LeishMANIAdb
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TPT domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPT domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QJ56_LEIMA
TriTrypDb:
LmjF.06.0230 * , LMJLV39_060007400 * , LMJSD75_060007400 *
Length:
335

Annotations

LeishMANIAdb annotations

Although obviously looks like a transporter, only very weak homologies exist outside KInetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3
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Expansion

Sequence features

Q4QJ56
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ56

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 215 219 PF00656 0.740
CLV_NRD_NRD_1 102 104 PF00675 0.778
CLV_NRD_NRD_1 151 153 PF00675 0.513
CLV_NRD_NRD_1 67 69 PF00675 0.807
CLV_NRD_NRD_1 79 81 PF00675 0.746
CLV_NRD_NRD_1 9 11 PF00675 0.452
CLV_PCSK_KEX2_1 102 104 PF00082 0.769
CLV_PCSK_KEX2_1 151 153 PF00082 0.513
CLV_PCSK_KEX2_1 9 11 PF00082 0.452
CLV_PCSK_SKI1_1 14 18 PF00082 0.316
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Homologs

ProteinTaxonomySequence identityCoverage
E9AKQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS