Kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ35_LEIMA

TriTrypDb:

LmjF.06.0430 , LMJLV39_060010000 , LMJSD75_060010000

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005819	spindle	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJ35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ35

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003774	cytoskeletal motor activity	1	2
GO:0003777	microtubule motor activity	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.739
CLV_NRD_NRD_1	280	282	PF00675	0.584
CLV_NRD_NRD_1	303	305	PF00675	0.405
CLV_NRD_NRD_1	423	425	PF00675	0.599
CLV_NRD_NRD_1	468	470	PF00675	0.548
CLV_NRD_NRD_1	516	518	PF00675	0.535
CLV_NRD_NRD_1	608	610	PF00675	0.483
CLV_NRD_NRD_1	636	638	PF00675	0.560
CLV_PCSK_FUR_1	421	425	PF00082	0.485
CLV_PCSK_FUR_1	634	638	PF00082	0.533
CLV_PCSK_KEX2_1	303	305	PF00082	0.407
CLV_PCSK_KEX2_1	423	425	PF00082	0.599
CLV_PCSK_KEX2_1	516	518	PF00082	0.407
CLV_PCSK_KEX2_1	608	610	PF00082	0.480
CLV_PCSK_KEX2_1	636	638	PF00082	0.560
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.489
CLV_PCSK_SKI1_1	274	278	PF00082	0.547
CLV_PCSK_SKI1_1	408	412	PF00082	0.452
CLV_PCSK_SKI1_1	42	46	PF00082	0.513
CLV_PCSK_SKI1_1	60	64	PF00082	0.576
DEG_APCC_KENBOX_2	195	199	PF00400	0.755
DEG_Nend_UBRbox_2	1	3	PF02207	0.593
DEG_SPOP_SBC_1	13	17	PF00917	0.825
DEG_SPOP_SBC_1	62	66	PF00917	0.636
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.383
DOC_MAPK_DCC_7	351	361	PF00069	0.402
DOC_MAPK_gen_1	303	311	PF00069	0.355
DOC_MAPK_gen_1	608	618	PF00069	0.517
DOC_MAPK_MEF2A_6	539	547	PF00069	0.425
DOC_PP4_FxxP_1	254	257	PF00568	0.484
DOC_USP7_MATH_1	126	130	PF00917	0.400
DOC_USP7_MATH_1	14	18	PF00917	0.753
DOC_USP7_MATH_1	157	161	PF00917	0.575
DOC_USP7_MATH_1	21	25	PF00917	0.787
DOC_USP7_MATH_1	272	276	PF00917	0.557
DOC_USP7_MATH_1	336	340	PF00917	0.547
DOC_USP7_MATH_1	449	453	PF00917	0.642
DOC_USP7_MATH_1	62	66	PF00917	0.636
DOC_USP7_MATH_1	666	670	PF00917	0.603
DOC_USP7_MATH_1	86	90	PF00917	0.765
DOC_USP7_MATH_1	92	96	PF00917	0.640
DOC_USP7_UBL2_3	42	46	PF12436	0.537
DOC_WW_Pin1_4	15	20	PF00397	0.801
DOC_WW_Pin1_4	153	158	PF00397	0.480
DOC_WW_Pin1_4	88	93	PF00397	0.574
LIG_14-3-3_CanoR_1	112	120	PF00244	0.505
LIG_14-3-3_CanoR_1	149	154	PF00244	0.407
LIG_14-3-3_CanoR_1	303	307	PF00244	0.383
LIG_14-3-3_CanoR_1	387	395	PF00244	0.445
LIG_14-3-3_CanoR_1	539	547	PF00244	0.553
LIG_14-3-3_CanoR_1	6	11	PF00244	0.690
LIG_14-3-3_CanoR_1	60	70	PF00244	0.508
LIG_14-3-3_CanoR_1	625	632	PF00244	0.547
LIG_14-3-3_CanoR_1	642	650	PF00244	0.424
LIG_14-3-3_CanoR_1	84	92	PF00244	0.530
LIG_14-3-3_CterR_2	685	690	PF00244	0.596
LIG_Actin_WH2_2	561	576	PF00022	0.477
LIG_BIR_III_4	192	196	PF00653	0.679
LIG_BRCT_BRCA1_1	101	105	PF00533	0.444
LIG_BRCT_BRCA1_1	135	139	PF00533	0.369
LIG_BRCT_BRCA1_1	508	512	PF00533	0.546
LIG_EH1_1	395	403	PF00400	0.395
LIG_FHA_1	221	227	PF00498	0.595
LIG_FHA_1	284	290	PF00498	0.350
LIG_FHA_1	351	357	PF00498	0.362
LIG_FHA_1	463	469	PF00498	0.429
LIG_FHA_1	506	512	PF00498	0.504
LIG_FHA_1	587	593	PF00498	0.411
LIG_FHA_1	627	633	PF00498	0.552
LIG_FHA_2	192	198	PF00498	0.773
LIG_FHA_2	308	314	PF00498	0.327
LIG_FHA_2	352	358	PF00498	0.353
LIG_FHA_2	501	507	PF00498	0.579
LIG_LIR_Apic_2	152	157	PF02991	0.417
LIG_LIR_Apic_2	253	257	PF02991	0.484
LIG_LIR_Gen_1	136	145	PF02991	0.373
LIG_LIR_Gen_1	308	317	PF02991	0.330
LIG_LIR_Gen_1	509	518	PF02991	0.539
LIG_LIR_Gen_1	64	75	PF02991	0.467
LIG_LIR_Nem_3	136	140	PF02991	0.380
LIG_LIR_Nem_3	227	233	PF02991	0.507
LIG_LIR_Nem_3	308	314	PF02991	0.331
LIG_LIR_Nem_3	509	515	PF02991	0.541
LIG_LIR_Nem_3	64	70	PF02991	0.473
LIG_NRBOX	351	357	PF00104	0.326
LIG_Pex14_1	101	105	PF04695	0.443
LIG_SH2_CRK	154	158	PF00017	0.445
LIG_SH2_CRK	67	71	PF00017	0.452
LIG_SH2_NCK_1	10	14	PF00017	0.720
LIG_SH2_NCK_1	295	299	PF00017	0.437
LIG_SH2_PTP2	137	140	PF00017	0.491
LIG_SH2_PTP2	363	366	PF00017	0.355
LIG_SH2_SRC	120	123	PF00017	0.441
LIG_SH2_SRC	295	298	PF00017	0.430
LIG_SH2_STAP1	10	14	PF00017	0.631
LIG_SH2_STAP1	120	124	PF00017	0.521
LIG_SH2_STAT5	137	140	PF00017	0.363
LIG_SH2_STAT5	363	366	PF00017	0.360
LIG_SH2_STAT5	571	574	PF00017	0.493
LIG_SH2_STAT5	591	594	PF00017	0.462
LIG_SH2_STAT5	67	70	PF00017	0.495
LIG_SH3_3	120	126	PF00018	0.402
LIG_SH3_3	138	144	PF00018	0.349
LIG_SH3_3	249	255	PF00018	0.437
LIG_SH3_3	258	264	PF00018	0.404
LIG_SH3_3	273	279	PF00018	0.321
LIG_SH3_3	291	297	PF00018	0.370
LIG_SH3_3	669	675	PF00018	0.640
LIG_SH3_3	69	75	PF00018	0.601
LIG_SUMO_SIM_par_1	365	371	PF11976	0.449
LIG_TYR_ITIM	361	366	PF00017	0.379
LIG_UBA3_1	602	610	PF00899	0.493
MOD_CK1_1	129	135	PF00069	0.462
MOD_CK1_1	147	153	PF00069	0.346
MOD_CK1_1	15	21	PF00069	0.748
MOD_CK1_1	206	212	PF00069	0.675
MOD_CK1_1	305	311	PF00069	0.354
MOD_CK1_1	368	374	PF00069	0.356
MOD_CK1_1	381	387	PF00069	0.406
MOD_CK1_1	390	396	PF00069	0.516
MOD_CK1_1	47	53	PF00069	0.552
MOD_CK1_1	638	644	PF00069	0.507
MOD_CK1_1	65	71	PF00069	0.471
MOD_CK1_1	662	668	PF00069	0.663
MOD_CK1_1	88	94	PF00069	0.795
MOD_CK2_1	191	197	PF00069	0.792
MOD_CK2_1	209	215	PF00069	0.485
MOD_CK2_1	351	357	PF00069	0.357
MOD_CK2_1	500	506	PF00069	0.505
MOD_CK2_1	53	59	PF00069	0.475
MOD_CK2_1	545	551	PF00069	0.422
MOD_Cter_Amidation	301	304	PF01082	0.443
MOD_GlcNHglycan	132	135	PF01048	0.427
MOD_GlcNHglycan	146	149	PF01048	0.394
MOD_GlcNHglycan	201	204	PF01048	0.630
MOD_GlcNHglycan	211	214	PF01048	0.784
MOD_GlcNHglycan	23	26	PF01048	0.788
MOD_GlcNHglycan	340	343	PF01048	0.616
MOD_GlcNHglycan	372	375	PF01048	0.346
MOD_GlcNHglycan	546	550	PF01048	0.533
MOD_GlcNHglycan	55	58	PF01048	0.579
MOD_GlcNHglycan	574	577	PF01048	0.600
MOD_GlcNHglycan	643	646	PF01048	0.622
MOD_GlcNHglycan	680	683	PF01048	0.655
MOD_GlcNHglycan	685	688	PF01048	0.613
MOD_GlcNHglycan	96	99	PF01048	0.554
MOD_GSK3_1	126	133	PF00069	0.466
MOD_GSK3_1	149	156	PF00069	0.437
MOD_GSK3_1	15	22	PF00069	0.772
MOD_GSK3_1	199	206	PF00069	0.671
MOD_GSK3_1	2	9	PF00069	0.652
MOD_GSK3_1	215	222	PF00069	0.518
MOD_GSK3_1	298	305	PF00069	0.493
MOD_GSK3_1	347	354	PF00069	0.388
MOD_GSK3_1	529	536	PF00069	0.487
MOD_GSK3_1	58	65	PF00069	0.481
MOD_GSK3_1	592	599	PF00069	0.585
MOD_GSK3_1	649	656	PF00069	0.590
MOD_GSK3_1	658	665	PF00069	0.602
MOD_GSK3_1	80	87	PF00069	0.644
MOD_GSK3_1	88	95	PF00069	0.747
MOD_LATS_1	51	57	PF00433	0.472
MOD_N-GLC_1	105	110	PF02516	0.408
MOD_N-GLC_1	129	134	PF02516	0.508
MOD_N-GLC_1	449	454	PF02516	0.511
MOD_NEK2_1	105	110	PF00069	0.423
MOD_NEK2_1	347	352	PF00069	0.398
MOD_NEK2_1	378	383	PF00069	0.397
MOD_NEK2_1	4	9	PF00069	0.683
MOD_NEK2_1	462	467	PF00069	0.552
MOD_NEK2_1	534	539	PF00069	0.525
MOD_NEK2_1	545	550	PF00069	0.492
MOD_NEK2_1	653	658	PF00069	0.628
MOD_PIKK_1	147	153	PF00454	0.419
MOD_PIKK_1	201	207	PF00454	0.683
MOD_PIKK_1	506	512	PF00454	0.461
MOD_PIKK_1	527	533	PF00454	0.509
MOD_PIKK_1	534	540	PF00454	0.448
MOD_PIKK_1	586	592	PF00454	0.580
MOD_PIKK_1	666	672	PF00454	0.669
MOD_PIKK_1	8	14	PF00454	0.742
MOD_PIKK_1	86	92	PF00454	0.695
MOD_PIKK_1	99	105	PF00454	0.459
MOD_PKA_2	302	308	PF00069	0.386
MOD_PKA_2	441	447	PF00069	0.461
MOD_PKA_2	538	544	PF00069	0.552
MOD_PKA_2	624	630	PF00069	0.521
MOD_PKA_2	635	641	PF00069	0.485
MOD_PKA_2	653	659	PF00069	0.489
MOD_Plk_1	105	111	PF00069	0.441
MOD_Plk_1	284	290	PF00069	0.350
MOD_Plk_1	323	329	PF00069	0.407
MOD_Plk_1	545	551	PF00069	0.422
MOD_Plk_1	586	592	PF00069	0.605
MOD_Plk_4	133	139	PF00069	0.407
MOD_Plk_4	149	155	PF00069	0.447
MOD_Plk_4	272	278	PF00069	0.479
MOD_Plk_4	307	313	PF00069	0.377
MOD_Plk_4	351	357	PF00069	0.329
MOD_ProDKin_1	15	21	PF00069	0.802
MOD_ProDKin_1	153	159	PF00069	0.485
MOD_ProDKin_1	88	94	PF00069	0.573
MOD_SUMO_rev_2	275	284	PF00179	0.528
MOD_SUMO_rev_2	344	353	PF00179	0.444
MOD_SUMO_rev_2	546	554	PF00179	0.452
TRG_DiLeu_BaEn_1	324	329	PF01217	0.340
TRG_DiLeu_BaEn_4	513	519	PF01217	0.449
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.444
TRG_ENDOCYTIC_2	120	123	PF00928	0.409
TRG_ENDOCYTIC_2	137	140	PF00928	0.309
TRG_ENDOCYTIC_2	230	233	PF00928	0.500
TRG_ENDOCYTIC_2	295	298	PF00928	0.426
TRG_ENDOCYTIC_2	363	366	PF00928	0.355
TRG_ENDOCYTIC_2	67	70	PF00928	0.435
TRG_ER_diArg_1	264	267	PF00400	0.461
TRG_ER_diArg_1	420	423	PF00400	0.593
TRG_ER_diArg_1	515	517	PF00400	0.538
TRG_ER_diArg_1	609	612	PF00400	0.522
TRG_ER_diArg_1	636	639	PF00400	0.589
TRG_ER_diArg_1	70	73	PF00400	0.495
TRG_NLS_MonoCore_2	607	612	PF00514	0.563
TRG_NLS_MonoExtC_3	607	613	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC06	Leptomonas seymouri	72%	99%
A0A0S4KIG4	Bodo saltans	28%	94%
A0A1X0NKL3	Trypanosomatidae	54%	100%
A0A3R7LWH4	Trypanosoma rangeli	52%	100%
A0A3S5H5Q4	Leishmania donovani	97%	100%
A4H4K9	Leishmania braziliensis	88%	100%
A4HST5	Leishmania infantum	97%	100%
C9ZTE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AKS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5DPG4	Trypanosoma cruzi	52%	100%