FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ51_LEIMA

TriTrypDb:

LmjF.06.0280 , LMJLV39_060007900 , LMJSD75_060007900

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0030870	Mre11 complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	7

Expansion

Sequence features

Q4QJ51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ51

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	7
GO:0000077	DNA damage checkpoint signaling	5	7
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006302	double-strand break repair	6	7
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0006996	organelle organization	4	2
GO:0007093	mitotic cell cycle checkpoint signaling	4	7
GO:0007095	mitotic G2 DNA damage checkpoint signaling	6	7
GO:0007165	signal transduction	2	7
GO:0007346	regulation of mitotic cell cycle	5	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0010389	regulation of G2/M transition of mitotic cell cycle	7	7
GO:0010564	regulation of cell cycle process	5	7
GO:0010948	negative regulation of cell cycle process	6	7
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	8	7
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	7
GO:0031570	DNA integrity checkpoint signaling	5	7
GO:0032392	DNA geometric change	7	2
GO:0032508	DNA duplex unwinding	8	2
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0035556	intracellular signal transduction	3	7
GO:0042770	signal transduction in response to DNA damage	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044773	mitotic DNA damage checkpoint signaling	6	7
GO:0044774	mitotic DNA integrity checkpoint signaling	5	7
GO:0044818	mitotic G2/M transition checkpoint	5	7
GO:0045786	negative regulation of cell cycle	5	7
GO:0045930	negative regulation of mitotic cell cycle	6	7
GO:0046483	heterocycle metabolic process	3	7
GO:0048519	negative regulation of biological process	3	7
GO:0048523	negative regulation of cellular process	4	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0050896	response to stimulus	1	7
GO:0051276	chromosome organization	5	2
GO:0051716	cellular response to stimulus	2	7
GO:0051726	regulation of cell cycle	4	7
GO:0065007	biological regulation	1	7
GO:0071103	DNA conformation change	6	2
GO:0071704	organic substance metabolic process	2	7
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901987	regulation of cell cycle phase transition	6	7
GO:1901988	negative regulation of cell cycle phase transition	7	7
GO:1901990	regulation of mitotic cell cycle phase transition	6	7
GO:1901991	negative regulation of mitotic cell cycle phase transition	7	7
GO:1902749	regulation of cell cycle G2/M phase transition	7	7
GO:1902750	negative regulation of cell cycle G2/M phase transition	8	7
GO:1903047	mitotic cell cycle process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003684	damaged DNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.587
CLV_C14_Caspase3-7	430	434	PF00656	0.347
CLV_C14_Caspase3-7	609	613	PF00656	0.655
CLV_C14_Caspase3-7	66	70	PF00656	0.388
CLV_MEL_PAP_1	539	545	PF00089	0.352
CLV_NRD_NRD_1	133	135	PF00675	0.657
CLV_NRD_NRD_1	408	410	PF00675	0.436
CLV_NRD_NRD_1	573	575	PF00675	0.609
CLV_NRD_NRD_1	604	606	PF00675	0.621
CLV_NRD_NRD_1	707	709	PF00675	0.527
CLV_NRD_NRD_1	765	767	PF00675	0.610
CLV_NRD_NRD_1	771	773	PF00675	0.620
CLV_NRD_NRD_1	775	777	PF00675	0.619
CLV_PCSK_FUR_1	705	709	PF00082	0.547
CLV_PCSK_KEX2_1	135	137	PF00082	0.672
CLV_PCSK_KEX2_1	407	409	PF00082	0.425
CLV_PCSK_KEX2_1	573	575	PF00082	0.609
CLV_PCSK_KEX2_1	604	606	PF00082	0.608
CLV_PCSK_KEX2_1	707	709	PF00082	0.527
CLV_PCSK_KEX2_1	764	766	PF00082	0.602
CLV_PCSK_KEX2_1	771	773	PF00082	0.620
CLV_PCSK_KEX2_1	775	777	PF00082	0.619
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.672
CLV_PCSK_PC7_1	771	777	PF00082	0.551
CLV_PCSK_SKI1_1	348	352	PF00082	0.435
CLV_PCSK_SKI1_1	409	413	PF00082	0.433
CLV_PCSK_SKI1_1	461	465	PF00082	0.501
CLV_PCSK_SKI1_1	476	480	PF00082	0.299
CLV_PCSK_SKI1_1	619	623	PF00082	0.657
CLV_PCSK_SKI1_1	682	686	PF00082	0.585
CLV_PCSK_SKI1_1	689	693	PF00082	0.562
DEG_APCC_DBOX_1	347	355	PF00400	0.422
DEG_APCC_DBOX_1	460	468	PF00400	0.458
DEG_COP1_1	713	722	PF00400	0.635
DEG_Nend_Nbox_1	1	3	PF02207	0.325
DEG_SCF_FBW7_1	254	261	PF00400	0.655
DEG_SCF_FBW7_1	375	380	PF00400	0.476
DEG_SPOP_SBC_1	455	459	PF00917	0.517
DOC_CKS1_1	314	319	PF01111	0.395
DOC_CYCLIN_RxL_1	405	416	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	648	654	PF00134	0.576
DOC_MAPK_gen_1	21	31	PF00069	0.438
DOC_MAPK_gen_1	282	292	PF00069	0.408
DOC_MAPK_gen_1	473	481	PF00069	0.421
DOC_MAPK_MEF2A_6	145	154	PF00069	0.490
DOC_MAPK_MEF2A_6	326	333	PF00069	0.424
DOC_MAPK_MEF2A_6	39	48	PF00069	0.392
DOC_PP1_RVXF_1	182	188	PF00149	0.347
DOC_PP1_RVXF_1	436	442	PF00149	0.440
DOC_PP2B_LxvP_1	375	378	PF13499	0.472
DOC_PP2B_LxvP_1	521	524	PF13499	0.443
DOC_PP2B_LxvP_1	692	695	PF13499	0.566
DOC_PP4_FxxP_1	160	163	PF00568	0.343
DOC_PP4_FxxP_1	617	620	PF00568	0.665
DOC_USP7_MATH_1	278	282	PF00917	0.477
DOC_USP7_MATH_1	334	338	PF00917	0.490
DOC_USP7_MATH_1	342	346	PF00917	0.450
DOC_USP7_MATH_1	386	390	PF00917	0.564
DOC_USP7_MATH_1	394	398	PF00917	0.398
DOC_USP7_MATH_1	455	459	PF00917	0.497
DOC_USP7_MATH_1	466	470	PF00917	0.374
DOC_USP7_MATH_1	541	545	PF00917	0.408
DOC_USP7_MATH_1	548	552	PF00917	0.460
DOC_USP7_MATH_1	636	640	PF00917	0.620
DOC_USP7_MATH_1	668	672	PF00917	0.626
DOC_USP7_MATH_1	677	681	PF00917	0.545
DOC_USP7_MATH_1	826	830	PF00917	0.587
DOC_USP7_MATH_1	839	843	PF00917	0.555
DOC_USP7_UBL2_3	685	689	PF12436	0.584
DOC_WW_Pin1_4	107	112	PF00397	0.658
DOC_WW_Pin1_4	254	259	PF00397	0.591
DOC_WW_Pin1_4	260	265	PF00397	0.585
DOC_WW_Pin1_4	313	318	PF00397	0.329
DOC_WW_Pin1_4	325	330	PF00397	0.492
DOC_WW_Pin1_4	373	378	PF00397	0.519
DOC_WW_Pin1_4	6	11	PF00397	0.484
DOC_WW_Pin1_4	783	788	PF00397	0.590
DOC_WW_Pin1_4	90	95	PF00397	0.655
LIG_14-3-3_CanoR_1	138	148	PF00244	0.610
LIG_14-3-3_CanoR_1	166	170	PF00244	0.414
LIG_14-3-3_CanoR_1	238	246	PF00244	0.657
LIG_14-3-3_CanoR_1	285	291	PF00244	0.398
LIG_14-3-3_CanoR_1	498	504	PF00244	0.421
LIG_14-3-3_CanoR_1	542	550	PF00244	0.393
LIG_14-3-3_CanoR_1	573	581	PF00244	0.600
LIG_14-3-3_CanoR_1	619	624	PF00244	0.569
LIG_Actin_WH2_2	169	186	PF00022	0.371
LIG_APCC_ABBA_1	3	8	PF00400	0.377
LIG_APCC_ABBA_1	478	483	PF00400	0.351
LIG_BIR_III_2	576	580	PF00653	0.661
LIG_BRCT_BRCA1_1	747	751	PF00533	0.576
LIG_BRCT_BRCA1_1	841	845	PF00533	0.585
LIG_Clathr_ClatBox_1	185	189	PF01394	0.353
LIG_Clathr_ClatBox_1	698	702	PF01394	0.578
LIG_CtBP_PxDLS_1	245	251	PF00389	0.521
LIG_deltaCOP1_diTrp_1	612	617	PF00928	0.674
LIG_EVH1_1	521	525	PF00568	0.455
LIG_EVH1_1	654	658	PF00568	0.561
LIG_FHA_1	153	159	PF00498	0.419
LIG_FHA_1	171	177	PF00498	0.475
LIG_FHA_1	221	227	PF00498	0.605
LIG_FHA_1	293	299	PF00498	0.365
LIG_FHA_1	300	306	PF00498	0.406
LIG_FHA_1	41	47	PF00498	0.377
LIG_FHA_1	414	420	PF00498	0.402
LIG_FHA_1	482	488	PF00498	0.444
LIG_FHA_1	545	551	PF00498	0.480
LIG_FHA_1	642	648	PF00498	0.550
LIG_FHA_1	714	720	PF00498	0.629
LIG_FHA_1	73	79	PF00498	0.435
LIG_FHA_2	508	514	PF00498	0.384
LIG_FHA_2	533	539	PF00498	0.424
LIG_FHA_2	555	561	PF00498	0.574
LIG_FHA_2	87	93	PF00498	0.633
LIG_LIR_Apic_2	157	163	PF02991	0.404
LIG_LIR_Apic_2	337	342	PF02991	0.458
LIG_LIR_Apic_2	616	620	PF02991	0.629
LIG_LIR_Gen_1	167	176	PF02991	0.438
LIG_LIR_Gen_1	416	425	PF02991	0.401
LIG_LIR_Gen_1	535	543	PF02991	0.443
LIG_LIR_Gen_1	612	621	PF02991	0.603
LIG_LIR_Gen_1	748	758	PF02991	0.628
LIG_LIR_Gen_1	842	853	PF02991	0.545
LIG_LIR_Nem_3	167	172	PF02991	0.446
LIG_LIR_Nem_3	344	350	PF02991	0.372
LIG_LIR_Nem_3	410	415	PF02991	0.352
LIG_LIR_Nem_3	416	420	PF02991	0.341
LIG_LIR_Nem_3	505	511	PF02991	0.339
LIG_LIR_Nem_3	535	539	PF02991	0.444
LIG_LIR_Nem_3	612	617	PF02991	0.609
LIG_LIR_Nem_3	748	754	PF02991	0.628
LIG_LIR_Nem_3	842	848	PF02991	0.556
LIG_LIR_Nem_3	9	15	PF02991	0.423
LIG_OCRL_FandH_1	469	481	PF00620	0.359
LIG_Pex14_1	2	6	PF04695	0.326
LIG_Pex14_1	346	350	PF04695	0.373
LIG_REV1ctd_RIR_1	468	477	PF16727	0.369
LIG_SH2_CRK	287	291	PF00017	0.431
LIG_SH2_CRK	508	512	PF00017	0.336
LIG_SH2_CRK	652	656	PF00017	0.561
LIG_SH2_NCK_1	122	126	PF00017	0.576
LIG_SH2_NCK_1	287	291	PF00017	0.405
LIG_SH2_NCK_1	652	656	PF00017	0.561
LIG_SH2_SRC	122	125	PF00017	0.532
LIG_SH2_SRC	339	342	PF00017	0.460
LIG_SH2_SRC	425	428	PF00017	0.335
LIG_SH2_SRC	431	434	PF00017	0.360
LIG_SH2_STAP1	425	429	PF00017	0.321
LIG_SH2_STAT5	339	342	PF00017	0.436
LIG_SH2_STAT5	401	404	PF00017	0.367
LIG_SH2_STAT5	431	434	PF00017	0.352
LIG_SH3_1	326	332	PF00018	0.418
LIG_SH3_1	519	525	PF00018	0.451
LIG_SH3_1	652	658	PF00018	0.562
LIG_SH3_3	326	332	PF00018	0.418
LIG_SH3_3	483	489	PF00018	0.486
LIG_SH3_3	519	525	PF00018	0.451
LIG_SH3_3	576	582	PF00018	0.591
LIG_SH3_3	652	658	PF00018	0.562
LIG_SH3_3	691	697	PF00018	0.562
LIG_SUMO_SIM_anti_2	644	649	PF11976	0.558
LIG_SUMO_SIM_par_1	63	72	PF11976	0.378
LIG_SUMO_SIM_par_1	696	703	PF11976	0.573
LIG_SUMO_SIM_par_1	806	816	PF11976	0.585
LIG_TRAF2_1	535	538	PF00917	0.432
LIG_TRAF2_1	557	560	PF00917	0.618
LIG_TRAF2_1	561	564	PF00917	0.613
LIG_TRFH_1	373	377	PF08558	0.473
LIG_TRFH_1	652	656	PF08558	0.561
LIG_TYR_ITIM	506	511	PF00017	0.339
LIG_WRC_WIRS_1	467	472	PF05994	0.341
MOD_CDK_SPxxK_3	783	790	PF00069	0.630
MOD_CK1_1	139	145	PF00069	0.589
MOD_CK1_1	220	226	PF00069	0.535
MOD_CK1_1	244	250	PF00069	0.507
MOD_CK1_1	413	419	PF00069	0.411
MOD_CK1_1	456	462	PF00069	0.526
MOD_CK1_1	502	508	PF00069	0.408
MOD_CK1_1	544	550	PF00069	0.389
MOD_CK1_1	713	719	PF00069	0.632
MOD_CK2_1	224	230	PF00069	0.643
MOD_CK2_1	354	360	PF00069	0.520
MOD_CK2_1	507	513	PF00069	0.342
MOD_CK2_1	532	538	PF00069	0.432
MOD_CK2_1	554	560	PF00069	0.569
MOD_Cter_Amidation	571	574	PF01082	0.608
MOD_Cter_Amidation	773	776	PF01082	0.551
MOD_GlcNHglycan	138	141	PF01048	0.748
MOD_GlcNHglycan	142	145	PF01048	0.781
MOD_GlcNHglycan	189	193	PF01048	0.363
MOD_GlcNHglycan	219	222	PF01048	0.513
MOD_GlcNHglycan	226	229	PF01048	0.604
MOD_GlcNHglycan	233	236	PF01048	0.600
MOD_GlcNHglycan	242	246	PF01048	0.413
MOD_GlcNHglycan	251	254	PF01048	0.547
MOD_GlcNHglycan	258	261	PF01048	0.585
MOD_GlcNHglycan	356	359	PF01048	0.582
MOD_GlcNHglycan	388	391	PF01048	0.499
MOD_GlcNHglycan	412	415	PF01048	0.428
MOD_GlcNHglycan	442	446	PF01048	0.450
MOD_GlcNHglycan	449	452	PF01048	0.482
MOD_GlcNHglycan	543	546	PF01048	0.357
MOD_GlcNHglycan	638	641	PF01048	0.619
MOD_GlcNHglycan	666	669	PF01048	0.616
MOD_GlcNHglycan	670	673	PF01048	0.585
MOD_GlcNHglycan	679	682	PF01048	0.500
MOD_GlcNHglycan	747	750	PF01048	0.573
MOD_GlcNHglycan	779	782	PF01048	0.616
MOD_GlcNHglycan	828	831	PF01048	0.684
MOD_GlcNHglycan	837	840	PF01048	0.564
MOD_GlcNHglycan	841	844	PF01048	0.513
MOD_GSK3_1	136	143	PF00069	0.644
MOD_GSK3_1	215	222	PF00069	0.455
MOD_GSK3_1	224	231	PF00069	0.560
MOD_GSK3_1	254	261	PF00069	0.686
MOD_GSK3_1	294	301	PF00069	0.370
MOD_GSK3_1	33	40	PF00069	0.394
MOD_GSK3_1	373	380	PF00069	0.727
MOD_GSK3_1	453	460	PF00069	0.494
MOD_GSK3_1	544	551	PF00069	0.460
MOD_GSK3_1	625	632	PF00069	0.564
MOD_GSK3_1	63	70	PF00069	0.428
MOD_GSK3_1	664	671	PF00069	0.565
MOD_GSK3_1	818	825	PF00069	0.662
MOD_GSK3_1	835	842	PF00069	0.485
MOD_GSK3_1	86	93	PF00069	0.647
MOD_N-GLC_1	481	486	PF02516	0.453
MOD_N-GLC_1	636	641	PF02516	0.621
MOD_NEK2_1	188	193	PF00069	0.409
MOD_NEK2_1	246	251	PF00069	0.503
MOD_NEK2_1	292	297	PF00069	0.367
MOD_NEK2_1	42	47	PF00069	0.381
MOD_NEK2_1	432	437	PF00069	0.345
MOD_NEK2_1	453	458	PF00069	0.561
MOD_NEK2_1	48	53	PF00069	0.485
MOD_NEK2_1	549	554	PF00069	0.462
MOD_NEK2_1	597	602	PF00069	0.607
MOD_NEK2_1	67	72	PF00069	0.373
MOD_NEK2_1	710	715	PF00069	0.546
MOD_NEK2_1	822	827	PF00069	0.639
MOD_NEK2_2	466	471	PF00069	0.342
MOD_NEK2_2	514	519	PF00069	0.424
MOD_NEK2_2	638	643	PF00069	0.524
MOD_PIKK_1	220	226	PF00454	0.600
MOD_PIKK_1	228	234	PF00454	0.586
MOD_PIKK_1	246	252	PF00454	0.483
MOD_PIKK_1	563	569	PF00454	0.646
MOD_PKA_1	765	771	PF00069	0.612
MOD_PKA_2	165	171	PF00069	0.464
MOD_PKA_2	354	360	PF00069	0.487
MOD_PKA_2	541	547	PF00069	0.392
MOD_PKA_2	572	578	PF00069	0.605
MOD_PKA_2	597	603	PF00069	0.627
MOD_PKA_2	765	771	PF00069	0.612
MOD_PKB_1	134	142	PF00069	0.636
MOD_Plk_1	188	194	PF00069	0.367
MOD_Plk_1	33	39	PF00069	0.393
MOD_Plk_1	366	372	PF00069	0.557
MOD_Plk_1	68	74	PF00069	0.381
MOD_Plk_1	839	845	PF00069	0.506
MOD_Plk_2-3	427	433	PF00069	0.339
MOD_Plk_2-3	507	513	PF00069	0.386
MOD_Plk_2-3	86	92	PF00069	0.598
MOD_Plk_4	342	348	PF00069	0.514
MOD_Plk_4	427	433	PF00069	0.355
MOD_Plk_4	466	472	PF00069	0.346
MOD_Plk_4	507	513	PF00069	0.451
MOD_Plk_4	710	716	PF00069	0.550
MOD_ProDKin_1	107	113	PF00069	0.649
MOD_ProDKin_1	254	260	PF00069	0.590
MOD_ProDKin_1	313	319	PF00069	0.328
MOD_ProDKin_1	325	331	PF00069	0.497
MOD_ProDKin_1	373	379	PF00069	0.522
MOD_ProDKin_1	6	12	PF00069	0.480
MOD_ProDKin_1	783	789	PF00069	0.591
MOD_ProDKin_1	90	96	PF00069	0.656
MOD_SUMO_rev_2	631	636	PF00179	0.632
TRG_DiLeu_BaEn_1	507	512	PF01217	0.339
TRG_DiLeu_LyEn_5	483	488	PF01217	0.484
TRG_ENDOCYTIC_2	287	290	PF00928	0.367
TRG_ENDOCYTIC_2	425	428	PF00928	0.340
TRG_ENDOCYTIC_2	508	511	PF00928	0.338
TRG_ENDOCYTIC_2	657	660	PF00928	0.572
TRG_ER_diArg_1	133	136	PF00400	0.555
TRG_ER_diArg_1	406	409	PF00400	0.310
TRG_ER_diArg_1	604	607	PF00400	0.610
TRG_ER_diArg_1	705	708	PF00400	0.546
TRG_ER_diArg_1	764	766	PF00400	0.638
TRG_NES_CRM1_1	410	421	PF08389	0.324
TRG_NLS_MonoExtC_3	133	138	PF00514	0.661
TRG_NLS_MonoExtN_4	133	139	PF00514	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V8	Leptomonas seymouri	46%	95%
A0A3S5H5P2	Leishmania donovani	92%	100%
A4H4J4	Leishmania braziliensis	73%	100%
A4HSR9	Leishmania infantum	92%	100%
E9AKQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%