Putative 60S ribosomal protein L19

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L19, putative

Species:

Leishmania major

UniProt:

Q4QJ39_LEIMA

TriTrypDb:

LmjF.06.0410 , LMJLV39_060009600 , LMJSD75_060009800

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0005737	cytoplasm	2	3
GO:0015934	large ribosomal subunit	4	13
GO:0022625	cytosolic large ribosomal subunit	5	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0044391	ribosomal subunit	3	13
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	13

Expansion

Sequence features

Q4QJ39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ39

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13
GO:0043043	peptide biosynthetic process	5	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043603	amide metabolic process	3	13
GO:0043604	amide biosynthetic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.246
CLV_NRD_NRD_1	117	119	PF00675	0.347
CLV_NRD_NRD_1	123	125	PF00675	0.347
CLV_NRD_NRD_1	126	128	PF00675	0.347
CLV_NRD_NRD_1	193	195	PF00675	0.544
CLV_NRD_NRD_1	209	211	PF00675	0.575
CLV_NRD_NRD_1	57	59	PF00675	0.347
CLV_NRD_NRD_1	61	63	PF00675	0.347
CLV_NRD_NRD_1	71	73	PF00675	0.347
CLV_NRD_NRD_1	83	85	PF00675	0.322
CLV_PCSK_FUR_1	153	157	PF00082	0.347
CLV_PCSK_FUR_1	207	211	PF00082	0.547
CLV_PCSK_KEX2_1	100	102	PF00082	0.367
CLV_PCSK_KEX2_1	117	119	PF00082	0.347
CLV_PCSK_KEX2_1	123	125	PF00082	0.347
CLV_PCSK_KEX2_1	155	157	PF00082	0.347
CLV_PCSK_KEX2_1	200	202	PF00082	0.688
CLV_PCSK_KEX2_1	209	211	PF00082	0.579
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.347
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.688
CLV_PCSK_PC7_1	205	211	PF00082	0.546
CLV_PCSK_SKI1_1	123	127	PF00082	0.347
CLV_PCSK_SKI1_1	63	67	PF00082	0.347
CLV_PCSK_SKI1_1	73	77	PF00082	0.347
CLV_PCSK_SKI1_1	84	88	PF00082	0.347
DOC_USP7_MATH_1	225	229	PF00917	0.707
DOC_USP7_MATH_1	232	236	PF00917	0.745
DOC_USP7_UBL2_3	166	170	PF12436	0.504
DOC_USP7_UBL2_3	195	199	PF12436	0.501
DOC_USP7_UBL2_3	263	267	PF12436	0.672
DOC_USP7_UBL2_3	59	63	PF12436	0.347
LIG_14-3-3_CanoR_1	10	14	PF00244	0.471
LIG_14-3-3_CanoR_1	58	62	PF00244	0.347
LIG_CtBP_PxDLS_1	3	7	PF00389	0.461
LIG_NRBOX	121	127	PF00104	0.347
LIG_SUMO_SIM_par_1	2	9	PF11976	0.462
LIG_UBA3_1	121	128	PF00899	0.347
MOD_CK1_1	5	11	PF00069	0.465
MOD_CK1_1	57	63	PF00069	0.355
MOD_Cter_Amidation	98	101	PF01082	0.347
MOD_GlcNHglycan	227	230	PF01048	0.726
MOD_GlcNHglycan	234	237	PF01048	0.746
MOD_GSK3_1	2	9	PF00069	0.462
MOD_N-GLC_1	15	20	PF02516	0.456
MOD_NEK2_1	30	35	PF00069	0.455
MOD_NEK2_1	4	9	PF00069	0.462
MOD_PIKK_1	15	21	PF00454	0.452
MOD_PKA_2	57	63	PF00069	0.347
MOD_PKA_2	9	15	PF00069	0.469
MOD_Plk_4	30	36	PF00069	0.436
MOD_SUMO_for_1	165	168	PF00179	0.492
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.347
TRG_ENDOCYTIC_2	140	143	PF00928	0.347
TRG_ER_diArg_1	116	118	PF00400	0.347
TRG_ER_diArg_1	122	124	PF00400	0.347
TRG_ER_diArg_1	207	210	PF00400	0.561
TRG_ER_diArg_1	39	42	PF00400	0.347
TRG_ER_diArg_1	80	83	PF00400	0.347
TRG_ER_diLys_1	263	267	PF00400	0.752
TRG_NLS_Bipartite_1	117	131	PF00514	0.455
TRG_NLS_MonoExtC_3	126	132	PF00514	0.455
TRG_NLS_MonoExtC_3	262	267	PF00514	0.751
TRG_NLS_MonoExtN_4	124	131	PF00514	0.455
TRG_NLS_MonoExtN_4	261	267	PF00514	0.744
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS2	Leptomonas seymouri	94%	100%
A0A1X0NL07	Trypanosomatidae	84%	100%
A0A3R7MF58	Trypanosoma rangeli	85%	90%
A0A3S5H5Q3	Leishmania donovani	99%	100%
A4H4K5	Leishmania braziliensis	97%	100%
A4H4K7	Leishmania braziliensis	97%	99%
A4HST1	Leishmania infantum	99%	100%
A4HST3	Leishmania infantum	99%	100%
C9ZTD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	100%
D0VWQ5	Canis lupus familiaris	55%	100%
E9AKR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P49693	Arabidopsis thaliana	61%	100%
P84098	Homo sapiens	55%	100%
P84099	Mus musculus	55%	100%
P84100	Rattus norvegicus	55%	100%
Q3T0W9	Bos taurus	55%	100%
Q4QJ37	Leishmania major	100%	100%
Q5RB99	Pongo abelii	55%	100%
Q7ZYS1	Xenopus laevis	53%	100%
Q8HXN9	Macaca fascicularis	55%	100%
Q9LUQ6	Arabidopsis thaliana	60%	100%
Q9SRX2	Arabidopsis thaliana	61%	100%