Leucine zipper transcription factor-like protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ54_LEIMA

TriTrypDb:

LmjF.06.0250 , LMJLV39_060007600 , LMJSD75_060007600

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QJ54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ54

Function

Biological processes
Term	Name	Level	Count
GO:0032879	regulation of localization	3	2
GO:0032880	regulation of protein localization	5	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0060341	regulation of cellular localization	4	2
GO:0065007	biological regulation	1	2
GO:1903564	regulation of protein localization to cilium	6	2
GO:1903565	negative regulation of protein localization to cilium	6	2
GO:1903828	negative regulation of protein localization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.514
CLV_NRD_NRD_1	201	203	PF00675	0.649
CLV_PCSK_KEX2_1	155	157	PF00082	0.467
CLV_PCSK_KEX2_1	201	203	PF00082	0.643
CLV_PCSK_KEX2_1	225	227	PF00082	0.555
CLV_PCSK_KEX2_1	30	32	PF00082	0.381
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.408
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.552
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.405
CLV_PCSK_SKI1_1	104	108	PF00082	0.615
CLV_PCSK_SKI1_1	242	246	PF00082	0.433
CLV_PCSK_SKI1_1	31	35	PF00082	0.475
CLV_PCSK_SKI1_1	86	90	PF00082	0.475
CLV_Separin_Metazoa	83	87	PF03568	0.482
DEG_Nend_UBRbox_2	1	3	PF02207	0.599
DOC_MAPK_gen_1	28	35	PF00069	0.491
DOC_MAPK_gen_1	94	103	PF00069	0.445
DOC_MAPK_MEF2A_6	94	103	PF00069	0.480
LIG_14-3-3_CanoR_1	173	183	PF00244	0.533
LIG_14-3-3_CanoR_1	23	27	PF00244	0.525
LIG_14-3-3_CanoR_1	231	241	PF00244	0.441
LIG_14-3-3_CanoR_1	94	100	PF00244	0.485
LIG_FHA_1	126	132	PF00498	0.620
LIG_FHA_1	177	183	PF00498	0.523
LIG_FHA_1	96	102	PF00498	0.443
LIG_FHA_2	133	139	PF00498	0.504
LIG_FHA_2	211	217	PF00498	0.525
LIG_FHA_2	49	55	PF00498	0.427
LIG_FHA_2	70	76	PF00498	0.533
LIG_GBD_Chelix_1	55	63	PF00786	0.476
LIG_LIR_Gen_1	165	172	PF02991	0.418
LIG_LIR_Gen_1	235	246	PF02991	0.459
LIG_LIR_Nem_3	165	171	PF02991	0.416
LIG_LIR_Nem_3	235	241	PF02991	0.462
LIG_LIR_Nem_3	263	269	PF02991	0.482
LIG_PCNA_TLS_4	12	19	PF02747	0.403
LIG_Pex14_1	46	50	PF04695	0.552
LIG_REV1ctd_RIR_1	16	24	PF16727	0.522
LIG_SH2_CRK	168	172	PF00017	0.427
LIG_SH2_CRK	238	242	PF00017	0.494
LIG_SH2_NCK_1	50	54	PF00017	0.428
LIG_SH2_SRC	262	265	PF00017	0.457
LIG_SH2_STAP1	168	172	PF00017	0.427
LIG_SH2_STAT5	168	171	PF00017	0.487
LIG_SH2_STAT5	50	53	PF00017	0.406
LIG_SUMO_SIM_par_1	132	138	PF11976	0.508
LIG_SUMO_SIM_par_1	97	102	PF11976	0.482
LIG_TRAF2_1	135	138	PF00917	0.593
LIG_TRAF2_1	213	216	PF00917	0.518
LIG_TYR_ITSM	234	241	PF00017	0.500
MOD_CK1_1	125	131	PF00069	0.628
MOD_CK1_1	176	182	PF00069	0.519
MOD_CK1_1	22	28	PF00069	0.499
MOD_CK2_1	132	138	PF00069	0.624
MOD_CK2_1	174	180	PF00069	0.534
MOD_CK2_1	210	216	PF00069	0.464
MOD_CK2_1	48	54	PF00069	0.439
MOD_CK2_1	69	75	PF00069	0.555
MOD_GlcNHglycan	124	127	PF01048	0.555
MOD_GlcNHglycan	137	142	PF01048	0.565
MOD_GlcNHglycan	36	40	PF01048	0.500
MOD_GlcNHglycan	80	83	PF01048	0.401
MOD_GSK3_1	162	169	PF00069	0.447
MOD_GSK3_1	206	213	PF00069	0.536
MOD_GSK3_1	31	38	PF00069	0.444
MOD_GSK3_1	74	81	PF00069	0.479
MOD_NEK2_1	19	24	PF00069	0.448
MOD_NEK2_1	210	215	PF00069	0.525
MOD_NEK2_1	232	237	PF00069	0.443
MOD_NEK2_1	74	79	PF00069	0.482
MOD_PIKK_1	166	172	PF00454	0.533
MOD_PIKK_1	233	239	PF00454	0.442
MOD_PIKK_1	69	75	PF00454	0.488
MOD_PKA_2	174	180	PF00069	0.529
MOD_PKA_2	19	25	PF00069	0.491
MOD_PKA_2	95	101	PF00069	0.443
MOD_Plk_1	31	37	PF00069	0.488
MOD_Plk_4	102	108	PF00069	0.470
MOD_SUMO_for_1	224	227	PF00179	0.548
MOD_SUMO_rev_2	100	106	PF00179	0.462
MOD_SUMO_rev_2	149	157	PF00179	0.417
TRG_ENDOCYTIC_2	168	171	PF00928	0.427
TRG_ENDOCYTIC_2	238	241	PF00928	0.436
TRG_ER_diArg_1	172	175	PF00400	0.607
TRG_ER_diArg_1	94	97	PF00400	0.503
TRG_NES_CRM1_1	57	71	PF08389	0.499
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I805	Leptomonas seymouri	77%	100%
A0A1X0NJT8	Trypanosomatidae	40%	82%
A0A3S7WPD4	Leishmania donovani	98%	100%
A0A422MY50	Trypanosoma rangeli	46%	92%
A4H4J1	Leishmania braziliensis	88%	100%
A4HSR6	Leishmania infantum	98%	100%
E9AKQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q3ZBL4	Bos taurus	25%	93%
Q4R6V9	Macaca fascicularis	26%	93%
Q562C6	Rattus norvegicus	24%	93%
Q5RBR4	Pongo abelii	25%	93%
Q9JHQ5	Mus musculus	25%	93%
Q9NQ48	Homo sapiens	25%	93%
V5BAA5	Trypanosoma cruzi	42%	98%