Basic immunoglobulin-like variable motif-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ24_LEIMA

TriTrypDb:

LmjF.06.0540 , LMJLV39_060011100 , LMJSD75_060011100

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	634	638	PF00656	0.694
CLV_C14_Caspase3-7	70	74	PF00656	0.804
CLV_C14_Caspase3-7	750	754	PF00656	0.699
CLV_NRD_NRD_1	118	120	PF00675	0.796
CLV_NRD_NRD_1	395	397	PF00675	0.658
CLV_NRD_NRD_1	424	426	PF00675	0.749
CLV_PCSK_KEX2_1	424	426	PF00082	0.749
CLV_PCSK_SKI1_1	119	123	PF00082	0.784
CLV_PCSK_SKI1_1	212	216	PF00082	0.426
CLV_PCSK_SKI1_1	332	336	PF00082	0.605
CLV_PCSK_SKI1_1	575	579	PF00082	0.748
CLV_PCSK_SKI1_1	62	66	PF00082	0.684
DEG_COP1_1	86	96	PF00400	0.647
DEG_SCF_FBW7_1	1	6	PF00400	0.720
DEG_SCF_FBW7_1	568	573	PF00400	0.649
DEG_SPOP_SBC_1	665	669	PF00917	0.893
DOC_CKS1_1	187	192	PF01111	0.544
DOC_CYCLIN_RxL_1	742	753	PF00134	0.742
DOC_CYCLIN_yCln2_LP_2	559	565	PF00134	0.890
DOC_PP2B_LxvP_1	215	218	PF13499	0.647
DOC_PP4_FxxP_1	270	273	PF00568	0.647
DOC_PP4_FxxP_1	366	369	PF00568	0.680
DOC_PP4_FxxP_1	582	585	PF00568	0.751
DOC_USP7_MATH_1	14	18	PF00917	0.643
DOC_USP7_MATH_1	176	180	PF00917	0.722
DOC_USP7_MATH_1	3	7	PF00917	0.791
DOC_USP7_MATH_1	311	315	PF00917	0.560
DOC_USP7_MATH_1	427	431	PF00917	0.665
DOC_USP7_MATH_1	51	55	PF00917	0.744
DOC_USP7_MATH_1	528	532	PF00917	0.818
DOC_USP7_MATH_1	546	550	PF00917	0.585
DOC_USP7_MATH_1	570	574	PF00917	0.688
DOC_USP7_MATH_1	583	587	PF00917	0.510
DOC_USP7_MATH_1	589	593	PF00917	0.671
DOC_USP7_MATH_1	627	631	PF00917	0.861
DOC_USP7_MATH_1	647	651	PF00917	0.538
DOC_USP7_MATH_1	654	658	PF00917	0.757
DOC_USP7_MATH_1	659	663	PF00917	0.674
DOC_USP7_MATH_1	665	669	PF00917	0.598
DOC_USP7_MATH_1	69	73	PF00917	0.625
DOC_USP7_MATH_1	691	695	PF00917	0.881
DOC_USP7_MATH_1	700	704	PF00917	0.717
DOC_USP7_UBL2_3	120	124	PF12436	0.783
DOC_USP7_UBL2_3	428	432	PF12436	0.844
DOC_WW_Pin1_4	177	182	PF00397	0.781
DOC_WW_Pin1_4	186	191	PF00397	0.603
DOC_WW_Pin1_4	406	411	PF00397	0.664
DOC_WW_Pin1_4	544	549	PF00397	0.840
DOC_WW_Pin1_4	552	557	PF00397	0.707
DOC_WW_Pin1_4	564	569	PF00397	0.685
DOC_WW_Pin1_4	622	627	PF00397	0.805
DOC_WW_Pin1_4	660	665	PF00397	0.853
DOC_WW_Pin1_4	666	671	PF00397	0.799
DOC_WW_Pin1_4	696	701	PF00397	0.831
DOC_WW_Pin1_4	86	91	PF00397	0.743
LIG_14-3-3_CanoR_1	256	265	PF00244	0.542
LIG_14-3-3_CanoR_1	396	405	PF00244	0.514
LIG_14-3-3_CanoR_1	484	490	PF00244	0.693
LIG_14-3-3_CanoR_1	530	540	PF00244	0.785
LIG_14-3-3_CanoR_1	55	63	PF00244	0.680
LIG_14-3-3_CanoR_1	629	634	PF00244	0.791
LIG_14-3-3_CanoR_1	745	750	PF00244	0.876
LIG_APCC_ABBA_1	721	726	PF00400	0.573
LIG_BIR_III_2	48	52	PF00653	0.767
LIG_BIR_III_4	588	592	PF00653	0.681
LIG_BIR_III_4	637	641	PF00653	0.736
LIG_BRCT_BRCA1_1	408	412	PF00533	0.510
LIG_deltaCOP1_diTrp_1	276	282	PF00928	0.652
LIG_FHA_1	166	172	PF00498	0.790
LIG_FHA_1	187	193	PF00498	0.650
LIG_FHA_1	315	321	PF00498	0.510
LIG_FHA_1	323	329	PF00498	0.635
LIG_FHA_1	362	368	PF00498	0.493
LIG_FHA_1	377	383	PF00498	0.563
LIG_FHA_1	461	467	PF00498	0.707
LIG_FHA_1	493	499	PF00498	0.759
LIG_FHA_1	5	11	PF00498	0.796
LIG_FHA_1	545	551	PF00498	0.815
LIG_FHA_1	567	573	PF00498	0.750
LIG_FHA_1	594	600	PF00498	0.641
LIG_FHA_2	120	126	PF00498	0.738
LIG_FHA_2	203	209	PF00498	0.675
LIG_FHA_2	530	536	PF00498	0.870
LIG_FHA_2	615	621	PF00498	0.644
LIG_LIR_Apic_2	364	369	PF02991	0.673
LIG_LIR_Apic_2	581	585	PF02991	0.751
LIG_LIR_Gen_1	238	247	PF02991	0.577
LIG_LIR_Nem_3	238	243	PF02991	0.565
LIG_LIR_Nem_3	271	277	PF02991	0.640
LIG_LIR_Nem_3	409	415	PF02991	0.488
LIG_LIR_Nem_3	741	747	PF02991	0.653
LIG_LYPXL_SIV_4	489	497	PF13949	0.670
LIG_MLH1_MIPbox_1	408	412	PF16413	0.669
LIG_PALB2_WD40_1	287	295	PF16756	0.584
LIG_PCNA_yPIPBox_3	285	297	PF02747	0.593
LIG_PDZ_Class_3	758	763	PF00595	0.764
LIG_Pex14_1	106	110	PF04695	0.781
LIG_Pex14_2	270	274	PF04695	0.637
LIG_PTB_Apo_2	238	245	PF02174	0.570
LIG_PTB_Phospho_1	238	244	PF10480	0.570
LIG_REV1ctd_RIR_1	410	417	PF16727	0.644
LIG_SH2_CRK	240	244	PF00017	0.569
LIG_SH2_CRK	350	354	PF00017	0.578
LIG_SH2_GRB2like	321	324	PF00017	0.571
LIG_SH2_NCK_1	490	494	PF00017	0.668
LIG_SH2_NCK_1	728	732	PF00017	0.712
LIG_SH2_SRC	242	245	PF00017	0.568
LIG_SH2_SRC	29	32	PF00017	0.775
LIG_SH2_SRC	356	359	PF00017	0.605
LIG_SH2_SRC	728	731	PF00017	0.700
LIG_SH2_STAP1	394	398	PF00017	0.642
LIG_SH2_STAP1	490	494	PF00017	0.755
LIG_SH2_STAT5	23	26	PF00017	0.797
LIG_SH2_STAT5	242	245	PF00017	0.568
LIG_SH2_STAT5	29	32	PF00017	0.716
LIG_SH2_STAT5	306	309	PF00017	0.441
LIG_SH3_3	109	115	PF00018	0.648
LIG_SH3_3	175	181	PF00018	0.721
LIG_SH3_3	366	372	PF00018	0.548
LIG_SH3_3	468	474	PF00018	0.782
LIG_SH3_3	545	551	PF00018	0.854
LIG_SH3_3	574	580	PF00018	0.739
LIG_SH3_3	655	661	PF00018	0.700
LIG_SH3_3	8	14	PF00018	0.752
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.707
LIG_SUMO_SIM_par_1	494	501	PF11976	0.671
LIG_TRAF2_1	260	263	PF00917	0.641
LIG_TRAF2_1	605	608	PF00917	0.687
LIG_TRAF2_1	617	620	PF00917	0.801
LIG_TRAF2_1	738	741	PF00917	0.639
LIG_TYR_ITIM	354	359	PF00017	0.594
LIG_WRC_WIRS_1	107	112	PF05994	0.552
MOD_CDC14_SPxK_1	699	702	PF00782	0.801
MOD_CDK_SPK_2	666	671	PF00069	0.806
MOD_CDK_SPK_2	86	91	PF00069	0.743
MOD_CDK_SPxK_1	696	702	PF00069	0.809
MOD_CDK_SPxxK_3	622	629	PF00069	0.717
MOD_CDK_SPxxK_3	666	673	PF00069	0.804
MOD_CK1_1	235	241	PF00069	0.471
MOD_CK1_1	314	320	PF00069	0.665
MOD_CK1_1	507	513	PF00069	0.799
MOD_CK1_1	531	537	PF00069	0.697
MOD_CK1_1	54	60	PF00069	0.723
MOD_CK1_1	549	555	PF00069	0.765
MOD_CK1_1	564	570	PF00069	0.745
MOD_CK1_1	625	631	PF00069	0.687
MOD_CK1_1	748	754	PF00069	0.734
MOD_CK1_1	755	761	PF00069	0.682
MOD_CK2_1	119	125	PF00069	0.782
MOD_CK2_1	257	263	PF00069	0.599
MOD_CK2_1	427	433	PF00069	0.717
MOD_CK2_1	54	60	PF00069	0.824
MOD_CK2_1	614	620	PF00069	0.644
MOD_CK2_1	647	653	PF00069	0.847
MOD_GlcNHglycan	16	19	PF01048	0.817
MOD_GlcNHglycan	173	176	PF01048	0.750
MOD_GlcNHglycan	249	252	PF01048	0.641
MOD_GlcNHglycan	313	316	PF01048	0.663
MOD_GlcNHglycan	40	43	PF01048	0.756
MOD_GlcNHglycan	486	489	PF01048	0.827
MOD_GlcNHglycan	490	493	PF01048	0.803
MOD_GlcNHglycan	506	509	PF01048	0.569
MOD_GlcNHglycan	551	554	PF01048	0.676
MOD_GlcNHglycan	57	60	PF01048	0.624
MOD_GlcNHglycan	584	588	PF01048	0.833
MOD_GlcNHglycan	619	623	PF01048	0.716
MOD_GlcNHglycan	629	632	PF01048	0.791
MOD_GlcNHglycan	750	753	PF01048	0.653
MOD_GSK3_1	115	122	PF00069	0.648
MOD_GSK3_1	142	149	PF00069	0.816
MOD_GSK3_1	158	165	PF00069	0.512
MOD_GSK3_1	197	204	PF00069	0.563
MOD_GSK3_1	280	287	PF00069	0.636
MOD_GSK3_1	30	37	PF00069	0.659
MOD_GSK3_1	371	378	PF00069	0.481
MOD_GSK3_1	445	452	PF00069	0.841
MOD_GSK3_1	484	491	PF00069	0.864
MOD_GSK3_1	51	58	PF00069	0.873
MOD_GSK3_1	529	536	PF00069	0.722
MOD_GSK3_1	566	573	PF00069	0.742
MOD_GSK3_1	589	596	PF00069	0.684
MOD_GSK3_1	614	621	PF00069	0.714
MOD_GSK3_1	625	632	PF00069	0.692
MOD_GSK3_1	65	72	PF00069	0.722
MOD_GSK3_1	660	667	PF00069	0.820
MOD_GSK3_1	696	703	PF00069	0.746
MOD_GSK3_1	743	750	PF00069	0.739
MOD_N-GLC_1	284	289	PF02516	0.599
MOD_N-GLC_1	322	327	PF02516	0.651
MOD_N-GLC_1	4	9	PF02516	0.827
MOD_N-GLC_1	753	758	PF02516	0.785
MOD_N-GLC_2	679	681	PF02516	0.746
MOD_NEK2_1	221	226	PF00069	0.535
MOD_NEK2_1	247	252	PF00069	0.496
MOD_NEK2_1	4	9	PF00069	0.705
MOD_NEK2_1	497	502	PF00069	0.718
MOD_NEK2_1	563	568	PF00069	0.752
MOD_NEK2_1	743	748	PF00069	0.654
MOD_NEK2_2	376	381	PF00069	0.626
MOD_NEK2_2	427	432	PF00069	0.661
MOD_NEK2_2	589	594	PF00069	0.718
MOD_PIKK_1	100	106	PF00454	0.799
MOD_PIKK_1	133	139	PF00454	0.713
MOD_PIKK_1	257	263	PF00454	0.599
MOD_PIKK_1	396	402	PF00454	0.628
MOD_PIKK_1	466	472	PF00454	0.717
MOD_PIKK_1	672	678	PF00454	0.789
MOD_PIKK_1	691	697	PF00454	0.810
MOD_PIKK_1	71	77	PF00454	0.886
MOD_PKA_1	119	125	PF00069	0.782
MOD_PKA_1	396	402	PF00069	0.628
MOD_PKA_2	483	489	PF00069	0.699
MOD_PKA_2	529	535	PF00069	0.784
MOD_PKA_2	54	60	PF00069	0.679
MOD_PKB_1	133	141	PF00069	0.806
MOD_Plk_1	284	290	PF00069	0.601
MOD_Plk_1	376	382	PF00069	0.599
MOD_Plk_2-3	125	131	PF00069	0.648
MOD_Plk_4	162	168	PF00069	0.766
MOD_Plk_4	235	241	PF00069	0.488
MOD_Plk_4	242	248	PF00069	0.420
MOD_Plk_4	263	269	PF00069	0.589
MOD_Plk_4	284	290	PF00069	0.601
MOD_Plk_4	376	382	PF00069	0.470
MOD_Plk_4	492	498	PF00069	0.845
MOD_Plk_4	589	595	PF00069	0.700
MOD_ProDKin_1	177	183	PF00069	0.781
MOD_ProDKin_1	186	192	PF00069	0.596
MOD_ProDKin_1	406	412	PF00069	0.658
MOD_ProDKin_1	544	550	PF00069	0.840
MOD_ProDKin_1	552	558	PF00069	0.708
MOD_ProDKin_1	564	570	PF00069	0.682
MOD_ProDKin_1	622	628	PF00069	0.805
MOD_ProDKin_1	660	666	PF00069	0.857
MOD_ProDKin_1	696	702	PF00069	0.829
MOD_ProDKin_1	86	92	PF00069	0.742
MOD_SUMO_rev_2	404	410	PF00179	0.640
TRG_DiLeu_BaEn_3	262	268	PF01217	0.627
TRG_DiLeu_BaEn_4	210	216	PF01217	0.429
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.637
TRG_ENDOCYTIC_2	240	243	PF00928	0.570
TRG_ENDOCYTIC_2	244	247	PF00928	0.534
TRG_ENDOCYTIC_2	356	359	PF00928	0.605
TRG_ER_diArg_1	132	135	PF00400	0.762
TRG_ER_diArg_1	301	304	PF00400	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPG2	Leishmania donovani	88%	88%
A4H4M0	Leishmania braziliensis	60%	90%
E9AG67	Leishmania infantum	89%	78%
E9AKT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%