SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SpoU rRNA Methylase family, putative

Species:

Leishmania major

UniProt:

Q4QJ28_LEIMA

TriTrypDb:

LmjF.06.0500 , LMJLV39_060010700 , LMJSD75_060010700

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ28

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008649	rRNA methyltransferase activity	5	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016435	rRNA (guanine) methyltransferase activity	6	2
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140102	catalytic activity, acting on a rRNA	4	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.569
CLV_NRD_NRD_1	168	170	PF00675	0.655
CLV_NRD_NRD_1	209	211	PF00675	0.457
CLV_NRD_NRD_1	356	358	PF00675	0.663
CLV_NRD_NRD_1	495	497	PF00675	0.678
CLV_PCSK_KEX2_1	168	170	PF00082	0.621
CLV_PCSK_KEX2_1	209	211	PF00082	0.457
CLV_PCSK_KEX2_1	356	358	PF00082	0.666
CLV_PCSK_KEX2_1	495	497	PF00082	0.678
CLV_PCSK_SKI1_1	14	18	PF00082	0.635
CLV_PCSK_SKI1_1	181	185	PF00082	0.487
CLV_PCSK_SKI1_1	270	274	PF00082	0.272
CLV_PCSK_SKI1_1	403	407	PF00082	0.411
DEG_APCC_DBOX_1	107	115	PF00400	0.405
DEG_APCC_DBOX_1	198	206	PF00400	0.396
DEG_SPOP_SBC_1	144	148	PF00917	0.557
DEG_SPOP_SBC_1	239	243	PF00917	0.557
DEG_SPOP_SBC_1	309	313	PF00917	0.552
DEG_SPOP_SBC_1	74	78	PF00917	0.582
DOC_CYCLIN_RxL_1	400	411	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.505
DOC_MAPK_gen_1	209	216	PF00069	0.428
DOC_MAPK_gen_1	499	507	PF00069	0.657
DOC_MAPK_MEF2A_6	188	196	PF00069	0.394
DOC_MAPK_MEF2A_6	501	509	PF00069	0.507
DOC_PP1_SILK_1	266	271	PF00149	0.548
DOC_PP2B_LxvP_1	190	193	PF13499	0.503
DOC_USP7_MATH_1	144	148	PF00917	0.733
DOC_USP7_MATH_1	244	248	PF00917	0.620
DOC_USP7_MATH_1	291	295	PF00917	0.476
DOC_USP7_MATH_1	309	313	PF00917	0.438
DOC_USP7_MATH_1	323	327	PF00917	0.484
DOC_USP7_MATH_1	359	363	PF00917	0.686
DOC_USP7_MATH_1	472	476	PF00917	0.659
DOC_USP7_MATH_1	477	481	PF00917	0.600
DOC_USP7_MATH_1	82	86	PF00917	0.766
DOC_USP7_MATH_1	91	95	PF00917	0.573
DOC_WW_Pin1_4	25	30	PF00397	0.581
DOC_WW_Pin1_4	365	370	PF00397	0.815
DOC_WW_Pin1_4	427	432	PF00397	0.564
DOC_WW_Pin1_4	70	75	PF00397	0.651
DOC_WW_Pin1_4	96	101	PF00397	0.726
LIG_14-3-3_CanoR_1	176	183	PF00244	0.501
LIG_14-3-3_CanoR_1	284	293	PF00244	0.507
LIG_14-3-3_CanoR_1	295	301	PF00244	0.413
LIG_14-3-3_CanoR_1	318	324	PF00244	0.552
LIG_14-3-3_CanoR_1	440	444	PF00244	0.758
LIG_Actin_WH2_2	37	54	PF00022	0.521
LIG_Actin_WH2_2	421	439	PF00022	0.622
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_BIR_III_1	1	5	PF00653	0.494
LIG_BIR_III_3	1	5	PF00653	0.494
LIG_BRCT_BRCA1_1	296	300	PF00533	0.503
LIG_BRCT_BRCA1_1	312	316	PF00533	0.503
LIG_FHA_1	11	17	PF00498	0.655
LIG_FHA_1	288	294	PF00498	0.472
LIG_FHA_1	296	302	PF00498	0.466
LIG_FHA_1	312	318	PF00498	0.414
LIG_FHA_1	452	458	PF00498	0.619
LIG_FHA_1	48	54	PF00498	0.444
LIG_FHA_1	62	68	PF00498	0.515
LIG_LIR_Gen_1	175	185	PF02991	0.484
LIG_LIR_Nem_3	175	180	PF02991	0.494
LIG_LIR_Nem_3	271	277	PF02991	0.471
LIG_MYND_1	102	106	PF01753	0.477
LIG_SH2_CRK	177	181	PF00017	0.506
LIG_SH2_CRK	38	42	PF00017	0.525
LIG_SH2_STAP1	38	42	PF00017	0.525
LIG_SH2_STAT3	221	224	PF00017	0.508
LIG_SH2_STAT5	115	118	PF00017	0.442
LIG_SH2_STAT5	177	180	PF00017	0.457
LIG_SH3_3	28	34	PF00018	0.517
LIG_SH3_3	520	526	PF00018	0.521
LIG_SUMO_SIM_anti_2	339	346	PF11976	0.543
LIG_SxIP_EBH_1	23	32	PF03271	0.549
LIG_TRAF2_1	120	123	PF00917	0.580
LIG_TRAF2_1	447	450	PF00917	0.655
LIG_WW_1	35	38	PF00397	0.596
MOD_CDK_SPK_2	427	432	PF00069	0.612
MOD_CDK_SPxxK_3	25	32	PF00069	0.609
MOD_CK1_1	175	181	PF00069	0.580
MOD_CK1_1	294	300	PF00069	0.497
MOD_CK1_1	310	316	PF00069	0.551
MOD_CK1_1	330	336	PF00069	0.679
MOD_CK1_1	368	374	PF00069	0.741
MOD_CK1_1	377	383	PF00069	0.768
MOD_CK1_1	480	486	PF00069	0.689
MOD_CK1_1	78	84	PF00069	0.808
MOD_CK2_1	117	123	PF00069	0.503
MOD_CK2_1	336	342	PF00069	0.681
MOD_CK2_1	444	450	PF00069	0.766
MOD_GlcNHglycan	22	25	PF01048	0.464
MOD_GlcNHglycan	246	249	PF01048	0.599
MOD_GlcNHglycan	325	328	PF01048	0.439
MOD_GlcNHglycan	338	341	PF01048	0.582
MOD_GlcNHglycan	361	364	PF01048	0.708
MOD_GlcNHglycan	382	385	PF01048	0.775
MOD_GlcNHglycan	479	482	PF01048	0.722
MOD_GlcNHglycan	5	8	PF01048	0.727
MOD_GlcNHglycan	517	520	PF01048	0.466
MOD_GlcNHglycan	77	80	PF01048	0.819
MOD_GlcNHglycan	94	97	PF01048	0.460
MOD_GSK3_1	145	152	PF00069	0.734
MOD_GSK3_1	235	242	PF00069	0.606
MOD_GSK3_1	287	294	PF00069	0.478
MOD_GSK3_1	307	314	PF00069	0.377
MOD_GSK3_1	323	330	PF00069	0.670
MOD_GSK3_1	343	350	PF00069	0.572
MOD_GSK3_1	43	50	PF00069	0.450
MOD_GSK3_1	473	480	PF00069	0.720
MOD_GSK3_1	508	515	PF00069	0.405
MOD_GSK3_1	70	77	PF00069	0.749
MOD_GSK3_1	78	85	PF00069	0.621
MOD_GSK3_1	92	99	PF00069	0.603
MOD_N-GLC_1	19	24	PF02516	0.529
MOD_N-GLC_1	359	364	PF02516	0.673
MOD_N-GLC_2	396	398	PF02516	0.551
MOD_NEK2_1	10	15	PF00069	0.626
MOD_NEK2_1	186	191	PF00069	0.522
MOD_NEK2_1	216	221	PF00069	0.431
MOD_NEK2_1	317	322	PF00069	0.456
MOD_NEK2_1	331	336	PF00069	0.600
MOD_NEK2_1	347	352	PF00069	0.404
MOD_NEK2_1	436	441	PF00069	0.689
MOD_NEK2_1	473	478	PF00069	0.664
MOD_OFUCOSY	391	398	PF10250	0.502
MOD_PIKK_1	317	323	PF00454	0.480
MOD_PKA_2	10	16	PF00069	0.545
MOD_PKA_2	175	181	PF00069	0.506
MOD_PKA_2	294	300	PF00069	0.462
MOD_PKA_2	317	323	PF00069	0.567
MOD_PKA_2	436	442	PF00069	0.663
MOD_PKA_2	67	73	PF00069	0.584
MOD_Plk_1	117	123	PF00069	0.536
MOD_Plk_1	216	222	PF00069	0.425
MOD_Plk_1	377	383	PF00069	0.724
MOD_Plk_1	473	479	PF00069	0.745
MOD_Plk_1	503	509	PF00069	0.503
MOD_Plk_4	249	255	PF00069	0.485
MOD_Plk_4	343	349	PF00069	0.493
MOD_Plk_4	43	49	PF00069	0.374
MOD_Plk_4	512	518	PF00069	0.474
MOD_ProDKin_1	25	31	PF00069	0.575
MOD_ProDKin_1	365	371	PF00069	0.811
MOD_ProDKin_1	427	433	PF00069	0.567
MOD_ProDKin_1	70	76	PF00069	0.650
MOD_ProDKin_1	96	102	PF00069	0.720
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.649
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.516
TRG_ENDOCYTIC_2	177	180	PF00928	0.379
TRG_ENDOCYTIC_2	38	41	PF00928	0.527
TRG_ER_diArg_1	167	169	PF00400	0.714
TRG_ER_diArg_1	494	496	PF00400	0.627
TRG_NLS_MonoExtN_4	168	173	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C1	Leptomonas seymouri	48%	100%
A0A1X0NKH6	Trypanosomatidae	29%	100%
A0A3R7KE58	Trypanosoma rangeli	33%	100%
A0A3S5H5Q8	Leishmania donovani	93%	100%
A4H4L6	Leishmania braziliensis	72%	93%
A4HSU2	Leishmania infantum	93%	100%
C9ZTF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AKS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BT12	Trypanosoma cruzi	31%	100%