C3H1-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 35

Species:

Leishmania major

UniProt:

Q4QJ41_LEIMA

TriTrypDb:

LmjF.06.0380 , LMJLV39_060009300 , LMJSD75_060009300

Length:

401

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005741	mitochondrial outer membrane	5	2
GO:0005929	cilium	4	13
GO:0016020	membrane	2	6
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13

Expansion

Sequence features

Q4QJ41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ41

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003729	mRNA binding	5	10
GO:0005488	binding	1	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.437
CLV_C14_Caspase3-7	56	60	PF00656	0.552
CLV_NRD_NRD_1	227	229	PF00675	0.632
CLV_NRD_NRD_1	257	259	PF00675	0.613
CLV_PCSK_FUR_1	38	42	PF00082	0.645
CLV_PCSK_KEX2_1	227	229	PF00082	0.771
CLV_PCSK_KEX2_1	257	259	PF00082	0.748
CLV_PCSK_KEX2_1	40	42	PF00082	0.665
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.646
CLV_PCSK_SKI1_1	257	261	PF00082	0.700
CLV_PCSK_SKI1_1	7	11	PF00082	0.196
DEG_APCC_DBOX_1	6	14	PF00400	0.196
DEG_SPOP_SBC_1	326	330	PF00917	0.489
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.487
DOC_PP2B_LxvP_1	341	344	PF13499	0.484
DOC_USP7_MATH_1	267	271	PF00917	0.581
DOC_USP7_MATH_1	286	290	PF00917	0.238
DOC_USP7_MATH_1	314	318	PF00917	0.433
DOC_USP7_MATH_1	379	383	PF00917	0.550
DOC_WW_Pin1_4	12	17	PF00397	0.368
DOC_WW_Pin1_4	364	369	PF00397	0.566
LIG_14-3-3_CanoR_1	207	212	PF00244	0.445
LIG_14-3-3_CanoR_1	258	264	PF00244	0.504
LIG_APCC_ABBA_1	107	112	PF00400	0.405
LIG_APCC_ABBAyCdc20_2	46	52	PF00400	0.428
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BRCT_BRCA1_1	323	327	PF00533	0.510
LIG_EH_1	218	222	PF12763	0.400
LIG_FHA_1	15	21	PF00498	0.238
LIG_FHA_1	297	303	PF00498	0.401
LIG_FHA_1	327	333	PF00498	0.443
LIG_FHA_2	61	67	PF00498	0.475
LIG_LIR_Gen_1	105	115	PF02991	0.382
LIG_LIR_Gen_1	206	216	PF02991	0.398
LIG_LIR_Nem_3	105	110	PF02991	0.427
LIG_LIR_Nem_3	48	53	PF02991	0.455
LIG_SH2_NCK_1	311	315	PF00017	0.443
LIG_SH2_PTP2	293	296	PF00017	0.262
LIG_SH2_SRC	135	138	PF00017	0.311
LIG_SH2_SRC	293	296	PF00017	0.275
LIG_SH2_SRC	361	364	PF00017	0.457
LIG_SH2_STAP1	361	365	PF00017	0.458
LIG_SH2_STAP1	50	54	PF00017	0.411
LIG_SH2_STAT5	135	138	PF00017	0.311
LIG_SH2_STAT5	293	296	PF00017	0.265
LIG_SH2_STAT5	53	56	PF00017	0.425
LIG_SH2_STAT5	78	81	PF00017	0.448
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.343
LIG_SUMO_SIM_anti_2	387	392	PF11976	0.377
LIG_TRAF2_1	65	68	PF00917	0.496
LIG_TYR_ITIM	133	138	PF00017	0.362
LIG_UBA3_1	143	148	PF00899	0.353
MOD_CK1_1	127	133	PF00069	0.354
MOD_CK1_1	139	145	PF00069	0.354
MOD_CK1_1	22	28	PF00069	0.606
MOD_CK1_1	309	315	PF00069	0.569
MOD_CK1_1	328	334	PF00069	0.611
MOD_CK1_1	364	370	PF00069	0.718
MOD_CK1_1	57	63	PF00069	0.627
MOD_CK2_1	197	203	PF00069	0.478
MOD_CK2_1	309	315	PF00069	0.464
MOD_GlcNHglycan	160	164	PF01048	0.384
MOD_GlcNHglycan	24	27	PF01048	0.615
MOD_GlcNHglycan	315	319	PF01048	0.673
MOD_GlcNHglycan	56	59	PF01048	0.594
MOD_GSK3_1	12	19	PF00069	0.449
MOD_GSK3_1	123	130	PF00069	0.396
MOD_GSK3_1	203	210	PF00069	0.584
MOD_GSK3_1	259	266	PF00069	0.712
MOD_GSK3_1	305	312	PF00069	0.671
MOD_GSK3_1	321	328	PF00069	0.598
MOD_N-GLC_1	124	129	PF02516	0.423
MOD_N-GLC_1	250	255	PF02516	0.536
MOD_NEK2_1	159	164	PF00069	0.416
MOD_NEK2_1	177	182	PF00069	0.365
MOD_NEK2_1	189	194	PF00069	0.412
MOD_NEK2_1	259	264	PF00069	0.726
MOD_NEK2_1	327	332	PF00069	0.580
MOD_NEK2_1	386	391	PF00069	0.301
MOD_PIKK_1	373	379	PF00454	0.567
MOD_PK_1	197	203	PF00069	0.408
MOD_PKA_1	45	51	PF00069	0.580
MOD_PKB_1	334	342	PF00069	0.632
MOD_Plk_1	124	130	PF00069	0.422
MOD_Plk_1	139	145	PF00069	0.413
MOD_Plk_1	189	195	PF00069	0.455
MOD_Plk_1	197	203	PF00069	0.464
MOD_Plk_1	296	302	PF00069	0.659
MOD_Plk_1	361	367	PF00069	0.801
MOD_Plk_1	69	75	PF00069	0.727
MOD_Plk_4	124	130	PF00069	0.366
MOD_Plk_4	139	145	PF00069	0.354
MOD_Plk_4	16	22	PF00069	0.500
MOD_Plk_4	189	195	PF00069	0.465
MOD_Plk_4	197	203	PF00069	0.482
MOD_Plk_4	259	265	PF00069	0.628
MOD_Plk_4	306	312	PF00069	0.569
MOD_Plk_4	379	385	PF00069	0.561
MOD_Plk_4	386	392	PF00069	0.264
MOD_Plk_4	45	51	PF00069	0.692
MOD_ProDKin_1	12	18	PF00069	0.368
MOD_ProDKin_1	364	370	PF00069	0.729
MOD_SUMO_rev_2	233	238	PF00179	0.664
TRG_ENDOCYTIC_2	135	138	PF00928	0.370
TRG_ENDOCYTIC_2	208	211	PF00928	0.463
TRG_ER_diArg_1	226	228	PF00400	0.652
TRG_ER_diArg_1	257	259	PF00400	0.502
TRG_ER_diArg_1	334	337	PF00400	0.587
TRG_ER_diArg_1	340	343	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NM91	Trypanosomatidae	52%	97%
A0A3R7KZS1	Trypanosoma rangeli	51%	99%
A0A3S5H5P9	Leishmania donovani	96%	100%
A0A3S7X0C2	Leishmania donovani	22%	100%
A4H4K3	Leishmania braziliensis	86%	100%
A4HFD8	Leishmania braziliensis	23%	100%
A4HSS9	Leishmania infantum	96%	100%
A4I356	Leishmania infantum	22%	100%
C9ZTD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AKR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BXP3	Trypanosoma cruzi	58%	99%