LeishMANIAdb
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TPT domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPT domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QJ56_LEIMA
TriTrypDb:
LmjF.06.0230 * , LMJLV39_060007400 * , LMJSD75_060007400 *
Length:
335

Annotations

LeishMANIAdb annotations

Although obviously looks like a transporter, only very weak homologies exist outside KInetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

Q4QJ56
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ56

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 215 219 PF00656 0.740
CLV_NRD_NRD_1 102 104 PF00675 0.778
CLV_NRD_NRD_1 151 153 PF00675 0.513
CLV_NRD_NRD_1 67 69 PF00675 0.807
CLV_NRD_NRD_1 79 81 PF00675 0.746
CLV_NRD_NRD_1 9 11 PF00675 0.452
CLV_PCSK_KEX2_1 102 104 PF00082 0.769
CLV_PCSK_KEX2_1 151 153 PF00082 0.513
CLV_PCSK_KEX2_1 9 11 PF00082 0.452
CLV_PCSK_SKI1_1 14 18 PF00082 0.316
CLV_PCSK_SKI1_1 152 156 PF00082 0.496
CLV_PCSK_SKI1_1 206 210 PF00082 0.505
CLV_PCSK_SKI1_1 274 278 PF00082 0.489
DEG_APCC_DBOX_1 13 21 PF00400 0.483
DEG_Nend_UBRbox_4 1 3 PF02207 0.655
DEG_SPOP_SBC_1 44 48 PF00917 0.447
DOC_ANK_TNKS_1 323 330 PF00023 0.628
DOC_CDC14_PxL_1 25 33 PF14671 0.316
DOC_MAPK_gen_1 151 158 PF00069 0.704
DOC_MAPK_HePTP_8 148 160 PF00069 0.700
DOC_MAPK_MEF2A_6 151 160 PF00069 0.650
DOC_MAPK_MEF2A_6 53 60 PF00069 0.464
DOC_MAPK_RevD_3 137 152 PF00069 0.631
DOC_PP4_FxxP_1 27 30 PF00568 0.316
DOC_PP4_FxxP_1 323 326 PF00568 0.760
DOC_WW_Pin1_4 20 25 PF00397 0.549
DOC_WW_Pin1_4 85 90 PF00397 0.572
LIG_14-3-3_CanoR_1 274 282 PF00244 0.535
LIG_14-3-3_CanoR_1 43 51 PF00244 0.572
LIG_14-3-3_CanoR_1 94 99 PF00244 0.488
LIG_BRCT_BRCA1_1 247 251 PF00533 0.555
LIG_BRCT_BRCA1_1 45 49 PF00533 0.439
LIG_BRCT_BRCA1_1 51 55 PF00533 0.427
LIG_CtBP_PxDLS_1 30 34 PF00389 0.316
LIG_FHA_1 111 117 PF00498 0.553
LIG_FHA_1 169 175 PF00498 0.316
LIG_FHA_1 309 315 PF00498 0.375
LIG_LIR_Apic_2 26 30 PF02991 0.316
LIG_LIR_Apic_2 321 326 PF02991 0.698
LIG_LIR_Gen_1 194 205 PF02991 0.549
LIG_LIR_Gen_1 261 271 PF02991 0.549
LIG_LIR_Nem_3 194 200 PF02991 0.549
LIG_LIR_Nem_3 234 240 PF02991 0.549
LIG_LIR_Nem_3 261 266 PF02991 0.549
LIG_LIR_Nem_3 52 58 PF02991 0.461
LIG_Pex14_1 229 233 PF04695 0.549
LIG_Pex14_1 239 243 PF04695 0.476
LIG_SH2_CRK 233 237 PF00017 0.549
LIG_SH2_STAP1 233 237 PF00017 0.549
LIG_SH2_STAT5 233 236 PF00017 0.405
LIG_SH2_STAT5 263 266 PF00017 0.375
LIG_SH2_STAT5 50 53 PF00017 0.451
LIG_SUMO_SIM_par_1 29 34 PF11976 0.316
LIG_TYR_ITIM 231 236 PF00017 0.549
LIG_UBA3_1 135 144 PF00899 0.316
MOD_CK1_1 168 174 PF00069 0.316
MOD_CK1_1 23 29 PF00069 0.549
MOD_CK1_1 245 251 PF00069 0.503
MOD_CK1_1 275 281 PF00069 0.698
MOD_CK2_1 255 261 PF00069 0.425
MOD_CMANNOS 239 242 PF00535 0.645
MOD_Cter_Amidation 66 69 PF01082 0.683
MOD_GlcNHglycan 257 260 PF01048 0.518
MOD_GlcNHglycan 318 321 PF01048 0.441
MOD_GlcNHglycan 39 42 PF01048 0.672
MOD_GSK3_1 106 113 PF00069 0.563
MOD_GSK3_1 305 312 PF00069 0.433
MOD_GSK3_1 45 52 PF00069 0.467
MOD_GSK3_1 85 92 PF00069 0.642
MOD_N-GLC_1 127 132 PF02516 0.549
MOD_N-GLC_1 146 151 PF02516 0.277
MOD_NEK2_1 127 132 PF00069 0.549
MOD_NEK2_1 165 170 PF00069 0.549
MOD_NEK2_1 231 236 PF00069 0.425
MOD_NEK2_1 272 277 PF00069 0.589
MOD_NEK2_1 305 310 PF00069 0.375
MOD_NEK2_1 31 36 PF00069 0.569
MOD_NEK2_1 49 54 PF00069 0.370
MOD_PIKK_1 67 73 PF00454 0.578
MOD_PKA_2 42 48 PF00069 0.579
MOD_PKA_2 67 73 PF00069 0.486
MOD_PKA_2 93 99 PF00069 0.489
MOD_Plk_1 127 133 PF00069 0.549
MOD_Plk_1 146 152 PF00069 0.479
MOD_Plk_4 127 133 PF00069 0.549
MOD_Plk_4 154 160 PF00069 0.650
MOD_Plk_4 224 230 PF00069 0.549
MOD_Plk_4 23 29 PF00069 0.316
MOD_Plk_4 231 237 PF00069 0.427
MOD_Plk_4 262 268 PF00069 0.549
MOD_Plk_4 305 311 PF00069 0.549
MOD_Plk_4 45 51 PF00069 0.532
MOD_Plk_4 94 100 PF00069 0.488
MOD_ProDKin_1 20 26 PF00069 0.549
MOD_ProDKin_1 85 91 PF00069 0.576
TRG_ENDOCYTIC_2 132 135 PF00928 0.549
TRG_ENDOCYTIC_2 233 236 PF00928 0.549
TRG_ENDOCYTIC_2 243 246 PF00928 0.404
TRG_ENDOCYTIC_2 263 266 PF00928 0.549
TRG_ER_diArg_1 150 152 PF00400 0.730
TRG_ER_diArg_1 9 11 PF00400 0.652
TRG_Pf-PMV_PEXEL_1 103 108 PF00026 0.681

Homologs

Protein Taxonomy Sequence identity Coverage
E9AKQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS