Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ12_LEIMA

TriTrypDb:

LmjF.06.0660 , LMJLV39_060012400 , LMJSD75_060012300

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.711
CLV_C14_Caspase3-7	201	205	PF00656	0.752
CLV_C14_Caspase3-7	610	614	PF00656	0.763
CLV_NRD_NRD_1	252	254	PF00675	0.824
CLV_NRD_NRD_1	255	257	PF00675	0.766
CLV_NRD_NRD_1	276	278	PF00675	0.735
CLV_NRD_NRD_1	401	403	PF00675	0.757
CLV_NRD_NRD_1	411	413	PF00675	0.713
CLV_NRD_NRD_1	58	60	PF00675	0.717
CLV_PCSK_KEX2_1	11	13	PF00082	0.856
CLV_PCSK_KEX2_1	222	224	PF00082	0.771
CLV_PCSK_KEX2_1	252	254	PF00082	0.824
CLV_PCSK_KEX2_1	401	403	PF00082	0.757
CLV_PCSK_KEX2_1	411	413	PF00082	0.713
CLV_PCSK_KEX2_1	58	60	PF00082	0.717
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.758
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.771
CLV_PCSK_SKI1_1	277	281	PF00082	0.796
CLV_PCSK_SKI1_1	451	455	PF00082	0.693
DEG_SPOP_SBC_1	125	129	PF00917	0.590
DEG_SPOP_SBC_1	240	244	PF00917	0.619
DOC_CKS1_1	384	389	PF01111	0.719
DOC_CYCLIN_RxL_1	448	455	PF00134	0.658
DOC_MAPK_FxFP_2	676	679	PF00069	0.666
DOC_MAPK_MEF2A_6	555	564	PF00069	0.721
DOC_PP2B_LxvP_1	308	311	PF13499	0.710
DOC_PP2B_LxvP_1	562	565	PF13499	0.711
DOC_PP4_FxxP_1	404	407	PF00568	0.777
DOC_PP4_FxxP_1	676	679	PF00568	0.666
DOC_PP4_MxPP_1	434	437	PF00568	0.755
DOC_USP7_MATH_1	117	121	PF00917	0.656
DOC_USP7_MATH_1	125	129	PF00917	0.656
DOC_USP7_MATH_1	18	22	PF00917	0.787
DOC_USP7_MATH_1	212	216	PF00917	0.751
DOC_USP7_MATH_1	240	244	PF00917	0.835
DOC_USP7_MATH_1	325	329	PF00917	0.814
DOC_USP7_MATH_1	33	37	PF00917	0.643
DOC_USP7_MATH_1	330	334	PF00917	0.775
DOC_USP7_MATH_1	47	51	PF00917	0.627
DOC_USP7_MATH_1	497	501	PF00917	0.676
DOC_USP7_MATH_1	513	517	PF00917	0.639
DOC_USP7_MATH_1	539	543	PF00917	0.633
DOC_USP7_MATH_1	549	553	PF00917	0.558
DOC_USP7_MATH_1	617	621	PF00917	0.783
DOC_USP7_MATH_1	90	94	PF00917	0.846
DOC_USP7_MATH_1	98	102	PF00917	0.607
DOC_USP7_UBL2_3	7	11	PF12436	0.718
DOC_WW_Pin1_4	131	136	PF00397	0.737
DOC_WW_Pin1_4	206	211	PF00397	0.785
DOC_WW_Pin1_4	222	227	PF00397	0.600
DOC_WW_Pin1_4	245	250	PF00397	0.641
DOC_WW_Pin1_4	261	266	PF00397	0.548
DOC_WW_Pin1_4	295	300	PF00397	0.728
DOC_WW_Pin1_4	321	326	PF00397	0.810
DOC_WW_Pin1_4	383	388	PF00397	0.729
DOC_WW_Pin1_4	403	408	PF00397	0.593
DOC_WW_Pin1_4	52	57	PF00397	0.678
DOC_WW_Pin1_4	581	586	PF00397	0.596
DOC_WW_Pin1_4	60	65	PF00397	0.723
LIG_14-3-3_CanoR_1	126	135	PF00244	0.656
LIG_14-3-3_CanoR_1	281	290	PF00244	0.687
LIG_14-3-3_CanoR_1	411	417	PF00244	0.677
LIG_14-3-3_CanoR_1	425	435	PF00244	0.686
LIG_14-3-3_CanoR_1	517	527	PF00244	0.610
LIG_BRCT_BRCA1_1	672	676	PF00533	0.648
LIG_CSL_BTD_1	132	135	PF09270	0.738
LIG_FHA_1	197	203	PF00498	0.859
LIG_FHA_1	206	212	PF00498	0.701
LIG_FHA_1	33	39	PF00498	0.773
LIG_FHA_1	436	442	PF00498	0.760
LIG_FHA_1	464	470	PF00498	0.727
LIG_FHA_1	472	478	PF00498	0.641
LIG_FHA_1	651	657	PF00498	0.680
LIG_FHA_2	132	138	PF00498	0.744
LIG_FHA_2	199	205	PF00498	0.751
LIG_FHA_2	359	365	PF00498	0.749
LIG_FHA_2	644	650	PF00498	0.680
LIG_FHA_2	94	100	PF00498	0.733
LIG_LIR_Apic_2	431	436	PF02991	0.777
LIG_LIR_Apic_2	673	679	PF02991	0.657
LIG_LIR_Gen_1	386	396	PF02991	0.600
LIG_LIR_Nem_3	386	391	PF02991	0.601
LIG_LIR_Nem_3	618	624	PF02991	0.710
LIG_Pex14_1	400	404	PF04695	0.778
LIG_SH2_CRK	388	392	PF00017	0.601
LIG_SH2_CRK	433	437	PF00017	0.593
LIG_SH2_CRK	621	625	PF00017	0.710
LIG_SH2_NCK_1	414	418	PF00017	0.795
LIG_SH2_SRC	648	651	PF00017	0.691
LIG_SH2_STAT3	630	633	PF00017	0.561
LIG_SH2_STAT5	295	298	PF00017	0.744
LIG_SH2_STAT5	315	318	PF00017	0.614
LIG_SH2_STAT5	414	417	PF00017	0.794
LIG_SH2_STAT5	440	443	PF00017	0.762
LIG_SH2_STAT5	553	556	PF00017	0.589
LIG_SH2_STAT5	634	637	PF00017	0.737
LIG_SH3_3	189	195	PF00018	0.829
LIG_SH3_3	213	219	PF00018	0.747
LIG_SH3_3	293	299	PF00018	0.725
LIG_SH3_3	301	307	PF00018	0.613
LIG_SH3_3	319	325	PF00018	0.563
LIG_SH3_3	342	348	PF00018	0.722
LIG_SH3_3	389	395	PF00018	0.785
LIG_SH3_3	496	502	PF00018	0.676
LIG_SH3_3	509	515	PF00018	0.556
LIG_SH3_3	621	627	PF00018	0.736
LIG_SH3_3	84	90	PF00018	0.821
LIG_SH3_CIN85_PxpxPR_1	247	252	PF14604	0.711
LIG_SH3_CIN85_PxpxPR_1	307	312	PF14604	0.673
LIG_SxIP_EBH_1	401	414	PF03271	0.782
LIG_TRAF2_1	623	626	PF00917	0.706
LIG_TYR_ITIM	619	624	PF00017	0.708
LIG_UBA3_1	458	463	PF00899	0.505
LIG_WW_3	448	452	PF00397	0.728
MOD_CDK_SPK_2	222	227	PF00069	0.791
MOD_CDK_SPK_2	60	65	PF00069	0.720
MOD_CDK_SPxK_1	52	58	PF00069	0.643
MOD_CDK_SPxxK_3	245	252	PF00069	0.637
MOD_CDK_SPxxK_3	52	59	PF00069	0.621
MOD_CK1_1	127	133	PF00069	0.813
MOD_CK1_1	158	164	PF00069	0.779
MOD_CK1_1	225	231	PF00069	0.772
MOD_CK1_1	239	245	PF00069	0.608
MOD_CK1_1	259	265	PF00069	0.606
MOD_CK1_1	328	334	PF00069	0.818
MOD_CK1_1	429	435	PF00069	0.577
MOD_CK1_1	5	11	PF00069	0.714
MOD_CK1_1	521	527	PF00069	0.709
MOD_CK1_1	63	69	PF00069	0.731
MOD_CK1_1	644	650	PF00069	0.680
MOD_CK1_1	93	99	PF00069	0.793
MOD_CK2_1	131	137	PF00069	0.747
MOD_CK2_1	31	37	PF00069	0.606
MOD_CK2_1	358	364	PF00069	0.752
MOD_CK2_1	643	649	PF00069	0.685
MOD_CK2_1	93	99	PF00069	0.797
MOD_GlcNHglycan	20	23	PF01048	0.737
MOD_GlcNHglycan	238	241	PF01048	0.789
MOD_GlcNHglycan	396	399	PF01048	0.664
MOD_GlcNHglycan	428	431	PF01048	0.602
MOD_GlcNHglycan	45	48	PF01048	0.737
MOD_GlcNHglycan	49	52	PF01048	0.743
MOD_GlcNHglycan	490	493	PF01048	0.724
MOD_GlcNHglycan	532	535	PF01048	0.745
MOD_GlcNHglycan	541	544	PF01048	0.575
MOD_GlcNHglycan	615	618	PF01048	0.724
MOD_GlcNHglycan	649	653	PF01048	0.576
MOD_GSK3_1	125	132	PF00069	0.788
MOD_GSK3_1	172	179	PF00069	0.796
MOD_GSK3_1	235	242	PF00069	0.754
MOD_GSK3_1	252	259	PF00069	0.611
MOD_GSK3_1	260	267	PF00069	0.669
MOD_GSK3_1	268	275	PF00069	0.573
MOD_GSK3_1	321	328	PF00069	0.821
MOD_GSK3_1	358	365	PF00069	0.730
MOD_GSK3_1	43	50	PF00069	0.805
MOD_GSK3_1	458	465	PF00069	0.691
MOD_GSK3_1	521	528	PF00069	0.678
MOD_GSK3_1	539	546	PF00069	0.538
MOD_GSK3_1	613	620	PF00069	0.685
MOD_GSK3_1	644	651	PF00069	0.693
MOD_GSK3_1	90	97	PF00069	0.743
MOD_N-GLC_1	158	163	PF02516	0.605
MOD_N-GLC_1	601	606	PF02516	0.683
MOD_NEK2_1	329	334	PF00069	0.602
MOD_NEK2_1	458	463	PF00069	0.621
MOD_NEK2_1	530	535	PF00069	0.712
MOD_NEK2_1	554	559	PF00069	0.643
MOD_NEK2_2	671	676	PF00069	0.543
MOD_NEK2_2	98	103	PF00069	0.650
MOD_NMyristoyl	1	7	PF02799	0.833
MOD_PIKK_1	147	153	PF00454	0.705
MOD_PIKK_1	172	178	PF00454	0.750
MOD_PIKK_1	181	187	PF00454	0.665
MOD_PIKK_1	268	274	PF00454	0.681
MOD_PIKK_1	365	371	PF00454	0.588
MOD_PIKK_1	386	392	PF00454	0.745
MOD_PIKK_1	554	560	PF00454	0.742
MOD_PIKK_1	91	97	PF00454	0.726
MOD_PK_1	256	262	PF00069	0.845
MOD_PK_1	378	384	PF00069	0.564
MOD_PKA_1	252	258	PF00069	0.811
MOD_PKA_2	125	131	PF00069	0.650
MOD_PKA_2	252	258	PF00069	0.841
MOD_PKA_2	268	274	PF00069	0.586
MOD_PKA_2	280	286	PF00069	0.575
MOD_PKA_2	335	341	PF00069	0.564
MOD_PKA_2	362	368	PF00069	0.738
MOD_PKA_2	377	383	PF00069	0.580
MOD_PKA_2	426	432	PF00069	0.799
MOD_PKA_2	554	560	PF00069	0.724
MOD_Plk_1	378	384	PF00069	0.564
MOD_Plk_1	617	623	PF00069	0.701
MOD_Plk_1	641	647	PF00069	0.673
MOD_Plk_1	98	104	PF00069	0.769
MOD_Plk_4	429	435	PF00069	0.771
MOD_Plk_4	549	555	PF00069	0.588
MOD_Plk_4	671	677	PF00069	0.545
MOD_ProDKin_1	131	137	PF00069	0.736
MOD_ProDKin_1	206	212	PF00069	0.783
MOD_ProDKin_1	222	228	PF00069	0.601
MOD_ProDKin_1	245	251	PF00069	0.637
MOD_ProDKin_1	261	267	PF00069	0.549
MOD_ProDKin_1	295	301	PF00069	0.727
MOD_ProDKin_1	321	327	PF00069	0.808
MOD_ProDKin_1	383	389	PF00069	0.727
MOD_ProDKin_1	403	409	PF00069	0.698
MOD_ProDKin_1	52	58	PF00069	0.678
MOD_ProDKin_1	581	587	PF00069	0.599
MOD_ProDKin_1	60	66	PF00069	0.723
MOD_SUMO_for_1	221	224	PF00179	0.701
MOD_SUMO_rev_2	157	166	PF00179	0.712
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.661
TRG_DiLeu_BaLyEn_6	465	470	PF01217	0.471
TRG_ENDOCYTIC_2	388	391	PF00928	0.603
TRG_ENDOCYTIC_2	621	624	PF00928	0.709
TRG_ER_diArg_1	251	253	PF00400	0.820
TRG_ER_diArg_1	400	402	PF00400	0.745
TRG_ER_diArg_1	410	412	PF00400	0.682
TRG_ER_diArg_1	425	428	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.749
TRG_Pf-PMV_PEXEL_1	374	379	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5R7	Leishmania donovani	86%	100%
A4H4N1	Leishmania braziliensis	45%	100%
A4HSV7	Leishmania infantum	86%	100%
E9AKU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%