Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ25_LEIMA

TriTrypDb:

LmjF.06.0530 , LMJLV39_060011000 , LMJSD75_060011000

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.596
CLV_PCSK_KEX2_1	208	210	PF00082	0.586
CLV_PCSK_KEX2_1	96	98	PF00082	0.478
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.478
CLV_PCSK_SKI1_1	166	170	PF00082	0.683
CLV_PCSK_SKI1_1	31	35	PF00082	0.433
CLV_PCSK_SKI1_1	93	97	PF00082	0.539
DEG_APCC_DBOX_1	30	38	PF00400	0.433
DOC_CKS1_1	234	239	PF01111	0.422
DOC_CYCLIN_RxL_1	240	249	PF00134	0.484
DOC_PP1_RVXF_1	241	248	PF00149	0.389
DOC_PP2B_LxvP_1	35	38	PF13499	0.539
DOC_USP7_MATH_1	100	104	PF00917	0.440
DOC_USP7_MATH_1	12	16	PF00917	0.699
DOC_USP7_MATH_1	131	135	PF00917	0.764
DOC_USP7_MATH_1	149	153	PF00917	0.657
DOC_USP7_MATH_1	191	195	PF00917	0.708
DOC_USP7_MATH_1	5	9	PF00917	0.694
DOC_USP7_MATH_1	57	61	PF00917	0.599
DOC_WW_Pin1_4	139	144	PF00397	0.718
DOC_WW_Pin1_4	161	166	PF00397	0.722
DOC_WW_Pin1_4	233	238	PF00397	0.421
DOC_WW_Pin1_4	40	45	PF00397	0.676
LIG_14-3-3_CanoR_1	159	168	PF00244	0.666
LIG_14-3-3_CanoR_1	172	178	PF00244	0.484
LIG_14-3-3_CanoR_1	289	294	PF00244	0.575
LIG_14-3-3_CanoR_1	83	91	PF00244	0.603
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BRCT_BRCA1_1	291	295	PF00533	0.635
LIG_CSL_BTD_1	221	224	PF09270	0.398
LIG_CSL_BTD_1	234	237	PF09270	0.395
LIG_deltaCOP1_diTrp_1	238	247	PF00928	0.399
LIG_FHA_1	17	23	PF00498	0.697
LIG_FHA_1	171	177	PF00498	0.610
LIG_FHA_1	234	240	PF00498	0.423
LIG_FHA_1	28	34	PF00498	0.539
LIG_HCF-1_HBM_1	249	252	PF13415	0.460
LIG_LIR_Gen_1	249	259	PF02991	0.377
LIG_LIR_Nem_3	213	217	PF02991	0.629
LIG_LIR_Nem_3	249	255	PF02991	0.385
LIG_REV1ctd_RIR_1	88	97	PF16727	0.494
LIG_SH2_CRK	252	256	PF00017	0.431
LIG_SH2_NCK_1	69	73	PF00017	0.455
LIG_SH2_SRC	273	276	PF00017	0.423
LIG_SH2_SRC	69	72	PF00017	0.516
LIG_SH2_STAP1	273	277	PF00017	0.407
LIG_SH2_STAP1	80	84	PF00017	0.414
LIG_SH2_STAT5	156	159	PF00017	0.676
LIG_SH2_STAT5	246	249	PF00017	0.547
LIG_SH3_3	194	200	PF00018	0.674
LIG_SH3_3	41	47	PF00018	0.692
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.539
LIG_SUMO_SIM_par_1	230	236	PF11976	0.442
LIG_TRAF2_1	142	145	PF00917	0.645
LIG_UBA3_1	33	39	PF00899	0.563
MOD_CAAXbox	293	296	PF01239	0.651
MOD_CDK_SPK_2	161	166	PF00069	0.595
MOD_CK1_1	130	136	PF00069	0.740
MOD_CK1_1	15	21	PF00069	0.599
MOD_CK1_1	189	195	PF00069	0.705
MOD_CK1_1	43	49	PF00069	0.560
MOD_CK1_1	7	13	PF00069	0.633
MOD_CK2_1	139	145	PF00069	0.663
MOD_CMANNOS	222	225	PF00535	0.511
MOD_GlcNHglycan	128	132	PF01048	0.755
MOD_GlcNHglycan	15	18	PF01048	0.607
MOD_GlcNHglycan	151	154	PF01048	0.661
MOD_GlcNHglycan	173	176	PF01048	0.572
MOD_GlcNHglycan	188	191	PF01048	0.659
MOD_GlcNHglycan	7	10	PF01048	0.667
MOD_GlcNHglycan	85	88	PF01048	0.617
MOD_GSK3_1	111	118	PF00069	0.627
MOD_GSK3_1	12	19	PF00069	0.611
MOD_GSK3_1	127	134	PF00069	0.660
MOD_N-GLC_1	12	17	PF02516	0.746
MOD_N-GLC_1	131	136	PF02516	0.602
MOD_NEK2_1	255	260	PF00069	0.419
MOD_NEK2_2	264	269	PF00069	0.318
MOD_PIKK_1	159	165	PF00454	0.653
MOD_PIKK_1	179	185	PF00454	0.423
MOD_PKA_2	158	164	PF00069	0.600
MOD_PKA_2	171	177	PF00069	0.490
MOD_PKA_2	255	261	PF00069	0.420
MOD_PKA_2	283	289	PF00069	0.666
MOD_PKB_1	287	295	PF00069	0.635
MOD_Plk_4	201	207	PF00069	0.534
MOD_Plk_4	210	216	PF00069	0.497
MOD_Plk_4	227	233	PF00069	0.493
MOD_ProDKin_1	139	145	PF00069	0.712
MOD_ProDKin_1	161	167	PF00069	0.722
MOD_ProDKin_1	233	239	PF00069	0.421
MOD_ProDKin_1	40	46	PF00069	0.668
MOD_SUMO_for_1	168	171	PF00179	0.679
MOD_SUMO_rev_2	189	197	PF00179	0.491
TRG_ENDOCYTIC_2	252	255	PF00928	0.373
TRG_ER_diArg_1	207	209	PF00400	0.601
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B6	Leptomonas seymouri	67%	97%
A0A1X0NKM4	Trypanosomatidae	42%	98%
A0A3S7WPG5	Leishmania donovani	92%	100%
A0A422NGX7	Trypanosoma rangeli	41%	100%
A4H4L9	Leishmania braziliensis	78%	95%
A4HSU5	Leishmania infantum	92%	100%
C9ZTF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AKT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B7V6	Trypanosoma cruzi	44%	100%