Hyccin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Hyccin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ43_LEIMA

TriTrypDb:

LmjF.06.0360 , LMJLV39_060009000 , LMJSD75_060009100

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.665
CLV_C14_Caspase3-7	431	435	PF00656	0.650
CLV_NRD_NRD_1	103	105	PF00675	0.558
CLV_NRD_NRD_1	259	261	PF00675	0.553
CLV_NRD_NRD_1	339	341	PF00675	0.601
CLV_NRD_NRD_1	396	398	PF00675	0.589
CLV_NRD_NRD_1	402	404	PF00675	0.558
CLV_PCSK_KEX2_1	103	105	PF00082	0.540
CLV_PCSK_KEX2_1	339	341	PF00082	0.596
CLV_PCSK_KEX2_1	395	397	PF00082	0.602
CLV_PCSK_KEX2_1	404	406	PF00082	0.556
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.613
CLV_PCSK_SKI1_1	104	108	PF00082	0.705
CLV_PCSK_SKI1_1	154	158	PF00082	0.592
CLV_PCSK_SKI1_1	217	221	PF00082	0.545
CLV_PCSK_SKI1_1	327	331	PF00082	0.712
CLV_PCSK_SKI1_1	334	338	PF00082	0.629
CLV_PCSK_SKI1_1	397	401	PF00082	0.585
CLV_PCSK_SKI1_1	40	44	PF00082	0.429
DEG_APCC_DBOX_1	216	224	PF00400	0.524
DOC_CYCLIN_yClb5_NLxxxL_5	239	245	PF00134	0.559
DOC_MAPK_gen_1	196	204	PF00069	0.620
DOC_MAPK_gen_1	395	401	PF00069	0.726
DOC_PP2B_LxvP_1	233	236	PF13499	0.582
DOC_PP2B_LxvP_1	379	382	PF13499	0.699
DOC_USP7_MATH_1	134	138	PF00917	0.665
DOC_USP7_MATH_1	169	173	PF00917	0.459
DOC_USP7_MATH_1	286	290	PF00917	0.617
DOC_USP7_MATH_1	419	423	PF00917	0.602
DOC_USP7_MATH_1	50	54	PF00917	0.593
DOC_USP7_MATH_1	60	64	PF00917	0.538
DOC_WW_Pin1_4	205	210	PF00397	0.567
DOC_WW_Pin1_4	266	271	PF00397	0.557
DOC_WW_Pin1_4	80	85	PF00397	0.434
LIG_14-3-3_CanoR_1	154	159	PF00244	0.608
LIG_14-3-3_CanoR_1	184	188	PF00244	0.524
LIG_14-3-3_CanoR_1	239	244	PF00244	0.484
LIG_14-3-3_CanoR_1	249	257	PF00244	0.422
LIG_14-3-3_CanoR_1	260	265	PF00244	0.544
LIG_14-3-3_CanoR_1	284	293	PF00244	0.715
LIG_14-3-3_CanoR_1	33	39	PF00244	0.609
LIG_14-3-3_CanoR_1	407	417	PF00244	0.745
LIG_Actin_WH2_2	139	156	PF00022	0.552
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_Clathr_ClatBox_1	254	258	PF01394	0.589
LIG_Clathr_ClatBox_1	436	440	PF01394	0.678
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.549
LIG_DLG_GKlike_1	260	267	PF00625	0.504
LIG_FHA_1	250	256	PF00498	0.491
LIG_FHA_1	290	296	PF00498	0.659
LIG_FHA_1	404	410	PF00498	0.747
LIG_FHA_1	423	429	PF00498	0.662
LIG_FHA_1	431	437	PF00498	0.700
LIG_FHA_2	196	202	PF00498	0.628
LIG_FHA_2	429	435	PF00498	0.690
LIG_FHA_2	8	14	PF00498	0.624
LIG_GBD_Chelix_1	88	96	PF00786	0.668
LIG_LIR_Gen_1	222	232	PF02991	0.489
LIG_LIR_Gen_1	263	272	PF02991	0.419
LIG_LIR_Gen_1	35	45	PF02991	0.578
LIG_LIR_Gen_1	367	374	PF02991	0.631
LIG_LIR_Nem_3	222	227	PF02991	0.455
LIG_LIR_Nem_3	231	235	PF02991	0.518
LIG_LIR_Nem_3	263	267	PF02991	0.409
LIG_LIR_Nem_3	35	41	PF02991	0.487
LIG_LIR_Nem_3	367	371	PF02991	0.623
LIG_NRBOX	222	228	PF00104	0.507
LIG_PDZ_Class_3	446	451	PF00595	0.678
LIG_SH2_CRK	161	165	PF00017	0.417
LIG_SH2_GRB2like	161	164	PF00017	0.416
LIG_SH2_SRC	314	317	PF00017	0.608
LIG_SH2_STAP1	264	268	PF00017	0.420
LIG_SH2_STAT5	145	148	PF00017	0.415
LIG_SH2_STAT5	161	164	PF00017	0.635
LIG_SH2_STAT5	232	235	PF00017	0.449
LIG_SH2_STAT5	373	376	PF00017	0.625
LIG_Sin3_1	223	233	PF02671	0.474
LIG_SUMO_SIM_par_1	251	258	PF11976	0.589
LIG_SUMO_SIM_par_1	269	276	PF11976	0.301
LIG_SUMO_SIM_par_1	431	440	PF11976	0.699
LIG_TYR_ITIM	262	267	PF00017	0.421
LIG_UBA3_1	92	101	PF00899	0.537
LIG_WRC_WIRS_1	174	179	PF05994	0.512
MOD_CDK_SPxK_1	80	86	PF00069	0.428
MOD_CK1_1	21	27	PF00069	0.600
MOD_CK1_1	248	254	PF00069	0.477
MOD_CK1_1	289	295	PF00069	0.602
MOD_CK1_1	319	325	PF00069	0.690
MOD_CK1_1	389	395	PF00069	0.671
MOD_CK1_1	422	428	PF00069	0.591
MOD_CK2_1	134	140	PF00069	0.687
MOD_CK2_1	195	201	PF00069	0.640
MOD_CK2_1	231	237	PF00069	0.497
MOD_CK2_1	260	266	PF00069	0.583
MOD_Cter_Amidation	258	261	PF01082	0.558
MOD_Cter_Amidation	331	334	PF01082	0.740
MOD_GlcNHglycan	166	169	PF01048	0.484
MOD_GlcNHglycan	171	174	PF01048	0.464
MOD_GlcNHglycan	214	217	PF01048	0.522
MOD_GlcNHglycan	284	287	PF01048	0.676
MOD_GlcNHglycan	306	309	PF01048	0.516
MOD_GlcNHglycan	323	327	PF01048	0.434
MOD_GlcNHglycan	34	37	PF01048	0.585
MOD_GlcNHglycan	388	391	PF01048	0.659
MOD_GlcNHglycan	421	424	PF01048	0.742
MOD_GlcNHglycan	52	55	PF01048	0.477
MOD_GlcNHglycan	56	59	PF01048	0.599
MOD_GlcNHglycan	75	78	PF01048	0.418
MOD_GlcNHglycan	80	83	PF01048	0.630
MOD_GSK3_1	169	176	PF00069	0.484
MOD_GSK3_1	207	214	PF00069	0.514
MOD_GSK3_1	244	251	PF00069	0.423
MOD_GSK3_1	262	269	PF00069	0.494
MOD_GSK3_1	273	280	PF00069	0.463
MOD_GSK3_1	282	289	PF00069	0.363
MOD_GSK3_1	403	410	PF00069	0.711
MOD_GSK3_1	50	57	PF00069	0.621
MOD_N-GLC_1	114	119	PF02516	0.500
MOD_N-GLC_1	159	164	PF02516	0.644
MOD_N-GLC_1	239	244	PF02516	0.517
MOD_NEK2_1	177	182	PF00069	0.461
MOD_NEK2_1	219	224	PF00069	0.463
MOD_NEK2_1	244	249	PF00069	0.457
MOD_NEK2_1	277	282	PF00069	0.556
MOD_NEK2_1	304	309	PF00069	0.676
MOD_NEK2_1	34	39	PF00069	0.598
MOD_NEK2_1	348	353	PF00069	0.516
MOD_NEK2_1	358	363	PF00069	0.560
MOD_NEK2_1	92	97	PF00069	0.566
MOD_OFUCOSY	105	112	PF10250	0.706
MOD_PIKK_1	114	120	PF00454	0.734
MOD_PKA_1	260	266	PF00069	0.505
MOD_PKA_1	403	409	PF00069	0.673
MOD_PKA_2	183	189	PF00069	0.471
MOD_PKA_2	248	254	PF00069	0.507
MOD_PKA_2	32	38	PF00069	0.627
MOD_PKB_1	405	413	PF00069	0.663
MOD_Plk_1	239	245	PF00069	0.498
MOD_Plk_2-3	231	237	PF00069	0.497
MOD_Plk_4	177	183	PF00069	0.478
MOD_Plk_4	21	27	PF00069	0.586
MOD_Plk_4	219	225	PF00069	0.443
MOD_Plk_4	239	245	PF00069	0.229
MOD_Plk_4	92	98	PF00069	0.554
MOD_ProDKin_1	205	211	PF00069	0.570
MOD_ProDKin_1	266	272	PF00069	0.555
MOD_ProDKin_1	80	86	PF00069	0.428
MOD_SUMO_for_1	309	312	PF00179	0.607
MOD_SUMO_rev_2	325	335	PF00179	0.712
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.583
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.611
TRG_ENDOCYTIC_2	161	164	PF00928	0.494
TRG_ENDOCYTIC_2	232	235	PF00928	0.480
TRG_ENDOCYTIC_2	264	267	PF00928	0.411
TRG_ENDOCYTIC_2	38	41	PF00928	0.467
TRG_ER_diArg_1	338	340	PF00400	0.625
TRG_ER_diArg_1	395	397	PF00400	0.650
TRG_NLS_MonoExtC_3	402	407	PF00514	0.652
TRG_NLS_MonoExtN_4	403	408	PF00514	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ7	Leptomonas seymouri	46%	100%
A0A1X0NL47	Trypanosomatidae	33%	98%
A0A3S5H5P7	Leishmania donovani	95%	100%
A0A3S5IR10	Trypanosoma rangeli	30%	97%
A4H4K1	Leishmania braziliensis	78%	100%
A4HSS7	Leishmania infantum	95%	100%
C9ZTC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	98%
E9AKR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BA95	Trypanosoma cruzi	32%	98%