Leucine zipper transcription factor-like protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ54_LEIMA

TriTrypDb:

LmjF.06.0250 , LMJLV39_060007600 , LMJSD75_060007600

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

Q4QJ54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ54

Function

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Biological processes
Term	Name	Level	Count
GO:0032879	regulation of localization	3	2
GO:0032880	regulation of protein localization	5	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0060341	regulation of cellular localization	4	2
GO:0065007	biological regulation	1	2
GO:1903564	regulation of protein localization to cilium	6	2
GO:1903565	negative regulation of protein localization to cilium	6	2

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.514
CLV_NRD_NRD_1	201	203	PF00675	0.649
CLV_PCSK_KEX2_1	155	157	PF00082	0.467
CLV_PCSK_KEX2_1	201	203	PF00082	0.643
CLV_PCSK_KEX2_1	225	227	PF00082	0.555
CLV_PCSK_KEX2_1	30	32	PF00082	0.381
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.408
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.552
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.405
CLV_PCSK_SKI1_1	104	108	PF00082	0.615

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I805	Leptomonas seymouri	77%	100%
A0A1X0NJT8	Trypanosomatidae	40%	82%
A0A3S7WPD4	Leishmania donovani	98%	100%
A0A422MY50	Trypanosoma rangeli	46%	92%
A4H4J1	Leishmania braziliensis	88%	100%
A4HSR6	Leishmania infantum	98%	100%
E9AKQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q3ZBL4	Bos taurus	25%	93%
Q4R6V9	Macaca fascicularis	26%	93%
Q562C6	Rattus norvegicus	24%	93%

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