Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 34

Species:

Leishmania major

UniProt:

Q4QJ55_LEIMA

TriTrypDb:

LmjF.06.0240 , LMJLV39_060007500 , LMJSD75_060007500

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	4
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QJ55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.654
CLV_C14_Caspase3-7	628	632	PF00656	0.576
CLV_C14_Caspase3-7	648	652	PF00656	0.603
CLV_NRD_NRD_1	123	125	PF00675	0.358
CLV_NRD_NRD_1	271	273	PF00675	0.495
CLV_NRD_NRD_1	593	595	PF00675	0.644
CLV_NRD_NRD_1	754	756	PF00675	0.715
CLV_PCSK_KEX2_1	123	125	PF00082	0.511
CLV_PCSK_KEX2_1	271	273	PF00082	0.495
CLV_PCSK_KEX2_1	4	6	PF00082	0.543
CLV_PCSK_KEX2_1	593	595	PF00082	0.644
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.543
CLV_PCSK_SKI1_1	196	200	PF00082	0.685
CLV_PCSK_SKI1_1	425	429	PF00082	0.475
CLV_PCSK_SKI1_1	577	581	PF00082	0.694
CLV_PCSK_SKI1_1	599	603	PF00082	0.530
CLV_PCSK_SKI1_1	697	701	PF00082	0.742
DEG_SCF_FBW7_1	732	739	PF00400	0.677
DOC_CKS1_1	154	159	PF01111	0.643
DOC_CKS1_1	578	583	PF01111	0.798
DOC_CKS1_1	733	738	PF01111	0.800
DOC_CYCLIN_RxL_1	147	158	PF00134	0.547
DOC_CYCLIN_RxL_1	319	330	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	356	362	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	522	528	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	796	802	PF00134	0.602
DOC_MAPK_gen_1	123	129	PF00069	0.393
DOC_MAPK_gen_1	319	328	PF00069	0.584
DOC_MAPK_MEF2A_6	319	328	PF00069	0.519
DOC_MAPK_MEF2A_6	36	45	PF00069	0.461
DOC_MAPK_MEF2A_6	537	544	PF00069	0.534
DOC_PP1_RVXF_1	148	155	PF00149	0.480
DOC_PP1_RVXF_1	635	641	PF00149	0.549
DOC_PP2B_LxvP_1	507	510	PF13499	0.575
DOC_PP2B_PxIxI_1	633	639	PF00149	0.433
DOC_PP4_FxxP_1	154	157	PF00568	0.535
DOC_PP4_FxxP_1	341	344	PF00568	0.684
DOC_PP4_FxxP_1	445	448	PF00568	0.490
DOC_PP4_FxxP_1	715	718	PF00568	0.647
DOC_USP7_MATH_1	159	163	PF00917	0.580
DOC_USP7_MATH_1	298	302	PF00917	0.529
DOC_USP7_MATH_1	411	415	PF00917	0.621
DOC_USP7_MATH_1	421	425	PF00917	0.482
DOC_USP7_MATH_1	452	456	PF00917	0.449
DOC_USP7_MATH_1	667	671	PF00917	0.767
DOC_USP7_MATH_1	736	740	PF00917	0.711
DOC_USP7_MATH_1	745	749	PF00917	0.622
DOC_USP7_MATH_1	762	766	PF00917	0.684
DOC_USP7_MATH_1	768	772	PF00917	0.669
DOC_USP7_MATH_1	817	821	PF00917	0.620
DOC_USP7_MATH_2	554	560	PF00917	0.707
DOC_WW_Pin1_4	153	158	PF00397	0.485
DOC_WW_Pin1_4	22	27	PF00397	0.431
DOC_WW_Pin1_4	550	555	PF00397	0.682
DOC_WW_Pin1_4	577	582	PF00397	0.786
DOC_WW_Pin1_4	732	737	PF00397	0.791
LIG_14-3-3_CanoR_1	124	130	PF00244	0.441
LIG_14-3-3_CanoR_1	136	141	PF00244	0.560
LIG_14-3-3_CanoR_1	352	356	PF00244	0.615
LIG_14-3-3_CanoR_1	423	428	PF00244	0.708
LIG_14-3-3_CanoR_1	464	473	PF00244	0.460
LIG_14-3-3_CanoR_1	506	510	PF00244	0.520
LIG_14-3-3_CanoR_1	54	60	PF00244	0.377
LIG_14-3-3_CanoR_1	610	620	PF00244	0.518
LIG_14-3-3_CanoR_1	627	631	PF00244	0.512
LIG_APCC_ABBA_1	390	395	PF00400	0.513
LIG_BIR_III_2	631	635	PF00653	0.362
LIG_BRCT_BRCA1_1	24	28	PF00533	0.566
LIG_BRCT_BRCA1_1	423	427	PF00533	0.466
LIG_BRCT_BRCA1_1	454	458	PF00533	0.379
LIG_BRCT_BRCA1_1	466	470	PF00533	0.434
LIG_EH_1	708	712	PF12763	0.607
LIG_EVH1_1	715	719	PF00568	0.702
LIG_FHA_1	286	292	PF00498	0.674
LIG_FHA_1	352	358	PF00498	0.537
LIG_FHA_1	449	455	PF00498	0.579
LIG_FHA_1	466	472	PF00498	0.376
LIG_FHA_1	530	536	PF00498	0.569
LIG_FHA_1	539	545	PF00498	0.386
LIG_FHA_1	550	556	PF00498	0.687
LIG_FHA_1	88	94	PF00498	0.491
LIG_FHA_2	309	315	PF00498	0.542
LIG_FHA_2	45	51	PF00498	0.542
LIG_FHA_2	464	470	PF00498	0.399
LIG_FHA_2	514	520	PF00498	0.632
LIG_FHA_2	56	62	PF00498	0.510
LIG_FHA_2	626	632	PF00498	0.606
LIG_FHA_2	670	676	PF00498	0.772
LIG_FHA_2	770	776	PF00498	0.767
LIG_Integrin_RGD_1	785	787	PF01839	0.730
LIG_LIR_Apic_2	128	134	PF02991	0.468
LIG_LIR_Apic_2	255	261	PF02991	0.651
LIG_LIR_Apic_2	443	448	PF02991	0.484
LIG_LIR_Apic_2	778	784	PF02991	0.774
LIG_LIR_Gen_1	102	111	PF02991	0.443
LIG_LIR_Gen_1	143	154	PF02991	0.442
LIG_LIR_Gen_1	160	171	PF02991	0.439
LIG_LIR_Gen_1	388	398	PF02991	0.505
LIG_LIR_Gen_1	402	412	PF02991	0.443
LIG_LIR_Gen_1	44	51	PF02991	0.347
LIG_LIR_Gen_1	455	463	PF02991	0.460
LIG_LIR_Gen_1	467	478	PF02991	0.400
LIG_LIR_Gen_1	492	503	PF02991	0.595
LIG_LIR_Nem_3	102	106	PF02991	0.478
LIG_LIR_Nem_3	143	149	PF02991	0.415
LIG_LIR_Nem_3	160	166	PF02991	0.526
LIG_LIR_Nem_3	232	238	PF02991	0.515
LIG_LIR_Nem_3	25	31	PF02991	0.453
LIG_LIR_Nem_3	388	393	PF02991	0.498
LIG_LIR_Nem_3	402	407	PF02991	0.397
LIG_LIR_Nem_3	424	430	PF02991	0.605
LIG_LIR_Nem_3	44	48	PF02991	0.550
LIG_LIR_Nem_3	443	449	PF02991	0.375
LIG_LIR_Nem_3	455	459	PF02991	0.444
LIG_LIR_Nem_3	467	473	PF02991	0.408
LIG_LIR_Nem_3	492	498	PF02991	0.590
LIG_LIR_Nem_3	600	605	PF02991	0.608
LIG_MYND_1	732	736	PF01753	0.550
LIG_PAM2_1	706	718	PF00658	0.687
LIG_PCNA_yPIPBox_3	4	14	PF02747	0.553
LIG_Pex14_1	258	262	PF04695	0.623
LIG_Pex14_1	442	446	PF04695	0.472
LIG_Pex14_2	24	28	PF04695	0.566
LIG_Pex14_2	640	644	PF04695	0.557
LIG_Pex14_2	711	715	PF04695	0.616
LIG_REV1ctd_RIR_1	26	36	PF16727	0.469
LIG_SH2_CRK	146	150	PF00017	0.558
LIG_SH2_CRK	175	179	PF00017	0.574
LIG_SH2_CRK	495	499	PF00017	0.612
LIG_SH2_NCK_1	279	283	PF00017	0.557
LIG_SH2_PTP2	131	134	PF00017	0.548
LIG_SH2_PTP2	446	449	PF00017	0.467
LIG_SH2_SRC	146	149	PF00017	0.547
LIG_SH2_SRC	279	282	PF00017	0.532
LIG_SH2_SRC	446	449	PF00017	0.500
LIG_SH2_STAP1	14	18	PF00017	0.552
LIG_SH2_STAP1	262	266	PF00017	0.562
LIG_SH2_STAT3	14	17	PF00017	0.552
LIG_SH2_STAT3	307	310	PF00017	0.629
LIG_SH2_STAT3	312	315	PF00017	0.539
LIG_SH2_STAT3	612	615	PF00017	0.484
LIG_SH2_STAT3	63	66	PF00017	0.590
LIG_SH2_STAT5	103	106	PF00017	0.415
LIG_SH2_STAT5	131	134	PF00017	0.421
LIG_SH2_STAT5	163	166	PF00017	0.493
LIG_SH2_STAT5	223	226	PF00017	0.697
LIG_SH2_STAT5	238	241	PF00017	0.627
LIG_SH2_STAT5	245	248	PF00017	0.601
LIG_SH2_STAT5	312	315	PF00017	0.507
LIG_SH2_STAT5	404	407	PF00017	0.541
LIG_SH2_STAT5	446	449	PF00017	0.401
LIG_SH2_STAT5	495	498	PF00017	0.520
LIG_SH2_STAT5	612	615	PF00017	0.440
LIG_SH2_STAT5	714	717	PF00017	0.598
LIG_SH2_STAT5	724	727	PF00017	0.662
LIG_SH2_STAT5	822	825	PF00017	0.578
LIG_SH2_STAT5	837	840	PF00017	0.584
LIG_SH3_1	583	589	PF00018	0.800
LIG_SH3_1	714	720	PF00018	0.714
LIG_SH3_2	578	583	PF14604	0.762
LIG_SH3_3	163	169	PF00018	0.610
LIG_SH3_3	20	26	PF00018	0.539
LIG_SH3_3	45	51	PF00018	0.584
LIG_SH3_3	514	520	PF00018	0.533
LIG_SH3_3	575	581	PF00018	0.749
LIG_SH3_3	583	589	PF00018	0.758
LIG_SH3_3	713	719	PF00018	0.635
LIG_SUMO_SIM_anti_2	378	388	PF11976	0.668
LIG_SUMO_SIM_anti_2	490	495	PF11976	0.602
LIG_SUMO_SIM_par_1	353	358	PF11976	0.524
LIG_SUMO_SIM_par_1	38	44	PF11976	0.606
LIG_TRAF2_1	376	379	PF00917	0.625
LIG_TRAF2_1	516	519	PF00917	0.681
LIG_TRAF2_1	58	61	PF00917	0.544
LIG_TRAF2_1	792	795	PF00917	0.621
LIG_TYR_ITIM	493	498	PF00017	0.593
LIG_WRC_WIRS_1	42	47	PF05994	0.556
LIG_WRC_WIRS_1	470	475	PF05994	0.428
LIG_WW_3	585	589	PF00397	0.756
MOD_CDK_SPxK_1	577	583	PF00069	0.756
MOD_CK1_1	200	206	PF00069	0.723
MOD_CK1_1	351	357	PF00069	0.618
MOD_CK1_1	550	556	PF00069	0.694
MOD_CK1_1	669	675	PF00069	0.743
MOD_CK1_1	687	693	PF00069	0.494
MOD_CK1_1	738	744	PF00069	0.794
MOD_CK1_1	820	826	PF00069	0.572
MOD_CK2_1	308	314	PF00069	0.550
MOD_CK2_1	44	50	PF00069	0.532
MOD_CK2_1	463	469	PF00069	0.426
MOD_CK2_1	513	519	PF00069	0.600
MOD_CK2_1	55	61	PF00069	0.499
MOD_CK2_1	550	556	PF00069	0.686
MOD_CK2_1	670	676	PF00069	0.781
MOD_CK2_1	789	795	PF00069	0.641
MOD_CK2_1	815	821	PF00069	0.546
MOD_Cter_Amidation	269	272	PF01082	0.627
MOD_DYRK1A_RPxSP_1	577	581	PF00069	0.725
MOD_GlcNHglycan	300	303	PF01048	0.715
MOD_GlcNHglycan	370	373	PF01048	0.639
MOD_GlcNHglycan	401	404	PF01048	0.616
MOD_GlcNHglycan	442	445	PF01048	0.394
MOD_GlcNHglycan	460	463	PF01048	0.469
MOD_GlcNHglycan	559	562	PF01048	0.734
MOD_GlcNHglycan	660	663	PF01048	0.793
MOD_GlcNHglycan	738	741	PF01048	0.765
MOD_GlcNHglycan	764	767	PF01048	0.705
MOD_GlcNHglycan	817	820	PF01048	0.546
MOD_GSK3_1	132	139	PF00069	0.553
MOD_GSK3_1	153	160	PF00069	0.532
MOD_GSK3_1	196	203	PF00069	0.656
MOD_GSK3_1	239	246	PF00069	0.656
MOD_GSK3_1	283	290	PF00069	0.681
MOD_GSK3_1	399	406	PF00069	0.512
MOD_GSK3_1	421	428	PF00069	0.645
MOD_GSK3_1	448	455	PF00069	0.445
MOD_GSK3_1	465	472	PF00069	0.339
MOD_GSK3_1	505	512	PF00069	0.562
MOD_GSK3_1	546	553	PF00069	0.628
MOD_GSK3_1	593	600	PF00069	0.610
MOD_GSK3_1	621	628	PF00069	0.490
MOD_GSK3_1	654	661	PF00069	0.770
MOD_GSK3_1	666	673	PF00069	0.715
MOD_GSK3_1	683	690	PF00069	0.687
MOD_GSK3_1	732	739	PF00069	0.728
MOD_GSK3_1	743	750	PF00069	0.589
MOD_GSK3_1	820	827	PF00069	0.546
MOD_GSK3_1	88	95	PF00069	0.439
MOD_N-GLC_1	368	373	PF02516	0.670
MOD_NEK2_1	125	130	PF00069	0.413
MOD_NEK2_1	197	202	PF00069	0.734
MOD_NEK2_1	458	463	PF00069	0.425
MOD_NEK2_1	505	510	PF00069	0.574
MOD_NEK2_1	547	552	PF00069	0.586
MOD_NEK2_1	815	820	PF00069	0.460
MOD_NEK2_1	824	829	PF00069	0.465
MOD_NEK2_2	114	119	PF00069	0.429
MOD_NEK2_2	452	457	PF00069	0.490
MOD_PIKK_1	611	617	PF00454	0.564
MOD_PIKK_1	621	627	PF00454	0.596
MOD_PIKK_1	684	690	PF00454	0.741
MOD_PIKK_1	775	781	PF00454	0.797
MOD_PIKK_1	789	795	PF00454	0.711
MOD_PK_1	136	142	PF00069	0.555
MOD_PK_1	597	603	PF00069	0.574
MOD_PKA_1	593	599	PF00069	0.641
MOD_PKA_2	224	230	PF00069	0.727
MOD_PKA_2	351	357	PF00069	0.623
MOD_PKA_2	463	469	PF00069	0.439
MOD_PKA_2	505	511	PF00069	0.569
MOD_PKA_2	593	599	PF00069	0.625
MOD_PKA_2	626	632	PF00069	0.581
MOD_PKB_1	423	431	PF00069	0.626
MOD_Plk_1	625	631	PF00069	0.573
MOD_Plk_1	72	78	PF00069	0.479
MOD_Plk_1	820	826	PF00069	0.506
MOD_Plk_2-3	626	632	PF00069	0.387
MOD_Plk_4	159	165	PF00069	0.520
MOD_Plk_4	308	314	PF00069	0.524
MOD_Plk_4	351	357	PF00069	0.537
MOD_Plk_4	403	409	PF00069	0.550
MOD_Plk_4	489	495	PF00069	0.447
MOD_Plk_4	720	726	PF00069	0.727
MOD_ProDKin_1	153	159	PF00069	0.500
MOD_ProDKin_1	22	28	PF00069	0.438
MOD_ProDKin_1	550	556	PF00069	0.686
MOD_ProDKin_1	577	583	PF00069	0.790
MOD_ProDKin_1	732	738	PF00069	0.795
MOD_SUMO_for_1	31	34	PF00179	0.531
TRG_DiLeu_BaEn_2	808	814	PF01217	0.435
TRG_DiLeu_BaEn_4	703	709	PF01217	0.672
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.517
TRG_ENDOCYTIC_2	103	106	PF00928	0.415
TRG_ENDOCYTIC_2	146	149	PF00928	0.518
TRG_ENDOCYTIC_2	163	166	PF00928	0.456
TRG_ENDOCYTIC_2	404	407	PF00928	0.541
TRG_ENDOCYTIC_2	446	449	PF00928	0.401
TRG_ENDOCYTIC_2	495	498	PF00928	0.605
TRG_ER_diArg_1	123	125	PF00400	0.358
TRG_ER_diArg_1	271	273	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6D8	Leptomonas seymouri	59%	83%
A0A3S5H5N9	Leishmania donovani	93%	100%
A0A422MY92	Trypanosoma rangeli	29%	100%
A4H4J0	Leishmania braziliensis	82%	86%
A4HSR5	Leishmania infantum	94%	100%
C9ZTB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
E9AKQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BEV7	Trypanosoma cruzi	30%	100%