U-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QJ27_LEIMA

TriTrypDb:

LmjF.06.0510 , LMJLV39_060010800 , LMJSD75_060010800

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QJ27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ27

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.721
CLV_C14_Caspase3-7	551	555	PF00656	0.693
CLV_C14_Caspase3-7	566	570	PF00656	0.643
CLV_NRD_NRD_1	236	238	PF00675	0.587
CLV_NRD_NRD_1	486	488	PF00675	0.434
CLV_NRD_NRD_1	494	496	PF00675	0.407
CLV_NRD_NRD_1	499	501	PF00675	0.415
CLV_NRD_NRD_1	66	68	PF00675	0.450
CLV_PCSK_FUR_1	234	238	PF00082	0.418
CLV_PCSK_FUR_1	64	68	PF00082	0.501
CLV_PCSK_KEX2_1	236	238	PF00082	0.587
CLV_PCSK_KEX2_1	485	487	PF00082	0.431
CLV_PCSK_KEX2_1	494	496	PF00082	0.458
CLV_PCSK_KEX2_1	590	592	PF00082	0.275
CLV_PCSK_KEX2_1	64	66	PF00082	0.453
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.275
CLV_PCSK_SKI1_1	188	192	PF00082	0.409
CLV_PCSK_SKI1_1	242	246	PF00082	0.428
CLV_PCSK_SKI1_1	306	310	PF00082	0.441
CLV_PCSK_SKI1_1	314	318	PF00082	0.418
CLV_PCSK_SKI1_1	487	491	PF00082	0.377
CLV_PCSK_SKI1_1	501	505	PF00082	0.394
CLV_PCSK_SKI1_1	59	63	PF00082	0.493
DEG_APCC_DBOX_1	619	627	PF00400	0.426
DEG_Nend_UBRbox_3	1	3	PF02207	0.513
DEG_ODPH_VHL_1	39	51	PF01847	0.522
DEG_ODPH_VHL_1	458	471	PF01847	0.413
DEG_SCF_FBW7_1	98	105	PF00400	0.654
DEG_SPOP_SBC_1	103	107	PF00917	0.712
DEG_SPOP_SBC_1	444	448	PF00917	0.494
DEG_SPOP_SBC_1	557	561	PF00917	0.704
DEG_SPOP_SBC_1	563	567	PF00917	0.653
DOC_CKS1_1	348	353	PF01111	0.637
DOC_CYCLIN_RxL_1	484	491	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.706
DOC_CYCLIN_yCln2_LP_2	505	511	PF00134	0.732
DOC_MAPK_gen_1	500	507	PF00069	0.610
DOC_MAPK_MEF2A_6	38	47	PF00069	0.312
DOC_MAPK_MEF2A_6	500	507	PF00069	0.627
DOC_MAPK_RevD_3	49	65	PF00069	0.690
DOC_PP1_RVXF_1	502	508	PF00149	0.628
DOC_PP1_RVXF_1	57	64	PF00149	0.694
DOC_PP1_RVXF_1	632	638	PF00149	0.460
DOC_PP2B_LxvP_1	509	512	PF13499	0.623
DOC_PP2B_LxvP_1	514	517	PF13499	0.593
DOC_PP4_FxxP_1	507	510	PF00568	0.669
DOC_USP7_MATH_1	103	107	PF00917	0.666
DOC_USP7_MATH_1	171	175	PF00917	0.578
DOC_USP7_MATH_1	200	204	PF00917	0.637
DOC_USP7_MATH_1	265	269	PF00917	0.617
DOC_USP7_MATH_1	338	342	PF00917	0.703
DOC_USP7_MATH_1	352	356	PF00917	0.701
DOC_USP7_MATH_1	444	448	PF00917	0.532
DOC_USP7_MATH_1	460	464	PF00917	0.418
DOC_USP7_MATH_1	563	567	PF00917	0.680
DOC_USP7_MATH_1	7	11	PF00917	0.410
DOC_USP7_MATH_1	73	77	PF00917	0.716
DOC_WW_Pin1_4	3	8	PF00397	0.404
DOC_WW_Pin1_4	323	328	PF00397	0.741
DOC_WW_Pin1_4	333	338	PF00397	0.707
DOC_WW_Pin1_4	347	352	PF00397	0.762
DOC_WW_Pin1_4	362	367	PF00397	0.700
DOC_WW_Pin1_4	446	451	PF00397	0.487
DOC_WW_Pin1_4	521	526	PF00397	0.683
DOC_WW_Pin1_4	568	573	PF00397	0.667
DOC_WW_Pin1_4	98	103	PF00397	0.659
LIG_14-3-3_CanoR_1	127	131	PF00244	0.723
LIG_14-3-3_CanoR_1	150	155	PF00244	0.696
LIG_14-3-3_CanoR_1	162	166	PF00244	0.624
LIG_14-3-3_CanoR_1	188	194	PF00244	0.599
LIG_14-3-3_CanoR_1	367	372	PF00244	0.689
LIG_14-3-3_CanoR_1	430	436	PF00244	0.476
LIG_14-3-3_CanoR_1	442	450	PF00244	0.533
LIG_14-3-3_CanoR_1	487	497	PF00244	0.548
LIG_14-3-3_CanoR_1	74	79	PF00244	0.676
LIG_APCC_ABBA_1	530	535	PF00400	0.613
LIG_BIR_III_2	569	573	PF00653	0.696
LIG_BRCT_BRCA1_1	285	289	PF00533	0.681
LIG_BRCT_BRCA1_1	304	308	PF00533	0.572
LIG_BRCT_BRCA1_1	405	409	PF00533	0.347
LIG_EVH1_1	507	511	PF00568	0.611
LIG_FHA_1	151	157	PF00498	0.610
LIG_FHA_1	258	264	PF00498	0.625
LIG_FHA_1	341	347	PF00498	0.725
LIG_FHA_1	408	414	PF00498	0.409
LIG_FHA_1	430	436	PF00498	0.491
LIG_FHA_1	451	457	PF00498	0.401
LIG_FHA_1	575	581	PF00498	0.592
LIG_FHA_2	278	284	PF00498	0.687
LIG_FHA_2	559	565	PF00498	0.701
LIG_GBD_Chelix_1	43	51	PF00786	0.532
LIG_Integrin_isoDGR_2	177	179	PF01839	0.432
LIG_LIR_Apic_2	331	337	PF02991	0.724
LIG_LIR_Gen_1	129	138	PF02991	0.669
LIG_LIR_Gen_1	149	157	PF02991	0.606
LIG_LIR_Nem_3	129	133	PF02991	0.671
LIG_LIR_Nem_3	149	155	PF02991	0.621
LIG_LIR_Nem_3	239	244	PF02991	0.629
LIG_LIR_Nem_3	584	589	PF02991	0.537
LIG_PDZ_Class_1	654	659	PF00595	0.627
LIG_Pex14_1	130	134	PF04695	0.675
LIG_Pex14_1	30	34	PF04695	0.312
LIG_Pex14_2	193	197	PF04695	0.606
LIG_SH2_CRK	334	338	PF00017	0.751
LIG_SH2_NCK_1	334	338	PF00017	0.699
LIG_SH2_NCK_1	650	654	PF00017	0.559
LIG_SH2_STAP1	122	126	PF00017	0.678
LIG_SH2_STAP1	650	654	PF00017	0.594
LIG_SH2_STAT5	154	157	PF00017	0.605
LIG_SH2_STAT5	212	215	PF00017	0.612
LIG_SH2_STAT5	376	379	PF00017	0.388
LIG_SH2_STAT5	470	473	PF00017	0.315
LIG_SH2_STAT5	650	653	PF00017	0.538
LIG_SH2_STAT5	78	81	PF00017	0.677
LIG_SH3_1	334	340	PF00018	0.746
LIG_SH3_2	510	515	PF14604	0.583
LIG_SH3_3	142	148	PF00018	0.629
LIG_SH3_3	334	340	PF00018	0.727
LIG_SH3_3	345	351	PF00018	0.755
LIG_SH3_3	437	443	PF00018	0.513
LIG_SH3_3	454	460	PF00018	0.411
LIG_SH3_3	505	511	PF00018	0.650
LIG_SUMO_SIM_anti_2	137	143	PF11976	0.648
LIG_SUMO_SIM_anti_2	410	417	PF11976	0.437
LIG_SUMO_SIM_par_1	139	146	PF11976	0.666
LIG_TRAF2_1	280	283	PF00917	0.599
LIG_TRAF2_1	519	522	PF00917	0.563
LIG_TRAF2_1	610	613	PF00917	0.495
LIG_TRAF2_2	597	602	PF00917	0.475
LIG_TRFH_1	507	511	PF08558	0.659
LIG_UBA3_1	585	590	PF00899	0.475
LIG_WRC_WIRS_1	190	195	PF05994	0.602
MOD_CDK_SPK_2	362	367	PF00069	0.759
MOD_CDK_SPK_2	570	575	PF00069	0.678
MOD_CDK_SPxxK_3	568	575	PF00069	0.686
MOD_CK1_1	143	149	PF00069	0.610
MOD_CK1_1	192	198	PF00069	0.619
MOD_CK1_1	219	225	PF00069	0.661
MOD_CK1_1	248	254	PF00069	0.669
MOD_CK1_1	298	304	PF00069	0.634
MOD_CK1_1	336	342	PF00069	0.724
MOD_CK1_1	356	362	PF00069	0.785
MOD_CK1_1	446	452	PF00069	0.573
MOD_CK2_1	265	271	PF00069	0.648
MOD_CK2_1	277	283	PF00069	0.666
MOD_CK2_1	285	291	PF00069	0.641
MOD_CK2_1	323	329	PF00069	0.757
MOD_CK2_1	607	613	PF00069	0.495
MOD_Cter_Amidation	234	237	PF01082	0.525
MOD_GlcNHglycan	117	120	PF01048	0.551
MOD_GlcNHglycan	173	176	PF01048	0.383
MOD_GlcNHglycan	200	203	PF01048	0.506
MOD_GlcNHglycan	221	224	PF01048	0.463
MOD_GlcNHglycan	228	231	PF01048	0.510
MOD_GlcNHglycan	238	241	PF01048	0.535
MOD_GlcNHglycan	297	300	PF01048	0.538
MOD_GlcNHglycan	362	365	PF01048	0.581
MOD_GlcNHglycan	387	390	PF01048	0.312
MOD_GlcNHglycan	539	543	PF01048	0.410
MOD_GlcNHglycan	566	569	PF01048	0.598
MOD_GlcNHglycan	643	646	PF01048	0.340
MOD_GlcNHglycan	83	86	PF01048	0.494
MOD_GSK3_1	146	153	PF00069	0.629
MOD_GSK3_1	188	195	PF00069	0.618
MOD_GSK3_1	208	215	PF00069	0.551
MOD_GSK3_1	245	252	PF00069	0.688
MOD_GSK3_1	283	290	PF00069	0.725
MOD_GSK3_1	298	305	PF00069	0.641
MOD_GSK3_1	3	10	PF00069	0.477
MOD_GSK3_1	336	343	PF00069	0.729
MOD_GSK3_1	352	359	PF00069	0.691
MOD_GSK3_1	399	406	PF00069	0.445
MOD_GSK3_1	444	451	PF00069	0.578
MOD_GSK3_1	558	565	PF00069	0.683
MOD_GSK3_1	570	577	PF00069	0.650
MOD_GSK3_1	74	81	PF00069	0.702
MOD_GSK3_1	98	105	PF00069	0.663
MOD_N-GLC_1	74	79	PF02516	0.478
MOD_NEK2_1	1	6	PF00069	0.455
MOD_NEK2_1	126	131	PF00069	0.654
MOD_NEK2_1	189	194	PF00069	0.628
MOD_NEK2_1	205	210	PF00069	0.630
MOD_NEK2_1	245	250	PF00069	0.738
MOD_NEK2_1	277	282	PF00069	0.752
MOD_NEK2_1	285	290	PF00069	0.674
MOD_NEK2_1	295	300	PF00069	0.594
MOD_NEK2_1	34	39	PF00069	0.301
MOD_NEK2_1	385	390	PF00069	0.312
MOD_NEK2_1	45	50	PF00069	0.647
MOD_NEK2_1	628	633	PF00069	0.581
MOD_NEK2_1	648	653	PF00069	0.637
MOD_NEK2_1	79	84	PF00069	0.759
MOD_NEK2_1	97	102	PF00069	0.579
MOD_PIKK_1	367	373	PF00454	0.718
MOD_PKA_1	236	242	PF00069	0.684
MOD_PKA_2	126	132	PF00069	0.714
MOD_PKA_2	161	167	PF00069	0.623
MOD_PKA_2	236	242	PF00069	0.655
MOD_PKA_2	429	435	PF00069	0.469
MOD_PKA_2	574	580	PF00069	0.598
MOD_PKA_2	607	613	PF00069	0.495
MOD_PKA_2	73	79	PF00069	0.624
MOD_PKB_1	234	242	PF00069	0.605
MOD_Plk_1	353	359	PF00069	0.686
MOD_Plk_1	628	634	PF00069	0.510
MOD_Plk_1	74	80	PF00069	0.676
MOD_Plk_2-3	602	608	PF00069	0.475
MOD_Plk_4	140	146	PF00069	0.655
MOD_Plk_4	193	199	PF00069	0.619
MOD_Plk_4	200	206	PF00069	0.623
MOD_Plk_4	208	214	PF00069	0.625
MOD_Plk_4	257	263	PF00069	0.603
MOD_Plk_4	29	35	PF00069	0.291
MOD_Plk_4	353	359	PF00069	0.702
MOD_Plk_4	39	45	PF00069	0.291
MOD_Plk_4	74	80	PF00069	0.769
MOD_ProDKin_1	3	9	PF00069	0.402
MOD_ProDKin_1	323	329	PF00069	0.744
MOD_ProDKin_1	333	339	PF00069	0.706
MOD_ProDKin_1	347	353	PF00069	0.759
MOD_ProDKin_1	362	368	PF00069	0.698
MOD_ProDKin_1	446	452	PF00069	0.488
MOD_ProDKin_1	521	527	PF00069	0.682
MOD_ProDKin_1	568	574	PF00069	0.660
MOD_ProDKin_1	98	104	PF00069	0.661
TRG_DiLeu_BaEn_1	526	531	PF01217	0.548
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.662
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.693
TRG_ENDOCYTIC_2	154	157	PF00928	0.605
TRG_ER_diArg_1	234	237	PF00400	0.691
TRG_ER_diArg_1	484	487	PF00400	0.607
TRG_ER_diArg_1	494	496	PF00400	0.656
TRG_ER_diArg_1	63	66	PF00400	0.650
TRG_ER_diArg_1	637	640	PF00400	0.559
TRG_NES_CRM1_1	307	320	PF08389	0.638
TRG_Pf-PMV_PEXEL_1	591	596	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIV8	Leptomonas seymouri	50%	100%
A0A3S5H5Q9	Leishmania donovani	93%	100%
A4H4L7	Leishmania braziliensis	78%	87%
A4HSU3	Leishmania infantum	93%	100%
E9AKT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%