Pyr_redox_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ29_LEIMA

TriTrypDb:

LmjF.06.0490 , LMJLV39_060010600 , LMJSD75_060010600

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.580
CLV_C14_Caspase3-7	395	399	PF00656	0.491
CLV_NRD_NRD_1	37	39	PF00675	0.565
CLV_NRD_NRD_1	425	427	PF00675	0.519
CLV_NRD_NRD_1	462	464	PF00675	0.559
CLV_PCSK_KEX2_1	266	268	PF00082	0.593
CLV_PCSK_KEX2_1	37	39	PF00082	0.571
CLV_PCSK_KEX2_1	425	427	PF00082	0.519
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.605
CLV_PCSK_SKI1_1	123	127	PF00082	0.525
CLV_PCSK_SKI1_1	266	270	PF00082	0.584
CLV_PCSK_SKI1_1	28	32	PF00082	0.704
CLV_PCSK_SKI1_1	282	286	PF00082	0.523
CLV_PCSK_SKI1_1	344	348	PF00082	0.615
CLV_PCSK_SKI1_1	378	382	PF00082	0.537
CLV_PCSK_SKI1_1	470	474	PF00082	0.546
DEG_APCC_DBOX_1	362	370	PF00400	0.557
DEG_SCF_FBW7_1	18	24	PF00400	0.728
DEG_SCF_FBW7_1	97	104	PF00400	0.479
DOC_ANK_TNKS_1	56	63	PF00023	0.482
DOC_CKS1_1	18	23	PF01111	0.730
DOC_CKS1_1	278	283	PF01111	0.595
DOC_CKS1_1	362	367	PF01111	0.550
DOC_CKS1_1	98	103	PF01111	0.481
DOC_CYCLIN_RxL_1	120	128	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.486
DOC_MAPK_DCC_7	215	225	PF00069	0.491
DOC_MAPK_gen_1	246	255	PF00069	0.582
DOC_MAPK_gen_1	37	44	PF00069	0.574
DOC_MAPK_MEF2A_6	246	255	PF00069	0.631
DOC_MAPK_MEF2A_6	296	305	PF00069	0.552
DOC_PP1_RVXF_1	121	128	PF00149	0.515
DOC_PP1_RVXF_1	194	200	PF00149	0.449
DOC_PP1_RVXF_1	244	251	PF00149	0.583
DOC_PP1_RVXF_1	318	324	PF00149	0.677
DOC_PP2B_LxvP_1	253	256	PF13499	0.658
DOC_PP2B_LxvP_1	303	306	PF13499	0.710
DOC_PP2B_LxvP_1	65	68	PF13499	0.490
DOC_PP4_FxxP_1	367	370	PF00568	0.536
DOC_USP7_MATH_1	116	120	PF00917	0.516
DOC_USP7_MATH_1	162	166	PF00917	0.562
DOC_USP7_MATH_1	189	193	PF00917	0.580
DOC_USP7_MATH_1	21	25	PF00917	0.770
DOC_USP7_MATH_1	386	390	PF00917	0.666
DOC_USP7_UBL2_3	460	464	PF12436	0.628
DOC_WW_Pin1_4	145	150	PF00397	0.491
DOC_WW_Pin1_4	17	22	PF00397	0.765
DOC_WW_Pin1_4	266	271	PF00397	0.591
DOC_WW_Pin1_4	277	282	PF00397	0.594
DOC_WW_Pin1_4	361	366	PF00397	0.544
DOC_WW_Pin1_4	97	102	PF00397	0.485
LIG_14-3-3_CanoR_1	123	128	PF00244	0.523
LIG_14-3-3_CanoR_1	313	323	PF00244	0.584
LIG_14-3-3_CanoR_1	344	354	PF00244	0.541
LIG_14-3-3_CanoR_1	438	442	PF00244	0.674
LIG_AP2alpha_1	402	406	PF02296	0.442
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BIR_III_4	398	402	PF00653	0.404
LIG_BRCT_BRCA1_1	147	151	PF00533	0.462
LIG_FHA_1	198	204	PF00498	0.485
LIG_FHA_1	300	306	PF00498	0.592
LIG_FHA_1	329	335	PF00498	0.575
LIG_FHA_1	94	100	PF00498	0.514
LIG_FHA_2	224	230	PF00498	0.545
LIG_FHA_2	278	284	PF00498	0.602
LIG_FHA_2	302	308	PF00498	0.588
LIG_LIR_Apic_2	364	370	PF02991	0.532
LIG_LIR_Gen_1	126	134	PF02991	0.537
LIG_LIR_Gen_1	247	258	PF02991	0.670
LIG_LIR_Gen_1	389	399	PF02991	0.610
LIG_LIR_Nem_3	126	130	PF02991	0.536
LIG_LIR_Nem_3	206	210	PF02991	0.419
LIG_LIR_Nem_3	247	253	PF02991	0.670
LIG_LIR_Nem_3	295	301	PF02991	0.551
LIG_LIR_Nem_3	389	394	PF02991	0.649
LIG_LIR_Nem_3	440	444	PF02991	0.670
LIG_LIR_Nem_3	468	472	PF02991	0.605
LIG_Pex14_2	264	268	PF04695	0.621
LIG_Pex14_2	343	347	PF04695	0.613
LIG_Pex14_2	402	406	PF04695	0.442
LIG_SH2_CRK	362	366	PF00017	0.539
LIG_SH2_PTP2	476	479	PF00017	0.596
LIG_SH2_STAT3	45	48	PF00017	0.670
LIG_SH2_STAT5	207	210	PF00017	0.421
LIG_SH2_STAT5	337	340	PF00017	0.556
LIG_SH2_STAT5	45	48	PF00017	0.614
LIG_SH2_STAT5	476	479	PF00017	0.596
LIG_SH2_STAT5	58	61	PF00017	0.323
LIG_SH3_3	110	116	PF00018	0.500
LIG_SH3_3	12	18	PF00018	0.728
LIG_SH3_3	253	259	PF00018	0.581
LIG_SH3_3	95	101	PF00018	0.495
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.582
LIG_SUMO_SIM_par_1	274	280	PF11976	0.582
LIG_SUMO_SIM_par_1	301	307	PF11976	0.610
LIG_SUMO_SIM_par_1	95	100	PF11976	0.497
LIG_TRAF2_1	226	229	PF00917	0.570
LIG_TYR_ITIM	439	444	PF00017	0.686
LIG_WRC_WIRS_1	124	129	PF05994	0.513
LIG_WW_2	256	259	PF00397	0.583
MOD_CDK_SPK_2	277	282	PF00069	0.594
MOD_CK1_1	114	120	PF00069	0.523
MOD_CK1_1	316	322	PF00069	0.623
MOD_CK1_1	437	443	PF00069	0.666
MOD_CK1_1	468	474	PF00069	0.548
MOD_CK2_1	223	229	PF00069	0.540
MOD_Cter_Amidation	4	7	PF01082	0.751
MOD_GlcNHglycan	116	119	PF01048	0.519
MOD_GlcNHglycan	160	163	PF01048	0.508
MOD_GlcNHglycan	191	194	PF01048	0.549
MOD_GlcNHglycan	200	203	PF01048	0.489
MOD_GlcNHglycan	23	26	PF01048	0.762
MOD_GlcNHglycan	331	334	PF01048	0.606
MOD_GlcNHglycan	357	360	PF01048	0.570
MOD_GSK3_1	158	165	PF00069	0.500
MOD_GSK3_1	17	24	PF00069	0.683
MOD_GSK3_1	240	247	PF00069	0.659
MOD_GSK3_1	284	291	PF00069	0.534
MOD_GSK3_1	400	407	PF00069	0.518
MOD_GSK3_1	93	100	PF00069	0.507
MOD_N-GLC_1	111	116	PF02516	0.523
MOD_N-GLC_1	299	304	PF02516	0.594
MOD_N-GLC_1	352	357	PF02516	0.632
MOD_NEK2_1	111	116	PF00069	0.514
MOD_NEK2_1	244	249	PF00069	0.729
MOD_NEK2_1	292	297	PF00069	0.561
MOD_NEK2_1	314	319	PF00069	0.595
MOD_NEK2_1	328	333	PF00069	0.574
MOD_NEK2_1	354	359	PF00069	0.548
MOD_NEK2_1	408	413	PF00069	0.472
MOD_NEK2_2	284	289	PF00069	0.530
MOD_NEK2_2	386	391	PF00069	0.672
MOD_OFUCOSY	167	174	PF10250	0.454
MOD_PIKK_1	101	107	PF00454	0.356
MOD_PIKK_1	269	275	PF00454	0.580
MOD_PIKK_1	51	57	PF00454	0.535
MOD_PIKK_1	85	91	PF00454	0.610
MOD_PKA_2	197	203	PF00069	0.591
MOD_PKA_2	240	246	PF00069	0.722
MOD_PKA_2	288	294	PF00069	0.548
MOD_PKA_2	437	443	PF00069	0.666
MOD_PKA_2	93	99	PF00069	0.511
MOD_PKB_1	196	204	PF00069	0.462
MOD_Plk_1	111	117	PF00069	0.514
MOD_Plk_1	221	227	PF00069	0.527
MOD_Plk_1	299	305	PF00069	0.597
MOD_Plk_4	116	122	PF00069	0.509
MOD_Plk_4	147	153	PF00069	0.478
MOD_Plk_4	288	294	PF00069	0.548
MOD_Plk_4	338	344	PF00069	0.553
MOD_Plk_4	437	443	PF00069	0.636
MOD_Plk_4	475	481	PF00069	0.557
MOD_Plk_4	93	99	PF00069	0.511
MOD_ProDKin_1	145	151	PF00069	0.489
MOD_ProDKin_1	17	23	PF00069	0.765
MOD_ProDKin_1	266	272	PF00069	0.587
MOD_ProDKin_1	277	283	PF00069	0.594
MOD_ProDKin_1	361	367	PF00069	0.536
MOD_ProDKin_1	97	103	PF00069	0.480
MOD_SUMO_for_1	157	160	PF00179	0.429
MOD_SUMO_rev_2	277	287	PF00179	0.591
TRG_ENDOCYTIC_2	207	210	PF00928	0.405
TRG_ENDOCYTIC_2	441	444	PF00928	0.688
TRG_ENDOCYTIC_2	476	479	PF00928	0.596
TRG_ENDOCYTIC_2	58	61	PF00928	0.389
TRG_ER_diArg_1	195	198	PF00400	0.460
TRG_ER_diArg_1	425	427	PF00400	0.519
TRG_NLS_MonoExtC_3	462	467	PF00514	0.628
TRG_NLS_MonoExtN_4	460	467	PF00514	0.628
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I218	Leptomonas seymouri	89%	84%
A0A0S4KH91	Bodo saltans	71%	91%
A0A1X0NLE5	Trypanosomatidae	75%	80%
A0A3S5IR64	Trypanosoma rangeli	81%	83%
A0A3S7WPF9	Leishmania donovani	99%	100%
A4H4L5	Leishmania braziliensis	95%	82%
A4HSU1	Leishmania infantum	99%	100%
C9ZTF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	85%
E9AKS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%