Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania major

UniProt:

Q4QJ48_LEIMA

TriTrypDb:

LmjF.06.0310 , LMJLV39_060008400 , LMJSD75_060008400

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QJ48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ48

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.680
CLV_C14_Caspase3-7	311	315	PF00656	0.577
CLV_NRD_NRD_1	209	211	PF00675	0.226
CLV_NRD_NRD_1	664	666	PF00675	0.456
CLV_PCSK_KEX2_1	150	152	PF00082	0.293
CLV_PCSK_KEX2_1	208	210	PF00082	0.251
CLV_PCSK_KEX2_1	285	287	PF00082	0.297
CLV_PCSK_KEX2_1	524	526	PF00082	0.521
CLV_PCSK_KEX2_1	664	666	PF00082	0.468
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.293
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.354
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.521
CLV_PCSK_PC7_1	205	211	PF00082	0.210
CLV_PCSK_SKI1_1	55	59	PF00082	0.305
DEG_APCC_DBOX_1	19	27	PF00400	0.660
DOC_CDC14_PxL_1	423	431	PF14671	0.200
DOC_CDC14_PxL_1	610	618	PF14671	0.331
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	627	633	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	635	641	PF00134	0.490
DOC_MAPK_gen_1	242	249	PF00069	0.211
DOC_MAPK_gen_1	524	532	PF00069	0.323
DOC_MAPK_HePTP_8	239	251	PF00069	0.220
DOC_MAPK_MEF2A_6	242	251	PF00069	0.320
DOC_MAPK_MEF2A_6	524	532	PF00069	0.357
DOC_MAPK_MEF2A_6	80	87	PF00069	0.524
DOC_MAPK_NFAT4_5	80	88	PF00069	0.604
DOC_PP1_RVXF_1	125	131	PF00149	0.606
DOC_PP2B_LxvP_1	445	448	PF13499	0.374
DOC_PP2B_LxvP_1	627	630	PF13499	0.358
DOC_PP4_FxxP_1	598	601	PF00568	0.271
DOC_SPAK_OSR1_1	111	115	PF12202	0.413
DOC_USP7_MATH_1	137	141	PF00917	0.529
DOC_USP7_MATH_1	303	307	PF00917	0.552
DOC_USP7_MATH_1	431	435	PF00917	0.582
DOC_USP7_MATH_1	450	454	PF00917	0.325
DOC_USP7_MATH_1	566	570	PF00917	0.485
DOC_USP7_MATH_1	585	589	PF00917	0.490
DOC_USP7_UBL2_3	308	312	PF12436	0.410
DOC_WW_Pin1_4	58	63	PF00397	0.483
LIG_14-3-3_CanoR_1	20	29	PF00244	0.557
LIG_14-3-3_CanoR_1	502	506	PF00244	0.491
LIG_14-3-3_CanoR_1	80	86	PF00244	0.519
LIG_BIR_II_1	1	5	PF00653	0.733
LIG_BRCT_BRCA1_1	258	262	PF00533	0.273
LIG_BRCT_BRCA1_1	335	339	PF00533	0.384
LIG_BRCT_BRCA1_1	433	437	PF00533	0.491
LIG_BRCT_BRCA1_1	438	442	PF00533	0.432
LIG_BRCT_BRCA1_1	468	472	PF00533	0.317
LIG_BRCT_BRCA1_1	499	503	PF00533	0.460
LIG_CaM_NSCaTE_8	222	229	PF13499	0.241
LIG_CSL_BTD_1	553	556	PF09270	0.397
LIG_FHA_1	253	259	PF00498	0.424
LIG_FHA_1	506	512	PF00498	0.325
LIG_FHA_1	555	561	PF00498	0.239
LIG_FHA_1	59	65	PF00498	0.570
LIG_FHA_1	80	86	PF00498	0.573
LIG_FHA_2	270	276	PF00498	0.607
LIG_FHA_2	341	347	PF00498	0.461
LIG_FHA_2	348	354	PF00498	0.498
LIG_GBD_Chelix_1	87	95	PF00786	0.230
LIG_LIR_Apic_2	46	52	PF02991	0.624
LIG_LIR_Apic_2	597	601	PF02991	0.302
LIG_LIR_Gen_1	200	211	PF02991	0.519
LIG_LIR_Gen_1	403	413	PF02991	0.295
LIG_LIR_Gen_1	439	450	PF02991	0.337
LIG_LIR_Gen_1	500	511	PF02991	0.485
LIG_LIR_Gen_1	516	523	PF02991	0.334
LIG_LIR_Gen_1	571	580	PF02991	0.511
LIG_LIR_Gen_1	607	618	PF02991	0.271
LIG_LIR_Gen_1	632	641	PF02991	0.282
LIG_LIR_Nem_3	165	171	PF02991	0.313
LIG_LIR_Nem_3	200	206	PF02991	0.530
LIG_LIR_Nem_3	219	225	PF02991	0.345
LIG_LIR_Nem_3	229	234	PF02991	0.350
LIG_LIR_Nem_3	403	408	PF02991	0.289
LIG_LIR_Nem_3	420	426	PF02991	0.360
LIG_LIR_Nem_3	434	440	PF02991	0.514
LIG_LIR_Nem_3	469	473	PF02991	0.296
LIG_LIR_Nem_3	504	510	PF02991	0.307
LIG_LIR_Nem_3	516	521	PF02991	0.335
LIG_LIR_Nem_3	571	577	PF02991	0.472
LIG_LIR_Nem_3	607	613	PF02991	0.265
LIG_LIR_Nem_3	632	636	PF02991	0.282
LIG_LRP6_Inhibitor_1	647	653	PF00058	0.188
LIG_MLH1_MIPbox_1	433	437	PF16413	0.571
LIG_PDZ_Class_2	671	676	PF00595	0.587
LIG_Pex14_1	220	224	PF04695	0.375
LIG_Pex14_1	405	409	PF04695	0.285
LIG_Pex14_1	424	428	PF04695	0.329
LIG_Pex14_2	108	112	PF04695	0.406
LIG_Pex14_2	186	190	PF04695	0.365
LIG_Pex14_2	263	267	PF04695	0.285
LIG_Pex14_2	438	442	PF04695	0.366
LIG_Pex14_2	468	472	PF04695	0.306
LIG_Pex14_2	492	496	PF04695	0.365
LIG_Pex14_2	503	507	PF04695	0.365
LIG_SH2_CRK	119	123	PF00017	0.512
LIG_SH2_CRK	168	172	PF00017	0.321
LIG_SH2_CRK	203	207	PF00017	0.515
LIG_SH2_CRK	384	388	PF00017	0.346
LIG_SH2_CRK	409	413	PF00017	0.355
LIG_SH2_CRK	440	444	PF00017	0.338
LIG_SH2_CRK	473	477	PF00017	0.298
LIG_SH2_CRK	574	578	PF00017	0.218
LIG_SH2_CRK	97	101	PF00017	0.527
LIG_SH2_GRB2like	328	331	PF00017	0.391
LIG_SH2_NCK_1	409	413	PF00017	0.416
LIG_SH2_NCK_1	473	477	PF00017	0.300
LIG_SH2_NCK_1	574	578	PF00017	0.299
LIG_SH2_NCK_1	97	101	PF00017	0.391
LIG_SH2_PTP2	49	52	PF00017	0.614
LIG_SH2_PTP2	529	532	PF00017	0.400
LIG_SH2_SRC	49	52	PF00017	0.620
LIG_SH2_STAP1	102	106	PF00017	0.530
LIG_SH2_STAP1	148	152	PF00017	0.501
LIG_SH2_STAP1	203	207	PF00017	0.486
LIG_SH2_STAP1	384	388	PF00017	0.394
LIG_SH2_STAP1	409	413	PF00017	0.284
LIG_SH2_STAP1	440	444	PF00017	0.328
LIG_SH2_STAP1	546	550	PF00017	0.406
LIG_SH2_STAP1	574	578	PF00017	0.339
LIG_SH2_STAT3	509	512	PF00017	0.358
LIG_SH2_STAT5	148	151	PF00017	0.498
LIG_SH2_STAT5	153	156	PF00017	0.340
LIG_SH2_STAT5	28	31	PF00017	0.550
LIG_SH2_STAT5	436	439	PF00017	0.350
LIG_SH2_STAT5	444	447	PF00017	0.340
LIG_SH2_STAT5	470	473	PF00017	0.261
LIG_SH2_STAT5	49	52	PF00017	0.609
LIG_SH2_STAT5	494	497	PF00017	0.450
LIG_SH2_STAT5	509	512	PF00017	0.260
LIG_SH2_STAT5	529	532	PF00017	0.305
LIG_SH2_STAT5	538	541	PF00017	0.291
LIG_SH2_STAT5	551	554	PF00017	0.395
LIG_SH2_STAT5	89	92	PF00017	0.517
LIG_SH3_3	460	466	PF00018	0.280
LIG_SH3_3	631	637	PF00018	0.396
LIG_SUMO_SIM_anti_2	410	416	PF11976	0.399
LIG_SUMO_SIM_anti_2	519	524	PF11976	0.315
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.251
LIG_SUMO_SIM_par_1	385	391	PF11976	0.300
LIG_SUMO_SIM_par_1	556	562	PF11976	0.329
LIG_TRFH_1	633	637	PF08558	0.291
LIG_TYR_ITIM	117	122	PF00017	0.299
LIG_TYR_ITIM	166	171	PF00017	0.377
LIG_TYR_ITIM	407	412	PF00017	0.374
LIG_TYR_ITIM	471	476	PF00017	0.338
LIG_TYR_ITIM	95	100	PF00017	0.451
LIG_WRC_WIRS_1	187	192	PF05994	0.251
LIG_WRC_WIRS_1	451	456	PF05994	0.335
MOD_CK1_1	213	219	PF00069	0.350
MOD_CK1_1	359	365	PF00069	0.410
MOD_CK1_1	391	397	PF00069	0.347
MOD_CK1_1	497	503	PF00069	0.352
MOD_CK2_1	269	275	PF00069	0.499
MOD_CK2_1	303	309	PF00069	0.435
MOD_CK2_1	312	318	PF00069	0.382
MOD_CMANNOS	220	223	PF00535	0.251
MOD_GlcNHglycan	114	117	PF01048	0.277
MOD_GlcNHglycan	175	179	PF01048	0.355
MOD_GlcNHglycan	212	215	PF01048	0.358
MOD_GlcNHglycan	226	229	PF01048	0.397
MOD_GlcNHglycan	23	26	PF01048	0.555
MOD_GlcNHglycan	258	261	PF01048	0.387
MOD_GlcNHglycan	305	308	PF01048	0.258
MOD_GlcNHglycan	314	317	PF01048	0.303
MOD_GlcNHglycan	321	324	PF01048	0.498
MOD_GlcNHglycan	334	338	PF01048	0.442
MOD_GlcNHglycan	476	479	PF01048	0.444
MOD_GlcNHglycan	515	518	PF01048	0.437
MOD_GlcNHglycan	646	650	PF01048	0.516
MOD_GSK3_1	209	216	PF00069	0.278
MOD_GSK3_1	252	259	PF00069	0.456
MOD_GSK3_1	297	304	PF00069	0.376
MOD_GSK3_1	396	403	PF00069	0.294
MOD_GSK3_1	497	504	PF00069	0.364
MOD_GSK3_1	583	590	PF00069	0.375
MOD_GSK3_1	600	607	PF00069	0.320
MOD_N-GLC_1	21	26	PF02516	0.406
MOD_NEK2_1	107	112	PF00069	0.292
MOD_NEK2_1	128	133	PF00069	0.376
MOD_NEK2_1	146	151	PF00069	0.283
MOD_NEK2_1	186	191	PF00069	0.332
MOD_NEK2_1	224	229	PF00069	0.326
MOD_NEK2_1	297	302	PF00069	0.327
MOD_NEK2_1	382	387	PF00069	0.366
MOD_NEK2_1	388	393	PF00069	0.350
MOD_NEK2_1	396	401	PF00069	0.329
MOD_NEK2_1	407	412	PF00069	0.320
MOD_NEK2_1	472	477	PF00069	0.356
MOD_NEK2_1	501	506	PF00069	0.361
MOD_NEK2_1	583	588	PF00069	0.355
MOD_NEK2_1	70	75	PF00069	0.369
MOD_NEK2_1	95	100	PF00069	0.354
MOD_NEK2_2	340	345	PF00069	0.343
MOD_NEK2_2	431	436	PF00069	0.423
MOD_NEK2_2	450	455	PF00069	0.337
MOD_PIKK_1	252	258	PF00454	0.200
MOD_PK_1	121	127	PF00069	0.452
MOD_PKA_1	173	179	PF00069	0.360
MOD_PKA_1	209	215	PF00069	0.187
MOD_PKA_2	209	215	PF00069	0.187
MOD_PKA_2	301	307	PF00069	0.204
MOD_PKA_2	501	507	PF00069	0.350
MOD_PKA_2	566	572	PF00069	0.339
MOD_PKA_2	79	85	PF00069	0.414
MOD_PKB_1	208	216	PF00069	0.200
MOD_Plk_1	21	27	PF00069	0.413
MOD_Plk_1	546	552	PF00069	0.346
MOD_Plk_4	213	219	PF00069	0.340
MOD_Plk_4	226	232	PF00069	0.334
MOD_Plk_4	356	362	PF00069	0.348
MOD_Plk_4	382	388	PF00069	0.352
MOD_Plk_4	396	402	PF00069	0.312
MOD_Plk_4	431	437	PF00069	0.439
MOD_Plk_4	450	456	PF00069	0.338
MOD_Plk_4	546	552	PF00069	0.310
MOD_Plk_4	554	560	PF00069	0.308
MOD_Plk_4	568	574	PF00069	0.371
MOD_Plk_4	590	596	PF00069	0.339
MOD_Plk_4	629	635	PF00069	0.369
MOD_Plk_4	95	101	PF00069	0.349
MOD_ProDKin_1	58	64	PF00069	0.322
MOD_SUMO_for_1	172	175	PF00179	0.197
MOD_SUMO_for_1	284	287	PF00179	0.392
MOD_SUMO_rev_2	240	245	PF00179	0.409
MOD_SUMO_rev_2	30	39	PF00179	0.688
MOD_SUMO_rev_2	306	313	PF00179	0.372
MOD_SUMO_rev_2	593	601	PF00179	0.200
TRG_ENDOCYTIC_2	102	105	PF00928	0.360
TRG_ENDOCYTIC_2	119	122	PF00928	0.321
TRG_ENDOCYTIC_2	168	171	PF00928	0.336
TRG_ENDOCYTIC_2	203	206	PF00928	0.338
TRG_ENDOCYTIC_2	384	387	PF00928	0.347
TRG_ENDOCYTIC_2	409	412	PF00928	0.358
TRG_ENDOCYTIC_2	440	443	PF00928	0.352
TRG_ENDOCYTIC_2	444	447	PF00928	0.352
TRG_ENDOCYTIC_2	473	476	PF00928	0.351
TRG_ENDOCYTIC_2	529	532	PF00928	0.491
TRG_ENDOCYTIC_2	574	577	PF00928	0.340
TRG_ENDOCYTIC_2	97	100	PF00928	0.371
TRG_ER_diArg_1	18	21	PF00400	0.590
TRG_ER_diArg_1	207	210	PF00400	0.271
TRG_NES_CRM1_1	446	460	PF08389	0.301
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	48%	96%
A0A0N1HY49	Leptomonas seymouri	66%	100%
A0A0N1HZ06	Leptomonas seymouri	43%	100%
A0A0N1IHL1	Leptomonas seymouri	43%	95%
A0A0N1PAY4	Leptomonas seymouri	42%	77%
A0A0N1PB77	Leptomonas seymouri	39%	100%
A0A0N1PBZ2	Leptomonas seymouri	48%	100%
A0A0N1PCC1	Leptomonas seymouri	53%	100%
A0A0S4INN8	Bodo saltans	29%	100%
A0A381MBI0	Leishmania infantum	44%	100%
A0A3Q8I8X7	Leishmania donovani	44%	100%
A0A3Q8IAZ0	Leishmania donovani	43%	97%
A0A3Q8IH50	Leishmania donovani	49%	94%
A0A3Q8IVN0	Leishmania donovani	40%	100%
A0A3R7M4J1	Trypanosoma rangeli	45%	100%
A0A3S5H5P4	Leishmania donovani	94%	100%
A0A3S5H5V2	Leishmania donovani	46%	100%
A0A3S5H6F6	Leishmania donovani	43%	97%
A0A3S5H763	Leishmania donovani	49%	100%
A0A3S7WR10	Leishmania donovani	45%	91%
A0A3S7WR14	Leishmania donovani	44%	99%
A0A3S7WR15	Leishmania donovani	41%	80%
A0A3S7WR24	Leishmania donovani	43%	96%
A4H4T8	Leishmania braziliensis	45%	100%
A4H5Y4	Leishmania braziliensis	46%	100%
A4H617	Leishmania braziliensis	44%	97%
A4H618	Leishmania braziliensis	45%	99%
A4H619	Leishmania braziliensis	45%	97%
A4H620	Leishmania braziliensis	50%	96%
A4H6C3	Leishmania braziliensis	46%	100%
A4HNH7	Leishmania braziliensis	39%	100%
A4HSS2	Leishmania infantum	95%	100%
A4HUE4	Leishmania infantum	45%	91%
A4HUE5	Leishmania infantum	41%	98%
A4HUE6	Leishmania infantum	44%	99%
A4HUE7	Leishmania infantum	42%	97%
A4HUE8	Leishmania infantum	43%	96%
A4HUF4	Leishmania infantum	43%	97%
A4HUF5	Leishmania infantum	48%	100%
A4HYA9	Leishmania infantum	49%	100%
A4IC33	Leishmania infantum	40%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	97%
E9AG72	Leishmania infantum	46%	100%
E9AI40	Leishmania braziliensis	44%	99%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	95%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4QDC4	Leishmania major	52%	100%
Q4QH81	Leishmania major	46%	100%
Q4QHH7	Leishmania major	50%	100%
Q4QHH8	Leishmania major	43%	100%
Q4QHH9	Leishmania major	43%	100%
Q4QHI0	Leishmania major	42%	100%
Q4QHI1	Leishmania major	45%	100%
Q4QHI2	Leishmania major	44%	100%
Q4QIU9	Leishmania major	47%	100%
Q7KIP2	Leishmania major	39%	98%