DUF3849 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ30_LEIMA

TriTrypDb:

LmjF.06.0480 , LMJLV39_060010500 , LMJSD75_060010500

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.686
CLV_NRD_NRD_1	16	18	PF00675	0.422
CLV_NRD_NRD_1	95	97	PF00675	0.370
CLV_PCSK_KEX2_1	115	117	PF00082	0.316
CLV_PCSK_KEX2_1	95	97	PF00082	0.373
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.568
CLV_PCSK_SKI1_1	168	172	PF00082	0.442
CLV_PCSK_SKI1_1	17	21	PF00082	0.428
DOC_CYCLIN_RxL_1	13	23	PF00134	0.509
DOC_MAPK_gen_1	102	111	PF00069	0.415
DOC_MAPK_gen_1	135	144	PF00069	0.535
DOC_MAPK_gen_1	95	101	PF00069	0.347
DOC_MAPK_HePTP_8	99	111	PF00069	0.509
DOC_MAPK_MEF2A_6	102	111	PF00069	0.452
DOC_MAPK_MEF2A_6	135	144	PF00069	0.524
DOC_MAPK_NFAT4_5	104	112	PF00069	0.423
DOC_USP7_MATH_1	178	182	PF00917	0.487
DOC_USP7_MATH_1	270	274	PF00917	0.674
DOC_USP7_MATH_1	57	61	PF00917	0.586
DOC_WW_Pin1_4	278	283	PF00397	0.664
LIG_14-3-3_CanoR_1	139	145	PF00244	0.486
LIG_CtBP_PxDLS_1	49	53	PF00389	0.425
LIG_DLG_GKlike_1	102	109	PF00625	0.514
LIG_FHA_1	253	259	PF00498	0.571
LIG_FHA_1	92	98	PF00498	0.537
LIG_FHA_2	122	128	PF00498	0.660
LIG_FHA_2	282	288	PF00498	0.671
LIG_FHA_2	45	51	PF00498	0.468
LIG_GBD_Chelix_1	77	85	PF00786	0.369
LIG_IBAR_NPY_1	245	247	PF08397	0.516
LIG_IRF3_LxIS_1	136	143	PF10401	0.615
LIG_LIR_Gen_1	287	296	PF02991	0.666
LIG_LIR_Nem_3	172	176	PF02991	0.499
LIG_LIR_Nem_3	231	237	PF02991	0.514
LIG_LIR_Nem_3	287	291	PF02991	0.705
LIG_PCNA_yPIPBox_3	183	196	PF02747	0.518
LIG_SH2_CRK	176	180	PF00017	0.508
LIG_SH2_CRK	223	227	PF00017	0.564
LIG_SH2_STAP1	146	150	PF00017	0.534
LIG_SH2_STAP1	176	180	PF00017	0.508
LIG_SH2_STAT5	247	250	PF00017	0.574
LIG_SH2_STAT5	9	12	PF00017	0.395
LIG_SH3_3	197	203	PF00018	0.554
LIG_SUMO_SIM_par_1	280	287	PF11976	0.512
LIG_TRAF2_1	319	322	PF00917	0.667
MOD_CK1_1	273	279	PF00069	0.712
MOD_CK1_1	281	287	PF00069	0.738
MOD_CK2_1	281	287	PF00069	0.726
MOD_CK2_1	316	322	PF00069	0.669
MOD_CK2_1	44	50	PF00069	0.513
MOD_GlcNHglycan	176	179	PF01048	0.553
MOD_GlcNHglycan	191	195	PF01048	0.552
MOD_GlcNHglycan	276	279	PF01048	0.734
MOD_GlcNHglycan	59	62	PF01048	0.618
MOD_GSK3_1	174	181	PF00069	0.541
MOD_GSK3_1	270	277	PF00069	0.711
MOD_GSK3_1	287	294	PF00069	0.729
MOD_NEK2_1	140	145	PF00069	0.474
MOD_NEK2_1	179	184	PF00069	0.578
MOD_PIKK_1	317	323	PF00454	0.670
MOD_PKA_2	140	146	PF00069	0.472
MOD_PKA_2	174	180	PF00069	0.574
MOD_PKA_2	317	323	PF00069	0.670
MOD_PKA_2	57	63	PF00069	0.647
MOD_Plk_1	102	108	PF00069	0.524
MOD_Plk_1	291	297	PF00069	0.718
MOD_Plk_2-3	287	293	PF00069	0.638
MOD_Plk_2-3	44	50	PF00069	0.526
MOD_Plk_4	202	208	PF00069	0.461
MOD_Plk_4	210	216	PF00069	0.447
MOD_ProDKin_1	278	284	PF00069	0.668
TRG_ENDOCYTIC_2	176	179	PF00928	0.560
TRG_ENDOCYTIC_2	212	215	PF00928	0.558
TRG_ENDOCYTIC_2	223	226	PF00928	0.542
TRG_ENDOCYTIC_2	238	241	PF00928	0.515
TRG_ENDOCYTIC_2	9	12	PF00928	0.400
TRG_ER_diArg_1	134	137	PF00400	0.620
TRG_ER_diArg_1	139	142	PF00400	0.488
TRG_ER_diArg_1	95	97	PF00400	0.378
TRG_NES_CRM1_1	76	89	PF08389	0.442
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVD6	Leptomonas seymouri	59%	99%
A0A0S4KF96	Bodo saltans	31%	100%
A0A1X0NKJ3	Trypanosomatidae	44%	100%
A0A3S5H5Q7	Leishmania donovani	97%	100%
A4H4L4	Leishmania braziliensis	83%	100%
A4HSU0	Leishmania infantum	96%	100%
C9ZTF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AKS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B7V1	Trypanosoma cruzi	48%	100%