TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ34_LEIMA

TriTrypDb:

LmjF.06.0440 , LMJLV39_060010100 , LMJSD75_060010100

Length:

993

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QJ34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.705
CLV_C14_Caspase3-7	484	488	PF00656	0.715
CLV_C14_Caspase3-7	606	610	PF00656	0.748
CLV_C14_Caspase3-7	943	947	PF00656	0.787
CLV_NRD_NRD_1	294	296	PF00675	0.651
CLV_NRD_NRD_1	297	299	PF00675	0.622
CLV_NRD_NRD_1	414	416	PF00675	0.667
CLV_NRD_NRD_1	663	665	PF00675	0.843
CLV_PCSK_FUR_1	295	299	PF00082	0.658
CLV_PCSK_KEX2_1	293	295	PF00082	0.642
CLV_PCSK_KEX2_1	297	299	PF00082	0.606
CLV_PCSK_KEX2_1	414	416	PF00082	0.667
CLV_PCSK_KEX2_1	658	660	PF00082	0.870
CLV_PCSK_KEX2_1	663	665	PF00082	0.786
CLV_PCSK_KEX2_1	980	982	PF00082	0.620
CLV_PCSK_PC1ET2_1	658	660	PF00082	0.793
CLV_PCSK_PC1ET2_1	980	982	PF00082	0.620
CLV_PCSK_PC7_1	293	299	PF00082	0.657
CLV_PCSK_PC7_1	659	665	PF00082	0.761
CLV_PCSK_SKI1_1	235	239	PF00082	0.647
CLV_PCSK_SKI1_1	25	29	PF00082	0.751
CLV_PCSK_SKI1_1	414	418	PF00082	0.668
CLV_PCSK_SKI1_1	427	431	PF00082	0.540
CLV_PCSK_SKI1_1	806	810	PF00082	0.784
CLV_PCSK_SKI1_1	928	932	PF00082	0.776
CLV_Separin_Metazoa	188	192	PF03568	0.635
DEG_APCC_DBOX_1	24	32	PF00400	0.750
DEG_APCC_DBOX_1	430	438	PF00400	0.790
DEG_APCC_DBOX_1	927	935	PF00400	0.777
DEG_Nend_Nbox_1	1	3	PF02207	0.837
DEG_SPOP_SBC_1	547	551	PF00917	0.752
DEG_SPOP_SBC_1	817	821	PF00917	0.774
DEG_SPOP_SBC_1	917	921	PF00917	0.748
DEG_SPOP_SBC_1	972	976	PF00917	0.788
DOC_CKS1_1	810	815	PF01111	0.665
DOC_CKS1_1	843	848	PF01111	0.727
DOC_CYCLIN_RxL_1	801	814	PF00134	0.699
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.789
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.720
DOC_MAPK_MEF2A_6	465	472	PF00069	0.713
DOC_MAPK_MEF2A_6	706	713	PF00069	0.864
DOC_PP2B_LxvP_1	131	134	PF13499	0.582
DOC_PP2B_LxvP_1	430	433	PF13499	0.773
DOC_PP2B_LxvP_1	75	78	PF13499	0.801
DOC_PP2B_LxvP_1	826	829	PF13499	0.817
DOC_PP2B_LxvP_1	87	90	PF13499	0.633
DOC_PP4_FxxP_1	208	211	PF00568	0.590
DOC_PP4_FxxP_1	566	569	PF00568	0.570
DOC_PP4_FxxP_1	886	889	PF00568	0.806
DOC_USP7_MATH_1	254	258	PF00917	0.604
DOC_USP7_MATH_1	37	41	PF00917	0.723
DOC_USP7_MATH_1	518	522	PF00917	0.828
DOC_USP7_MATH_1	547	551	PF00917	0.737
DOC_USP7_MATH_1	607	611	PF00917	0.792
DOC_USP7_MATH_1	61	65	PF00917	0.601
DOC_USP7_MATH_1	674	678	PF00917	0.842
DOC_USP7_MATH_1	779	783	PF00917	0.822
DOC_USP7_MATH_1	78	82	PF00917	0.757
DOC_USP7_MATH_1	811	815	PF00917	0.641
DOC_USP7_MATH_1	916	920	PF00917	0.759
DOC_USP7_MATH_1	973	977	PF00917	0.808
DOC_USP7_MATH_1	985	989	PF00917	0.830
DOC_USP7_MATH_2	779	785	PF00917	0.609
DOC_USP7_MATH_2	825	831	PF00917	0.796
DOC_USP7_UBL2_3	530	534	PF12436	0.785
DOC_USP7_UBL2_3	654	658	PF12436	0.676
DOC_WW_Pin1_4	176	181	PF00397	0.714
DOC_WW_Pin1_4	252	257	PF00397	0.623
DOC_WW_Pin1_4	33	38	PF00397	0.783
DOC_WW_Pin1_4	486	491	PF00397	0.692
DOC_WW_Pin1_4	565	570	PF00397	0.679
DOC_WW_Pin1_4	632	637	PF00397	0.786
DOC_WW_Pin1_4	772	777	PF00397	0.742
DOC_WW_Pin1_4	783	788	PF00397	0.768
DOC_WW_Pin1_4	809	814	PF00397	0.643
DOC_WW_Pin1_4	842	847	PF00397	0.827
DOC_WW_Pin1_4	85	90	PF00397	0.742
DOC_WW_Pin1_4	975	980	PF00397	0.761
LIG_14-3-3_CanoR_1	191	200	PF00244	0.549
LIG_14-3-3_CanoR_1	298	307	PF00244	0.674
LIG_14-3-3_CanoR_1	390	398	PF00244	0.666
LIG_14-3-3_CanoR_1	56	66	PF00244	0.775
LIG_14-3-3_CanoR_1	588	592	PF00244	0.750
LIG_14-3-3_CanoR_1	70	76	PF00244	0.650
LIG_14-3-3_CanoR_1	963	969	PF00244	0.799
LIG_14-3-3_CanoR_1	981	985	PF00244	0.664
LIG_14-3-3_CterR_2	989	993	PF00244	0.820
LIG_BIR_III_4	946	950	PF00653	0.789
LIG_BRCT_BRCA1_1	746	750	PF00533	0.644
LIG_CtBP_PxDLS_1	710	714	PF00389	0.783
LIG_deltaCOP1_diTrp_1	351	358	PF00928	0.608
LIG_FHA_1	177	183	PF00498	0.701
LIG_FHA_1	216	222	PF00498	0.597
LIG_FHA_1	280	286	PF00498	0.362
LIG_FHA_1	302	308	PF00498	0.637
LIG_FHA_1	330	336	PF00498	0.728
LIG_FHA_1	377	383	PF00498	0.647
LIG_FHA_1	390	396	PF00498	0.440
LIG_FHA_1	797	803	PF00498	0.769
LIG_FHA_1	861	867	PF00498	0.824
LIG_FHA_1	895	901	PF00498	0.694
LIG_FHA_1	9	15	PF00498	0.706
LIG_FHA_2	919	925	PF00498	0.844
LIG_FHA_2	981	987	PF00498	0.685
LIG_LIR_Apic_2	207	211	PF02991	0.595
LIG_LIR_Apic_2	556	562	PF02991	0.726
LIG_LIR_Gen_1	194	205	PF02991	0.639
LIG_LIR_Nem_3	156	162	PF02991	0.634
LIG_LIR_Nem_3	194	200	PF02991	0.625
LIG_LIR_Nem_3	408	413	PF02991	0.649
LIG_LIR_Nem_3	820	826	PF02991	0.823
LIG_MYND_1	134	138	PF01753	0.659
LIG_PCNA_yPIPBox_3	530	543	PF02747	0.755
LIG_Pex14_2	867	871	PF04695	0.777
LIG_PTAP_UEV_1	775	780	PF05743	0.763
LIG_SH2_CRK	159	163	PF00017	0.653
LIG_SH2_CRK	266	270	PF00017	0.594
LIG_SH2_CRK	559	563	PF00017	0.736
LIG_SH2_CRK	567	571	PF00017	0.700
LIG_SH2_GRB2like	378	381	PF00017	0.651
LIG_SH2_NCK_1	567	571	PF00017	0.824
LIG_SH2_NCK_1	892	896	PF00017	0.806
LIG_SH2_NCK_1	9	13	PF00017	0.780
LIG_SH2_SRC	575	578	PF00017	0.772
LIG_SH2_STAP1	378	382	PF00017	0.647
LIG_SH2_STAP1	575	579	PF00017	0.769
LIG_SH2_STAT3	499	502	PF00017	0.838
LIG_SH2_STAT5	378	381	PF00017	0.651
LIG_SH2_STAT5	878	881	PF00017	0.809
LIG_SH2_STAT5	892	895	PF00017	0.512
LIG_SH3_3	132	138	PF00018	0.728
LIG_SH3_3	430	436	PF00018	0.789
LIG_SH3_3	691	697	PF00018	0.860
LIG_SH3_3	765	771	PF00018	0.679
LIG_SH3_3	773	779	PF00018	0.777
LIG_SH3_3	83	89	PF00018	0.843
LIG_SH3_3	92	98	PF00018	0.565
LIG_SH3_3	926	932	PF00018	0.830
LIG_SUMO_SIM_anti_2	281	288	PF11976	0.372
LIG_SUMO_SIM_par_1	10	19	PF11976	0.592
LIG_SUMO_SIM_par_1	805	812	PF11976	0.668
LIG_SUMO_SIM_par_1	824	831	PF11976	0.797
LIG_TRAF2_1	185	188	PF00917	0.687
LIG_TRAF2_1	391	394	PF00917	0.647
LIG_UBA3_1	212	217	PF00899	0.618
LIG_WRC_WIRS_1	407	412	PF05994	0.656
MOD_CDC14_SPxK_1	635	638	PF00782	0.635
MOD_CDK_SPK_2	975	980	PF00069	0.728
MOD_CDK_SPxK_1	632	638	PF00069	0.640
MOD_CDK_SPxK_1	975	981	PF00069	0.769
MOD_CK1_1	376	382	PF00069	0.608
MOD_CK1_1	40	46	PF00069	0.733
MOD_CK1_1	537	543	PF00069	0.716
MOD_CK1_1	621	627	PF00069	0.838
MOD_CK1_1	628	634	PF00069	0.720
MOD_CK1_1	662	668	PF00069	0.846
MOD_CK1_1	678	684	PF00069	0.648
MOD_CK1_1	751	757	PF00069	0.708
MOD_CK1_1	761	767	PF00069	0.671
MOD_CK1_1	772	778	PF00069	0.610
MOD_CK1_1	81	87	PF00069	0.806
MOD_CK1_1	860	866	PF00069	0.808
MOD_CK1_1	938	944	PF00069	0.844
MOD_CK1_1	967	973	PF00069	0.833
MOD_CK1_1	975	981	PF00069	0.703
MOD_CK2_1	236	242	PF00069	0.638
MOD_CK2_1	345	351	PF00069	0.575
MOD_CK2_1	936	942	PF00069	0.845
MOD_CK2_1	980	986	PF00069	0.737
MOD_Cter_Amidation	656	659	PF01082	0.795
MOD_DYRK1A_RPxSP_1	783	787	PF00069	0.607
MOD_GlcNHglycan	201	206	PF01048	0.561
MOD_GlcNHglycan	316	319	PF01048	0.709
MOD_GlcNHglycan	509	512	PF01048	0.853
MOD_GlcNHglycan	526	529	PF01048	0.588
MOD_GlcNHglycan	535	539	PF01048	0.577
MOD_GlcNHglycan	555	558	PF01048	0.607
MOD_GlcNHglycan	571	574	PF01048	0.590
MOD_GlcNHglycan	577	580	PF01048	0.747
MOD_GlcNHglycan	583	586	PF01048	0.640
MOD_GlcNHglycan	59	62	PF01048	0.796
MOD_GlcNHglycan	605	608	PF01048	0.726
MOD_GlcNHglycan	627	630	PF01048	0.796
MOD_GlcNHglycan	688	691	PF01048	0.700
MOD_GlcNHglycan	746	749	PF01048	0.587
MOD_GlcNHglycan	776	779	PF01048	0.704
MOD_GlcNHglycan	787	790	PF01048	0.766
MOD_GlcNHglycan	793	796	PF01048	0.561
MOD_GlcNHglycan	814	817	PF01048	0.736
MOD_GlcNHglycan	835	838	PF01048	0.814
MOD_GlcNHglycan	850	853	PF01048	0.621
MOD_GlcNHglycan	858	862	PF01048	0.731
MOD_GlcNHglycan	938	941	PF01048	0.830
MOD_GlcNHglycan	975	978	PF01048	0.736
MOD_GSK3_1	162	169	PF00069	0.608
MOD_GSK3_1	176	183	PF00069	0.618
MOD_GSK3_1	27	34	PF00069	0.662
MOD_GSK3_1	365	372	PF00069	0.656
MOD_GSK3_1	37	44	PF00069	0.670
MOD_GSK3_1	376	383	PF00069	0.471
MOD_GSK3_1	453	460	PF00069	0.734
MOD_GSK3_1	512	519	PF00069	0.840
MOD_GSK3_1	522	529	PF00069	0.684
MOD_GSK3_1	542	549	PF00069	0.723
MOD_GSK3_1	55	62	PF00069	0.556
MOD_GSK3_1	565	572	PF00069	0.635
MOD_GSK3_1	575	582	PF00069	0.687
MOD_GSK3_1	583	590	PF00069	0.675
MOD_GSK3_1	603	610	PF00069	0.592
MOD_GSK3_1	621	628	PF00069	0.605
MOD_GSK3_1	674	681	PF00069	0.788
MOD_GSK3_1	744	751	PF00069	0.657
MOD_GSK3_1	757	764	PF00069	0.657
MOD_GSK3_1	770	777	PF00069	0.673
MOD_GSK3_1	779	786	PF00069	0.725
MOD_GSK3_1	8	15	PF00069	0.636
MOD_GSK3_1	81	88	PF00069	0.754
MOD_GSK3_1	812	819	PF00069	0.801
MOD_GSK3_1	890	897	PF00069	0.824
MOD_GSK3_1	907	914	PF00069	0.567
MOD_GSK3_1	916	923	PF00069	0.668
MOD_GSK3_1	930	937	PF00069	0.614
MOD_GSK3_1	963	970	PF00069	0.826
MOD_GSK3_1	971	978	PF00069	0.715
MOD_GSK3_1	980	987	PF00069	0.576
MOD_N-GLC_1	176	181	PF02516	0.706
MOD_N-GLC_1	299	304	PF02516	0.607
MOD_N-GLC_1	40	45	PF02516	0.586
MOD_N-GLC_1	522	527	PF02516	0.722
MOD_N-GLC_1	659	664	PF02516	0.636
MOD_N-GLC_2	261	263	PF02516	0.574
MOD_NEK2_1	216	221	PF00069	0.597
MOD_NEK2_1	285	290	PF00069	0.533
MOD_NEK2_1	299	304	PF00069	0.429
MOD_NEK2_1	307	312	PF00069	0.579
MOD_NEK2_1	468	473	PF00069	0.693
MOD_NEK2_1	505	510	PF00069	0.846
MOD_NEK2_1	542	547	PF00069	0.746
MOD_NEK2_1	548	553	PF00069	0.709
MOD_NEK2_1	55	60	PF00069	0.713
MOD_NEK2_1	581	586	PF00069	0.787
MOD_NEK2_1	8	13	PF00069	0.630
MOD_NEK2_1	934	939	PF00069	0.846
MOD_NEK2_1	984	989	PF00069	0.717
MOD_OFUCOSY	38	45	PF10250	0.588
MOD_PIKK_1	345	351	PF00454	0.653
MOD_PIKK_1	389	395	PF00454	0.648
MOD_PIKK_1	537	543	PF00454	0.771
MOD_PIKK_1	761	767	PF00454	0.714
MOD_PIKK_1	918	924	PF00454	0.790
MOD_PKA_1	980	986	PF00069	0.737
MOD_PKA_2	369	375	PF00069	0.697
MOD_PKA_2	389	395	PF00069	0.318
MOD_PKA_2	55	61	PF00069	0.638
MOD_PKA_2	587	593	PF00069	0.783
MOD_PKA_2	662	668	PF00069	0.846
MOD_PKA_2	752	758	PF00069	0.749
MOD_PKA_2	769	775	PF00069	0.853
MOD_PKA_2	980	986	PF00069	0.649
MOD_PKB_1	455	463	PF00069	0.488
MOD_PKB_1	522	530	PF00069	0.791
MOD_Plk_1	113	119	PF00069	0.795
MOD_Plk_1	31	37	PF00069	0.745
MOD_Plk_1	985	991	PF00069	0.787
MOD_Plk_4	12	18	PF00069	0.750
MOD_Plk_4	166	172	PF00069	0.623
MOD_Plk_4	380	386	PF00069	0.636
MOD_Plk_4	758	764	PF00069	0.747
MOD_Plk_4	819	825	PF00069	0.805
MOD_ProDKin_1	176	182	PF00069	0.709
MOD_ProDKin_1	252	258	PF00069	0.618
MOD_ProDKin_1	33	39	PF00069	0.783
MOD_ProDKin_1	486	492	PF00069	0.695
MOD_ProDKin_1	565	571	PF00069	0.686
MOD_ProDKin_1	632	638	PF00069	0.788
MOD_ProDKin_1	772	778	PF00069	0.743
MOD_ProDKin_1	783	789	PF00069	0.769
MOD_ProDKin_1	809	815	PF00069	0.642
MOD_ProDKin_1	842	848	PF00069	0.830
MOD_ProDKin_1	85	91	PF00069	0.743
MOD_ProDKin_1	975	981	PF00069	0.763
MOD_SUMO_rev_2	214	219	PF00179	0.613
TRG_DiLeu_BaEn_1	281	286	PF01217	0.364
TRG_DiLeu_BaEn_3	187	193	PF01217	0.634
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.652
TRG_ENDOCYTIC_2	159	162	PF00928	0.645
TRG_ENDOCYTIC_2	197	200	PF00928	0.627
TRG_ENDOCYTIC_2	266	269	PF00928	0.583
TRG_ENDOCYTIC_2	594	597	PF00928	0.644
TRG_ENDOCYTIC_2	823	826	PF00928	0.819
TRG_ENDOCYTIC_2	891	894	PF00928	0.807
TRG_ER_diArg_1	293	295	PF00400	0.642
TRG_ER_diArg_1	297	299	PF00400	0.606
TRG_ER_diArg_1	413	415	PF00400	0.659
TRG_NES_CRM1_1	146	156	PF08389	0.608
TRG_NES_CRM1_1	281	292	PF08389	0.613
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPE9	Leishmania donovani	90%	100%
A4H4L0	Leishmania braziliensis	67%	100%
A4HST6	Leishmania infantum	91%	100%
E9AKS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%