Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QJ33_LEIMA

TriTrypDb:

LmjF.06.0450 , LMJLV39_060010200 , LMJSD75_060010200

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.690
CLV_C14_Caspase3-7	208	212	PF00656	0.741
CLV_C14_Caspase3-7	279	283	PF00656	0.713
CLV_C14_Caspase3-7	28	32	PF00656	0.773
CLV_C14_Caspase3-7	68	72	PF00656	0.747
CLV_NRD_NRD_1	247	249	PF00675	0.781
CLV_NRD_NRD_1	303	305	PF00675	0.774
CLV_NRD_NRD_1	394	396	PF00675	0.618
CLV_NRD_NRD_1	5	7	PF00675	0.685
CLV_NRD_NRD_1	96	98	PF00675	0.769
CLV_PCSK_KEX2_1	246	248	PF00082	0.717
CLV_PCSK_KEX2_1	328	330	PF00082	0.586
CLV_PCSK_KEX2_1	5	7	PF00082	0.684
CLV_PCSK_KEX2_1	96	98	PF00082	0.769
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.657
CLV_PCSK_SKI1_1	258	262	PF00082	0.674
CLV_PCSK_SKI1_1	97	101	PF00082	0.616
DEG_SPOP_SBC_1	10	14	PF00917	0.791
DEG_SPOP_SBC_1	264	268	PF00917	0.722
DEG_SPOP_SBC_1	64	68	PF00917	0.708
DEG_SPOP_SBC_1	70	74	PF00917	0.807
DEG_SPOP_SBC_1	81	85	PF00917	0.624
DOC_ANK_TNKS_1	452	459	PF00023	0.646
DOC_CYCLIN_yClb1_LxF_4	256	261	PF00134	0.612
DOC_MAPK_DCC_7	342	351	PF00069	0.707
DOC_MAPK_gen_1	113	123	PF00069	0.713
DOC_MAPK_gen_1	401	410	PF00069	0.656
DOC_MAPK_MEF2A_6	219	226	PF00069	0.795
DOC_MAPK_MEF2A_6	342	351	PF00069	0.707
DOC_MAPK_MEF2A_6	376	384	PF00069	0.544
DOC_MAPK_NFAT4_5	219	227	PF00069	0.794
DOC_PP1_RVXF_1	256	262	PF00149	0.615
DOC_PP4_FxxP_1	143	146	PF00568	0.585
DOC_PP4_FxxP_1	18	21	PF00568	0.727
DOC_USP7_MATH_1	102	106	PF00917	0.655
DOC_USP7_MATH_1	340	344	PF00917	0.733
DOC_USP7_MATH_1	347	351	PF00917	0.642
DOC_USP7_MATH_1	427	431	PF00917	0.803
DOC_USP7_MATH_1	51	55	PF00917	0.691
DOC_USP7_MATH_1	69	73	PF00917	0.685
DOC_USP7_UBL2_3	392	396	PF12436	0.777
DOC_WW_Pin1_4	249	254	PF00397	0.703
DOC_WW_Pin1_4	265	270	PF00397	0.714
LIG_14-3-3_CanoR_1	138	144	PF00244	0.818
LIG_14-3-3_CanoR_1	16	21	PF00244	0.636
LIG_14-3-3_CanoR_1	162	168	PF00244	0.579
LIG_14-3-3_CanoR_1	271	277	PF00244	0.723
LIG_14-3-3_CanoR_1	329	337	PF00244	0.761
LIG_14-3-3_CanoR_1	44	50	PF00244	0.770
LIG_14-3-3_CanoR_1	5	11	PF00244	0.637
LIG_Actin_WH2_2	256	273	PF00022	0.575
LIG_BRCT_BRCA1_1	14	18	PF00533	0.725
LIG_BRCT_BRCA1_1	412	416	PF00533	0.678
LIG_FHA_1	155	161	PF00498	0.710
LIG_FHA_1	178	184	PF00498	0.782
LIG_FHA_1	230	236	PF00498	0.658
LIG_FHA_1	24	30	PF00498	0.572
LIG_FHA_1	65	71	PF00498	0.775
LIG_FHA_2	206	212	PF00498	0.727
LIG_FHA_2	351	357	PF00498	0.694
LIG_FHA_2	75	81	PF00498	0.734
LIG_LIR_Apic_2	141	146	PF02991	0.583
LIG_LIR_Apic_2	15	21	PF02991	0.726
LIG_LIR_Gen_1	75	82	PF02991	0.812
LIG_LIR_Nem_3	387	393	PF02991	0.555
LIG_LIR_Nem_3	40	46	PF02991	0.759
LIG_LIR_Nem_3	75	81	PF02991	0.813
LIG_SH2_CRK	377	381	PF00017	0.663
LIG_SH2_CRK	43	47	PF00017	0.725
LIG_SH2_CRK	7	11	PF00017	0.727
LIG_SH2_GRB2like	377	380	PF00017	0.664
LIG_SH2_NCK_1	7	11	PF00017	0.727
LIG_SH2_STAT5	330	333	PF00017	0.701
LIG_SH3_1	334	340	PF00018	0.624
LIG_SH3_2	253	258	PF14604	0.570
LIG_SH3_2	337	342	PF14604	0.621
LIG_SH3_3	158	164	PF00018	0.695
LIG_SH3_3	194	200	PF00018	0.732
LIG_SH3_3	234	240	PF00018	0.697
LIG_SH3_3	250	256	PF00018	0.681
LIG_SH3_3	334	340	PF00018	0.624
LIG_SH3_3	96	102	PF00018	0.699
LIG_TRAF2_1	192	195	PF00917	0.663
LIG_TRAF2_1	240	243	PF00917	0.701
LIG_TRAF2_1	370	373	PF00917	0.676
LIG_WRC_WIRS_1	348	353	PF05994	0.575
LIG_WW_3	93	97	PF00397	0.707
MOD_CDC14_SPxK_1	268	271	PF00782	0.806
MOD_CDK_SPxK_1	265	271	PF00069	0.803
MOD_CK1_1	141	147	PF00069	0.675
MOD_CK1_1	150	156	PF00069	0.618
MOD_CK1_1	177	183	PF00069	0.679
MOD_CK1_1	19	25	PF00069	0.632
MOD_CK1_1	275	281	PF00069	0.616
MOD_CK1_1	34	40	PF00069	0.782
MOD_CK1_1	350	356	PF00069	0.565
MOD_CK1_1	42	48	PF00069	0.742
MOD_CK1_1	65	71	PF00069	0.789
MOD_CK1_1	72	78	PF00069	0.701
MOD_CK1_1	8	14	PF00069	0.674
MOD_CK1_1	86	92	PF00069	0.719
MOD_CK2_1	102	108	PF00069	0.725
MOD_CK2_1	189	195	PF00069	0.693
MOD_CK2_1	350	356	PF00069	0.792
MOD_CK2_1	367	373	PF00069	0.530
MOD_GlcNHglycan	118	121	PF01048	0.644
MOD_GlcNHglycan	274	277	PF01048	0.691
MOD_GlcNHglycan	38	42	PF01048	0.640
MOD_GlcNHglycan	429	432	PF01048	0.705
MOD_GlcNHglycan	53	56	PF01048	0.731
MOD_GlcNHglycan	67	70	PF01048	0.713
MOD_GlcNHglycan	85	88	PF01048	0.715
MOD_GlcNHglycan	91	94	PF01048	0.760
MOD_GSK3_1	112	119	PF00069	0.790
MOD_GSK3_1	141	148	PF00069	0.770
MOD_GSK3_1	150	157	PF00069	0.811
MOD_GSK3_1	19	26	PF00069	0.668
MOD_GSK3_1	206	213	PF00069	0.593
MOD_GSK3_1	324	331	PF00069	0.593
MOD_GSK3_1	347	354	PF00069	0.614
MOD_GSK3_1	45	52	PF00069	0.747
MOD_GSK3_1	5	12	PF00069	0.680
MOD_GSK3_1	55	62	PF00069	0.716
MOD_GSK3_1	65	72	PF00069	0.642
MOD_GSK3_1	76	83	PF00069	0.644
MOD_LATS_1	4	10	PF00433	0.685
MOD_N-GLC_1	126	131	PF02516	0.589
MOD_N-GLC_1	177	182	PF02516	0.732
MOD_N-GLC_1	189	194	PF02516	0.567
MOD_N-GLC_1	29	34	PF02516	0.720
MOD_NEK2_1	410	415	PF00069	0.692
MOD_NEK2_1	82	87	PF00069	0.787
MOD_NEK2_2	347	352	PF00069	0.576
MOD_PK_1	304	310	PF00069	0.524
MOD_PK_1	6	12	PF00069	0.707
MOD_PKA_1	304	310	PF00069	0.602
MOD_PKA_1	328	334	PF00069	0.580
MOD_PKA_1	5	11	PF00069	0.726
MOD_PKA_2	270	276	PF00069	0.750
MOD_PKA_2	303	309	PF00069	0.659
MOD_PKA_2	328	334	PF00069	0.770
MOD_PKA_2	351	357	PF00069	0.604
MOD_PKA_2	5	11	PF00069	0.709
MOD_PKB_1	302	310	PF00069	0.530
MOD_Plk_1	206	212	PF00069	0.740
MOD_Plk_1	410	416	PF00069	0.714
MOD_Plk_4	163	169	PF00069	0.579
MOD_Plk_4	31	37	PF00069	0.703
MOD_Plk_4	45	51	PF00069	0.703
MOD_ProDKin_1	249	255	PF00069	0.705
MOD_ProDKin_1	265	271	PF00069	0.718
TRG_DiLeu_BaEn_1	389	394	PF01217	0.530
TRG_ENDOCYTIC_2	377	380	PF00928	0.742
TRG_ENDOCYTIC_2	43	46	PF00928	0.726
TRG_ENDOCYTIC_2	7	10	PF00928	0.724
TRG_ER_diArg_1	245	248	PF00400	0.706
TRG_ER_diArg_1	301	304	PF00400	0.548
TRG_ER_diArg_1	5	7	PF00400	0.680
TRG_ER_diArg_1	95	97	PF00400	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T5	Leptomonas seymouri	37%	93%
A0A3S5H5Q5	Leishmania donovani	82%	100%
A4H4L1	Leishmania braziliensis	50%	91%
A4HST7	Leishmania infantum	82%	100%
E9AKS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%