Putative 60S ribosomal protein L19

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L19, putative

Species:

Leishmania major

UniProt:

Q4QJ37_LEIMA

TriTrypDb:

LmjF.06.0410 , LMJLV39_060009600 , LMJSD75_060009800

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0005737	cytoplasm	2	3
GO:0015934	large ribosomal subunit	4	13
GO:0022625	cytosolic large ribosomal subunit	5	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0044391	ribosomal subunit	3	13
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	13

Expansion

Sequence features

Q4QJ37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ37

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13
GO:0043043	peptide biosynthetic process	5	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043603	amide metabolic process	3	13
GO:0043604	amide biosynthetic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.326
CLV_NRD_NRD_1	106	108	PF00675	0.361
CLV_NRD_NRD_1	173	175	PF00675	0.628
CLV_NRD_NRD_1	189	191	PF00675	0.611
CLV_NRD_NRD_1	37	39	PF00675	0.286
CLV_NRD_NRD_1	41	43	PF00675	0.286
CLV_NRD_NRD_1	51	53	PF00675	0.286
CLV_NRD_NRD_1	63	65	PF00675	0.262
CLV_NRD_NRD_1	80	82	PF00675	0.286
CLV_NRD_NRD_1	97	99	PF00675	0.153
CLV_PCSK_FUR_1	133	137	PF00082	0.286
CLV_PCSK_FUR_1	187	191	PF00082	0.589
CLV_PCSK_KEX2_1	103	105	PF00082	0.286
CLV_PCSK_KEX2_1	135	137	PF00082	0.286
CLV_PCSK_KEX2_1	180	182	PF00082	0.769
CLV_PCSK_KEX2_1	189	191	PF00082	0.635
CLV_PCSK_KEX2_1	80	82	PF00082	0.286
CLV_PCSK_KEX2_1	97	99	PF00082	0.146
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.286
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.769
CLV_PCSK_PC7_1	185	191	PF00082	0.593
CLV_PCSK_SKI1_1	103	107	PF00082	0.286
CLV_PCSK_SKI1_1	43	47	PF00082	0.286
CLV_PCSK_SKI1_1	53	57	PF00082	0.286
CLV_PCSK_SKI1_1	64	68	PF00082	0.286
DOC_USP7_MATH_1	205	209	PF00917	0.666
DOC_USP7_MATH_1	212	216	PF00917	0.681
DOC_USP7_UBL2_3	146	150	PF12436	0.538
DOC_USP7_UBL2_3	175	179	PF12436	0.564
DOC_USP7_UBL2_3	250	254	PF12436	0.646
DOC_USP7_UBL2_3	39	43	PF12436	0.286
LIG_14-3-3_CanoR_1	38	42	PF00244	0.293
LIG_NRBOX	101	107	PF00104	0.286
LIG_UBA3_1	101	108	PF00899	0.286
MOD_CK1_1	37	43	PF00069	0.294
MOD_Cter_Amidation	78	81	PF01082	0.286
MOD_GlcNHglycan	207	210	PF01048	0.678
MOD_GlcNHglycan	214	217	PF01048	0.669
MOD_NEK2_1	10	15	PF00069	0.401
MOD_PKA_2	37	43	PF00069	0.286
MOD_Plk_4	10	16	PF00069	0.378
MOD_SUMO_for_1	145	148	PF00179	0.526
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.313
TRG_ENDOCYTIC_2	120	123	PF00928	0.313
TRG_ER_diArg_1	102	104	PF00400	0.286
TRG_ER_diArg_1	187	190	PF00400	0.628
TRG_ER_diArg_1	19	22	PF00400	0.312
TRG_ER_diArg_1	60	63	PF00400	0.286
TRG_ER_diArg_1	96	98	PF00400	0.286
TRG_ER_diLys_1	250	254	PF00400	0.674
TRG_NLS_Bipartite_1	97	111	PF00514	0.401
TRG_NLS_MonoExtC_3	106	112	PF00514	0.401
TRG_NLS_MonoExtC_3	249	254	PF00514	0.670
TRG_NLS_MonoExtN_4	104	111	PF00514	0.401
TRG_NLS_MonoExtN_4	248	254	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS2	Leptomonas seymouri	94%	98%
A0A1X0NL07	Trypanosomatidae	84%	96%
A0A3R7MF58	Trypanosoma rangeli	86%	86%
A0A3S5H5Q3	Leishmania donovani	99%	100%
A4H4K5	Leishmania braziliensis	97%	100%
A4H4K7	Leishmania braziliensis	97%	94%
A4HST1	Leishmania infantum	99%	100%
A4HST3	Leishmania infantum	99%	100%
C9ZTD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	98%
D0VWQ5	Canis lupus familiaris	55%	100%
E9AKR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O02639	Caenorhabditis elegans	56%	100%
P0DJ60	Tetrahymena thermophila (strain SB210)	55%	100%
P14329	Dictyostelium discoideum	59%	100%
P49693	Arabidopsis thaliana	61%	100%
P84098	Homo sapiens	55%	100%
P84099	Mus musculus	55%	100%
P84100	Rattus norvegicus	55%	100%
Q3T0W9	Bos taurus	55%	100%
Q4QJ39	Leishmania major	100%	95%
Q5RB99	Pongo abelii	55%	100%
Q7ZYS1	Xenopus laevis	53%	100%
Q8HXN9	Macaca fascicularis	55%	100%
Q9LUQ6	Arabidopsis thaliana	60%	100%
Q9SRX2	Arabidopsis thaliana	61%	100%