00069	0.659
MOD_GSK3_1	216	223	PF00069	0.527
MOD_GSK3_1	276	283	PF00069	0.644
MOD_N-GLC_2	164	166	PF02516	0.313
MOD_NEK2_1	1	6	PF00069	0.653
MOD_NEK2_1	12	17	PF00069	0.599
MOD_NEK2_1	200	205	PF00069	0.362
MOD_NEK2_1	213	218	PF00069	0.583
MOD_NEK2_1	222	227	PF00069	0.463
MOD_NEK2_1	243	248	PF00069	0.493
MOD_NEK2_1	92	97	PF00069	0.453
MOD_NEK2_1	98	103	PF00069	0.360
MOD_PIKK_1	213	219	PF00454	0.437
MOD_PIKK_1	38	44	PF00454	0.331
MOD_PKA_1	276	282	PF00069	0.446
MOD_PKA_2	229	235	PF00069	0.591
MOD_PKA_2	276	282	PF00069	0.446
MOD_Plk_1	93	99	PF00069	0.339
MOD_ProDKin_1	105	111	PF00069	0.331
MOD_ProDKin_1	168	174	PF00069	0.462
MOD_ProDKin_1	253	259	PF00069	0.475
MOD_ProDKin_1	45	51	PF00069	0.536
MOD_SUMO_rev_2	254	263	PF00179	0.478
TRG_DiLeu_BaEn_1	154	159	PF01217	0.402
TRG_DiLeu_BaEn_4	69	75	PF01217	0.238
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.634
TRG_ENDOCYTIC_2	132	135	PF00928	0.434
TRG_ENDOCYTIC_2	139	142	PF00928	0.319
TRG_ER_diArg_1	109	111	PF00400	0.318
TRG_ER_diArg_1	24	26	PF00400	0.249
TRG_NLS_MonoExtN_4	273	280	PF00514	0.446
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.629
TRG_PTS2	1	43	PF00400	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY2	Leptomonas seymouri	57%	97%
A0A0S4KGV5	Bodo saltans	30%	100%
A0A1X0NK20	Trypanosomatidae	32%	91%
A0A3R7M8M9	Trypanosoma rangeli	35%	100%
A0A3S7WPB5	Leishmania donovani	92%	100%
A4H4I8	Leishmania braziliensis	75%	100%
A4HSR3	Leishmania infantum	91%	100%
C9ZTB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AKQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q13938	Homo sapiens	29%	100%
V5B5T8	Trypanosoma cruzi	35%	100%