Folliculin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Folliculin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ40_LEIMA

TriTrypDb:

LmjF.06.0390 , LMJLV39_060009400 , LMJSD75_060009400

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.419
CLV_C14_Caspase3-7	611	615	PF00656	0.539
CLV_NRD_NRD_1	11	13	PF00675	0.511
CLV_NRD_NRD_1	400	402	PF00675	0.615
CLV_NRD_NRD_1	642	644	PF00675	0.603
CLV_NRD_NRD_1	838	840	PF00675	0.468
CLV_PCSK_KEX2_1	11	13	PF00082	0.601
CLV_PCSK_KEX2_1	221	223	PF00082	0.392
CLV_PCSK_KEX2_1	402	404	PF00082	0.613
CLV_PCSK_KEX2_1	838	840	PF00082	0.540
CLV_PCSK_KEX2_1	879	881	PF00082	0.555
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.451
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.624
CLV_PCSK_PC1ET2_1	879	881	PF00082	0.451
CLV_PCSK_PC7_1	834	840	PF00082	0.445
CLV_PCSK_SKI1_1	142	146	PF00082	0.438
CLV_PCSK_SKI1_1	441	445	PF00082	0.414
CLV_PCSK_SKI1_1	839	843	PF00082	0.504
CLV_PCSK_SKI1_1	860	864	PF00082	0.594
CLV_PCSK_SKI1_1	93	97	PF00082	0.427
DEG_APCC_DBOX_1	520	528	PF00400	0.436
DEG_SCF_TRCP1_1	481	487	PF00400	0.564
DEG_SPOP_SBC_1	699	703	PF00917	0.595
DOC_CKS1_1	227	232	PF01111	0.461
DOC_CKS1_1	690	695	PF01111	0.583
DOC_CYCLIN_RxL_1	139	148	PF00134	0.445
DOC_CYCLIN_RxL_1	62	74	PF00134	0.359
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.436
DOC_MAPK_DCC_7	741	751	PF00069	0.413
DOC_MAPK_gen_1	221	227	PF00069	0.363
DOC_MAPK_JIP1_4	747	753	PF00069	0.510
DOC_MAPK_MEF2A_6	116	125	PF00069	0.375
DOC_MAPK_MEF2A_6	547	555	PF00069	0.462
DOC_MAPK_MEF2A_6	896	904	PF00069	0.606
DOC_PP1_RVXF_1	365	371	PF00149	0.428
DOC_PP2B_LxvP_1	133	136	PF13499	0.463
DOC_PP2B_LxvP_1	311	314	PF13499	0.503
DOC_PP2B_LxvP_1	69	72	PF13499	0.404
DOC_SPAK_OSR1_1	347	351	PF12202	0.538
DOC_USP7_MATH_1	36	40	PF00917	0.458
DOC_USP7_MATH_1	424	428	PF00917	0.629
DOC_USP7_MATH_1	512	516	PF00917	0.510
DOC_USP7_MATH_1	642	646	PF00917	0.592
DOC_USP7_MATH_1	699	703	PF00917	0.636
DOC_USP7_MATH_1	75	79	PF00917	0.508
DOC_USP7_MATH_1	786	790	PF00917	0.783
DOC_WW_Pin1_4	226	231	PF00397	0.425
DOC_WW_Pin1_4	315	320	PF00397	0.628
DOC_WW_Pin1_4	378	383	PF00397	0.461
DOC_WW_Pin1_4	484	489	PF00397	0.745
DOC_WW_Pin1_4	490	495	PF00397	0.776
DOC_WW_Pin1_4	530	535	PF00397	0.477
DOC_WW_Pin1_4	558	563	PF00397	0.498
DOC_WW_Pin1_4	603	608	PF00397	0.508
DOC_WW_Pin1_4	677	682	PF00397	0.691
DOC_WW_Pin1_4	689	694	PF00397	0.582
LIG_14-3-3_CanoR_1	280	285	PF00244	0.432
LIG_14-3-3_CanoR_1	321	330	PF00244	0.627
LIG_14-3-3_CanoR_1	403	408	PF00244	0.725
LIG_14-3-3_CanoR_1	441	450	PF00244	0.489
LIG_14-3-3_CanoR_1	568	572	PF00244	0.497
LIG_14-3-3_CanoR_1	600	606	PF00244	0.542
LIG_14-3-3_CanoR_1	734	743	PF00244	0.672
LIG_14-3-3_CanoR_1	762	767	PF00244	0.482
LIG_14-3-3_CanoR_1	773	777	PF00244	0.651
LIG_14-3-3_CanoR_1	896	904	PF00244	0.562
LIG_APCC_ABBA_1	61	66	PF00400	0.485
LIG_APCC_ABBAyCdc20_2	93	99	PF00400	0.429
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_BRCT_BRCA1_1	15	19	PF00533	0.553
LIG_BRCT_BRCA1_1	512	516	PF00533	0.471
LIG_BRCT_BRCA1_1	57	61	PF00533	0.359
LIG_BRCT_BRCA1_1	836	840	PF00533	0.507
LIG_Clathr_ClatBox_1	261	265	PF01394	0.639
LIG_Clathr_ClatBox_1	290	294	PF01394	0.295
LIG_deltaCOP1_diTrp_1	15	23	PF00928	0.518
LIG_FHA_1	139	145	PF00498	0.500
LIG_FHA_1	19	25	PF00498	0.533
LIG_FHA_1	227	233	PF00498	0.344
LIG_FHA_1	26	32	PF00498	0.547
LIG_FHA_1	271	277	PF00498	0.615
LIG_FHA_1	372	378	PF00498	0.581
LIG_FHA_1	455	461	PF00498	0.470
LIG_FHA_1	661	667	PF00498	0.605
LIG_FHA_1	713	719	PF00498	0.487
LIG_FHA_1	814	820	PF00498	0.471
LIG_FHA_1	851	857	PF00498	0.533
LIG_FHA_2	431	437	PF00498	0.636
LIG_FHA_2	467	473	PF00498	0.546
LIG_FHA_2	773	779	PF00498	0.614
LIG_FHA_2	798	804	PF00498	0.700
LIG_FHA_2	864	870	PF00498	0.625
LIG_Integrin_isoDGR_2	365	367	PF01839	0.406
LIG_IRF3_LxIS_1	897	903	PF10401	0.609
LIG_LIR_Gen_1	452	460	PF02991	0.412
LIG_LIR_Gen_1	468	478	PF02991	0.368
LIG_LIR_Gen_1	52	61	PF02991	0.325
LIG_LIR_Gen_1	570	580	PF02991	0.490
LIG_LIR_Gen_1	818	826	PF02991	0.425
LIG_LIR_Gen_1	894	905	PF02991	0.574
LIG_LIR_LC3C_4	714	719	PF02991	0.440
LIG_LIR_Nem_3	277	282	PF02991	0.426
LIG_LIR_Nem_3	433	438	PF02991	0.501
LIG_LIR_Nem_3	452	456	PF02991	0.343
LIG_LIR_Nem_3	468	474	PF02991	0.339
LIG_LIR_Nem_3	52	56	PF02991	0.351
LIG_LIR_Nem_3	570	576	PF02991	0.494
LIG_LIR_Nem_3	58	64	PF02991	0.357
LIG_LIR_Nem_3	765	769	PF02991	0.368
LIG_LIR_Nem_3	818	823	PF02991	0.414
LIG_LIR_Nem_3	866	871	PF02991	0.435
LIG_LIR_Nem_3	894	900	PF02991	0.584
LIG_LYPXL_yS_3	214	217	PF13949	0.398
LIG_NRBOX	256	262	PF00104	0.617
LIG_NRBOX	306	312	PF00104	0.398
LIG_PCNA_yPIPBox_3	247	261	PF02747	0.531
LIG_Pex14_2	19	23	PF04695	0.462
LIG_Pex14_2	470	474	PF04695	0.394
LIG_PTB_Apo_2	861	868	PF02174	0.405
LIG_PTB_Phospho_1	861	867	PF10480	0.406
LIG_SH2_CRK	3	7	PF00017	0.534
LIG_SH2_CRK	53	57	PF00017	0.277
LIG_SH2_CRK	760	764	PF00017	0.367
LIG_SH2_NCK_1	340	344	PF00017	0.383
LIG_SH2_STAP1	155	159	PF00017	0.410
LIG_SH2_STAP1	53	57	PF00017	0.277
LIG_SH2_STAP1	767	771	PF00017	0.390
LIG_SH2_STAT3	546	549	PF00017	0.503
LIG_SH2_STAT5	3	6	PF00017	0.579
LIG_SH2_STAT5	752	755	PF00017	0.396
LIG_SH3_3	210	216	PF00018	0.397
LIG_SH3_3	224	230	PF00018	0.316
LIG_SH3_3	311	317	PF00018	0.584
LIG_SH3_3	556	562	PF00018	0.515
LIG_SUMO_SIM_anti_2	34	40	PF11976	0.390
LIG_SUMO_SIM_anti_2	376	381	PF11976	0.405
LIG_SUMO_SIM_anti_2	523	528	PF11976	0.490
LIG_SUMO_SIM_anti_2	566	573	PF11976	0.577
LIG_SUMO_SIM_anti_2	662	669	PF11976	0.488
LIG_SUMO_SIM_anti_2	714	720	PF11976	0.497
LIG_SUMO_SIM_par_1	662	669	PF11976	0.488
LIG_TRAF2_1	414	417	PF00917	0.596
LIG_TRFH_1	603	607	PF08558	0.559
LIG_TYR_ITSM	864	871	PF00017	0.530
LIG_WRPW_2	279	282	PF00400	0.412
LIG_WRPW_2	61	64	PF00400	0.406
LIG_WW_1	271	274	PF00397	0.636
LIG_WW_3	5	9	PF00397	0.534
MOD_CDC14_SPxK_1	318	321	PF00782	0.520
MOD_CDK_SPxK_1	315	321	PF00069	0.506
MOD_CK1_1	108	114	PF00069	0.491
MOD_CK1_1	249	255	PF00069	0.679
MOD_CK1_1	324	330	PF00069	0.578
MOD_CK1_1	378	384	PF00069	0.476
MOD_CK1_1	442	448	PF00069	0.489
MOD_CK1_1	473	479	PF00069	0.504
MOD_CK1_1	484	490	PF00069	0.657
MOD_CK1_1	493	499	PF00069	0.461
MOD_CK1_1	510	516	PF00069	0.312
MOD_CK1_1	533	539	PF00069	0.491
MOD_CK1_1	557	563	PF00069	0.530
MOD_CK1_1	564	570	PF00069	0.449
MOD_CK1_1	606	612	PF00069	0.525
MOD_CK1_1	703	709	PF00069	0.648
MOD_CK1_1	711	717	PF00069	0.432
MOD_CK1_1	737	743	PF00069	0.734
MOD_CK1_1	825	831	PF00069	0.467
MOD_CK1_1	895	901	PF00069	0.706
MOD_CK2_1	108	114	PF00069	0.353
MOD_CK2_1	249	255	PF00069	0.701
MOD_CK2_1	354	360	PF00069	0.442
MOD_CK2_1	411	417	PF00069	0.699
MOD_CK2_1	430	436	PF00069	0.618
MOD_CK2_1	46	52	PF00069	0.459
MOD_CK2_1	466	472	PF00069	0.400
MOD_CK2_1	642	648	PF00069	0.589
MOD_CK2_1	662	668	PF00069	0.505
MOD_CK2_1	786	792	PF00069	0.620
MOD_CK2_1	797	803	PF00069	0.701
MOD_CK2_1	825	831	PF00069	0.450
MOD_CK2_1	863	869	PF00069	0.484
MOD_GlcNHglycan	107	110	PF01048	0.499
MOD_GlcNHglycan	147	150	PF01048	0.480
MOD_GlcNHglycan	327	330	PF01048	0.585
MOD_GlcNHglycan	412	416	PF01048	0.794
MOD_GlcNHglycan	441	444	PF01048	0.431
MOD_GlcNHglycan	475	478	PF01048	0.551
MOD_GlcNHglycan	480	484	PF01048	0.578
MOD_GlcNHglycan	509	512	PF01048	0.593
MOD_GlcNHglycan	530	533	PF01048	0.559
MOD_GlcNHglycan	556	559	PF01048	0.506
MOD_GlcNHglycan	610	613	PF01048	0.518
MOD_GlcNHglycan	644	647	PF01048	0.707
MOD_GlcNHglycan	73	76	PF01048	0.488
MOD_GlcNHglycan	77	80	PF01048	0.425
MOD_GlcNHglycan	824	827	PF01048	0.512
MOD_GSK3_1	270	277	PF00069	0.547
MOD_GSK3_1	321	328	PF00069	0.600
MOD_GSK3_1	37	44	PF00069	0.569
MOD_GSK3_1	371	378	PF00069	0.577
MOD_GSK3_1	454	461	PF00069	0.460
MOD_GSK3_1	466	473	PF00069	0.403
MOD_GSK3_1	486	493	PF00069	0.556
MOD_GSK3_1	506	513	PF00069	0.597
MOD_GSK3_1	554	561	PF00069	0.526
MOD_GSK3_1	563	570	PF00069	0.457
MOD_GSK3_1	606	613	PF00069	0.547
MOD_GSK3_1	699	706	PF00069	0.680
MOD_GSK3_1	708	715	PF00069	0.634
MOD_GSK3_1	71	78	PF00069	0.590
MOD_GSK3_1	733	740	PF00069	0.589
MOD_GSK3_1	772	779	PF00069	0.644
MOD_GSK3_1	846	853	PF00069	0.502
MOD_GSK3_1	888	895	PF00069	0.586
MOD_LATS_1	245	251	PF00433	0.611
MOD_N-GLC_1	422	427	PF02516	0.695
MOD_N-GLC_1	430	435	PF02516	0.653
MOD_N-GLC_1	863	868	PF02516	0.635
MOD_NEK2_1	105	110	PF00069	0.263
MOD_NEK2_1	127	132	PF00069	0.461
MOD_NEK2_1	145	150	PF00069	0.329
MOD_NEK2_1	157	162	PF00069	0.237
MOD_NEK2_1	199	204	PF00069	0.548
MOD_NEK2_1	232	237	PF00069	0.387
MOD_NEK2_1	439	444	PF00069	0.381
MOD_NEK2_1	56	61	PF00069	0.390
MOD_NEK2_1	585	590	PF00069	0.385
MOD_NEK2_1	704	709	PF00069	0.585
MOD_NEK2_1	88	93	PF00069	0.379
MOD_NEK2_1	900	905	PF00069	0.634
MOD_PIKK_1	249	255	PF00454	0.679
MOD_PIKK_1	37	43	PF00454	0.405
MOD_PIKK_1	533	539	PF00454	0.519
MOD_PIKK_1	735	741	PF00454	0.752
MOD_PIKK_1	846	852	PF00454	0.599
MOD_PIKK_1	874	880	PF00454	0.499
MOD_PKA_2	246	252	PF00069	0.666
MOD_PKA_2	567	573	PF00069	0.496
MOD_PKA_2	642	648	PF00069	0.645
MOD_PKA_2	733	739	PF00069	0.585
MOD_PKA_2	772	778	PF00069	0.644
MOD_PKA_2	895	901	PF00069	0.764
MOD_PKB_1	278	286	PF00069	0.373
MOD_PKB_1	401	409	PF00069	0.676
MOD_PKB_1	858	866	PF00069	0.472
MOD_Plk_1	274	280	PF00069	0.589
MOD_Plk_1	375	381	PF00069	0.505
MOD_Plk_1	451	457	PF00069	0.419
MOD_Plk_1	465	471	PF00069	0.389
MOD_Plk_1	668	674	PF00069	0.678
MOD_Plk_1	711	717	PF00069	0.560
MOD_Plk_1	863	869	PF00069	0.536
MOD_Plk_1	892	898	PF00069	0.697
MOD_Plk_2-3	466	472	PF00069	0.388
MOD_Plk_2-3	662	668	PF00069	0.505
MOD_Plk_2-3	888	894	PF00069	0.588
MOD_Plk_4	354	360	PF00069	0.346
MOD_Plk_4	375	381	PF00069	0.397
MOD_Plk_4	466	472	PF00069	0.369
MOD_Plk_4	512	518	PF00069	0.478
MOD_Plk_4	567	573	PF00069	0.475
MOD_Plk_4	585	591	PF00069	0.280
MOD_Plk_4	662	668	PF00069	0.620
MOD_Plk_4	712	718	PF00069	0.454
MOD_Plk_4	762	768	PF00069	0.422
MOD_Plk_4	772	778	PF00069	0.590
MOD_Plk_4	815	821	PF00069	0.502
MOD_ProDKin_1	226	232	PF00069	0.429
MOD_ProDKin_1	315	321	PF00069	0.632
MOD_ProDKin_1	378	384	PF00069	0.476
MOD_ProDKin_1	484	490	PF00069	0.744
MOD_ProDKin_1	530	536	PF00069	0.478
MOD_ProDKin_1	558	564	PF00069	0.499
MOD_ProDKin_1	603	609	PF00069	0.518
MOD_ProDKin_1	677	683	PF00069	0.685
MOD_ProDKin_1	689	695	PF00069	0.588
MOD_SUMO_for_1	149	152	PF00179	0.358
MOD_SUMO_for_1	19	22	PF00179	0.466
MOD_SUMO_for_1	262	265	PF00179	0.592
TRG_DiLeu_BaEn_1	52	57	PF01217	0.459
TRG_DiLeu_BaEn_1	831	836	PF01217	0.368
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.470
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.421
TRG_DiLeu_LyEn_5	831	836	PF01217	0.368
TRG_ENDOCYTIC_2	214	217	PF00928	0.398
TRG_ENDOCYTIC_2	53	56	PF00928	0.285
TRG_ENDOCYTIC_2	760	763	PF00928	0.366
TRG_ENDOCYTIC_2	868	871	PF00928	0.431
TRG_ER_diArg_1	10	12	PF00400	0.616
TRG_ER_diArg_1	123	126	PF00400	0.418
TRG_ER_diArg_1	367	370	PF00400	0.569
TRG_ER_diArg_1	400	403	PF00400	0.653
TRG_ER_diArg_1	838	840	PF00400	0.468
TRG_ER_diArg_1	857	860	PF00400	0.554
TRG_NLS_MonoExtC_3	400	405	PF00514	0.651
TRG_NLS_MonoExtN_4	401	406	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G5	Leptomonas seymouri	43%	100%
A0A1X0NMA5	Trypanosomatidae	31%	100%
A0A3S5H5Q0	Leishmania donovani	93%	100%
A0A422NGV5	Trypanosoma rangeli	32%	100%
A4H4K4	Leishmania braziliensis	81%	100%
A4HST0	Leishmania infantum	93%	100%
C9ZTD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%